CN106459980B - Tlr-4特异性适配体及其应用 - Google Patents

Tlr-4特异性适配体及其应用 Download PDF

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CN106459980B
CN106459980B CN201580034070.1A CN201580034070A CN106459980B CN 106459980 B CN106459980 B CN 106459980B CN 201580034070 A CN201580034070 A CN 201580034070A CN 106459980 B CN106459980 B CN 106459980B
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tlr
aptamer
seq
present
aptamers
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CN106459980A (zh
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I·丽萨苏阿因赫尔南德斯
V·M·冈萨雷斯穆尼奥斯
G·费尔南德斯戈麦斯查孔
M·á·摩洛桑切斯
M·E·马丁帕尔马
A·莫拉加韦内斯
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Merck Healthcare Group
Merck Patent GmbH
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Aupu Tower Target Corp
Aptatargets SL
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CN201580034070.1A 2014-06-24 2015-06-24 Tlr-4特异性适配体及其应用 Active CN106459980B (zh)

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ESP201430955 2014-06-24
ES201430955A ES2555160B1 (es) 2014-06-24 2014-06-24 Aptámeros específicos de TLR-4 y usos de los mismos
PCT/EP2015/064277 WO2015197706A1 (en) 2014-06-24 2015-06-24 Aptamers specific for tlr-4 and uses thereof

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ES2555160B1 (es) * 2014-06-24 2016-10-25 Aptus Biotech, S.L. Aptámeros específicos de TLR-4 y usos de los mismos
US11491181B2 (en) 2016-07-15 2022-11-08 President And Fellows Of Harvard College Glycolipid compositions and methods of use
EP3494994A1 (en) * 2017-12-07 2019-06-12 Universität zu Köln Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases
CN112218877B (zh) 2018-08-27 2025-07-25 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
WO2020065404A2 (en) 2018-09-28 2020-04-02 Augmanity Nano Ltd Methods and compositions for selection of functional aptamers
MX2021003421A (es) 2018-09-28 2021-06-15 Nutcracker Therapeutics Inc Formulaciones de nanoparticulas lipidicas que comprenden compuestos peptidicos cationicos lipidados para el suministro de acidos nucleicos.
AU2019352635B2 (en) 2018-10-02 2024-12-19 WearOptimo Pty Ltd Actuator system
EP3860453A4 (en) 2018-10-02 2022-08-03 Wearoptimo Pty Ltd Measurement system
WO2020069568A1 (en) 2018-10-02 2020-04-09 WearOptimo Pty Ltd Treatment delivery system
WO2020230108A1 (en) * 2019-05-16 2020-11-19 Aptatargets, S.L. Treatment of ischemic stroke with aptamers targeting tlr-4
CN111474336B (zh) * 2020-03-21 2023-07-28 南昌大学 一种铁氰化镍纳米粒化学发光适体传感器的制备方法及基于其检测8-OhdG的方法
US20230372407A1 (en) * 2020-06-15 2023-11-23 President And Fellows Of Harvard College Methods for modulating tlr4 signaling
CN114152599B (zh) * 2021-12-01 2023-10-13 中国农业大学 一种基于双劈裂功能核酸变构的孔雀石绿生物传感器
CN114836425A (zh) * 2022-02-25 2022-08-02 温州医科大学附属眼视光医院 检测小胶质细胞的核酸适体及应用
KR20250133725A (ko) 2023-01-05 2025-09-08 메르크 파텐트 게엠베하 허혈성 뇌졸중 및 두개강내 출혈을 치료하기 위한 ApTOLL 분자
AU2024275027A1 (en) 2023-05-22 2025-12-11 Merck Patent Gmbh New tlr-4 antagonist aptamers

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