JP2017527260A5 - - Google Patents
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- Publication number
- JP2017527260A5 JP2017527260A5 JP2016575345A JP2016575345A JP2017527260A5 JP 2017527260 A5 JP2017527260 A5 JP 2017527260A5 JP 2016575345 A JP2016575345 A JP 2016575345A JP 2016575345 A JP2016575345 A JP 2016575345A JP 2017527260 A5 JP2017527260 A5 JP 2017527260A5
- Authority
- JP
- Japan
- Prior art keywords
- tlr
- aptamer
- complex
- group
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP201430955. | 2014-06-24 | ||
| ES201430955A ES2555160B1 (es) | 2014-06-24 | 2014-06-24 | Aptámeros específicos de TLR-4 y usos de los mismos |
| PCT/EP2015/064277 WO2015197706A1 (en) | 2014-06-24 | 2015-06-24 | Aptamers specific for tlr-4 and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020082070A Division JP2020127422A (ja) | 2014-06-24 | 2020-05-07 | Ｔｌｒ−４特異的アプタマーおよびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527260A JP2017527260A (ja) | 2017-09-21 |
| JP2017527260A5 true JP2017527260A5 (enExample) | 2018-08-02 |
| JP6959738B2 JP6959738B2 (ja) | 2021-11-05 |
Family
ID=53496661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575345A Active JP6959738B2 (ja) | 2014-06-24 | 2015-06-24 | Ｔｌｒ−４特異的アプタマーおよびそれらの使用 |
| JP2020082070A Pending JP2020127422A (ja) | 2014-06-24 | 2020-05-07 | Ｔｌｒ−４特異的アプタマーおよびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020082070A Pending JP2020127422A (ja) | 2014-06-24 | 2020-05-07 | Ｔｌｒ−４特異的アプタマーおよびそれらの使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US10196642B2 (enExample) |
| EP (1) | EP3161139B1 (enExample) |
| JP (2) | JP6959738B2 (enExample) |
| KR (1) | KR102454682B1 (enExample) |
| CN (2) | CN106459980B (enExample) |
| AU (1) | AU2015279248B2 (enExample) |
| BR (1) | BR112016030172B1 (enExample) |
| CA (1) | CA2953020C (enExample) |
| DK (1) | DK3161139T3 (enExample) |
| ES (2) | ES2555160B1 (enExample) |
| MA (1) | MA40283A (enExample) |
| MX (1) | MX387405B (enExample) |
| PL (1) | PL3161139T3 (enExample) |
| PT (1) | PT3161139T (enExample) |
| RU (1) | RU2709718C9 (enExample) |
| SI (1) | SI3161139T1 (enExample) |
| WO (1) | WO2015197706A1 (enExample) |
| ZA (1) | ZA201700363B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10709776B2 (en) * | 2014-04-07 | 2020-07-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for producing outer membrane vesicles |
| ES2555160B1 (es) | 2014-06-24 | 2016-10-25 | Aptus Biotech, S.L. | Aptámeros específicos de TLR-4 y usos de los mismos |
| WO2018014012A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
| EP3494994A1 (en) * | 2017-12-07 | 2019-06-12 | Universität zu Köln | Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| CN113423833B (zh) * | 2018-09-28 | 2024-09-17 | 奥曼尼提纳米有限公司 | 用于选择功能性适体的方法和组合物 |
| US20210322575A1 (en) | 2018-09-28 | 2021-10-21 | Nutcracker Therapeutics, Inc. | Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery |
| WO2020069565A1 (en) | 2018-10-02 | 2020-04-09 | WearOptimo Pty Ltd | Measurement system |
| US12569679B2 (en) | 2018-10-02 | 2026-03-10 | WearOptimo Pty Ltd | Treatment delivery system |
| US12484814B2 (en) | 2018-10-02 | 2025-12-02 | WearOptimo Pty Ltd | Actuator system |
