|
US4172896A
(en)
|
1978-06-05 |
1979-10-30 |
Dainippon Pharmaceutical Co., Ltd. |
Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
|
|
US5049578A
(en)
|
1990-03-09 |
1991-09-17 |
E. R. Squibb & Sons, Inc. |
1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones
|
|
GB9217295D0
(en)
|
1992-08-14 |
1992-09-30 |
Wellcome Found |
Controlled released tablets
|
|
US5541231A
(en)
|
1993-07-30 |
1996-07-30 |
Glaxo Wellcome Inc. |
Stabilized Pharmaceutical
|
|
US5358970A
(en)
|
1993-08-12 |
1994-10-25 |
Burroughs Wellcome Co. |
Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
|
|
GB9315856D0
(en)
|
1993-07-30 |
1993-09-15 |
Wellcome Found |
Stabilized pharmaceutical
|
|
ATE250923T1
(de)
|
1997-07-29 |
2003-10-15 |
Alcon Lab Inc |
Galaktomannanpolymere und borat enthaltende augenarzneimittel
|
|
EP1051167A1
(en)
|
1998-01-29 |
2000-11-15 |
Sepracor, Inc. |
Pharmaceutical uses of optically pure (-) -bupropion
|
|
JP4633925B2
(ja)
|
1998-05-08 |
2011-02-16 |
スミスクライン ビーチャム ピー エル シー |
フェニル尿素およびフェニルチオ尿素誘導体
|
|
WO2000047577A1
(en)
|
1999-02-12 |
2000-08-17 |
Smithkline Beecham Plc |
Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
|
|
ES2231158T3
(es)
|
1999-02-12 |
2005-05-16 |
Smithkline Beecham Plc |
Derivados y fenil urea y fenil tiourea.
|
|
WO2000047576A1
(en)
|
1999-02-12 |
2000-08-17 |
Smithkline Beecham Plc |
Cinnamide derivatives as orexin-1 receptors antagonists
|
|
JP2003500385A
(ja)
|
1999-05-24 |
2003-01-07 |
コア・セラピューティクス,インコーポレイテッド |
Xa因子阻害剤
|
|
US8889112B2
(en)
|
1999-09-16 |
2014-11-18 |
Ocularis Pharma, Llc |
Ophthalmic formulations including selective alpha 1 antagonists
|
|
CA2408343A1
(en)
|
2000-05-11 |
2002-11-07 |
Banyu Pharmaceutical Co., Ltd. |
N-acyltetrahydroisoquinoline derivatives
|
|
EP1289955B1
(en)
|
2000-06-16 |
2005-04-13 |
Smithkline Beecham Plc |
Piperidines for use as orexin receptor antagonists
|
|
WO2002044172A1
(en)
|
2000-11-28 |
2002-06-06 |
Smithkline Beecham P.L.C. |
Morpholine derivatives as antagonists of orexin receptors
|
|
WO2002051232A2
(en)
|
2000-12-27 |
2002-07-04 |
Actelion Pharmaceuticals Ltd. |
Novel benzazepines and related heterocyclic derivatives
|
|
MXPA03010129A
(es)
|
2001-05-05 |
2004-03-10 |
Smithkline Beecham Plc |
N-aroilaminas-ciclicas.
