JP2017524654A - 育毛を刺激する小サイズの幹細胞の能力および当該幹細胞の使用 - Google Patents
育毛を刺激する小サイズの幹細胞の能力および当該幹細胞の使用 Download PDFInfo
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- C12N2502/00—Coculture with; Conditioned medium produced by
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Abstract
Description
本願は、2014年7月7日に出願された米国特許出願第62/021,362号および2014年9月19日に出願された米国特許出願第62/052,635号に基づく優先権の利益を主張し、当該出願の開示は参照により本明細書にその全体が組み込まれる。本発明は小サイズの幹細胞、特に8μm若しくは8μm未満の直径を有する小サイズの幹細胞、または当該幹細胞の馴化培地を活性成分として含有する、脱毛を予防し、育毛を刺激するための組成物、当該組成物を調製する方法並びに当該組成物の使用に関する。本発明は8μmまたは8μm未満の直径を有する小サイズの幹細胞の育毛刺激機能を利用する組成物の使用に関し、休止期における毛包幹細胞の活性を大きく高める。
1.幹細胞の調製
(1)幹細胞の単離
1‐1 肉眼による育毛の観測
2‐1 肉眼による育毛の観測
(1)インビトロ実験
Claims (14)
- 脱毛を予防し、育毛を刺激するための組成物であって、
8μmまたは8μm未満の直径を有する小サイズの幹細胞、または前記幹細胞の馴化培地を活性成分として備える、組成物。 - 8μmまたは8μm未満の直径を有する前記小サイズの幹細胞は、骨髄由来、臍帯血由来、脂肪由来、血液由来、肝臓および腸由来、皮膚由来、消化管由来、胎盤由来、神経由来、副腎由来、表皮由来、および子宮由来のヒト成体幹細胞、並びに胚性幹細胞から成る群から選択される少なくとも1つを含む、請求項1に記載の組成物。
- 8μmまたは8μm未満の直径を有する前記小サイズの幹細胞は、骨髄、臍帯血または脂肪由来である、請求項2に記載の組成物。
- 8μmまたは8μm未満の直径を有する前記小サイズの幹細胞は、前記臍帯血由来である、請求項3に記載の組成物。
- 8μmまたは8μm未満の直径を有する前記小サイズの幹細胞は、臍帯血由来の間葉系幹細胞である、請求項4に記載の組成物。
- 前記臍帯血はヒト由来である、請求項4に記載の組成物。
- 前記馴化培地はケラチノサイト‐無血清培地(K‐SFM)を含む、請求項1に記載の組成物。
- 8μmまたは8μm未満の直径を有する前記小サイズの幹細胞または前記幹細胞の前記馴化培地は、毛包幹細胞を活性化する、請求項1に記載の組成物。
- 8μmまたは8μm未満の直径を有する前記小サイズの幹細胞または前記幹細胞の前記馴化培地は、
(i)毛周期における休止期から成長期への転換のための時間を低減する、
(ii)毛周期制御を正常化する、および
(iii)乳頭細胞の生成を増加させる、
機能を有する、請求項8に記載の組成物。 - 前記組成物は、医薬組成物または化粧品組成物である、請求項1に記載の組成物。
- 注入を使用する経皮投与により請求項1から10のいずれか一項に記載の前記組成物を使用する方法。
- 前記注入は、シリンジ針の穴を上向きに置きながら対象の真皮に前記組成物を投与する方法である、請求項11に記載の方法。
- 活性成分として8μmまたは8μm未満の直径を有する小サイズの幹細胞または前記幹細胞の馴化培地を使用する脱毛を治療する方法。
- 8μmまたは8μm未満の直径を有する前記小サイズの幹細胞は臍帯血由来である、請求項13に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462021362P | 2014-07-07 | 2014-07-07 | |
US62/021,362 | 2014-07-07 | ||
US201462052635P | 2014-09-19 | 2014-09-19 | |
US62/052,635 | 2014-09-19 | ||
PCT/KR2015/002007 WO2016006788A1 (ko) | 2014-07-07 | 2015-03-02 | 작은 크기 줄기세포의 발모 촉진능 및 이의 용도 |
Publications (2)
Publication Number | Publication Date |
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JP2017524654A true JP2017524654A (ja) | 2017-08-31 |
JP6367372B2 JP6367372B2 (ja) | 2018-08-01 |
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JP2016569371A Active JP6367372B2 (ja) | 2014-07-07 | 2015-03-02 | 育毛を刺激する小サイズの幹細胞の能力および当該幹細胞の使用 |
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Country | Link |
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US (2) | US20160000698A1 (ja) |
EP (1) | EP3146973B1 (ja) |
JP (1) | JP6367372B2 (ja) |
KR (1) | KR20160145778A (ja) |
CN (1) | CN106659741B (ja) |
ES (1) | ES2799406T3 (ja) |
WO (1) | WO2016006788A1 (ja) |
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US11406668B2 (en) | 2017-10-02 | 2022-08-09 | Hirotaro FUKUOKA | Pharmaceutical composition for use in improving quality of scalp or skin, wound healing, or improving quality of hair |
CN108324993B (zh) * | 2018-01-15 | 2020-11-03 | 朱剑虹 | 一种诱导毛发再生的干细胞复合体、其制备方法及应用 |
CN110721197A (zh) * | 2018-06-28 | 2020-01-24 | 玛旺干细胞医学生物科技股份有限公司 | 促进毛发生长的组合物 |
KR20200020438A (ko) * | 2018-08-17 | 2020-02-26 | 고려대학교 산학협력단 | 태반유래 세포 조건화 배지에서의 모낭세포 기능강화 및 대량생산 방법 |
JP7246595B2 (ja) * | 2018-11-08 | 2023-03-28 | 国立大学法人横浜国立大学 | 毛包原基、毛包原基の製造方法、及び毛包原基に含まれる細胞の活性化方法 |
KR102141641B1 (ko) * | 2020-01-31 | 2020-08-06 | 주식회사 래디안 | 인간지방 유래 중간엽 줄기세포로부터 모유두세포로의 분화방법 |
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CN106659741B (zh) | 2020-03-17 |
JP6367372B2 (ja) | 2018-08-01 |
WO2016006788A1 (ko) | 2016-01-14 |
EP3146973A1 (en) | 2017-03-29 |
US20160000698A1 (en) | 2016-01-07 |
US20180008531A1 (en) | 2018-01-11 |
KR20160145778A (ko) | 2016-12-20 |
EP3146973A4 (en) | 2018-01-10 |
CN106659741A (zh) | 2017-05-10 |
EP3146973B1 (en) | 2020-05-06 |
ES2799406T3 (es) | 2020-12-17 |
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