JP2017526652A5 - - Google Patents
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- JP2017526652A5 JP2017526652A5 JP2017503957A JP2017503957A JP2017526652A5 JP 2017526652 A5 JP2017526652 A5 JP 2017526652A5 JP 2017503957 A JP2017503957 A JP 2017503957A JP 2017503957 A JP2017503957 A JP 2017503957A JP 2017526652 A5 JP2017526652 A5 JP 2017526652A5
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- JP
- Japan
- Prior art keywords
- antibody
- contacting
- composition
- cit
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028679P | 2014-07-24 | 2014-07-24 | |
| US62/028,679 | 2014-07-24 | ||
| PCT/US2015/040931 WO2016014360A1 (en) | 2014-07-24 | 2015-07-17 | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020199681A Division JP7219256B2 (ja) | 2014-07-24 | 2020-12-01 | 薬剤の少なくとも1つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526652A JP2017526652A (ja) | 2017-09-14 |
| JP2017526652A5 true JP2017526652A5 (https=) | 2018-08-30 |
| JP6956630B2 JP6956630B2 (ja) | 2021-11-02 |
Family
ID=55163580
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503957A Active JP6956630B2 (ja) | 2014-07-24 | 2015-07-17 | 薬剤の少なくとも1つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
| JP2020199681A Active JP7219256B2 (ja) | 2014-07-24 | 2020-12-01 | 薬剤の少なくとも1つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
| JP2023010054A Pending JP2023052645A (ja) | 2014-07-24 | 2023-01-26 | 薬剤の少なくとも1つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020199681A Active JP7219256B2 (ja) | 2014-07-24 | 2020-12-01 | 薬剤の少なくとも1つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
| JP2023010054A Pending JP2023052645A (ja) | 2014-07-24 | 2023-01-26 | 薬剤の少なくとも1つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11370838B2 (https=) |
| EP (1) | EP3172219A4 (https=) |
| JP (3) | JP6956630B2 (https=) |
| KR (1) | KR102463267B1 (https=) |
| CN (1) | CN106536540A (https=) |
| AR (1) | AR101304A1 (https=) |
| AU (2) | AU2015294389B2 (https=) |
| BR (1) | BR112017001403A2 (https=) |
| CA (1) | CA2955007C (https=) |
| IL (1) | IL250148B2 (https=) |
| MX (2) | MX2017001022A (https=) |
| MY (1) | MY198629A (https=) |
| RU (2) | RU2021106673A (https=) |
| SG (2) | SG11201700365TA (https=) |
| WO (1) | WO2016014360A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106536540A (zh) * | 2014-07-24 | 2017-03-22 | 基因泰克公司 | 将试剂缀合至含有至少一个三硫键的蛋白质中的巯基部分的方法 |
| JP7148524B2 (ja) | 2017-02-08 | 2022-10-05 | ファイザー・インク | キャップされたおよびキャップされていない抗体システインのための大規模産生プロセス、ならびに治療的タンパク質コンジュゲーションにおけるその使用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| EP0098110B1 (en) | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| JP2665353B2 (ja) * | 1988-09-10 | 1997-10-22 | 住商ファーマインターナショナル株式会社 | 双特異性抗体の製造法 |
| JPH0278699A (ja) | 1988-09-12 | 1990-03-19 | Green Cross Corp:The | ベンゾイルウレア系化合物・アルブミン複合体 |
| JPH02218700A (ja) * | 1989-02-17 | 1990-08-31 | Nippon Kayaku Co Ltd | 双特異性抗体及びそれを用いる養子免疫療法 |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| ZA955789B (en) | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| JPH11124395A (ja) | 1997-10-16 | 1999-05-11 | Seiwa Kasei Kk | システイン導入ペプチドおよびその製造方法 |
| SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
| CA2374050A1 (en) | 1999-05-20 | 2000-11-30 | Scios Inc. | Vascular endothelial growth factor dimers |
| WO2002062827A2 (en) | 2000-10-31 | 2002-08-15 | The Regents Of The University Of Colorado, A Body Corporate | Improved protein disaggregation and refolding using high pressure |
| SI1545613T1 (sl) | 2002-07-31 | 2011-11-30 | Seattle Genetics Inc | Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni |
| US20040048315A1 (en) | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| AU2004213053C1 (en) * | 2003-02-20 | 2009-07-16 | Seagen Inc. | Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| ATE555133T1 (de) * | 2003-11-13 | 2012-05-15 | Hanmi Holdings Co Ltd | Igg fc fragment für einen arzneimittelträger und verfahren zu dessen herstellung |