|
|
US20040192673A1
(en)
|
2001-05-05 |
2004-09-30 |
Pascale Gaillard |
N-aroyl cyclic amine derivatives as orexin receptor antagonists
|
|
GB0115862D0
(en)
|
2001-06-28 |
2001-08-22 |
Smithkline Beecham Plc |
Compounds
|
|
GB0124463D0
(en)
|
2001-10-11 |
2001-12-05 |
Smithkline Beecham Plc |
Compounds
|
|
GB0126292D0
(en)
|
2001-11-01 |
2002-01-02 |
Smithkline Beecham Plc |
Compounds
|
|
GB0127145D0
(en)
|
2001-11-10 |
2002-01-02 |
Smithkline Beecham |
Compounds
|
|
GB0130393D0
(en)
|
2001-12-19 |
2002-02-06 |
Smithkline Beecham Plc |
Compounds
|
|
GB0130341D0
(en)
|
2001-12-19 |
2002-02-06 |
Smithkline Beecham Plc |
Compounds
|
|
GB0130335D0
(en)
|
2001-12-19 |
2002-02-06 |
Smithkline Beecham Plc |
Compounds
|
|
CN1556705B
(zh)
|
2002-07-09 |
2010-04-28 |
埃科特莱茵药品有限公司 |
7,8,9,10-四氢-6H-氮杂卓并、6,7,8,9-四氢-吡啶并和2,3-二氢-2H-吡咯并[2,1-b]-喹唑啉酮衍生物
|
|
WO2004026866A1
(en)
|
2002-09-18 |
2004-04-01 |
Glaxo Group Limited |
N-aroyl cyclic amines as orexin receptor antagonists
|
|
RU2334735C2
(ru)
|
2002-10-11 |
2008-09-27 |
Актелион Фармасьютиклз Лтд. |
Производные сульфониламиноуксусной кислоты и их применение в качестве антагонистов рецепторов орексина
|
|
GB0225938D0
(en)
|
2002-11-06 |
2002-12-11 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0225944D0
(en)
|
2002-11-06 |
2002-12-11 |
Glaxo Group Ltd |
Novel compounds
|
|
GB0225884D0
(en)
|
2002-11-06 |
2002-12-11 |
Glaxo Group Ltd |
Novel compounds
|
|
AU2003299648A1
(en)
|
2002-12-12 |
2004-06-30 |
Janssen Pharmaceutica, N.V. |
Substituted 4-phenyl-(1,3)-dioxanes
|
|
ATE435210T1
(de)
|
2003-03-26 |
2009-07-15 |
Actelion Pharmaceuticals Ltd |
Tetrahydroisochinolylacetamidderivate zur verwendung als orexinrezeptorantagonisten
|
|
JP2007523846A
(ja)
|
2003-04-28 |
2007-08-23 |
アクテリオン ファマシューティカルズ リミテッド |
キノキサリノン誘導体
|
|
US6933289B2
(en)
|
2003-07-01 |
2005-08-23 |
Allergan, Inc. |
Inhibition of irritating side effects associated with use of a topical ophthalmic medication
|
|
CA2534484A1
(en)
|
2003-08-07 |
2005-02-17 |
Allergan, Inc. |
Compositions for delivery of therapeutics into the eyes and methods for making and using same
|
|
US20050059744A1
(en)
|
2003-09-12 |
2005-03-17 |
Allergan, Inc. |
Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
|
|
HUP0304101A3
(en)
|
2003-12-22 |
2008-10-28 |
Sanofi Aventis |
Pyrazole derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
|
|
HUP0400405A3
(en)
|
2004-02-10 |
2009-03-30 |
Sanofi Synthelabo |
Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
|
|
PT1751111E
(pt)
|
2004-03-01 |
2015-04-01 |
Actelion Pharmaceuticals Ltd |
Derivados de 1,2,3,4-tetrahidroisoquinolina substituída
|
|
WO2006067224A2
(en)
|
2004-12-23 |
2006-06-29 |
Biovitrum Ab (Publ) |
Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists
|
|
CA2603766A1
(en)
|
2005-04-12 |
2006-10-19 |
Merck & Co., Inc. |
Amidopropoxyphenyl orexin receptor antagonists
|
|
WO2007008276A2
(en)
|
2005-05-03 |
2007-01-18 |
Ensemble Discovery Corporation |
Turnover probes and use thereof for nucleic acid detection
