JP2017525343A5 - - Google Patents
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- JP2017525343A5 JP2017525343A5 JP2017501280A JP2017501280A JP2017525343A5 JP 2017525343 A5 JP2017525343 A5 JP 2017525343A5 JP 2017501280 A JP2017501280 A JP 2017501280A JP 2017501280 A JP2017501280 A JP 2017501280A JP 2017525343 A5 JP2017525343 A5 JP 2017525343A5
- Authority
- JP
- Japan
- Prior art keywords
- hil
- antigen
- binding
- nmol
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14176619 | 2014-07-10 | ||
| EP14176619.6 | 2014-07-10 | ||
| PCT/IB2015/055226 WO2016005950A1 (en) | 2014-07-10 | 2015-07-10 | Immune-stimulating monoclonal antibodies against human interleukin-2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525343A JP2017525343A (ja) | 2017-09-07 |
| JP2017525343A5 true JP2017525343A5 (https=) | 2018-08-16 |
| JP7209464B2 JP7209464B2 (ja) | 2023-01-20 |
Family
ID=51162588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017501280A Active JP7209464B2 (ja) | 2014-07-10 | 2015-07-10 | ヒトインターロイキン－２に対する免疫刺激性モノクローナル抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10894828B2 (https=) |
| EP (2) | EP3166973B1 (https=) |
| JP (1) | JP7209464B2 (https=) |
| CN (1) | CN106604932B (https=) |
| AU (1) | AU2015287227B2 (https=) |
| CA (1) | CA2954476C (https=) |
| DK (1) | DK3166973T3 (https=) |
| ES (2) | ES2779977T3 (https=) |
| WO (1) | WO2016005950A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116003593A (zh) * | 2016-01-11 | 2023-04-25 | 苏黎世大学 | 针对人白介素-2的免疫刺激性人源化单克隆抗体及其融合蛋白 |
| AU2017335771A1 (en) | 2016-09-28 | 2019-02-28 | Musc Foundation For Research Development | Antibodies that bind interleukin-2 and uses thereof |
| GB201621806D0 (en) * | 2016-12-21 | 2017-02-01 | Philogen Spa | Immunocytokines with progressive activation mechanism |
| WO2018156955A1 (en) * | 2017-02-23 | 2018-08-30 | City Of Hope | Methods for in vivo expansion of cd8+ t cells and prevention or treatment of gvhd |
| BR112019019595A2 (pt) * | 2017-03-23 | 2020-04-14 | Univ Pennsylvania | anticorpo, métodos para tratar uma doença ou distúrbio mediado pela via do complemento em um indivíduo e para reduzir a atividade de um sistema complemento de um indivíduo, e, célula |
| EP3630825B1 (en) * | 2017-05-25 | 2024-02-14 | Institute For Basic Science | Anti-human interleukin-2 antibodies and uses thereof |
| EP3768698B1 (en) | 2018-03-19 | 2025-02-12 | MultiVir Inc. | Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| CN115768483A (zh) | 2020-01-13 | 2023-03-07 | 西纳福克斯股份有限公司 | 抗体与免疫细胞衔接器的缀合物 |
| AU2021221287B2 (en) | 2020-02-16 | 2023-10-05 | Aulos Bioscience, Inc | Engineered anti-IL-2 antibodies |
| AR121891A1 (es) * | 2020-04-22 | 2022-07-20 | Merck Sharp & Dohme | CONJUGADOS DE INTERLEUCINA 2 HUMANA SESGADOS AL DÍMERO DEL RECEPTOR DE INTERLEUCINA 2 bgᶜ Y CONJUGADOS CON UN POLÍMERO HIDROSOLUBLE NO PEPTÍDICO |
| KR20230048151A (ko) * | 2020-08-18 | 2023-04-10 | 유니버시타트 취리히 | Cd25 편향된 항-il-2 항체 |
| CN116783213A (zh) * | 2020-08-18 | 2023-09-19 | 苏黎世大学 | Cd25偏向的抗il‐2抗体 |
