JP2017523209A5 - - Google Patents
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- JP2017523209A5 JP2017523209A5 JP2017505836A JP2017505836A JP2017523209A5 JP 2017523209 A5 JP2017523209 A5 JP 2017523209A5 JP 2017505836 A JP2017505836 A JP 2017505836A JP 2017505836 A JP2017505836 A JP 2017505836A JP 2017523209 A5 JP2017523209 A5 JP 2017523209A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- pharmaceutically acceptable
- acceptable salt
- membered
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 cyano, hydroxy Chemical group 0.000 claims 38
- 150000003839 salts Chemical class 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 11
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000004043 oxo group Chemical group O=* 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 6
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000001786 isothiazolyl group Chemical group 0.000 claims 4
- 125000002393 azetidinyl group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000002098 pyridazinyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- 125000001425 triazolyl group Chemical group 0.000 claims 3
- 125000001781 1,3,4-oxadiazolyl group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- MHCVCKDNQYMGEX-UHFFFAOYSA-N 1,1'-biphenyl;phenoxybenzene Chemical group C1=CC=CC=C1C1=CC=CC=C1.C=1C=CC=CC=1OC1=CC=CC=C1 MHCVCKDNQYMGEX-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- YDADFGXXCHDXFC-UHFFFAOYSA-N C(#N)C1=CC=C(C=N1)C1=C(N=C2N1N=CC=C2)C(=O)NC1CC1 Chemical compound C(#N)C1=CC=C(C=N1)C1=C(N=C2N1N=CC=C2)C(=O)NC1CC1 YDADFGXXCHDXFC-UHFFFAOYSA-N 0.000 claims 1
- KZFDLYSKEWBCTB-UHFFFAOYSA-N C1(CC1)NC(=O)C=1N=C2N(N=CC=C2)C=1C=1C=CC=2N(C=1)N=CN=2 Chemical compound C1(CC1)NC(=O)C=1N=C2N(N=CC=C2)C=1C=1C=CC=2N(C=1)N=CN=2 KZFDLYSKEWBCTB-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- IJGCWHSMOTWWLO-UHFFFAOYSA-N ClC1=CC(=C(C=C1F)C1=C(N=C2N1N=CC=C2)C(=O)NC1CC1)F Chemical compound ClC1=CC(=C(C=C1F)C1=C(N=C2N1N=CC=C2)C(=O)NC1CC1)F IJGCWHSMOTWWLO-UHFFFAOYSA-N 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- OUXBYUBGWJQGHZ-UHFFFAOYSA-N N1(CCC1)C(=O)C=1N=C2N(N=CC=C2)C=1C1=CC=C(C=C1)Cl Chemical compound N1(CCC1)C(=O)C=1N=C2N(N=CC=C2)C=1C1=CC=C(C=C1)Cl OUXBYUBGWJQGHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004622 benzoxazinyl group Chemical group O1NC(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims 1
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000005433 dihydrobenzodioxinyl group Chemical group O1C(COC2=C1C=CC=C2)* 0.000 claims 1
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004852 dihydrofuranyl group Chemical group O1C(CC=C1)* 0.000 claims 1
- 125000005057 dihydrothienyl group Chemical group S1C(CC=C1)* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000003384 isochromanyl group Chemical group C1(OCCC2=CC=CC=C12)* 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 125000004628 isothiazolidinyl group Chemical group S1N(CCC1)* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000003566 oxetanyl group Chemical group 0.000 claims 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000001984 thiazolidinyl group Chemical group 0.000 claims 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462033684P | 2014-08-06 | 2014-08-06 | |
| US62/033,684 | 2014-08-06 | ||
| US201562157129P | 2015-05-05 | 2015-05-05 | |
| US62/157,129 | 2015-05-05 | ||
