JP6959738B2 - Ｔｌｒ−４特異的アプタマーおよびそれらの使用 - Google Patents

Ｔｌｒ−４特異的アプタマーおよびそれらの使用 Download PDF

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JP6959738B2
JP6959738B2 JP2016575345A JP2016575345A JP6959738B2 JP 6959738 B2 JP6959738 B2 JP 6959738B2 JP 2016575345 A JP2016575345 A JP 2016575345A JP 2016575345 A JP2016575345 A JP 2016575345A JP 6959738 B2 JP6959738 B2 JP 6959738B2
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tlr
aptamer
seq
complex
present
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JP2017527260A5 (enExample
JP2017527260A (ja
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ヘルナンデス，イグナシオ リザソアイン
ムノス，ビクトル マヌエル ゴンザレス
ゴメス−チャコン，ジェロニモ フェルナンデス
サンチェス，マリア エンジェル モロ
パルマ，マ エレナ マーチン
イエベネ，アナ モラガ
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Aptatargets SL
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Aptatargets SL
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event

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JP2016575345A 2014-06-24 2015-06-24 Ｔｌｒ−４特異的アプタマーおよびそれらの使用 Active JP6959738B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP201430955. 2014-06-24
ES201430955A ES2555160B1 (es) 2014-06-24 2014-06-24 Aptámeros específicos de TLR-4 y usos de los mismos
PCT/EP2015/064277 WO2015197706A1 (en) 2014-06-24 2015-06-24 Aptamers specific for tlr-4 and uses thereof

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JP2017527260A5 JP2017527260A5 (enExample) 2018-08-02
JP6959738B2 true JP6959738B2 (ja) 2021-11-05

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CA3030974A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use
EP3494994A1 (en) * 2017-12-07 2019-06-12 Universität zu Köln Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases
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AU2019347774A1 (en) 2018-09-28 2021-03-25 Nutcracker Therapeutics, Inc. Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery
CN113423833B (zh) * 2018-09-28 2024-09-17 奥曼尼提纳米有限公司 用于选择功能性适体的方法和组合物
WO2020069569A1 (en) 2018-10-02 2020-04-09 WearOptimo Pty Ltd Actuator system
US20210338158A1 (en) 2018-10-02 2021-11-04 WearOptimo Pty Ltd Measurement system
US20220233572A1 (en) * 2019-05-16 2022-07-28 Aptatargets, S.L. Treatment of tlr-4 mediated diseases and conditions with aptamers targeting tlr-4
CN111474336B (zh) * 2020-03-21 2023-07-28 南昌大学 一种铁氰化镍纳米粒化学发光适体传感器的制备方法及基于其检测8-OhdG的方法
WO2021257494A1 (en) * 2020-06-15 2021-12-23 President And Fellows Of Harvard College Methods for modulating tlr4 signaling
CN114152599B (zh) * 2021-12-01 2023-10-13 中国农业大学 一种基于双劈裂功能核酸变构的孔雀石绿生物传感器
CN114836425A (zh) * 2022-02-25 2022-08-02 温州医科大学附属眼视光医院 检测小胶质细胞的核酸适体及应用
WO2024146930A1 (en) 2023-01-05 2024-07-11 Aptatargets, S.L. Aptoll molecules for the treatment of ischemic stroke and intracranial hemorrhages
WO2024240750A1 (en) 2023-05-22 2024-11-28 Aptatargets, S.L. New tlr-4 antagonist aptamers

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JP2020127422A (ja) 2020-08-27
PT3161139T (pt) 2020-10-23
KR20170021298A (ko) 2017-02-27
AU2015279248B2 (en) 2021-03-11
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KR102454682B1 (ko) 2022-10-13
US20170130227A1 (en) 2017-05-11
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US20230279402A1 (en) 2023-09-07
ES2555160B1 (es) 2016-10-25
MX2016016992A (es) 2017-05-03
SI3161139T1 (sl) 2020-12-31
RU2709718C9 (ru) 2020-02-06
ES2555160A1 (es) 2015-12-29
MA40283A (fr) 2017-05-03
CA2953020A1 (en) 2015-12-30
RU2016152094A (ru) 2018-07-26
WO2015197706A1 (en) 2015-12-30
JP2017527260A (ja) 2017-09-21
BR112016030172A2 (pt) 2017-11-14
MX387405B (es) 2025-03-18
CN112111495A (zh) 2020-12-22
CN106459980A (zh) 2017-02-22
US11591603B2 (en) 2023-02-28
PL3161139T3 (pl) 2021-01-11
ZA201700363B (en) 2018-11-28
US20190211334A1 (en) 2019-07-11
US20210130830A1 (en) 2021-05-06
BR112016030172B1 (pt) 2022-11-01
AU2015279248A1 (en) 2017-01-12
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