JP2014532411A5 - - Google Patents
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- Publication number
- JP2014532411A5 JP2014532411A5 JP2014539027A JP2014539027A JP2014532411A5 JP 2014532411 A5 JP2014532411 A5 JP 2014532411A5 JP 2014539027 A JP2014539027 A JP 2014539027A JP 2014539027 A JP2014539027 A JP 2014539027A JP 2014532411 A5 JP2014532411 A5 JP 2014532411A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide
- mhc
- chimeric
- hla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 175
- 229920001184 polypeptide Polymers 0.000 claims description 174
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 174
- 241000283984 Rodentia Species 0.000 claims description 64
- 239000002773 nucleotide Substances 0.000 claims description 34
- 125000003729 nucleotide group Chemical group 0.000 claims description 34
- 241001465754 Metazoa Species 0.000 claims description 33
- 230000001086 cytosolic effect Effects 0.000 claims description 22
- 108090000623 proteins and genes Proteins 0.000 claims description 19
- 102000004169 proteins and genes Human genes 0.000 claims description 19
- 230000001105 regulatory effect Effects 0.000 claims description 18
- 108010046732 HLA-DR4 Antigen Proteins 0.000 claims description 16
- 108010010378 HLA-DP Antigens Proteins 0.000 claims description 12
- 102000015789 HLA-DP Antigens Human genes 0.000 claims description 12
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims description 12
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 12
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 12
- 101100263837 Bovine ephemeral fever virus (strain BB7721) beta gene Proteins 0.000 claims description 3
- 101100316840 Enterobacteria phage P4 Beta gene Proteins 0.000 claims description 3
- 101150087698 alpha gene Proteins 0.000 claims description 3
- 101150062179 II gene Proteins 0.000 claims description 2
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims description 2
- 210000001161 mammalian embryo Anatomy 0.000 claims description 2
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 13
- 241001529936 Murinae Species 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 102000043131 MHC class II family Human genes 0.000 claims 2
- 108091054438 MHC class II family Proteins 0.000 claims 2
- 230000006269 (delayed) early viral mRNA transcription Effects 0.000 claims 1
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 230000006303 immediate early viral mRNA transcription Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161552584P | 2011-10-28 | 2011-10-28 | |
| US61/552,584 | 2011-10-28 | ||
| PCT/US2012/062029 WO2013063340A1 (en) | 2011-10-28 | 2012-10-26 | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017157497A Division JP6652529B2 (ja) | 2011-10-28 | 2017-08-17 | キメラ主要組織適合複合体（ｍｈｃ）ｉｉ分子を発現する遺伝子改変されたマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532411A JP2014532411A (ja) | 2014-12-08 |
| JP2014532411A5 true JP2014532411A5 (cg-RX-API-DMAC7.html) | 2015-12-17 |
| JP6285361B2 JP6285361B2 (ja) | 2018-02-28 |
Family
ID=47430036
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539027A Active JP6285361B2 (ja) | 2011-10-28 | 2012-10-26 | キメラ主要組織適合複合体（ｍｈｃ）ｉｉ分子を発現する遺伝子改変されたマウス |
| JP2017157497A Active JP6652529B2 (ja) | 2011-10-28 | 2017-08-17 | キメラ主要組織適合複合体（ｍｈｃ）ｉｉ分子を発現する遺伝子改変されたマウス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017157497A Active JP6652529B2 (ja) | 2011-10-28 | 2017-08-17 | キメラ主要組織適合複合体（ｍｈｃ）ｉｉ分子を発現する遺伝子改変されたマウス |
Country Status (25)
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2065730A3 (en) | 2006-04-26 | 2012-09-19 | L-3 Communications Security and Detection Systems, Inc. | Multi-source surveillance systems |
| WO2013063556A1 (en) | 2011-10-28 | 2013-05-02 | Regeneron Pharmaceuticals, Inc. | Humanized il-6 and il-6 receptor |
| LT3590332T (lt) | 2011-10-28 | 2022-08-10 | Regeneron Pharmaceuticals, Inc. | Genetiškai modifikuotos pelės, ekspresuojančios chimerines pagrindinio audinių dermės komplekso (mhc) ii molekules |