|
|
AU2006251590A1
(en)
|
2005-05-23 |
2006-11-30 |
Merck & Co., Inc. |
Proline bis-amide orexin receptor antagonists
|
|
JP2009503106A
(ja)
|
2005-08-04 |
2009-01-29 |
メルク エンド カムパニー インコーポレーテッド |
アミノエタンスルホンアミドオレキシン受容体アンタゴニスト
|
|
EP1922071A2
(en)
|
2005-08-26 |
2008-05-21 |
Merck & Co., Inc. |
Diazaspirodecane orexin receptor antagonists
|
|
US20090088452A1
(en)
|
2005-11-22 |
2009-04-02 |
Coleman Paul J |
Indole Orexin Receptor Antagonists
|
|
CN101009515A
(zh)
|
2006-01-24 |
2007-08-01 |
华为技术有限公司 |
通信终端设备管理方法及通信终端
|
|
TW200800020A
(en)
|
2006-01-26 |
2008-01-01 |
Basf Ag |
Methods to use 3-pyridyl derivatives as pesticides
|
|
FR2896798A1
(fr)
|
2006-01-27 |
2007-08-03 |
Sanofi Aventis Sa |
Derives de sulfonamides, leur preparation et leur application en therapeutique
|
|
FR2896799B1
(fr)
|
2006-02-02 |
2008-03-28 |
Sanofi Aventis Sa |
Derives de sulfonamides, leur preparation et leur application en therapeutique
|
|
US20090105318A1
(en)
|
2006-03-29 |
2009-04-23 |
Coleman Paul J |
Amidoethylthioether Orexin Receptor Antagonists
|
|
CN101460453B
(zh)
|
2006-04-11 |
2012-10-03 |
埃科特莱茵药品有限公司 |
磺酰胺化合物
|
|
DE602007012072D1
(de)
|
2006-04-26 |
2011-03-03 |
Actelion Pharmaceuticals Ltd |
Orantagonisten
|
|
WO2007143813A1
(en)
|
2006-06-16 |
2007-12-21 |
Husky Injection Molding Systems Ltd. |
Preventative maintenance update system
|
|
JP2009543785A
(ja)
|
2006-07-14 |
2009-12-10 |
メルク エンド カムパニー インコーポレーテッド |
架橋ジアゼパンオレキシン受容体アンタゴニスト
|
|
WO2008008551A2
(en)
|
2006-07-14 |
2008-01-17 |
Merck & Co., Inc. |
2-substituted proline bis-amide orexin receptor antagonists
|
|
EP2049529B1
(en)
|
2006-07-14 |
2010-08-11 |
Merck Sharp & Dohme Corp. |
Substituted diazepan orexin receptor antagonists
|
|
KR101113626B1
(ko)
|
2006-08-15 |
2012-02-17 |
액테리온 파마슈티칼 리미티드 |
오렉신 수용체 길항제로서 아제티딘 화합물
|
|
CN101511833A
(zh)
|
2006-08-28 |
2009-08-19 |
埃科特莱茵药品有限公司 |
1,4,5,6,7,8-六氢-1,2,5-三氮杂-甘菊环烃衍生物
|
|
US20100016401A1
(en)
|
2006-09-29 |
2010-01-21 |
Actelion Phamaceuticals Ltd. |
3-aza-bicyclo[3.1.0]hexane derivatives
|
|
ES2357992T3
(es)
|
2006-12-01 |
2011-05-04 |
Actelion Pharmaceuticals Ltd. |
Derivados de 3-heteroaril(amino o amido)-1-(bifenil o feniltiazolil)carbonilpiperidina como inhibidores del receptor de orexina.
|
|
PE20081229A1
(es)
|
2006-12-01 |
2008-08-28 |
Merck & Co Inc |
Antagonistas de receptor de orexina de diazepam sustituido
|
|
JP2010513466A
(ja)
|
2006-12-22 |
2010-04-30 |
アクテリオン ファーマシューティカルズ リミテッド |
5,6,7,8−テトラヒドロ−イミダゾ[1,5−a]ピラジン誘導体
|
|
AR064561A1
(es)
|
2006-12-28 |
2009-04-08 |
Actelion Pharmaceuticals Ltd |
Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina.
|
|
WO2008087611A2
(en)
|
2007-01-19 |
2008-07-24 |
Actelion Pharmaceuticals Ltd |
Pyrrolidine- and piperidine- bis-amide derivatives
|
|
JP2010520206A
(ja)
|
2007-03-02 |
2010-06-10 |
メルク・シャープ・エンド・ドーム・コーポレイション |
ビピリジンカルボキサミドオレキシン受容体アンタゴニスト
|
|
MX2009009121A
(es)
|
2007-03-05 |
2009-09-03 |
Hoffmann La Roche |
Aminoamidas como antagonistas de orexina.