| AU2020276703A1 (en) * | 2019-05-16 | 2021-12-09 | Merck Patent Gmbh | Treatment of TLR-4 mediated diseases and conditions with aptamers targeting TLR-4 |
| CN111474336B (zh) * | 2020-03-21 | 2023-07-28 | 南昌大学 | 一种铁氰化镍纳米粒化学发光适体传感器的制备方法及基于其检测8-OhdG的方法 |
| WO2021257494A1 (en) * | 2020-06-15 | 2021-12-23 | President And Fellows Of Harvard College | Methods for modulating tlr4 signaling |
| CN114152599B (zh) * | 2021-12-01 | 2023-10-13 | 中国农业大学 | 一种基于双劈裂功能核酸变构的孔雀石绿生物传感器 |
| CN114836425A (zh) * | 2022-02-25 | 2022-08-02 | 温州医科大学附属眼视光医院 | 检测小胶质细胞的核酸适体及应用 |
| US20260218202A1 (en) | 2023-01-05 | 2026-07-30 | Merck Patent Gmbh | Aptoll molecules for the treatment of ischemic stroke and intracranial hemorrhages |
| WO2024240750A1 (en) | 2023-05-22 | 2024-11-28 | Aptatargets, S.L. | New tlr-4 antagonist aptamers |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US248517A (en) | 1881-10-18 | Apparatus for transferring wood-graining | ||
| US690786A (en) | 1901-09-21 | 1902-01-07 | Andrew Stenger | Bung. |
| US763130A (en) | 1903-09-05 | 1904-06-21 | Paul Walther | Composition for artificial stone. |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| JPH088933B2 (ja) | 1987-07-10 | 1996-01-31 | 日本ゼオン株式会社 | カテ−テル |
| US5194599A (en) | 1988-09-23 | 1993-03-16 | Gilead Sciences, Inc. | Hydrogen phosphonodithioate compositions |
| US5264562A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences, Inc. | Oligonucleotide analogs with novel linkages |
| WO1992005186A1 (en) | 1990-09-20 | 1992-04-02 | Gilead Sciences | Modified internucleoside linkages |
| JPH117658A (ja) | 1997-04-25 | 1999-01-12 | Sony Corp | 光学記録媒体及び光学ディスク装置 |
| WO2001057259A1 (en) * | 2000-02-03 | 2001-08-09 | Research Development Foundation | Signaling aptamers that transduce molecular recognition to a differential signal |
| US20060257411A1 (en) * | 2005-05-06 | 2006-11-16 | Bruce Beutler | Compositions and methods for modulating cells via CD14 and toll-like receptor 4 signaling pathway |
| CN101227922A (zh) * | 2005-05-06 | 2008-07-23 | 斯克里普斯研究学院 | 经由CD14和Toll样受体4信号传导途径调节细胞的组合物和方法 |
| US20100015125A1 (en) * | 2005-06-17 | 2010-01-21 | University Of Rochester | Methods and compositions for enhancing immune memory by blocking intrahepatic activated t cell deletion |
| FR2892730A1 (fr) * | 2005-10-28 | 2007-05-04 | Biomerieux Sa | Methode pour detecter la presence ou le risque de developper un cancer |
| US20090317802A1 (en) * | 2005-12-09 | 2009-12-24 | Bhatia Sangeeta N | Compositions and Methods to Monitor RNA Delivery to Cells |
| EP1997902B1 (en) * | 2006-03-30 | 2013-09-18 | Hiroshima University | Screening method |
| EA201100811A1 (ru) | 2006-04-03 | 2012-06-29 | Сантарис Фарма А/С | Фармацевтическая композиция |
| US9012410B2 (en) * | 2006-12-13 | 2015-04-21 | Case Western Reserve University | Method of treating intrauterine inflammation |
| US8580756B2 (en) | 2007-03-22 | 2013-11-12 | Santaris Pharma A/S | Short oligomer antagonist compounds for the modulation of target mRNA |
| AU2008285626B2 (en) | 2007-08-03 | 2013-09-12 | Neuramedy Co., Ltd. | Use of TLR-2 antagonists for treatment of reperfusion injury and tissue damage |
| EP2365814A1 (en) * | 2008-11-04 | 2011-09-21 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 4 expression by antisense oligonucleotides |
