RU2709718C9 - Аптамеры, специфические в отношении tlr-4, и их применение - Google Patents

Аптамеры, специфические в отношении tlr-4, и их применение Download PDF

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RU2709718C9
RU2709718C9 RU2016152094A RU2016152094A RU2709718C9 RU 2709718 C9 RU2709718 C9 RU 2709718C9 RU 2016152094 A RU2016152094 A RU 2016152094A RU 2016152094 A RU2016152094 A RU 2016152094A RU 2709718 C9 RU2709718 C9 RU 2709718C9
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tlr
aptamer
seq
present
complex
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RU2709718C2 (ru
RU2016152094A (ru
RU2016152094A3 (enExample
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ЭРНАНДЕС Игнасио ЛИСАСОАИН
МУНЬОС Виктор Мануэль ГОНСАЛЕС
ГОМЕС-ЧАКОН Херонимо ФЕРНАНДЕС
САНЧЕС Мария Анхелес МОРО
ПАЛЬМА Мария Элена МАРТИН
ЕБЕНЕС Ана МОРАГА
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Аптатархетс, С.Л.
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    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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RU2016152094A 2014-06-24 2015-06-24 Аптамеры, специфические в отношении tlr-4, и их применение RU2709718C9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP201430955 2014-06-24
ES201430955A ES2555160B1 (es) 2014-06-24 2014-06-24 Aptámeros específicos de TLR-4 y usos de los mismos
PCT/EP2015/064277 WO2015197706A1 (en) 2014-06-24 2015-06-24 Aptamers specific for tlr-4 and uses thereof

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RU2016152094A RU2016152094A (ru) 2018-07-26
RU2016152094A3 RU2016152094A3 (enExample) 2019-01-29
RU2709718C2 RU2709718C2 (ru) 2019-12-19
RU2709718C9 true RU2709718C9 (ru) 2020-02-06

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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10709776B2 (en) * 2014-04-07 2020-07-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for producing outer membrane vesicles
ES2555160B1 (es) * 2014-06-24 2016-10-25 Aptus Biotech, S.L. Aptámeros específicos de TLR-4 y usos de los mismos
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use
EP3494994A1 (en) * 2017-12-07 2019-06-12 Universität zu Köln Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases
CN112218877B (zh) 2018-08-27 2025-07-25 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
WO2020065404A2 (en) 2018-09-28 2020-04-02 Augmanity Nano Ltd Methods and compositions for selection of functional aptamers
MX2021003421A (es) 2018-09-28 2021-06-15 Nutcracker Therapeutics Inc Formulaciones de nanoparticulas lipidicas que comprenden compuestos peptidicos cationicos lipidados para el suministro de acidos nucleicos.
AU2019352635B2 (en) 2018-10-02 2024-12-19 WearOptimo Pty Ltd Actuator system
EP3860453A4 (en) 2018-10-02 2022-08-03 Wearoptimo Pty Ltd Measurement system
WO2020069568A1 (en) 2018-10-02 2020-04-09 WearOptimo Pty Ltd Treatment delivery system
WO2020230108A1 (en) * 2019-05-16 2020-11-19 Aptatargets, S.L. Treatment of ischemic stroke with aptamers targeting tlr-4
CN111474336B (zh) * 2020-03-21 2023-07-28 南昌大学 一种铁氰化镍纳米粒化学发光适体传感器的制备方法及基于其检测8-OhdG的方法
US20230372407A1 (en) * 2020-06-15 2023-11-23 President And Fellows Of Harvard College Methods for modulating tlr4 signaling
CN114152599B (zh) * 2021-12-01 2023-10-13 中国农业大学 一种基于双劈裂功能核酸变构的孔雀石绿生物传感器
CN114836425A (zh) * 2022-02-25 2022-08-02 温州医科大学附属眼视光医院 检测小胶质细胞的核酸适体及应用
KR20250133725A (ko) 2023-01-05 2025-09-08 메르크 파텐트 게엠베하 허혈성 뇌졸중 및 두개강내 출혈을 치료하기 위한 ApTOLL 분자
AU2024275027A1 (en) 2023-05-22 2025-12-11 Merck Patent Gmbh New tlr-4 antagonist aptamers

