JP2016506761A5 - - Google Patents
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- JP2016506761A5 JP2016506761A5 JP2015558224A JP2015558224A JP2016506761A5 JP 2016506761 A5 JP2016506761 A5 JP 2016506761A5 JP 2015558224 A JP2015558224 A JP 2015558224A JP 2015558224 A JP2015558224 A JP 2015558224A JP 2016506761 A5 JP2016506761 A5 JP 2016506761A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide
- mouse
- mhc
- chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 121
- 229920001184 polypeptide Polymers 0.000 claims description 117
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 117
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 39
- 239000002773 nucleotide Substances 0.000 claims description 37
- 125000003729 nucleotide group Chemical group 0.000 claims description 37
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 31
- 241001465754 Metazoa Species 0.000 claims description 19
- 230000001086 cytosolic effect Effects 0.000 claims description 19
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims description 17
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 241000283984 Rodentia Species 0.000 claims description 3
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims description 3
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims description 3
- 210000004602 germ cell Anatomy 0.000 claims description 3
- 150000007523 nucleic acids Chemical group 0.000 claims 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 11
- 241001529936 Murinae Species 0.000 claims 2
- 108700039855 mouse a Proteins 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 70
- 241000699670 Mus sp. Species 0.000 description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361766762P | 2013-02-20 | 2013-02-20 | |
| US61/766,762 | 2013-02-20 | ||
| US201361890915P | 2013-10-15 | 2013-10-15 | |
| US61/890,915 | 2013-10-15 | ||
| PCT/US2014/017395 WO2014130671A1 (en) | 2013-02-20 | 2014-02-20 | Mice expressing humanized t-cell co-receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018100545A Division JP6752842B2 (ja) | 2013-02-20 | 2018-05-25 | ヒト化ｔ細胞補助受容体を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016506761A JP2016506761A (ja) | 2016-03-07 |
| JP2016506761A5 true JP2016506761A5 (cg-RX-API-DMAC7.html) | 2017-03-23 |
| JP6444895B2 JP6444895B2 (ja) | 2018-12-26 |
Family
ID=50236327
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015558224A Active JP6444895B2 (ja) | 2013-02-20 | 2014-02-20 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2018100545A Active JP6752842B2 (ja) | 2013-02-20 | 2018-05-25 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2020138641A Active JP7261772B2 (ja) | 2013-02-20 | 2020-08-19 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2022094953A Pending JP2022121465A (ja) | 2013-02-20 | 2022-06-13 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2023191033A Pending JP2023184695A (ja) | 2013-02-20 | 2023-11-08 | ヒト化ｔ細胞補助受容体を発現するマウス |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018100545A Active JP6752842B2 (ja) | 2013-02-20 | 2018-05-25 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2020138641A Active JP7261772B2 (ja) | 2013-02-20 | 2020-08-19 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2022094953A Pending JP2022121465A (ja) | 2013-02-20 | 2022-06-13 | ヒト化ｔ細胞補助受容体を発現するマウス |
| JP2023191033A Pending JP2023184695A (ja) | 2013-02-20 | 2023-11-08 | ヒト化ｔ細胞補助受容体を発現するマウス |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9848587B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2958938B1 (cg-RX-API-DMAC7.html) |
| JP (5) | JP6444895B2 (cg-RX-API-DMAC7.html) |
| KR (5) | KR102714111B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN105164153B (cg-RX-API-DMAC7.html) |
| AU (4) | AU2014218897C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2900832A1 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1121979T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2958938T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2736052T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20191280T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE045478T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT2958938T (cg-RX-API-DMAC7.html) |
| PL (1) | PL2958938T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2958938T (cg-RX-API-DMAC7.html) |
| RS (1) | RS58962B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2958938T1 (cg-RX-API-DMAC7.html) |
| SM (1) | SMT201900429T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014130671A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9043996B2 (en) | 2011-10-28 | 2015-06-02 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| LT3262932T (lt) | 2011-10-28 | 2019-08-26 | Regeneron Pharmaceuticals, Inc. | Pelės su genetiškai modifikuotu pagrindiniu histosuderinamumo kompleksu |
| LT3590332T (lt) | 2011-10-28 | 2022-08-10 | Regeneron Pharmaceuticals, Inc. | Genetiškai modifikuotos pelės, ekspresuojančios chimerines pagrindinio audinių dermės komplekso (mhc) ii molekules |
| US9591835B2 (en) | 2011-10-28 | 2017-03-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex animals |
| SMT201900429T1 (it) * | 2013-02-20 | 2019-09-09 | Regeneron Pharma | Topi esprimenti co-recettori umanizzati linfociti t |
