AR101304A1 - Métodos para conjugar un agente con una mitad tiol en una proteína que contiene al menos un enlace trisulfuro - Google Patents
Métodos para conjugar un agente con una mitad tiol en una proteína que contiene al menos un enlace trisulfuroInfo
- Publication number
- AR101304A1 AR101304A1 ARP150102358A ARP150102358A AR101304A1 AR 101304 A1 AR101304 A1 AR 101304A1 AR P150102358 A ARP150102358 A AR P150102358A AR P150102358 A ARP150102358 A AR P150102358A AR 101304 A1 AR101304 A1 AR 101304A1
- Authority
- AR
- Argentina
- Prior art keywords
- protein
- agent
- trisulfide
- conjug
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000611 antibody drug conjugate Substances 0.000 abstract 1
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000562 conjugate Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Métodos mejorados para conjugar un agente con una mitad tiol en una proteína que contiene al menos un enlace bisulfuro y al menos un enlace trisulfuro. Realizaciones ejemplares incluyen la producción de conjugados de anticuerpos-drogas sustancialmente libres de impurezas creados en presencia de mitades de sulfuros reactivos en el proceso de producción.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462028679P | 2014-07-24 | 2014-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR101304A1 true AR101304A1 (es) | 2016-12-07 |
Family
ID=55163580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150102358A AR101304A1 (es) | 2014-07-24 | 2015-07-24 | Métodos para conjugar un agente con una mitad tiol en una proteína que contiene al menos un enlace trisulfuro |
Country Status (15)
Country | Link |
---|---|
US (2) | US11370838B2 (es) |
EP (1) | EP3172219A4 (es) |
JP (3) | JP6956630B2 (es) |
KR (1) | KR102463267B1 (es) |
CN (1) | CN106536540A (es) |
AR (1) | AR101304A1 (es) |
AU (2) | AU2015294389B2 (es) |
BR (1) | BR112017001403A2 (es) |
CA (1) | CA2955007C (es) |
IL (1) | IL250148B2 (es) |
MX (2) | MX2017001022A (es) |
MY (1) | MY198629A (es) |
RU (2) | RU2021106673A (es) |
SG (2) | SG10202102467RA (es) |
WO (1) | WO2016014360A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2017001022A (es) * | 2014-07-24 | 2017-12-20 | Genentech Inc | Metodos para conjugar un agente a un resto tiol en una proteina que contiene al menos un enlace trisulfuro. |
KR102322530B1 (ko) * | 2017-02-08 | 2021-11-05 | 화이자 인코포레이티드 | 캡핑된 및 비-캡핑된 항체 시스테인의 대규모 제조 공정 및 치료 단백질 접합에서의 그의 용도 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
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US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
JP2665353B2 (ja) * | 1988-09-10 | 1997-10-22 | 住商ファーマインターナショナル株式会社 | 双特異性抗体の製造法 |
JPH0278699A (ja) | 1988-09-12 | 1990-03-19 | Green Cross Corp:The | ベンゾイルウレア系化合物・アルブミン複合体 |
JPH02218700A (ja) * | 1989-02-17 | 1990-08-31 | Nippon Kayaku Co Ltd | 双特異性抗体及びそれを用いる養子免疫療法 |
US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
ZA955789B (en) | 1994-07-15 | 1996-03-11 | Novo Nordisk As | A method of converting a hydrophobic derivative of a polypeptide into the native form |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
JPH11124395A (ja) | 1997-10-16 | 1999-05-11 | Seiwa Kasei Kk | システイン導入ペプチドおよびその製造方法 |
SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
JP2003500053A (ja) | 1999-05-20 | 2003-01-07 | サイオス,インコーポレーテッド | 血管内皮増殖因子ダイマー |
MXPA03003867A (es) | 2000-10-31 | 2004-10-15 | Univ Colorado Regents | Desagregacion mejorada de proteina y replegamiento utilizando alta presion. |
HUE027549T2 (hu) | 2002-07-31 | 2016-10-28 | Seattle Genetics Inc | Hatóanyagot tartalmazó konjugátumok és alkalmazásuk rák, autoimmun betegség vagy fertõzéses betegség kezelésére |
US20040048315A1 (en) | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
AU2004213053C1 (en) * | 2003-02-20 | 2009-07-16 | Seagen Inc. | Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
EP1682584B1 (en) | 2003-11-13 | 2013-04-17 | Hanmi Science Co., Ltd. | A pharmaceutical composition comprising an immunoglobulin fc region as a carrier |
