JP2017523143A5 - - Google Patents
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- JP2017523143A5 JP2017523143A5 JP2016572643A JP2016572643A JP2017523143A5 JP 2017523143 A5 JP2017523143 A5 JP 2017523143A5 JP 2016572643 A JP2016572643 A JP 2016572643A JP 2016572643 A JP2016572643 A JP 2016572643A JP 2017523143 A5 JP2017523143 A5 JP 2017523143A5
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- JP
- Japan
- Prior art keywords
- nhc
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462011961P | 2014-06-13 | 2014-06-13 | |
| US62/011,961 | 2014-06-13 | ||
| PCT/IB2015/054400 WO2015189791A1 (en) | 2014-06-13 | 2015-06-11 | Auristatin derivatives and conjugates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523143A JP2017523143A (ja) | 2017-08-17 |
| JP2017523143A5 true JP2017523143A5 (enExample) | 2018-07-19 |
| JP6681346B2 JP6681346B2 (ja) | 2020-04-15 |
Family
ID=53491655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572643A Expired - Fee Related JP6681346B2 (ja) | 2014-06-13 | 2015-06-11 | オーリスタチン誘導体およびその抱合体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9884817B2 (enExample) |
| EP (1) | EP3154997B9 (enExample) |
| JP (1) | JP6681346B2 (enExample) |
| KR (1) | KR20170016479A (enExample) |
| CN (1) | CN106573956A (enExample) |
| AU (1) | AU2015273098B2 (enExample) |
| BR (1) | BR112016028835A2 (enExample) |
| CA (1) | CA2951368A1 (enExample) |
| EA (1) | EA201692530A1 (enExample) |
| IL (1) | IL248961A0 (enExample) |
| MX (1) | MX2016016515A (enExample) |
| SG (1) | SG11201609462RA (enExample) |
| WO (1) | WO2015189791A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2900755C (en) * | 2013-02-08 | 2021-07-20 | Irm Llc | Specific sites for modifying antibodies to make immunoconjugates |
| FI3122757T3 (fi) * | 2014-02-28 | 2023-10-10 | Hangzhou Dac Biotech Co Ltd | Varautuneita linkkereitä ja niiden konjugointikäyttötapoja |
| EA201692530A1 (ru) * | 2014-06-13 | 2017-07-31 | Новартис Аг | Цитотоксические пептиды и их конъюгаты |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| SG11201802769RA (en) | 2015-10-29 | 2018-05-30 | Novartis Ag | Antibody conjugates comprising toll-like receptor agonist |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| ES2874974T3 (es) | 2016-05-11 | 2021-11-05 | Cytiva Bioprocess R & D Ab | Matriz de separación |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| JP7106187B2 (ja) | 2016-05-11 | 2022-07-26 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを保存する方法 |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| ES2909833T3 (es) | 2016-05-11 | 2022-05-10 | Cytiva Bioprocess R & D Ab | Método de limpieza y/o desinfección de una matriz de separación |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| CN110099697B (zh) | 2016-12-21 | 2023-11-28 | 诺华股份有限公司 | 用于消融造血干细胞的抗体药物缀合物 |
| JOP20190187A1 (ar) | 2017-02-03 | 2019-08-01 | Novartis Ag | مترافقات عقار جسم مضاد لـ ccr7 |
| MX2020004530A (es) * | 2017-11-18 | 2020-09-18 | Magalhaes Nzola De | Producto y proceso para emplear conjugados de union a antigeno basados en gc7 (n1-guanil-1,7-diaminoheptano) en terapia de cancer. |
| CN111328333B (zh) * | 2019-09-29 | 2023-10-03 | 烟台迈百瑞国际生物医药股份有限公司 | 一种酸法制备抗体药物偶联物中间体的方法及其应用 |
| CN113321702B (zh) * | 2020-02-28 | 2022-08-05 | 国家纳米科学中心 | 一种单甲基澳瑞他汀f甲酯前药及其制备方法和应用 |
| US20230181756A1 (en) | 2020-04-30 | 2023-06-15 | Novartis Ag | Ccr7 antibody drug conjugates for treating cancer |
| CN111675694B (zh) * | 2020-06-28 | 2021-11-26 | 山东大学 | 一种含肟基团的二芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用 |
| EP4319820A1 (en) | 2021-04-10 | 2024-02-14 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| JP7742892B2 (ja) | 2021-04-23 | 2025-09-22 | ジェンマブ エー／エス | 抗ｃｄ７０抗体、そのコンジュゲートおよびこれを使用する方法 |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| CN115957338B (zh) * | 2021-10-12 | 2025-11-18 | 成都科岭源医药技术有限公司 | 一种高稳定性的靶向接头-药物偶联物 |
| US20250049937A1 (en) * | 2021-12-23 | 2025-02-13 | Adcentrx Therapeutics Inc. | Novel auristatin analogs and immunoconjugates thereof |
| WO2025072406A1 (en) | 2023-09-26 | 2025-04-03 | Profoundbio Us Co. | Ptk7 binding agents, conjugates thereof and methods of using the same |
| TW202547866A (zh) | 2024-01-10 | 2025-12-16 | 丹麥商珍美寶股份有限公司 | Ｓｌｉｔｒｋ６結合劑、其共軛物及使用彼之方法 |
