|
WO1991017773A2
(de)
|
1990-05-18 |
1991-11-28 |
Boehringer Ingelheim International Gmbh |
Neue protein-polykation-konjugate
|
|
DE4104186A1
(de)
|
1991-02-12 |
1992-08-13 |
Genentech Inc |
Neue, ueber endozytose in hoehere eukaryotische zellen aufnehmbare, nukleinsaeure enthaltende komplexe
|
|
IL103059A0
(en)
|
1991-09-30 |
1993-02-21 |
Boehringer Ingelheim Int |
Conjugates for introducing nucleic acid into higher eucaryotic cells
|
|
NZ244306A
(en)
|
1991-09-30 |
1995-07-26 |
Boehringer Ingelheim Int |
Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
|
|
DE19726186A1
(de)
|
1997-06-20 |
1998-12-24 |
Boehringer Ingelheim Int |
Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
|
|
JP3785932B2
(ja)
|
1998-05-25 |
2006-06-14 |
日本新薬株式会社 |
核酸含有複合体製剤の製造方法
|
|
US6652886B2
(en)
|
2001-02-16 |
2003-11-25 |
Expression Genetics |
Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
|
|
US20040043030A1
(en)
|
2001-07-31 |
2004-03-04 |
Immunomedics, Inc. |
Polymeric delivery systems
|
|
GB0119346D0
(en)
|
2001-08-08 |
2001-10-03 |
Bioclones Proprietary Ltd |
Process for the maturation of dendritic cells
|
|
US7060498B1
(en)
|
2001-11-28 |
2006-06-13 |
Genta Salus Llc |
Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
|
|
KR20030043780A
(ko)
|
2001-11-28 |
2003-06-02 |
주식회사 바이오폴리메드 |
생체적합성 비항원성 공중합체와 그 결합체 및 이들의제조방법
|
|
AU2002236324A1
(en)
|
2002-02-28 |
2003-09-09 |
Jong Sang Park |
Cationic highly branched polyaminoester
|
|
SG166672A1
(en)
|
2002-08-06 |
2010-12-29 |
Intradigm Corp |
Methods of down regulating target gene expression in vivo by introduction of interfering rna
|
|
WO2004045491A2
(en)
*
|
2002-11-18 |
2004-06-03 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Targeted double stranded rna mediated cell killing
|
|
US8969543B2
(en)
|
2003-04-03 |
2015-03-03 |
Bioneer Corporation |
SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
|
|
AU2003219576A1
(en)
|
2003-04-03 |
2004-10-25 |
Korea Advanced Institute Of Science And Technology |
Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
|
|
US7727969B2
(en)
|
2003-06-06 |
2010-06-01 |
Massachusetts Institute Of Technology |
Controlled release nanoparticle having bound oligonucleotide for targeted delivery
|
|
US20050118718A1
(en)
|
2003-09-22 |
2005-06-02 |
University Of Utah Research Foundation |
Stabilization and controlled delivery of ionic biopharmaceuticals
|
|
US20050277575A1
(en)
|
2004-03-24 |
2005-12-15 |
Alexandre Semov |
Therapeutic compositions and methods for treating diseases that involve angiogenesis
|
|
WO2006054129A1
(en)
|
2004-11-19 |
2006-05-26 |
Institut Gustave Roussy |
Improved treatment of cancer by double-stranded rna
|
|
US7893244B2
(en)
|
2005-04-12 |
2011-02-22 |
Intradigm Corporation |
Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
|
|
CN101287500A
(zh)
*
|
2005-08-19 |
2008-10-15 |
恩多塞特公司 |
多药物配体缀合物
|
|
US20090011004A1
(en)
|
2005-12-30 |
2009-01-08 |
Philadelphia Health & Education Corp., D/B/A/ Drexel University Of College Of Medicine |
Improved carriers for delivery of nucleic acid agents to cells and tissues
|
|
US20070231392A1
(en)
|
2006-01-23 |
2007-10-04 |
Ernst Wagner |
CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY
|
|
US20070225213A1
(en)
|
2006-03-23 |
2007-09-27 |
Kosak Matthew K |
Nucleic acid carriers for delivery of therapeutic agents
|
|
WO2008105773A2
(en)
|
2006-03-31 |
2008-09-04 |
Massachusetts Institute Of Technology |
System for targeted delivery of therapeutic agents
|
|
WO2008124634A1
(en)
|
2007-04-04 |
2008-10-16 |
Massachusetts Institute Of Technology |
Polymer-encapsulated reverse micelles
|
|
DK2187965T3
(da)
|
2007-08-17 |
2020-01-20 |
Purdue Research Foundation |
Psma-bindingsligand-linker-konjugater og fremgangsmåder til anvendelse
|
|
WO2009030254A1
(en)
*
|
2007-09-04 |
2009-03-12 |
Curevac Gmbh |
Complexes of rna and cationic peptides for transfection and for immunostimulation
|
|
ATE530169T1
(de)
|
2007-09-28 |
2011-11-15 |
Bind Biosciences Inc |
Krebszellen-targeting mit nanopartikeln
|
|
MX2010003642A
(es)
|
2007-10-12 |
2010-08-09 |
Massachusetts Inst Technology |
Nanotecnologia de vacuna.
