JP2017526652A5 - - Google Patents
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- JP2017526652A5 JP2017526652A5 JP2017503957A JP2017503957A JP2017526652A5 JP 2017526652 A5 JP2017526652 A5 JP 2017526652A5 JP 2017503957 A JP2017503957 A JP 2017503957A JP 2017503957 A JP2017503957 A JP 2017503957A JP 2017526652 A5 JP2017526652 A5 JP 2017526652A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- contacting
- composition
- cit
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462028679P | 2014-07-24 | 2014-07-24 | |
| US62/028,679 | 2014-07-24 | ||
| PCT/US2015/040931 WO2016014360A1 (en) | 2014-07-24 | 2015-07-17 | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020199681A Division JP7219256B2 (ja) | 2014-07-24 | 2020-12-01 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526652A JP2017526652A (ja) | 2017-09-14 |
| JP2017526652A5 true JP2017526652A5 (https=) | 2018-08-30 |
| JP6956630B2 JP6956630B2 (ja) | 2021-11-02 |
Family
ID=55163580
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017503957A Active JP6956630B2 (ja) | 2014-07-24 | 2015-07-17 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
| JP2020199681A Active JP7219256B2 (ja) | 2014-07-24 | 2020-12-01 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
| JP2023010054A Pending JP2023052645A (ja) | 2014-07-24 | 2023-01-26 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020199681A Active JP7219256B2 (ja) | 2014-07-24 | 2020-12-01 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
| JP2023010054A Pending JP2023052645A (ja) | 2014-07-24 | 2023-01-26 | 薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11370838B2 (https=) |
| EP (1) | EP3172219A4 (https=) |
| JP (3) | JP6956630B2 (https=) |
| KR (1) | KR102463267B1 (https=) |
| CN (1) | CN106536540A (https=) |
| AR (1) | AR101304A1 (https=) |
| AU (2) | AU2015294389B2 (https=) |
| BR (1) | BR112017001403A2 (https=) |
| CA (1) | CA2955007C (https=) |
| IL (1) | IL250148B2 (https=) |
| MX (2) | MX2017001022A (https=) |
| MY (1) | MY198629A (https=) |
| RU (2) | RU2021106673A (https=) |
| SG (2) | SG11201700365TA (https=) |
| WO (1) | WO2016014360A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201700365TA (en) * | 2014-07-24 | 2017-02-27 | Genentech Inc | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
| JP7148524B2 (ja) * | 2017-02-08 | 2022-10-05 | ファイザー・インク | キャップされたおよびキャップされていない抗体システインのための大規模産生プロセス、ならびに治療的タンパク質コンジュゲーションにおけるその使用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| JP2665353B2 (ja) * | 1988-09-10 | 1997-10-22 | 住商ファーマインターナショナル株式会社 | 双特異性抗体の製造法 |
| JPH0278699A (ja) | 1988-09-12 | 1990-03-19 | Green Cross Corp:The | ベンゾイルウレア系化合物・アルブミン複合体 |
| JPH02218700A (ja) * | 1989-02-17 | 1990-08-31 | Nippon Kayaku Co Ltd | 双特異性抗体及びそれを用いる養子免疫療法 |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| ZA955789B (en) | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| JPH11124395A (ja) | 1997-10-16 | 1999-05-11 | Seiwa Kasei Kk | システイン導入ペプチドおよびその製造方法 |
| SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
| EP1183357A2 (en) | 1999-05-20 | 2002-03-06 | Scios Inc. | Vascular endothelial growth factor dimers |
| CA2434045A1 (en) | 2000-10-31 | 2002-08-15 | The Regents Of The University Of Colorado, A Body Corporate | Improved protein disaggregation and refolding using high pressure |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| US20040048315A1 (en) | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| JP5356648B2 (ja) | 2003-02-20 | 2013-12-04 | シアトル ジェネティックス， インコーポレイテッド | 抗ｃｄ７０抗体−医薬結合体、ならびに癌および免疫障害の処置のためのそれらの使用 |
| ES2383300T3 (es) | 2003-11-13 | 2012-06-20 | Hanmi Holdings Co., Ltd | Fragmento Fc de IgG para un vehículo de fármacos y procedimiento para su preparación |
| JP4942643B2 (ja) * | 2004-03-02 | 2012-05-30 | シアトル ジェネティックス， インコーポレイテッド | 部分的に付加された抗体およびそれらの結合体化方法 |