WO2005084390A2 (en) * | 2004-03-02 | 2005-09-15 | Seattle Genetics, Inc. | Partially loaded antibodies and methods of their conjugation |
AU2005249490B2 (en) * | 2004-06-01 | 2010-07-29 | Genentech, Inc. | Antibody drug conjugates and methods |
WO2006069940A1 (en) | 2004-12-29 | 2006-07-06 | Novo Nordisk Health Care Ag | Method for preventing formation of trisulfide derivatives of polypeptides |
TWI523864B (zh) * | 2006-05-30 | 2016-03-01 | 建南德克公司 | 抗體及免疫接合物及其用途 |
US20080220448A1 (en) | 2006-09-01 | 2008-09-11 | Blincko Stuart J | Antigenic protein conjugates and process for preparing same |
JP5394246B2 (ja) | 2007-03-30 | 2014-01-22 | ジェネンテック, インコーポレイテッド | 抗体及びイムノコンジュゲートとこれらの使用方法 |
US7723485B2 (en) * | 2007-05-08 | 2010-05-25 | Genentech, Inc. | Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates |
PE20140625A1 (es) | 2007-07-16 | 2014-05-29 | Genentech Inc | ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS |
EP2474557B1 (en) | 2007-07-16 | 2014-08-20 | Genentech, Inc. | Anti-CD79b antibodies and immunoconjugates and methods of use |
US8133970B2 (en) * | 2008-01-31 | 2012-03-13 | Georgia-Pacific Chemicals Llc | Oxidized and maleated derivative compositions |
RU2553566C2 (ru) | 2008-01-31 | 2015-06-20 | Дженентек, Инк. | АНТИ-CD79b АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
EP2483289B1 (en) * | 2009-10-02 | 2019-03-20 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
PL2542576T3 (pl) * | 2010-03-02 | 2016-10-31 | Sposoby badań przesiewowych przeciwciał | |
WO2012059873A2 (en) * | 2010-11-05 | 2012-05-10 | Covx Technologies Ireland, Ltd. | Anti-diabetic compounds |
EP3388443A1 (en) * | 2011-05-13 | 2018-10-17 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
HUE044633T2 (hu) * | 2011-10-27 | 2019-11-28 | Genmab As | Heterodimer fehérjék elõállítása |
WO2013093809A1 (en) * | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
EP2844300B1 (en) * | 2012-05-01 | 2018-10-17 | Genentech, Inc. | Anti-pmel17 antibodies and immunoconjugates |
JP2015521615A (ja) * | 2012-06-19 | 2015-07-30 | ポリセリックス・リミテッド | 抗体コンジュゲートの調製のための新規方法及び新規抗体コンジュゲート |
MX2017001022A (es) * | 2014-07-24 | 2017-12-20 | Genentech Inc | Metodos para conjugar un agente a un resto tiol en una proteina que contiene al menos un enlace trisulfuro. |
-
2015
- 2015-07-17 MX MX2017001022A patent/MX2017001022A/es unknown
- 2015-07-17 RU RU2021106673A patent/RU2021106673A/ru unknown
- 2015-07-17 SG SG10202102467RA patent/SG10202102467RA/en unknown
- 2015-07-17 EP EP15824358.4A patent/EP3172219A4/en active Pending
- 2015-07-17 BR BR112017001403A patent/BR112017001403A2/pt not_active Application Discontinuation
- 2015-07-17 MY MYPI2017000109A patent/MY198629A/en unknown
- 2015-07-17 AU AU2015294389A patent/AU2015294389B2/en not_active Expired - Fee Related
- 2015-07-17 WO PCT/US2015/040931 patent/WO2016014360A1/en active Application Filing
- 2015-07-17 CA CA2955007A patent/CA2955007C/en active Active
- 2015-07-17 JP JP2017503957A patent/JP6956630B2/ja active Active
- 2015-07-17 RU RU2017105428A patent/RU2744978C2/ru active
- 2015-07-17 KR KR1020177003843A patent/KR102463267B1/ko active IP Right Grant
- 2015-07-17 CN CN201580041071.9A patent/CN106536540A/zh active Pending
- 2015-07-17 SG SG11201700365TA patent/SG11201700365TA/en unknown
- 2015-07-24 AR ARP150102358A patent/AR101304A1/es unknown
-
2017
- 2017-01-16 IL IL250148A patent/IL250148B2/en unknown
- 2017-01-20 MX MX2022012589A patent/MX2022012589A/es unknown
- 2017-01-24 US US15/414,330 patent/US11370838B2/en active Active
-
2020
- 2020-12-01 JP JP2020199681A patent/JP7219256B2/ja active Active
-
2021
- 2021-07-27 AU AU2021209196A patent/AU2021209196B2/en active Active
-
2022
- 2022-05-24 US US17/752,631 patent/US20220372141A1/en active Pending
-
2023
- 2023-01-26 JP JP2023010054A patent/JP2023052645A/ja active Pending
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