| WO2025152969A1 (zh) * | 2024-01-15 | 2025-07-24 | 武汉人福创新药物研发中心有限公司 | 靶向化合物及其用途 |
| US20250381289A1 (en) | 2024-02-29 | 2025-12-18 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| SG87056A1 (en) | 1991-08-09 | 2002-03-19 | Teikoku Hormone Mfg Co Ltd | Novel tetrapeptide derivative |
| JP3469580B2 (ja) | 1993-10-01 | 2003-11-25 | 帝国臓器製薬株式会社 | 新規なペプチド誘導体 |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| CN1113066C (zh) | 1995-04-21 | 2003-07-02 | 帝国脏器制药株式会社 | 新型肽衍生物 |
| JP3614866B2 (ja) | 1997-06-12 | 2005-01-26 | リサーチ コーポレイション テクノロジーズ，インコーポレイティド | 人工抗体ポリペプチド |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| US7803915B2 (en) | 2001-06-20 | 2010-09-28 | Genentech, Inc. | Antibody compositions for the diagnosis and treatment of tumor |
| US20090068178A1 (en) | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| EP3434275A1 (en) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| JP2008519863A (ja) * | 2004-11-12 | 2008-06-12 | シアトル ジェネティクス インコーポレイティッド | Ｎ末端にアミノ安息香酸単位を有するオーリスタチン |
| AU2005316844A1 (en) | 2004-11-29 | 2006-06-22 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
| CN103127523A (zh) | 2005-06-20 | 2013-06-05 | Psma开发有限公司 | Psma抗体-药物缀合物 |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| WO2007103288A2 (en) | 2006-03-02 | 2007-09-13 | Seattle Genetics, Inc. | Engineered antibody drug conjugates |
| AR059900A1 (es) | 2006-03-17 | 2008-05-07 | Genentech Inc | Anticuerpos anti-tat226 e inmunoconjugados |
| WO2009052431A2 (en) | 2007-10-19 | 2009-04-23 | Seattle Genetics, Inc. | Cd19 binding agents and uses thereof |
| EP2265283B1 (en) | 2008-03-18 | 2014-09-03 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| ES2553874T3 (es) | 2010-09-29 | 2015-12-14 | Seattle Genetics, Inc. | N-Carboxialquil-auristatinas y su uso |
| ES3004351T3 (en) | 2010-10-22 | 2025-03-12 | Seagen Inc | Synergistic effects between auristatin-based antibody drug conjugates and inhibitors of the pi3k-akt mtor pathway |
| ES2531471T3 (es) | 2011-02-25 | 2015-03-16 | Lonza Ltd | Enlazador ramificado para conjugados de proteínas-fármacos |
| CA2829736C (en) | 2011-03-16 | 2020-07-21 | Seattle Genetics, Inc. | N-carboxyalkylauristatins and use thereof |
| EP3501546A3 (de) | 2011-04-21 | 2019-09-18 | Seattle Genetics, Inc. | Cystein-wirkstoff konjugate und ihre verwendung |
| CN103717595A (zh) | 2011-05-27 | 2014-04-09 | Ambrx公司 | 含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途 |
| JP2013100803A (ja) | 2011-08-09 | 2013-05-23 | Toru Shinohara | 水力発電装置および水力発電システム |
| TWI589592B (zh) | 2011-11-17 | 2017-07-01 | 輝瑞股份有限公司 | 胞毒性肽類以及其抗體藥物共軛體 |
| AU2012356894B2 (en) | 2011-12-23 | 2018-01-18 | Araris Biotech Ltd. | Enzymatic conjugation of polypeptides |
| JP6290187B2 (ja) | 2012-05-11 | 2018-03-07 | クランツ，アレクサンダー | 癌の処置のためのタンパク質の部位特異的標識及び標的送達 |
| SG11201407017WA (en) | 2012-06-04 | 2014-12-30 | Irm Llc | Site-specific labeling methods and molecules produced thereby |
| US20150314007A1 (en) | 2012-12-21 | 2015-11-05 | Glykos Finland Oy | Linker-payload molecule conjugates |
| JP6636925B2 (ja) * | 2013-12-17 | 2020-01-29 | ノバルティス アーゲー | 細胞障害性ペプチドおよびその抱合体 |
| EA201692530A1 (ru) * | 2014-06-13 | 2017-07-31 | Новартис Аг | Цитотоксические пептиды и их конъюгаты |
-
2015
- 2015-06-11 EA EA201692530A patent/EA201692530A1/ru unknown
- 2015-06-11 AU AU2015273098A patent/AU2015273098B2/en not_active Expired - Fee Related
- 2015-06-11 KR KR1020177000694A patent/KR20170016479A/ko not_active Withdrawn
- 2015-06-11 BR BR112016028835A patent/BR112016028835A2/pt not_active Application Discontinuation
- 2015-06-11 MX MX2016016515A patent/MX2016016515A/es unknown
- 2015-06-11 EP EP15732439.3A patent/EP3154997B9/en active Active
- 2015-06-11 US US15/317,532 patent/US9884817B2/en active Active
- 2015-06-11 CN CN201580043354.7A patent/CN106573956A/zh active Pending
- 2015-06-11 JP JP2016572643A patent/JP6681346B2/ja not_active Expired - Fee Related
- 2015-06-11 CA CA2951368A patent/CA2951368A1/en not_active Abandoned
- 2015-06-11 SG SG11201609462RA patent/SG11201609462RA/en unknown
- 2015-06-11 WO PCT/IB2015/054400 patent/WO2015189791A1/en not_active Ceased
-
2016
- 2016-11-14 IL IL248961A patent/IL248961A0/en unknown
-
2017
- 2017-11-27 US US15/822,930 patent/US10280139B2/en active Active