JP2018513683A5 - - Google Patents
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- JP2018513683A5 JP2018513683A5 JP2017552483A JP2017552483A JP2018513683A5 JP 2018513683 A5 JP2018513683 A5 JP 2018513683A5 JP 2017552483 A JP2017552483 A JP 2017552483A JP 2017552483 A JP2017552483 A JP 2017552483A JP 2018513683 A5 JP2018513683 A5 JP 2018513683A5
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- Japan
- Prior art keywords
- human
- polypeptide
- endogenous
- mhc
- chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 225
- 229920001184 polypeptide Polymers 0.000 claims description 221
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 221
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 91
- 108091008874 T cell receptors Proteins 0.000 claims description 89
- 239000002773 nucleotide Substances 0.000 claims description 84
- 125000003729 nucleotide group Chemical group 0.000 claims description 84
- 150000007523 nucleic acids Chemical group 0.000 claims description 80
- 230000001086 cytosolic effect Effects 0.000 claims description 57
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 55
- 108090000623 proteins and genes Proteins 0.000 claims description 54
- 210000004027 cell Anatomy 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 40
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 39
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims description 29
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 28
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 27
- 230000001105 regulatory effect Effects 0.000 claims description 24
- 239000000427 antigen Substances 0.000 claims description 23
- 108091007433 antigens Proteins 0.000 claims description 23
- 102000036639 antigens Human genes 0.000 claims description 23
- 108020004707 nucleic acids Proteins 0.000 claims description 21
- 102000039446 nucleic acids Human genes 0.000 claims description 21
- 101000937544 Homo sapiens Beta-2-microglobulin Proteins 0.000 claims description 13
- 241001465754 Metazoa Species 0.000 claims description 12
- 239000013604 expression vector Substances 0.000 claims description 12
- 102000047279 human B2M Human genes 0.000 claims description 9
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 8
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 8
- 230000006801 homologous recombination Effects 0.000 claims description 8
- 238000002744 homologous recombination Methods 0.000 claims description 8
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108091026890 Coding region Proteins 0.000 claims description 4
- 101000986086 Homo sapiens HLA class I histocompatibility antigen, A alpha chain Proteins 0.000 claims description 4
- GTJASUYQSYEAFD-NPRBSQQLSA-N 102643-50-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N)[C@@H](C)O)C1=CC=CC=C1 GTJASUYQSYEAFD-NPRBSQQLSA-N 0.000 claims description 3
- 108010010378 HLA-DP Antigens Proteins 0.000 claims description 3
- 102000015789 HLA-DP Antigens Human genes 0.000 claims description 3
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 241000283984 Rodentia Species 0.000 claims description 3
- 108010050138 synthetic joining segment peptide Proteins 0.000 claims description 3
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims description 2
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims description 2
- 101000986087 Homo sapiens HLA class I histocompatibility antigen, B alpha chain Proteins 0.000 claims description 2
- 101000986084 Homo sapiens HLA class I histocompatibility antigen, C alpha chain Proteins 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 210000004602 germ cell Anatomy 0.000 claims description 2
- 210000004408 hybridoma Anatomy 0.000 claims description 2
- 230000003612 virological effect Effects 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 14
- 230000003796 beauty Effects 0.000 claims 5
- 108700005092 MHC Class II Genes Proteins 0.000 claims 2
- 102000043129 MHC class I family Human genes 0.000 claims 2
- 108091054437 MHC class I family Proteins 0.000 claims 2
- 102000043131 MHC class II family Human genes 0.000 claims 2
- 108091054438 MHC class II family Proteins 0.000 claims 2
- 101100096028 Mus musculus Smok1 gene Proteins 0.000 claims 2
- 108700031361 Brachyury Proteins 0.000 claims 1
- 108010051539 HLA-DR2 Antigen Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000003918 fraction a Anatomy 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
- 230000006269 (delayed) early viral mRNA transcription Effects 0.000 description 4
- 101100263837 Bovine ephemeral fever virus (strain BB7721) beta gene Proteins 0.000 description 2
- 101100316840 Enterobacteria phage P4 Beta gene Proteins 0.000 description 2
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 2
- 108010075704 HLA-A Antigens Proteins 0.000 description 2
- 108010053491 HLA-DR beta-Chains Proteins 0.000 description 2
- 101150087698 alpha gene Proteins 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 108010086786 HLA-DQA1 antigen Proteins 0.000 description 1
- 108010067802 HLA-DR alpha-Chains Proteins 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 102000048974 human HLA-B Human genes 0.000 description 1