| NZ579482A (en) * | 2004-06-01 | 2011-02-25 | Genentech Inc | Antibody drug conjugates and methods |
| ATE463503T1 (de) * | 2004-12-29 | 2010-04-15 | Novo Nordisk Healthcare Ag | Verfahren zur verhinderung der bildung von trisulfidderivaten von polypeptiden |
| EP2032606B1 (en) * | 2006-05-30 | 2013-11-27 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| US20080220448A1 (en) | 2006-09-01 | 2008-09-11 | Blincko Stuart J | Antigenic protein conjugates and process for preparing same |
| JP5394246B2 (ja) | 2007-03-30 | 2014-01-22 | ジェネンテック， インコーポレイテッド | 抗体及びイムノコンジュゲートとこれらの使用方法 |
| CL2008001334A1 (es) * | 2007-05-08 | 2008-09-22 | Genentech Inc | Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer. |
| EP2176295B1 (en) | 2007-07-16 | 2014-11-19 | Genentech, Inc. | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| PE20090943A1 (es) | 2007-07-16 | 2009-08-05 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados |
| EP2249967B1 (en) * | 2008-01-31 | 2019-03-13 | Ingevity South Carolina, LLC | Oxidized and maleated derivative composition |
| KR101607346B1 (ko) | 2008-01-31 | 2016-03-29 | 제넨테크, 인크. | 항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법 |
| EP2483289B2 (en) * | 2009-10-02 | 2025-03-26 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
| PL2542576T3 (pl) * | 2010-03-02 | 2016-10-31 | Sposoby badań przesiewowych przeciwciał | |
| JP2014500248A (ja) * | 2010-11-05 | 2014-01-09 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗糖尿病化合物 |
| WO2012158551A1 (en) * | 2011-05-13 | 2012-11-22 | Biogen Idec Ma Inc. | Methods of preventing and removing trisulfide bonds |
| SG11201401422VA (en) * | 2011-10-27 | 2014-09-26 | Genmab As | Production of heterodimeric proteins |
| JP2015502397A (ja) * | 2011-12-23 | 2015-01-22 | ファイザー・インク | 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用 |
| US9056910B2 (en) * | 2012-05-01 | 2015-06-16 | Genentech, Inc. | Anti-PMEL17 antibodies and immunoconjugates |
| EP2861261A2 (en) * | 2012-06-19 | 2015-04-22 | Polytherics Limited | Process for preparation of antibody conjugates and antibody conjugates |
| SG11201700365TA (en) * | 2014-07-24 | 2017-02-27 | Genentech Inc | Methods of conjugating an agent to a thiol moiety in a protein that contains at least one trisulfide bond |
-
2015
- 2015-07-17 SG SG11201700365TA patent/SG11201700365TA/en unknown
- 2015-07-17 WO PCT/US2015/040931 patent/WO2016014360A1/en not_active Ceased
- 2015-07-17 CN CN201580041071.9A patent/CN106536540A/zh active Pending
- 2015-07-17 JP JP2017503957A patent/JP6956630B2/ja active Active
- 2015-07-17 BR BR112017001403A patent/BR112017001403A2/pt not_active Application Discontinuation
- 2015-07-17 SG SG10202102467RA patent/SG10202102467RA/en unknown
- 2015-07-17 CA CA2955007A patent/CA2955007C/en active Active
- 2015-07-17 MY MYPI2017000109A patent/MY198629A/en unknown
- 2015-07-17 AU AU2015294389A patent/AU2015294389B2/en not_active Expired - Fee Related
- 2015-07-17 RU RU2021106673A patent/RU2021106673A/ru unknown
- 2015-07-17 KR KR1020177003843A patent/KR102463267B1/ko active Active
- 2015-07-17 RU RU2017105428A patent/RU2744978C2/ru active
- 2015-07-17 MX MX2017001022A patent/MX2017001022A/es unknown
- 2015-07-17 EP EP15824358.4A patent/EP3172219A4/en active Pending
- 2015-07-24 AR ARP150102358A patent/AR101304A1/es not_active Application Discontinuation
-
2017
- 2017-01-16 IL IL250148A patent/IL250148B2/en unknown
- 2017-01-20 MX MX2022012589A patent/MX2022012589A/es unknown
- 2017-01-24 US US15/414,330 patent/US11370838B2/en active Active
-
2020
- 2020-12-01 JP JP2020199681A patent/JP7219256B2/ja active Active
-
2021
- 2021-07-27 AU AU2021209196A patent/AU2021209196B2/en not_active Ceased
-
2022
- 2022-05-24 US US17/752,631 patent/US20220372141A1/en not_active Abandoned
-
2023
- 2023-01-26 JP JP2023010054A patent/JP2023052645A/ja active Pending
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