|
|
ATE506343T1
(de)
|
2007-03-15 |
2011-05-15 |
Hoffmann La Roche |
Malonamide als orexin-antagonisten
|
|
CL2008000836A1
(es)
|
2007-03-26 |
2008-11-07 |
Actelion Pharmaceuticals Ltd |
Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras.
|
|
WO2008122513A1
(en)
|
2007-04-04 |
2008-10-16 |
F. Hoffmann-La Roche Ag |
Heterocycles as orexin antagonists
|
|
CA2685743A1
(en)
|
2007-05-14 |
2008-11-20 |
Actelion Pharmaceuticals Ltd |
2-cyclopropyl-thiazole derivatives
|
|
WO2008143856A1
(en)
|
2007-05-18 |
2008-11-27 |
Merck & Co., Inc. |
Oxo bridged diazepan orexin receptor antagonists
|
|
US8030495B2
(en)
|
2007-05-23 |
2011-10-04 |
Coleman Paul J |
Cyclopropyl pyrrolidine orexin receptor antagonists
|
|
UA99620C2
(en)
|
2007-05-23 |
2012-09-10 |
Мерк Шарп Энд Доме Корп. |
Pyridyl piperidine orexin receptor antagonists
|
|
CN101730696B
(zh)
|
2007-07-03 |
2013-01-09 |
埃科特莱茵药品有限公司 |
3-氮杂-二环[3.3.0]辛烷化合物
|
|
NZ583487A
(en)
|
2007-07-27 |
2011-09-30 |
Actelion Pharmaceuticals Ltd |
2-aza-bicyclo[3.3.0]octane derivatives
|
|
DE602008004265D1
(de)
|
2007-07-27 |
2011-02-10 |
Actelion Pharmaceuticals Ltd |
Trans-3-aza-bicyclo-ä3.1.0ü-hexan-derivate
|
|
US20090036422A1
(en)
|
2007-08-02 |
2009-02-05 |
Henner Knust |
Monoamide derivatives as orexin receptor antagonists
|
|
EP2184981A4
(en)
|
2007-08-09 |
2012-02-01 |
Merck Sharp & Dohme |
PYRIDINE carboxamide-orexin receptor Antagonist
|
|
NZ583823A
(en)
|
2007-08-10 |
2011-07-29 |
Cortex Pharma Inc |
Furazanes for enhancing glutamatergic synaptic responses
|
|
EP2188282B1
(en)
|
2007-08-15 |
2013-01-23 |
Actelion Pharmaceuticals Ltd. |
1,2-diamido-ethylene derivatives as orexin antagonists
|
|
EP2207778A2
(en)
|
2007-09-24 |
2010-07-21 |
Actelion Pharmaceuticals Ltd. |
Pyrrolidines and piperidines as orexin receptor antagonists
|
|
US8362009B2
(en)
|
2007-10-29 |
2013-01-29 |
Merck Sharp & Dohme Corp. |
Substituted diazepan orexin receptor antagonists
|
|
WO2009079637A1
(en)
|
2007-12-18 |
2009-06-25 |
Concert Pharmaceuticals, Inc. |
Tetrahydroisoquinoline derivatives
|
|
BRPI0821141A2
(pt)
|
2007-12-21 |
2015-06-16 |
Hoffmann La Roche |
Derivados de heteroarila como antagonistas do receptor de orexina
|
|
CN101918359B
(zh)
|
2008-01-21 |
2013-02-27 |
弗·哈夫曼-拉罗切有限公司 |
作为食欲肽拮抗剂的磺酰胺类化合物
|
|
MX2010007968A
(es)
|
2008-02-12 |
2010-08-04 |
Hoffmann La Roche |
Derivados de sulfonamida piperidina.