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| SMT201900429T1 (it) | 2013-02-20 | 2019-09-09 | Regeneron Pharma | Topi esprimenti co-recettori umanizzati linfociti t |
| EP2958937B1 (en) * | 2013-02-22 | 2018-08-15 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| JP6456350B2 (ja) * | 2013-03-11 | 2019-01-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ主要組織適合複合体（ｍｈｃ）クラスｉｉ分子を発現する遺伝子導入マウス |
| DK4269430T3 (da) | 2013-09-23 | 2025-08-18 | Regeneron Pharma | Ikke-menneskelige dyr, der har et humaniseret signalregulerende proteingen |
| SI3138397T1 (sl) * | 2013-10-15 | 2019-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizirane živali IL-15 |
| MY183188A (en) | 2013-11-19 | 2021-02-18 | Regeneron Pharma | Non-human animals having a humanized b-cell activating factor gene |
| ES2794942T3 (es) | 2014-04-08 | 2020-11-19 | Regeneron Pharma | Animales no humanos que tienen receptores Fc-gamma humanizados |
| NO2785538T3 (cg-RX-API-DMAC7.html) | 2014-05-07 | 2018-08-04 | ||
| WO2015196051A1 (en) * | 2014-06-19 | 2015-12-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| JP2017529841A (ja) | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ抗原受容体 |
| RS63410B1 (sr) | 2014-11-24 | 2022-08-31 | Regeneron Pharma | Ne-humane životinje koje eksprimiraju humanizovani cd3 kompleks |
| BR112017010490A2 (pt) | 2014-12-05 | 2018-04-03 | Regeneron Pharma | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. |
| LT3230320T (lt) | 2014-12-09 | 2021-01-11 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, išskyrus žmogų, turintys humanizuotą diferenciacijos klasterio 274 geną |
| DK3280257T3 (da) | 2015-04-06 | 2023-09-04 | Regeneron Pharma | Humaniseret T-celle-formidlet immunrespons i ikke-humane dyr |
| LT3376857T (lt) | 2015-11-20 | 2021-06-25 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, ne žmonės, turintys humanizuotą limfocitų aktyvavimo geną |
| CA3012693C (en) * | 2016-02-04 | 2022-08-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| EP3462853B1 (en) | 2016-06-03 | 2023-03-01 | Regeneron Pharmaceuticals, Inc. | Rodents expressing exogenous terminal deoxynucleotidyltransferase |
| AU2018375796B2 (en) | 2017-11-30 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TRKB locus |
| HUE070158T2 (hu) | 2018-03-24 | 2025-05-28 | Regeneron Pharma | Genetikailag módosított egerek vagy patkányok peptid-mhc komplexek elleni terápiás antitestek létrehozásra, ezek elõállítására szolgáló módszerek, valamint alkalmazásuk |
| AU2019242586B2 (en) | 2018-03-26 | 2025-09-11 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
| PL3823443T3 (pl) | 2018-07-16 | 2024-09-23 | Regeneron Pharmaceuticals, Inc. | Modele gryzoni z chorobą ditra i ich zastosowania |
| JP7685249B2 (ja) * | 2019-10-22 | 2025-05-29 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | トランスジェニックブタ、その作製方法と用途、およびヒト免疫系マウスの作製方法 |
| EP4069722A1 (en) | 2019-12-02 | 2022-10-12 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
| AU2022249328A1 (en) | 2021-03-31 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire |
| EP4536836A1 (en) | 2022-06-07 | 2025-04-16 | Regeneron Pharmaceuticals, Inc. | Pseudotyped viral particles for targeting tcr-expressing cells |
| KR20250035053A (ko) | 2022-06-07 | 2025-03-11 | 리제너론 파아마슈티컬스, 인크. | T 세포 활성을 조절하기 위한 다중특이적 분자 및 이의 용도 |
| KR20250077529A (ko) | 2022-09-22 | 2025-05-30 | 리제너론 파아마슈티컬스, 인크. | 인간 세포 면역계의 성분을 발현하는, 유전자적으로 변형된 마우스 |
| WO2024159071A1 (en) | 2023-01-27 | 2024-08-02 | Regeneron Pharmaceuticals, Inc. | Modified rhabdovirus glycoproteins and uses thereof |
| WO2025064470A1 (en) | 2023-09-19 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Viral peptides and uses thereof |
| WO2025064738A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Dntt 250-258 off-target peptides and uses thereof |
