JP2017529340A5 - - Google Patents
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- Publication number
- JP2017529340A5 JP2017529340A5 JP2017511926A JP2017511926A JP2017529340A5 JP 2017529340 A5 JP2017529340 A5 JP 2017529340A5 JP 2017511926 A JP2017511926 A JP 2017511926A JP 2017511926 A JP2017511926 A JP 2017511926A JP 2017529340 A5 JP2017529340 A5 JP 2017529340A5
- Authority
- JP
- Japan
- Prior art keywords
- imidazo
- pyridine
- carbonitrile
- methoxy
- methylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043590P | 2014-08-29 | 2014-08-29 | |
| US62/043,590 | 2014-08-29 | ||
| PCT/US2015/047401 WO2016033440A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529340A JP2017529340A (ja) | 2017-10-05 |
| JP2017529340A5 true JP2017529340A5 (cg-RX-API-DMAC7.html) | 2018-10-11 |
| JP6754353B2 JP6754353B2 (ja) | 2020-09-09 |
Family
ID=55400645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017511926A Active JP6754353B2 (ja) | 2014-08-29 | 2015-08-28 | ハンチントンタンパク質のイメージング用プローブ |
Country Status (20)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015308709B2 (en) | 2014-08-29 | 2020-01-02 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CN107108534B (zh) | 2014-08-29 | 2023-05-09 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| SI3197277T1 (sl) | 2014-08-29 | 2022-04-29 | Chdi Foundation, Inc. | Sonde za slikanje proteina huntingtina |
| CA2959531C (en) | 2014-08-29 | 2023-01-10 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| PL3340796T3 (pl) | 2015-08-28 | 2022-02-21 | Chdi Foundation, Inc. | Sondy do obrazowania białka huntingtyny |
| WO2019075402A1 (en) * | 2017-10-12 | 2019-04-18 | University Of Kansas | METHODS FOR TREATING GASTROINTESTINAL SYNDROME INDUCED BY RADIATION |
| US11389438B2 (en) | 2019-02-25 | 2022-07-19 | Chdi Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| CA3138873C (en) | 2019-05-09 | 2024-01-09 | Kyle Bradley Pascual CLAGG | Synthesis of labeled imidazo[1,2-a]pyrimidines |
| CN114773312B (zh) * | 2021-10-29 | 2024-03-26 | 北京鑫诺康桥药物研究有限公司 | 一种盐酸阿罗洛尔中间体的制备工艺 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10050663A1 (de) * | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
| CA2500358A1 (en) * | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | Probes for diseases in which amyloid accumulates, agents for staining amyloid, drugs for treatment and prophylaxis of diseases with accumulated amyloid, and probes for diagnosis of neurofibrillary tangles and agents for staining neurofibrillary tangles |
| CN101501033B (zh) * | 2006-06-21 | 2012-08-01 | 通用电气医疗有限公司 | 对淀粉状蛋白具有亲和性的化合物 |
| WO2008016648A2 (en) * | 2006-08-01 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions and methods |
| US20090252680A1 (en) * | 2006-11-17 | 2009-10-08 | Nihon- Medi-Physics Co., Ltd | Novel compound with affinity for amyloid |
| CA2670436A1 (en) * | 2006-11-30 | 2008-06-05 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| CA2676214A1 (en) | 2007-01-22 | 2008-07-31 | Astrazeneca Ab | Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives |
| AU2008319986A1 (en) * | 2007-10-30 | 2009-05-07 | Nihon Medi-Physics Co., Ltd. | Use of novel compound having affinity for amyloid, and process for production of the same |
| FR2928923B1 (fr) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| WO2010011964A2 (en) * | 2008-07-24 | 2010-01-28 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying ad pathology |
| JP5667058B2 (ja) | 2008-09-23 | 2015-02-12 | ウィスタ ラボラトリーズ リミテッド | 凝集したタウ分子に対するリガンド |
| WO2010141805A1 (en) * | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of trpa1 |
| CA2836872A1 (en) * | 2011-05-20 | 2012-11-29 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| CA2839199C (en) * | 2011-06-24 | 2018-11-06 | Nihon Medi-Physics Co., Ltd. | Novel compound with amyloid affinity |
| JP2013237655A (ja) | 2012-05-17 | 2013-11-28 | Kyoto Univ | コンフォメーション病診断用分子プローブ |
| MX2015005560A (es) * | 2012-11-14 | 2015-07-23 | Hoffmann La Roche | Derivados de imidazopiridina. |
| HRP20171219T1 (hr) | 2013-03-14 | 2017-11-03 | Galapagos Nv | Spojevi i njihovi farmaceutski pripravci, namijenjeni liječenju upalnih poremećaja |
| JP6182668B2 (ja) | 2013-09-26 | 2017-08-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 画像化ツールとしてのイミダゾ［１，２−ａ］ピリジン−７−アミン |
| CN107108534B (zh) | 2014-08-29 | 2023-05-09 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| CA2959531C (en) | 2014-08-29 | 2023-01-10 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| SI3197277T1 (sl) | 2014-08-29 | 2022-04-29 | Chdi Foundation, Inc. | Sonde za slikanje proteina huntingtina |
| AU2015308709B2 (en) | 2014-08-29 | 2020-01-02 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| PL3340796T3 (pl) | 2015-08-28 | 2022-02-21 | Chdi Foundation, Inc. | Sondy do obrazowania białka huntingtyny |
-
2015
- 2015-08-28 SI SI201531778T patent/SI3197277T1/sl unknown
- 2015-08-28 JP JP2017511926A patent/JP6754353B2/ja active Active
- 2015-08-28 US US15/507,203 patent/US11104691B2/en active Active
- 2015-08-28 BR BR112017004140-5A patent/BR112017004140B1/pt active IP Right Grant
- 2015-08-28 AU AU2015308769A patent/AU2015308769A1/en not_active Abandoned
- 2015-08-28 MX MX2017002702A patent/MX386798B/es unknown
- 2015-08-28 PT PT158362616T patent/PT3197277T/pt unknown
- 2015-08-28 WO PCT/US2015/047401 patent/WO2016033440A1/en not_active Ceased
- 2015-08-28 PL PL15836261T patent/PL3197277T3/pl unknown
- 2015-08-28 CA CA2959533A patent/CA2959533C/en active Active
- 2015-08-28 CN CN201580058314.XA patent/CN107105667B/zh active Active
- 2015-08-28 SG SG11201701592SA patent/SG11201701592SA/en unknown
- 2015-08-28 KR KR1020177007881A patent/KR102410733B1/ko active Active
- 2015-08-28 EA EA201790400A patent/EA039923B1/ru unknown
- 2015-08-28 HU HUE15836261A patent/HUE057702T2/hu unknown
- 2015-08-28 EP EP15836261.6A patent/EP3197277B1/en active Active
- 2015-08-28 DK DK15836261.6T patent/DK3197277T3/da active
- 2015-08-28 ES ES15836261T patent/ES2905095T3/es active Active
- 2015-08-28 HR HRP20220001TT patent/HRP20220001T1/hr unknown
-
2017
- 2017-02-26 IL IL250802A patent/IL250802B/en active IP Right Grant
-
2019
- 2019-12-20 AU AU2019283999A patent/AU2019283999B2/en active Active
-
2021
- 2021-06-21 US US17/353,627 patent/US11851446B2/en active Active
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