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138681A2 (en) * 2005-06-17 2006-12-28 University Of Rochester Methods and compositions for enhancing immune memory by blocking intrahepatic activated t cell deletion
RU2316599C2 (ru) * 2000-02-03 2008-02-10 Рисерч Дивелопмент Фаундейшн Передающие сигнал аптамеры, которые преобразуют сигнал распознавания молекулы в дифференциальный сигнал
WO2010060030A1 (en) * 2008-11-24 2010-05-27 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Tlr ligand-nucleic acid nanostructure as a novel immune modulatory agent and method of using the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5194599A (en) 1988-09-23 1993-03-16 Gilead Sciences, Inc. Hydrogen phosphonodithioate compositions
US5264562A (en) 1989-10-24 1993-11-23 Gilead Sciences, Inc. Oligonucleotide analogs with novel linkages
JPH06505704A (ja) 1990-09-20 1994-06-30 ギリアド　サイエンシズ，インコーポレイテッド 改変ヌクレオシド間結合
CN101227922A (zh) * 2005-05-06 2008-07-23 斯克里普斯研究学院 经由CD14和Toll样受体4信号传导途径调节细胞的组合物和方法
US20060257411A1 (en) * 2005-05-06 2006-11-16 Bruce Beutler Compositions and methods for modulating cells via CD14 and toll-like receptor 4 signaling pathway
FR2892730A1 (fr) * 2005-10-28 2007-05-04 Biomerieux Sa Methode pour detecter la presence ou le risque de developper un cancer
WO2007067733A2 (en) * 2005-12-09 2007-06-14 Massachusetts Institute Of Technology Compositions and methods to monitor rna delivery to cells
WO2008076804A2 (en) * 2006-12-13 2008-06-26 Case Western Reserve University Method of treating intrauterine inflammation
US20100111936A1 (en) * 2008-11-04 2010-05-06 Idera Pharmaceuticals, Inc. Modulation of Toll-Like Receptor 4 Expression by Antisense Oligonucleotides
EP2681315B1 (en) * 2011-03-03 2017-05-03 Quark Pharmaceuticals, Inc. Oligonucleotide modulators of the toll-like receptor pathway
CN103492572A (zh) * 2011-03-03 2014-01-01 夸克医药公司 用于治疗肺疾病和损伤的组合物和方法
ES2555160B1 (es) * 2014-06-24 2016-10-25 Aptus Biotech, S.L. Aptámeros específicos de TLR-4 y usos de los mismos

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2316599C2 (ru) * 2000-02-03 2008-02-10 Рисерч Дивелопмент Фаундейшн Передающие сигнал аптамеры, которые преобразуют сигнал распознавания молекулы в дифференциальный сигнал
WO2006138681A2 (en) * 2005-06-17 2006-12-28 University Of Rochester Methods and compositions for enhancing immune memory by blocking intrahepatic activated t cell deletion
WO2010060030A1 (en) * 2008-11-24 2010-05-27 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Tlr ligand-nucleic acid nanostructure as a novel immune modulatory agent and method of using the same

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EP3161139A1 (en) 2017-05-03
PT3161139T (pt) 2020-10-23
MX2016016992A (es) 2017-05-03
JP2020127422A (ja) 2020-08-27
ES2825106T3 (es) 2021-05-14
MA40283A (fr) 2017-05-03
RU2709718C2 (ru) 2019-12-19
EP3161139B1 (en) 2020-07-22
RU2016152094A (ru) 2018-07-26
CA2953020C (en) 2023-01-10
US10196642B2 (en) 2019-02-05
CA2953020A1 (en) 2015-12-30
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PL3161139T3 (pl) 2021-01-11
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US20170130227A1 (en) 2017-05-11
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