|
|
WO2009110939A2
(en)
|
2007-12-10 |
2009-09-11 |
Massachusetts Institute Of Technology |
Drug delivery system for pharmaceuticals and radiation
|
|
US20110038888A1
(en)
|
2008-01-10 |
2011-02-17 |
Peter Emtage |
Adjuvant compositions comprising poly-ic and a cationic polymer
|
|
WO2009131435A1
(en)
|
2008-04-23 |
2009-10-29 |
Erasmus University Medical Center Rotterdam |
Linker containing bungarotoxin and a binding peptide
|
|
EP2113257A1
(en)
|
2008-04-30 |
2009-11-04 |
Consorzio per il Centro di Biomedica Moleculare Scrl |
Polyelectrolyte with positive net charge for use as medicament and diagnostic for cancer
|
|
EP2123304A1
(en)
|
2008-05-23 |
2009-11-25 |
Freie Universität Berlin |
Compounds suited as nanocarriers for active agents and their use
|
|
WO2009151539A1
(en)
|
2008-05-24 |
2009-12-17 |
Sirnaomics, Inc. |
COMPOSITIONS AND METHODS USING siRNA MOLECULES FOR TREATMENT OF GLIOMAS
|
|
JP2011525180A
(ja)
|
2008-06-16 |
2011-09-15 |
バインド バイオサイエンシズ インコーポレイテッド |
治療的標的化ナノ粒子の製作に用いるためのジブロックコポリマーで官能化された標的薬の製造方法
|
|
PT3098239T
(pt)
*
|
2008-12-22 |
2020-01-15 |
Targimmune Therapeutics Ag |
Vetor de rna de cadeia dupla dirigido ao egfr para o tratamento sistémico de cancro
|
|
WO2010088927A1
(en)
|
2009-02-09 |
2010-08-12 |
Curevac Gmbh |
Use of pei for the improvement of endosomal release and expression of transfected nucleic acids, complexed with cationic or polycationic compounds
|
|
US20100266642A1
(en)
|
2009-02-20 |
2010-10-21 |
Bind Biosciences, Inc. |
Modified cells for targeted cell trafficking and uses thereof
|
|
AU2010232180B2
(en)
|
2009-03-31 |
2016-09-22 |
Japan As Represented By The Director-General Of National Institute Of Infectious Diseases |
Method for prophylaxis of influenza using vaccine for intranasal administration
|
|
WO2010127159A2
(en)
|
2009-04-30 |
2010-11-04 |
Intezyne Technologies, Incorporated |
Polymeric micelles for polynucleotide encapsulation
|
|
ES2368963B1
(es)
|
2009-07-04 |
2012-10-10 |
Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii |
Procedimiento de identificación de agentes terapéuticos contra el melanoma y uso de agente identificado.
|
|
CN101638484A
(zh)
*
|
2009-08-24 |
2010-02-03 |
中国科学院长春应用化学研究所 |
聚乙二醇单甲醚-聚2-甲基-2-羧基碳酸丙烯酯接枝聚乙烯亚胺共聚物与制法及应用
|
|
EP2509629A4
(en)
|
2009-12-09 |
2013-06-26 |
Ibc Pharmaceuticals Inc |
DNL ("DOCK-AND-LOCK") COMPLEXES FOR INTERFERING RNA ADMINISTRATION
|
|
EP2512487A4
(en)
|
2009-12-15 |
2013-08-07 |
|
THERAPEUTIC POLYMERNANOPARTICLES WITH CORTICOSTEROIDS AND METHOD FOR THE PRODUCTION AND USE THEREOF
|
|
JP5965844B2
(ja)
|
2009-12-15 |
2016-08-10 |
バインド セラピューティックス インコーポレイテッド |
高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物
|
|
EP2512459A4
(en)
|
2009-12-15 |
2013-08-07 |
|
THERAPEUTIC POLYMERIC NANOPARTICLES COMPRISING EPOTHILONE AND METHODS OF MAKING AND USING SAME
|
|
PH12012501596A1
(en)
|
2010-02-24 |
2017-02-03 |
Arrowhead Res Corporation |
Compositions for targeted delivery of sirna
|
|
EP3214174B1
(en)
|
2010-03-04 |
2019-10-16 |
InteRNA Technologies B.V. |
A mirna molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with emt
|
|
US20110256227A1
(en)
|
2010-04-14 |
2011-10-20 |
Intezyne Technologies, Inc. |
Controlled polyplex assembly
|
|
EP2395041A1
(en)
|
2010-06-10 |
2011-12-14 |
F. Hoffmann-La Roche AG |
Polymers for delivery of nucleic acids
|
|
WO2011154331A1
(en)
|
2010-06-10 |
2011-12-15 |
F. Hoffmann-La Roche Ag |
Polymers for delivery of nucleic acids
|
|
EP2591106A1
(en)
|
2010-07-06 |
2013-05-15 |
InteRNA Technologies B.V. |
Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
|
|
US20120207795A1
(en)
|
2010-07-13 |
2012-08-16 |
The Regents Of The University Of California |
Cationic polymer coated mesoporous silica nanoparticles and uses thereof
|
|
WO2012016188A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
|
FR2963350B1
(fr)
|
2010-07-30 |
2013-11-01 |
Univ D Evry Val D Essonne |
Nouveaux copolymeres a bloc et leurs utilisations pour delivrer une substance active dans une cellule.