| EP2958937B1 (en) | 2013-02-22 | 2018-08-15 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| DK4269430T3 (da) | 2013-09-23 | 2025-08-18 | Regeneron Pharma | Ikke-menneskelige dyr, der har et humaniseret signalregulerende proteingen |
| MY183188A (en) | 2013-11-19 | 2021-02-18 | Regeneron Pharma | Non-human animals having a humanized b-cell activating factor gene |
| ES2794942T3 (es) | 2014-04-08 | 2020-11-19 | Regeneron Pharma | Animales no humanos que tienen receptores Fc-gamma humanizados |
| NO2785538T3 (cg-RX-API-DMAC7.html) | 2014-05-07 | 2018-08-04 | ||
| WO2015196051A1 (en) | 2014-06-19 | 2015-12-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| JP2017529841A (ja) | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ抗原受容体 |
| RS63410B1 (sr) * | 2014-11-24 | 2022-08-31 | Regeneron Pharma | Ne-humane životinje koje eksprimiraju humanizovani cd3 kompleks |
| BR112017010490A2 (pt) | 2014-12-05 | 2018-04-03 | Regeneron Pharma | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. |
| LT3230320T (lt) * | 2014-12-09 | 2021-01-11 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, išskyrus žmogų, turintys humanizuotą diferenciacijos klasterio 274 geną |
| DK3280257T3 (da) * | 2015-04-06 | 2023-09-04 | Regeneron Pharma | Humaniseret T-celle-formidlet immunrespons i ikke-humane dyr |
| MA44907A (fr) * | 2015-09-11 | 2018-07-18 | Agenus Inc | Cellules hôtes génétiquement modifiées et leurs procédés d'utilisation |
| LT3376857T (lt) | 2015-11-20 | 2021-06-25 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, ne žmonės, turintys humanizuotą limfocitų aktyvavimo geną |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| WO2017150763A1 (ko) * | 2016-02-29 | 2017-09-08 | (주)메디톡스 | 인간 cd3 발현 동물모델 및 이의 용도 |
| EP3462853B1 (en) | 2016-06-03 | 2023-03-01 | Regeneron Pharmaceuticals, Inc. | Rodents expressing exogenous terminal deoxynucleotidyltransferase |
| AU2018375796B2 (en) | 2017-11-30 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TRKB locus |
| AU2019242586B2 (en) | 2018-03-26 | 2025-09-11 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
| MA52536A (fr) | 2018-04-19 | 2021-02-24 | Baylor College Medicine | Reprogrammation de lymphocytes t cd4 en lymphocytes cd8 cytotoxiques par expression forcée de récepteurs de lymphocytes t restreints à cd8ab et de classe 1 |
| PL3823443T3 (pl) | 2018-07-16 | 2024-09-23 | Regeneron Pharmaceuticals, Inc. | Modele gryzoni z chorobą ditra i ich zastosowania |
| US12234473B2 (en) | 2020-12-31 | 2025-02-25 | Immatics US, Inc. | CD8 polypeptides, compositions, and methods of using thereof |
| AU2022249328A1 (en) | 2021-03-31 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire |
| KR20250077529A (ko) | 2022-09-22 | 2025-05-30 | 리제너론 파아마슈티컬스, 인크. | 인간 세포 면역계의 성분을 발현하는, 유전자적으로 변형된 마우스 |
| TW202520975A (zh) | 2023-08-09 | 2025-06-01 | 英商劍橋企業有限公司 | 基因改造之囓齒動物及囓齒動物細胞以及其等用途 |
| GB2640828A (en) | 2024-04-22 | 2025-11-12 | T Therapeutics Ltd | Methods and products for the generation and identification of T cells and TCRs |
| GB202405657D0 (en) | 2024-04-22 | 2024-06-05 | T Therapeutics Ltd | T cell receptor identification and provision |
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| EP2958937B1 (en) | 2013-02-22 | 2018-08-15 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized major histocompatibility complex |
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| JP6456350B2 (ja) | 2013-03-11 | 2019-01-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ主要組織適合複合体（ｍｈｃ）クラスｉｉ分子を発現する遺伝子導入マウス |
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-
2014
- 2014-02-20 SM SM20190429T patent/SMT201900429T1/it unknown
- 2014-02-20 LT LTEP14708430.5T patent/LT2958938T/lt unknown
- 2014-02-20 RS RS20190870A patent/RS58962B1/sr unknown
- 2014-02-20 ES ES14708430T patent/ES2736052T3/es active Active
- 2014-02-20 EP EP14708430.5A patent/EP2958938B1/en active Active
- 2014-02-20 PL PL14708430T patent/PL2958938T3/pl unknown
- 2014-02-20 KR KR1020237031201A patent/KR102714111B1/ko active Active
- 2014-02-20 KR KR1020247032785A patent/KR20240147707A/ko active Pending
- 2014-02-20 JP JP2015558224A patent/JP6444895B2/ja active Active
- 2014-02-20 WO PCT/US2014/017395 patent/WO2014130671A1/en not_active Ceased
- 2014-02-20 AU AU2014218897A patent/AU2014218897C1/en active Active
- 2014-02-20 HR HRP20191280TT patent/HRP20191280T1/hr unknown
- 2014-02-20 DK DK14708430.5T patent/DK2958938T3/da active
- 2014-02-20 CN CN201480021698.3A patent/CN105164153B/zh active Active
- 2014-02-20 EP EP24155637.2A patent/EP4374690A3/en active Pending
- 2014-02-20 KR KR1020217032326A patent/KR102369454B1/ko active Active
- 2014-02-20 EP EP19159217.9A patent/EP3543253B1/en active Active
- 2014-02-20 ES ES19159217T patent/ES2987445T3/es active Active
- 2014-02-20 CN CN202010208901.5A patent/CN111484999B/zh active Active
- 2014-02-20 US US14/185,301 patent/US9848587B2/en active Active
- 2014-02-20 HU HUE14708430A patent/HUE045478T2/hu unknown
- 2014-02-20 PT PT14708430T patent/PT2958938T/pt unknown
- 2014-02-20 SI SI201431279T patent/SI2958938T1/sl unknown
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