|
|
AU2009215243A1
(en)
|
2008-02-21 |
2009-08-27 |
Actelion Pharmaceuticals Ltd. |
2-aza-bicyclo[2.2.1]heptane derivatives
|
|
GB0806536D0
(en)
|
2008-04-10 |
2008-05-14 |
Glaxo Group Ltd |
Novel compounds
|
|
US20110086889A1
(en)
|
2008-06-11 |
2011-04-14 |
Hamed Aissaoui |
Tetrazole compounds as orexin receptor antagonists
|
|
KR20110025915A
(ko)
|
2008-06-16 |
2011-03-14 |
에프. 호프만-라 로슈 아게 |
오렉시닌 수용체 길항제로서 헤테로방향족 모노아마이드
|
|
WO2009156951A2
(en)
|
2008-06-25 |
2009-12-30 |
Actelion Pharmaceuticals Ltd |
5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds
|
|
CN102083827A
(zh)
|
2008-07-07 |
2011-06-01 |
埃科特莱茵药品有限公司 |
作为食欲素受体拮抗剂的噻唑烷化合物
|
|
ES2386526T3
(es)
|
2008-07-29 |
2012-08-22 |
F. Hoffmann-La Roche Ag |
Pirrolidin-3-ilmetilaminas, como antagonistas de orexina
|
|
AR072899A1
(es)
|
2008-08-07 |
2010-09-29 |
Merck Sharp & Dohme |
Derivados de terpiridina-carboxamida antagonistas de receptores de orexina, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del insomnio y la obesidad.
|
|
EP2161266A1
(en)
|
2008-08-22 |
2010-03-10 |
EVOTEC Neurosciences GmbH |
Benzofuran derivatives as orexin receptor antagonists
|
|
WO2010038200A1
(en)
|
2008-10-01 |
2010-04-08 |
Actelion Pharmaceuticals Ltd |
Oxazolidine compounds as orexin receptor antagonists
|
|
CA2739344A1
(en)
|
2008-10-14 |
2010-04-22 |
Actelion Pharmaceuticals Ltd |
Phenethylamide derivatives and their heterocyclic analogues
|
|
US8710076B2
(en)
|
2008-10-21 |
2014-04-29 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted piperidine orexin receptor antagonists
|
|
AU2009307920A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
2,3-disubstituted piperidine orexin receptor antagonists
|
|
JP2012506374A
(ja)
|
2008-10-21 |
2012-03-15 |
メルク・シャープ・エンド・ドーム・コーポレイション |
2,5−二置換ピペリジンオレキシン受容体アンタゴニスト
|
|
CA2739919A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
2,4-disubstituted pyrrolidine orexin receptor antagonists
|
|
US8466281B2
(en)
|
2008-10-21 |
2013-06-18 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted morpholine orexin receptor antagonists
|
|
WO2010048017A1
(en)
|
2008-10-21 |
2010-04-29 |
Merck Sharp & Dohme Corp. |
Disubstituted azepan orexin receptor antagonists
|
|
US8703770B2
(en)
|
2008-10-30 |
2014-04-22 |
Merck Sharp & Dohme Corp. |
Pyridazine carboxamide orexin receptor antagonists
|
|
AU2009308980B2
(en)
|
2008-10-30 |
2013-02-28 |
Merck Sharp & Dohme Corp. |
Isonicotinamide orexin receptor antagonists
|
|
US8399494B2
(en)
|
2008-10-30 |
2013-03-19 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted phenyl carboxamide orexin receptor antagonists
|
|
JP2012509911A
(ja)
|
2008-11-26 |
2012-04-26 |
グラクソ グループ リミテッド |
新規の化合物
|
|
EP2358711A1
(en)
|
2008-11-26 |
2011-08-24 |
Glaxo Group Limited |
Piperidine derivatives useful as orexin receptor antagonists
|
|
WO2010060472A1
(en)