| AU2005218642B2 (en) * | 2004-03-02 | 2011-04-28 | Seagen Inc. | Partially loaded antibodies and methods of their conjugation |
| KR20120064120A (ko) * | 2004-06-01 | 2012-06-18 | 제넨테크, 인크. | 항체 약물 접합체 및 방법 |
| JP4865728B2 (ja) * | 2004-12-29 | 2012-02-01 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | ポリペプチドの三硫化物誘導体の形成を防止する方法 |
| ES2567402T3 (es) * | 2006-05-30 | 2016-04-22 | Genentech, Inc. | Anticuerpos anti CD22, sus inmunoconjugados y usos de los mismos |
| US20080220448A1 (en) | 2006-09-01 | 2008-09-11 | Blincko Stuart J | Antigenic protein conjugates and process for preparing same |
| JP5394246B2 (ja) | 2007-03-30 | 2014-01-22 | ジェネンテック, インコーポレイテッド | 抗体及びイムノコンジュゲートとこれらの使用方法 |
| EP2144628B1 (en) * | 2007-05-08 | 2012-10-17 | Genentech, Inc. | Cysteine engineered anti-muc16 antibodies and antibody drug conjugates |
| DK2474557T3 (da) | 2007-07-16 | 2014-11-10 | Genentech Inc | Anti-CD79b-antistoffer og immunkonjugater og fremgangsmåder til anvendelse |
| NZ583318A (en) | 2007-07-16 | 2012-07-27 | Genentech Inc | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| SG187517A1 (en) | 2008-01-31 | 2013-02-28 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
| MX2010008310A (es) * | 2008-01-31 | 2010-12-21 | Georgia Pacific Chemicals Llc | Composicion oxidada y maleatada modificada. |
| DK2483289T4 (da) * | 2009-10-02 | 2025-05-19 | Biogen Ma Inc | Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger |
| EP2542576B1 (en) * | 2010-03-02 | 2016-04-20 | Seattle Genetics, Inc. | Methods for screening antibodies |
| JP2014500248A (ja) * | 2010-11-05 | 2014-01-09 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗糖尿病化合物 |
| DK2707383T3 (en) * | 2011-05-13 | 2018-07-23 | Biogen Ma Inc | PROCEDURES FOR PREVENTION AND REMOVAL OF TRISULPHIDE BINDINGS |
| US10344050B2 (en) * | 2011-10-27 | 2019-07-09 | Genmab A/S | Production of heterodimeric proteins |
| JP2015502397A (ja) * | 2011-12-23 | 2015-01-22 | ファイザー・インク | 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用 |
| AU2013256596A1 (en) * | 2012-05-01 | 2014-10-09 | Genentech, Inc. | Anti-PMEL17 antibodies and immunoconjugates |
| MX2014015682A (es) * | 2012-06-19 | 2015-07-23 | Polytherics Ltd | Proceso novedoso para preparacion de conjugados de anticuerpo y conjugados de anticuerpo novedosos. |
| CN106536540A (zh) * | 2014-07-24 | 2017-03-22 | 基因泰克公司 | 将试剂缀合至含有至少一个三硫键的蛋白质中的巯基部分的方法 |
-
2015
- 2015-07-17 CN CN201580041071.9A patent/CN106536540A/zh active Pending
- 2015-07-17 JP JP2017503957A patent/JP6956630B2/ja active Active
- 2015-07-17 RU RU2021106673A patent/RU2021106673A/ru unknown
- 2015-07-17 EP EP15824358.4A patent/EP3172219A4/en active Pending
- 2015-07-17 MX MX2017001022A patent/MX2017001022A/es unknown
- 2015-07-17 MY MYPI2017000109A patent/MY198629A/en unknown
- 2015-07-17 WO PCT/US2015/040931 patent/WO2016014360A1/en not_active Ceased
- 2015-07-17 BR BR112017001403A patent/BR112017001403A2/pt not_active Application Discontinuation
- 2015-07-17 KR KR1020177003843A patent/KR102463267B1/ko active Active
- 2015-07-17 CA CA2955007A patent/CA2955007C/en active Active
- 2015-07-17 RU RU2017105428A patent/RU2744978C2/ru active
- 2015-07-17 SG SG11201700365TA patent/SG11201700365TA/en unknown
- 2015-07-17 AU AU2015294389A patent/AU2015294389B2/en not_active Expired - Fee Related
- 2015-07-17 SG SG10202102467RA patent/SG10202102467RA/en unknown
- 2015-07-24 AR ARP150102358A patent/AR101304A1/es not_active Application Discontinuation
-
2017
- 2017-01-16 IL IL250148A patent/IL250148B2/en unknown
- 2017-01-20 MX MX2022012589A patent/MX2022012589A/es unknown
- 2017-01-24 US US15/414,330 patent/US11370838B2/en active Active
-
2020
- 2020-12-01 JP JP2020199681A patent/JP7219256B2/ja active Active
-
2021
- 2021-07-27 AU AU2021209196A patent/AU2021209196B2/en not_active Ceased
-
2022
- 2022-05-24 US US17/752,631 patent/US20220372141A1/en not_active Abandoned
-
2023
- 2023-01-26 JP JP2023010054A patent/JP2023052645A/ja active Pending
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