| WO2010060030A1 (en) | 2008-11-24 | 2010-05-27 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona | Tlr ligand-nucleic acid nanostructure as a novel immune modulatory agent and method of using the same |
| US9034837B2 (en) | 2009-04-24 | 2015-05-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical compositions for treatment of HCV patients that are poor-responders to interferon |
| WO2012038851A1 (en) | 2010-09-24 | 2012-03-29 | Pfizer Inc. | Isoxazoline oximes as antiparasitic agents |
| AU2012223366B2 (en) * | 2011-03-03 | 2017-02-23 | Quark Pharmaceuticals, Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
| EP2681314B1 (en) * | 2011-03-03 | 2017-11-01 | Quark Pharmaceuticals, Inc. | Compositions and methods for treating lung disease and injury |
| ES2555160B1 (es) * | 2014-06-24 | 2016-10-25 | Aptus Biotech, S.L. | Aptámeros específicos de TLR-4 y usos de los mismos |
| WO2020069313A2 (en) | 2018-09-28 | 2020-04-02 | Henry Ford Health System | Use of extracellular vesicles in combination with tissue plasminogen activator and/or thrombectomy to treat stroke |
| AU2020276703A1 (en) | 2019-05-16 | 2021-12-09 | Merck Patent Gmbh | Treatment of TLR-4 mediated diseases and conditions with aptamers targeting TLR-4 |
| US20260218202A1 (en) | 2023-01-05 | 2026-07-30 | Merck Patent Gmbh | Aptoll molecules for the treatment of ischemic stroke and intracranial hemorrhages |
| WO2024240750A1 (en) | 2023-05-22 | 2024-11-28 | Aptatargets, S.L. | New tlr-4 antagonist aptamers |
-
2014
- 2014-06-24 ES ES201430955A patent/ES2555160B1/es not_active Expired - Fee Related
-
2015
- 2015-06-24 DK DK15732619.0T patent/DK3161139T3/da active
- 2015-06-24 JP JP2016575345A patent/JP6959738B2/ja active Active
- 2015-06-24 PT PT157326190T patent/PT3161139T/pt unknown
- 2015-06-24 WO PCT/EP2015/064277 patent/WO2015197706A1/en not_active Ceased
- 2015-06-24 MX MX2016016992A patent/MX387405B/es unknown
- 2015-06-24 AU AU2015279248A patent/AU2015279248B2/en active Active
- 2015-06-24 RU RU2016152094A patent/RU2709718C9/ru active
- 2015-06-24 CN CN201580034070.1A patent/CN106459980B/zh active Active
- 2015-06-24 CN CN202010953057.9A patent/CN112111495A/zh active Pending
- 2015-06-24 EP EP15732619.0A patent/EP3161139B1/en active Active
- 2015-06-24 ES ES15732619T patent/ES2825106T3/es active Active
- 2015-06-24 US US15/322,021 patent/US10196642B2/en active Active
- 2015-06-24 KR KR1020177001493A patent/KR102454682B1/ko active Active
- 2015-06-24 BR BR112016030172-2A patent/BR112016030172B1/pt active IP Right Grant
- 2015-06-24 PL PL15732619T patent/PL3161139T3/pl unknown
- 2015-06-24 CA CA2953020A patent/CA2953020C/en active Active
- 2015-06-24 MA MA040283A patent/MA40283A/fr unknown
- 2015-06-24 SI SI201531392T patent/SI3161139T1/sl unknown
-
2017
- 2017-01-17 ZA ZA2017/00363A patent/ZA201700363B/en unknown
-
2018
- 2018-12-14 US US16/220,726 patent/US10808252B2/en active Active
-
2020
- 2020-05-07 JP JP2020082070A patent/JP2020127422A/ja active Pending
- 2020-09-16 US US17/022,984 patent/US11591603B2/en active Active
-
2023
- 2023-01-19 US US18/156,936 patent/US12655435B2/en active Active
-
2026
- 2026-04-14 US US19/646,703 patent/US20260218204A1/en active Pending
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