|
2008-11-26 |
2010-06-03 |
Glaxo Group Limited |
Imidazopyridazine derivatives acting as orexin antagonists
|
|
EP2370427A1
(en)
|
2008-12-02 |
2011-10-05 |
Glaxo Group Limited |
N-{[(ir,4s,6r-3-(2-pyridinylcarbonyl)-3-azabicyclo [4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives and uses thereof
|
|
WO2010063663A1
(en)
|
2008-12-02 |
2010-06-10 |
Glaxo Group Limited |
N-{[(ir,4s,6r-3-(2-pyridinylcarbonyl)-3-azabicyclo [4.1.0]hept-4-yl] methyl}-2-heteroarylamine derivatives and uses thereof
|
|
JP2010155827A
(ja)
|
2008-12-04 |
2010-07-15 |
Takeda Chem Ind Ltd |
スピロ環化合物
|
|
GB0823467D0
(en)
|
2008-12-23 |
2009-01-28 |
Glaxo Group Ltd |
Novel Compounds
|
|
US20100222396A1
(en)
|
2009-01-30 |
2010-09-02 |
Novartis Ag |
4-aryl-butane-1,3-diamides
|
|
EA201171293A1
(ru)
|
2009-04-24 |
2012-05-30 |
Глэксо Груп Лимитед |
3-азабицикло[4.1.0]гептаны, применяемые в качестве антагонистов орексина
|
|
WO2011005636A1
(en)
|
2009-07-09 |
2011-01-13 |
Merck Sharp & Dohme Corp. |
Tetrahydronapthyridine orexin receptor antagonists
|
|
EP2275421A1
(en)
|
2009-07-15 |
2011-01-19 |
Rottapharm S.p.A. |
Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction
|
|
US8809380B2
(en)
|
2009-08-04 |
2014-08-19 |
Raqualia Pharma Inc. |
Picolinamide derivatives as TTX-S blockers
|
|
JP2013502447A
(ja)
|
2009-08-24 |
2013-01-24 |
グラクソ グループ リミテッド |
睡眠障害の治療のためのオレキシン受容体アンタゴニストとしての5−メチル−ピペリジン誘導体
|
|
US20120149711A1
(en)
|
2009-08-24 |
2012-06-14 |
Glaxo Group Limited |
Piperidine derivatives used as orexin antagonists
|
|
JP5848251B2
(ja)
|
2009-10-23 |
2016-01-27 |
ヤンセン ファーマシューティカ エヌ.ベー. |
オレキシン受容体調節因子としての縮合複素環式化合物
|
|
CA2778484C
(en)
|
2009-10-23 |
2018-07-31 |
Janssen Pharmaceutica Nv |
Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
|
|
WO2011050200A1
(en)
|
2009-10-23 |
2011-04-28 |
Janssen Pharmaceutica Nv |
Fused heterocyclic compounds as orexin receptor modulators
|
|
WO2011053522A1
(en)
|
2009-10-29 |
2011-05-05 |
Merck Sharp & Dohme Corp. |
Tertiary amide orexin receptor antagonists
|
|
US20120258957A1
(en)
|
2009-11-23 |
2012-10-11 |
Matilda Jane Bingham |
Heterocyclic derivatives
|
|
WO2011073316A1
(en)
|
2009-12-18 |
2011-06-23 |
Novartis Ag |
4-aryl-butane-1,3-diamides
|
|
JP2013515033A
(ja)
|
2009-12-21 |
2013-05-02 |
ノバルティス アーゲー |
オレキシン受容体アンタゴニストとしてのジアザ−スピロ[5.5]ウンデカン類
|
|
ES2460915T3
(es)
|
2009-12-21 |
2014-05-16 |
Novartis Ag |
Piridinas fusionadas con heteroarilo disustituido
|
|
WO2011138266A1
(en)
|
2010-05-03 |
2011-11-10 |
Evotec Ag |
Indolizine and imidazopyridine derivatives as orexin receptor antagonists
|
|
WO2011138265A2
(en)
|
2010-05-03 |
2011-11-10 |
Evotec Ag |
Indole and indazole derivatives as orexin receptor antagonists
|
|
NZ611865A
(en)
|
2010-12-17 |
2014-11-28 |
Taisho Pharmaceutical Co Ltd |
Pyrazole derivative
|
|
US20120165331A1
(en)
|
2010-12-22 |