| PCT/IB2015/055597 WO2016020786A1 (en) | 2014-08-06 | 2015-07-23 | Imidazopyridazine compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019065718A Division JP2019163256A (ja) | 2014-08-06 | 2019-03-29 | イミダゾピリダジン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523209A JP2017523209A (ja) | 2017-08-17 |
| JP2017523209A5 true JP2017523209A5 (OSRAM) | 2018-08-30 |
| JP6506833B2 JP6506833B2 (ja) | 2019-04-24 |
Family
ID=54065405
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505836A Active JP6506833B2 (ja) | 2014-08-06 | 2015-07-23 | イミダゾピリダジン化合物 |
| JP2019065718A Pending JP2019163256A (ja) | 2014-08-06 | 2019-03-29 | イミダゾピリダジン化合物 |
| JP2021037945A Active JP7074903B2 (ja) | 2014-08-06 | 2021-03-10 | イミダゾピリダジン化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019065718A Pending JP2019163256A (ja) | 2014-08-06 | 2019-03-29 | イミダゾピリダジン化合物 |
| JP2021037945A Active JP7074903B2 (ja) | 2014-08-06 | 2021-03-10 | イミダゾピリダジン化合物 |
Country Status (32)
| Country | Link |
|---|---|
| US (4) | US9598421B2 (OSRAM) |
| EP (1) | EP3177624B1 (OSRAM) |
| JP (3) | JP6506833B2 (OSRAM) |
| KR (1) | KR102061952B1 (OSRAM) |
| CN (1) | CN106795165B (OSRAM) |
| AP (1) | AP2017009744A0 (OSRAM) |
| AU (2) | AU2015298378B2 (OSRAM) |
| BR (1) | BR112017001334A2 (OSRAM) |
| CA (1) | CA2899294C (OSRAM) |
| CO (1) | CO2017000980A2 (OSRAM) |
| CR (1) | CR20170035A (OSRAM) |
| CU (1) | CU20170007A7 (OSRAM) |
| DK (1) | DK3177624T3 (OSRAM) |
| DO (1) | DOP2017000034A (OSRAM) |
| EA (1) | EA031201B1 (OSRAM) |
| EC (1) | ECSP17007336A (OSRAM) |
| ES (1) | ES2733502T3 (OSRAM) |
| GE (1) | GEP20196950B (OSRAM) |
| HU (1) | HUE044040T2 (OSRAM) |
| IL (2) | IL250478B (OSRAM) |
| MD (1) | MD20170011A2 (OSRAM) |
| MX (1) | MX376283B (OSRAM) |
| PE (1) | PE20170295A1 (OSRAM) |
| PH (1) | PH12017500095A1 (OSRAM) |
| PL (1) | PL3177624T3 (OSRAM) |
| PT (1) | PT3177624T (OSRAM) |
| SG (1) | SG11201700243YA (OSRAM) |
| SV (1) | SV2017005381A (OSRAM) |
| TN (1) | TN2017000031A1 (OSRAM) |
| TW (2) | TWI577681B (OSRAM) |
| UY (1) | UY36257A (OSRAM) |
| WO (1) | WO2016020786A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201591360A1 (ru) | 2013-02-19 | 2016-03-31 | Пфайзер Инк. | Азабензимидазолы в качестве ингибиторов изозимов фдэ4 для лечения цнс и других расстройств |
| EP3172210B1 (en) | 2014-07-24 | 2020-01-15 | Pfizer Inc | Pyrazolopyrimidine compounds |
| PT3177624T (pt) | 2014-08-06 | 2019-07-11 | Pfizer | Compostos de imidazopiridazina |
| CA3015166C (en) * | 2016-02-23 | 2021-08-03 | Pfizer Inc. | 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| US11370769B2 (en) | 2017-09-07 | 2022-06-28 | Board Of Regents Of The University Of Nebraska | TRPC5 inhibitors and methods of using same |
| EP3773538A1 (en) * | 2018-04-13 | 2021-02-17 | Healx Limited | Treatment of fragile x syndrome |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| EP3937942A4 (en) * | 2019-03-15 | 2022-11-16 | Skyhawk Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR CORRECTING ABERRANT SPLICING |
| CR20220160A (es) | 2019-09-16 | 2022-06-16 | Takeda Pharmaceuticals Co | Derivados de piridazin-3(2h)-ona fusionados con azol |
| JP7765386B2 (ja) * | 2019-10-21 | 2025-11-06 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 発達障害の予防、軽減又は治療のためのイミダゾピリミジン又はイミダゾトリアジン化合物の使用 |
| CN112194660B (zh) * | 2020-10-20 | 2021-12-03 | 常州大学 | 一种pde2抑制剂苯基吡唑并嘧啶类化合物及其制备方法 |
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