| CN117157107A (zh) | 2021-02-08 | 2023-12-01 | 西纳福克斯股份有限公司 | 多功能抗体 |
| WO2023061005A1 (zh) | 2021-10-14 | 2023-04-20 | 徕特康(苏州)生物制药有限公司 | 新型抗体-细胞因子融合蛋白及其制备方法和用途 |
| US11773160B1 (en) | 2022-08-05 | 2023-10-03 | Anaveon AG | Immune-stimulating IL-2 fusion proteins |
| CN119912559B (zh) * | 2025-01-22 | 2025-12-26 | 贵州中医药大学 | 一种新冠病毒变异株jn.1刺突s蛋白的单链抗体及其应用 |
| CN119775409B (zh) * | 2025-03-05 | 2025-07-11 | 深圳真实生物医药科技有限公司 | 靶向sost的抗体及其用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK174501B1 (da) | 1983-12-23 | 2003-04-28 | Hoffmann La Roche | Fremgangsmåde til fremstilling af interleukin-2 |
| JPS62269698A (ja) * | 1986-03-17 | 1987-11-24 | エフ．ホフマン ― ラ ロシュ アーゲー | Ｉｌ−２蛋白質に対するモノクロ−ナル抗体 |
| ES2308787T3 (es) | 1996-08-16 | 2008-12-01 | Schering Corporation | Antigenos de superficie de celular de mamiferos; reactivos relacionados. |
| US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| AU2003300184B8 (en) | 2002-12-30 | 2009-12-03 | 3M Innovative Properties Company | Immunostimulatory combinations |
| EP1765402A2 (en) | 2004-06-04 | 2007-03-28 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
| NZ563213A (en) * | 2005-06-01 | 2009-07-31 | Micromet Ag | Anti-IL2 antibodies |
| CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| WO2007095643A2 (en) * | 2006-02-16 | 2007-08-23 | Nascent Biologics, Inc. | Methods for improving immune function and methods for prevention or treatment of disease in a mammalian subject |
| CN101045923B (zh) * | 2006-03-31 | 2011-11-23 | 沈阳三生制药有限责任公司 | 生产一种白细胞介素类似物的方法 |
| PT2242773T (pt) | 2008-02-11 | 2017-09-15 | Cure Tech Ltd | Anticorpos monoclonais para o tratamento de tumores |
| PT3042917T (pt) | 2010-08-12 | 2018-05-02 | Lilly Co Eli | Anticorpos do péptido beta amilóide anti-n3pglu e seus usos |
| HUE029139T2 (hu) | 2011-02-10 | 2017-02-28 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
| WO2013157105A1 (ja) * | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| WO2015109212A1 (en) * | 2014-01-17 | 2015-07-23 | Pfizer Inc. | Anti-il-2 antibodies and compositions and uses thereof |
-
2015
- 2015-07-10 CA CA2954476A patent/CA2954476C/en active Active
- 2015-07-10 ES ES15759938T patent/ES2779977T3/es active Active
- 2015-07-10 EP EP15759938.2A patent/EP3166973B1/en active Active
- 2015-07-10 EP EP20158066.9A patent/EP3693389B1/en active Active
- 2015-07-10 ES ES20158066T patent/ES2989669T3/es active Active
- 2015-07-10 JP JP2017501280A patent/JP7209464B2/ja active Active
- 2015-07-10 AU AU2015287227A patent/AU2015287227B2/en not_active Ceased
- 2015-07-10 DK DK15759938.2T patent/DK3166973T3/da active
- 2015-07-10 US US15/324,468 patent/US10894828B2/en active Active
- 2015-07-10 CN CN201580048027.0A patent/CN106604932B/zh active Active
- 2015-07-10 WO PCT/IB2015/055226 patent/WO2016005950A1/en not_active Ceased
-
2020
- 2020-12-22 US US17/131,221 patent/US20210230269A1/en not_active Abandoned
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