2012-06-28 |
Sangamesh Badiger |
Di/tri-aza-spiro-C9-C11alkanes
|
|
US20120165339A1
(en)
|
2010-12-22 |
2012-06-28 |
Eisai R&D Management Co., Ltd. |
Cyclopropane derivatives
|
|
WO2012085857A1
(en)
|
2010-12-22 |
2012-06-28 |
Actelion Pharmaceuticals Ltd |
3,8-diaza-bicyclo[4.2.0]oct-3-yl amides
|
|
WO2012089607A1
(en)
|
2010-12-28 |
2012-07-05 |
Glaxo Group Limited |
Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors
|
|
WO2012089606A1
(en)
|
2010-12-28 |
2012-07-05 |
Glaxo Group Limited |
Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists
|
|
CA2823877C
(en)
|
2011-02-18 |
2020-01-07 |
Actelion Pharmaceuticals Ltd |
Novel pyrazole and imidazole derivatives useful as orexin antagonists
|
|
WO2012114252A1
(en)
|
2011-02-21 |
2012-08-30 |
Actelion Pharmaceuticals Ltd |
Novel indole and pyrrolopyridine amides
|
|
US9586962B2
(en)
|
2011-04-20 |
2017-03-07 |
Janssen Pharmaceutica Nv |
Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
|
|
EP2708537A4
(en)
|
2011-05-10 |
2014-10-01 |
Taisho Pharmaceutical Co Ltd |
HETEROAROMATIC RING DERIVATIVE
|
|
US20140228377A1
(en)
|
2011-07-05 |
2014-08-14 |
Taisho Pharmaceutical Co., Ltd. |
Methylpiperidine derivative
|
|
WO2013050938A1
(en)
|
2011-10-04 |
2013-04-11 |
Actelion Pharmaceuticals Ltd |
3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
|
|
AR088352A1
(es)
|
2011-10-19 |
2014-05-28 |
Merck Sharp & Dohme |
Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
|
|
WO2013059163A1
(en)
|
2011-10-21 |
2013-04-25 |
Merck Sharp & Dohme Corp. |
2,5-disubstituted thiomorpholine orexin receptor antagonists
|
|
EP2771346A4
(en)
|
2011-10-25 |
2015-06-03 |
Merck Sharp & Dohme |
ISOXAZOLOPYRIDIN-orexin
|
|
EP2771001A4
(en)
|
2011-10-25 |
2015-03-25 |
Merck Sharp & Dohme |
PIPERIDINYL-alkyne-orexin
|
|
AR088692A1
(es)
|
2011-11-08 |
2014-06-25 |
Actelion Pharmaceuticals Ltd |
Derivados de 2-(1,2,3-triazol-2-il)benzamina y 3-(1,2,3-triazol-2-il)picolinamida
|
|
ITMI20112329A1
(it)
|
2011-12-21 |
2013-06-22 |
Rottapharm Spa |
Nuovi derivati spiro amminici
|
|
NZ628491A
(en)
|
2012-02-07 |
2016-06-24 |
Eolas Therapeutics Inc |
Substituted prolines / piperidines as orexin receptor antagonists
|
|
US9440982B2
(en)
|
2012-02-07 |
2016-09-13 |
Eolas Therapeutics, Inc. |
Substituted prolines/piperidines as orexin receptor antagonists
|
|
WO2013123240A1
(en)
|
2012-02-17 |
2013-08-22 |
Eisai R&D Management Co., Ltd |
Methods and compounds useful in the synthesis of orexin-2 receptor antagonists
|
|
ITMI20120322A1
(it)
|
2012-03-01 |
2013-09-02 |
Rottapharm Spa |
Composti di 4,4-difluoro piperidina
|
|
ITMI20120424A1
(it)
|
2012-03-19 |
2013-09-20 |
Rottapharm Spa |
Composti chimici
|
|
WO2015123355A1
(en)
|
2014-02-12 |
2015-08-20 |
Eolas Therapeutics, Inc. |
Substituted prolines / piperidines as orexin receptor antagonists
|