| WO2025064761A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Kras10-18 g12d off-target peptides and uses thereof |
| WO2025136809A2 (en) | 2023-12-19 | 2025-06-26 | Regeneron Pharmaceuticals, Inc. | Foxp3 peptides and uses thereof |
| WO2025178991A1 (en) | 2024-02-21 | 2025-08-28 | Regeneron Pharmaceuticals, Inc. | Splicing factor gene mutation-associated neoantigenic peptides and uses thereof |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
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| LT3590332T (lt) | 2011-10-28 | 2022-08-10 | Regeneron Pharmaceuticals, Inc. | Genetiškai modifikuotos pelės, ekspresuojančios chimerines pagrindinio audinių dermės komplekso (mhc) ii molekules |
| SMT201900429T1 (it) | 2013-02-20 | 2019-09-09 | Regeneron Pharma | Topi esprimenti co-recettori umanizzati linfociti t |
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| DK3280257T3 (da) | 2015-04-06 | 2023-09-04 | Regeneron Pharma | Humaniseret T-celle-formidlet immunrespons i ikke-humane dyr |
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2012
- 2012-10-26 LT LTEP19189533.3T patent/LT3590332T/lt unknown
- 2012-10-26 DK DK19189533.3T patent/DK3590332T3/da active
- 2012-10-26 SG SG10201909638U patent/SG10201909638UA/en unknown
- 2012-10-26 SI SI201231738T patent/SI3272214T1/sl unknown
- 2012-10-26 SI SI201231999T patent/SI3590332T1/sl unknown
- 2012-10-26 MX MX2014004896A patent/MX355726B/es active IP Right Grant
- 2012-10-26 SG SG11201400938UA patent/SG11201400938UA/en unknown
- 2012-10-26 EP EP22152099.2A patent/EP4052572B8/en active Active
- 2012-10-26 ES ES19189533T patent/ES2914374T3/es active Active
- 2012-10-26 ES ES12806199.1T patent/ES2640241T3/es active Active
- 2012-10-26 PT PT191895333T patent/PT3590332T/pt unknown
- 2012-10-26 PL PL19189533T patent/PL3590332T3/pl unknown
- 2012-10-26 SM SM20170437T patent/SMT201700437T1/it unknown
- 2012-10-26 RU RU2014116577A patent/RU2660564C2/ru active
- 2012-10-26 CN CN201810239986.6A patent/CN108401986B/zh active Active
- 2012-10-26 SM SM20220205T patent/SMT202200205T1/it unknown
- 2012-10-26 PL PL17171524T patent/PL3272214T3/pl unknown
- 2012-10-26 RS RS20200224A patent/RS59997B1/sr unknown
- 2012-10-26 RS RS20170897A patent/RS56330B1/sr unknown
- 2012-10-26 BR BR112014009941-3A patent/BR112014009941B1/pt active IP Right Grant
- 2012-10-26 KR KR1020147014315A patent/KR101926442B1/ko active Active
- 2012-10-26 HR HRP20220616TT patent/HRP20220616T1/hr unknown
- 2012-10-26 SM SM20200114T patent/SMT202000114T1/it unknown
- 2012-10-26 PL PL12806199T patent/PL2770822T3/pl unknown
- 2012-10-26 ES ES17171524T patent/ES2774488T3/es active Active
- 2012-10-26 LT LTEP12806199.1T patent/LT2770822T/lt unknown
- 2012-10-26 RS RS20220473A patent/RS63220B1/sr unknown
- 2012-10-26 SG SG10201510056SA patent/SG10201510056SA/en unknown
- 2012-10-26 EP EP19189533.3A patent/EP3590332B1/en active Active
- 2012-10-26 CA CA2852962A patent/CA2852962C/en active Active
- 2012-10-26 DK DK12806199.1T patent/DK2770822T3/en active
- 2012-10-26 WO PCT/US2012/062029 patent/WO2013063340A1/en not_active Ceased
- 2012-10-26 PT PT171715246T patent/PT3272214T/pt unknown
- 2012-10-26 IN IN3892CHN2014 patent/IN2014CN03892A/en unknown
- 2012-10-26 JP JP2014539027A patent/JP6285361B2/ja active Active
- 2012-10-26 MX MX2017013492A patent/MX379060B/es unknown
- 2012-10-26 CN CN201810239690.4A patent/CN108707608A/zh active Pending
- 2012-10-26 LT LTEP17171524.6T patent/LT3272214T/lt unknown
- 2012-10-26 AU AU2012327205A patent/AU2012327205B2/en active Active
- 2012-10-26 PT PT128061991T patent/PT2770822T/pt unknown
- 2012-10-26 HR HRP20171327TT patent/HRP20171327T1/hr unknown
- 2012-10-26 US US13/661,116 patent/US8847005B2/en active Active
- 2012-10-26 KR KR1020187034955A patent/KR102113108B1/ko active Active
- 2012-10-26 EP EP17171524.6A patent/EP3272214B1/en active Active
- 2012-10-26 EP EP12806199.1A patent/EP2770822B9/en active Active
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