- 230000006303 immediate early viral mRNA transcription Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 108700043516 mouse H-2Kb Proteins 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143687P | 2015-04-06 | 2015-04-06 | |
| US62/143,687 | 2015-04-06 | ||
| US201562158804P | 2015-05-08 | 2015-05-08 | |
| US62/158,804 | 2015-05-08 | ||
| US201562186935P | 2015-06-30 | 2015-06-30 | |
| US62/186,935 | 2015-06-30 | ||
| PCT/US2016/026260 WO2016164492A2 (en) | 2015-04-06 | 2016-04-06 | Humanized t cell mediated immune responses in non-human animals |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020085069A Division JP2020115896A (ja) | 2015-04-06 | 2020-05-14 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513683A JP2018513683A (ja) | 2018-05-31 |
| JP2018513683A5 true JP2018513683A5 (cg-RX-API-DMAC7.html) | 2019-05-23 |
| JP6796597B2 JP6796597B2 (ja) | 2020-12-09 |
Family
ID=56926255
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552483A Active JP6796597B2 (ja) | 2015-04-06 | 2016-04-06 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2020085069A Withdrawn JP2020115896A (ja) | 2015-04-06 | 2020-05-14 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2022122754A Withdrawn JP2022140609A (ja) | 2015-04-06 | 2022-08-01 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2023179453A Active JP7763820B2 (ja) | 2015-04-06 | 2023-10-18 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2024114035A Active JP7555515B1 (ja) | 2015-04-06 | 2024-07-17 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020085069A Withdrawn JP2020115896A (ja) | 2015-04-06 | 2020-05-14 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2022122754A Withdrawn JP2022140609A (ja) | 2015-04-06 | 2022-08-01 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2023179453A Active JP7763820B2 (ja) | 2015-04-06 | 2023-10-18 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
| JP2024114035A Active JP7555515B1 (ja) | 2015-04-06 | 2024-07-17 | 非ヒト動物におけるヒト化ｔ細胞媒介性免疫応答 |
Country Status (24)
Families Citing this family (37)
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| IN2014CN03890A (cg-RX-API-DMAC7.html) | 2011-10-28 | 2015-10-16 | Regeneron Pharma | |
| LT3262932T (lt) | 2011-10-28 | 2019-08-26 | Regeneron Pharmaceuticals, Inc. | Pelės su genetiškai modifikuotu pagrindiniu histosuderinamumo kompleksu |
| SMT201900429T1 (it) | 2013-02-20 | 2019-09-09 | Regeneron Pharma | Topi esprimenti co-recettori umanizzati linfociti t |
| EP2958937B1 (en) | 2013-02-22 | 2018-08-15 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| LT3376857T (lt) | 2015-11-20 | 2021-06-25 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, ne žmonės, turintys humanizuotą limfocitų aktyvavimo geną |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| EP3462853B1 (en) | 2016-06-03 | 2023-03-01 | Regeneron Pharmaceuticals, Inc. | Rodents expressing exogenous terminal deoxynucleotidyltransferase |
| WO2019067875A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE |
| IL273828B2 (en) * | 2017-10-19 | 2024-06-01 | Cellectis Sa | Targeted gene integration of nk inhibitors genes for improved immune cells therapy |
| AU2018375796B2 (en) | 2017-11-30 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TRKB locus |
| US11747340B2 (en) | 2018-03-24 | 2023-09-05 | Regeneron Pharmaceuticals, Inc. | Systems and methods for identifying HLA-associated tumor peptides |
| AU2019242586B2 (en) | 2018-03-26 | 2025-09-11 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
| PL3823443T3 (pl) | 2018-07-16 | 2024-09-23 | Regeneron Pharmaceuticals, Inc. | Modele gryzoni z chorobą ditra i ich zastosowania |
| JP7569313B2 (ja) | 2018-10-23 | 2024-10-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｎｙ－ｅｓｏ－１ ｔ細胞受容体およびそれらの使用の方法 |
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| IL286905B2 (en) | 2019-04-04 | 2024-06-01 | Regeneron Pharma | Non-human animals containing the human coagulation factor 12 locus |
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| SG11202111256XA (en) | 2019-06-07 | 2021-11-29 | Regeneron Pharma | Non-human animals comprising a humanized albumin locus |
| EP4041868A1 (en) * | 2019-10-03 | 2022-08-17 | Regeneron Pharmaceuticals, Inc. | High-throughput method to screen cognate t cell and epitope reactivities in primary human cells |
| IL294988A (en) | 2020-01-24 | 2022-09-01 | Regeneron Pharma | Antigen preferentially expressed in melanoma t-cell receptors (prame) and methods of using them |
| AU2022249328A1 (en) * | 2021-03-31 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire |
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| CN113999873B (zh) * | 2021-12-31 | 2022-05-20 | 北京市疾病预防控制中心 | 一种基因修饰的非人动物的构建方法及其应用 |
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| KR20250077529A (ko) * | 2022-09-22 | 2025-05-30 | 리제너론 파아마슈티컬스, 인크. | 인간 세포 면역계의 성분을 발현하는, 유전자적으로 변형된 마우스 |
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| TW202520975A (zh) * | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
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