|
|
US8461224B2
(en)
|
2011-03-04 |
2013-06-11 |
National Health Research Institutes |
Single monomer derived linear-like copolymer comprising polyethylenimine and poly(ethylene glycol) for nucleic acid delivery
|
|
WO2012135592A2
(en)
|
2011-03-31 |
2012-10-04 |
The Johns Hopkins University |
Theranostic imaging agents and methods of use
|
|
US20140308363A1
(en)
|
2011-05-31 |
2014-10-16 |
Bind Therapeutics, Inc. |
Drug loaded polymeric nanoparticles and methods of making and using same
|
|
CN104583406A
(zh)
|
2012-05-02 |
2015-04-29 |
诺华股份有限公司 |
治疗kras相关疾病的有机组合物
|
|
KR20150037968A
(ko)
|
2012-07-12 |
2015-04-08 |
프로큐알 테라퓨틱스 엔.브이. |
살아있는 세포 내에 존재하는 목적 rna 분자의 서열을 변화시키기 위한 올리고뉴클레오타이드
|
|
CA2912975A1
(en)
|
2012-10-16 |
2014-04-24 |
William Marsh Rice University |
An improved nanovector based drug delivery system for overcoming drug resistance
|
|
US10201556B2
(en)
|
2012-11-06 |
2019-02-12 |
Interna Technologies B.V. |
Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated B-raf pathway
|
|
KR102318999B1
(ko)
|
2012-11-15 |
2021-10-29 |
엔도사이트, 인코포레이티드 |
Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트
|
|
JP6446269B2
(ja)
|
2012-12-06 |
2018-12-26 |
協和発酵バイオ株式会社 |
アジュバント用二重鎖リボ核酸
|
|
KR102285326B1
(ko)
|
2013-06-28 |
2021-08-04 |
에트리스 게엠베하 |
Rna를 세포에 도입하기 위한 조성물
|
|
CN104341488A
(zh)
|
2013-08-02 |
2015-02-11 |
复旦大学 |
c(LyP-1)多肽及其构建的纳米递药系统和应用
|
|
WO2015065773A1
(en)
|
2013-11-04 |
2015-05-07 |
Northeastern University |
System for co-delivery of polynucleotides and drugs into protease-expressing cells
|
|
US20160271268A1
(en)
|
2013-11-08 |
2016-09-22 |
Dana-Farber Cancer Institute, Inc. |
Nucleic acid nanostructures for in vivo agent delivery
|
|
EP3116547B1
(en)
|
2014-03-14 |
2019-06-05 |
Pfizer Inc |
Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
|
|
US10273484B2
(en)
|
2014-03-24 |
2019-04-30 |
Riboxx Gmbh |
Double-stranded RNA conjugates and their use
|
|
CN107073090A
(zh)
|
2014-04-30 |
2017-08-18 |
哈佛学院董事会 |
结合的疫苗装置和杀死癌细胞的方法
|
|
US10278991B2
(en)
|
2014-05-14 |
2019-05-07 |
Targimmune Therapeutics Ag |
Polyethyleneimine polyethyleneglycol vectors
|
|
WO2016123675A1
(en)
|
2015-02-05 |
2016-08-11 |
The University Of Queensland |
Targeting constructs for delivery of payloads
|
|
WO2016183447A1
(en)
|
2015-05-14 |
2016-11-17 |
The Johns Hopkins University |
Compositions of nucleic acid-containing nanoparticles for in vivo delivery
|
|
PT3319587T
(pt)
|
2015-11-17 |
2019-11-20 |
Bioncotech Therapeutics S L |
Nova composição farmacêutica que compreende partículas compreendendo um complexo de um polirribonuleótido de cadeia dupla e uma polialquilenoimina
|