JP2017520242A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017520242A5 JP2017520242A5 JP2016571259A JP2016571259A JP2017520242A5 JP 2017520242 A5 JP2017520242 A5 JP 2017520242A5 JP 2016571259 A JP2016571259 A JP 2016571259A JP 2016571259 A JP2016571259 A JP 2016571259A JP 2017520242 A5 JP2017520242 A5 JP 2017520242A5
- Authority
- JP
- Japan
- Prior art keywords
- culture medium
- liquid culture
- volume
- period
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000001963 growth medium Substances 0.000 claims 41
- 238000009630 liquid culture Methods 0.000 claims 40
- 238000000034 method Methods 0.000 claims 22
- 210000004962 mammalian cell Anatomy 0.000 claims 9
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 7
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 7
- 238000013019 agitation Methods 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 238000011534 incubation Methods 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 101000621344 Homo sapiens Protein Wnt-2 Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 102100022805 Protein Wnt-2 Human genes 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021116795A JP7350810B2 (ja) | 2014-06-06 | 2021-07-15 | 灌流培養方法およびその使用 |
| JP2023102970A JP7769663B2 (ja) | 2014-06-06 | 2023-06-23 | 灌流培養方法およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462009058P | 2014-06-06 | 2014-06-06 | |
| US62/009,058 | 2014-06-06 | ||
| PCT/US2015/034494 WO2015188106A2 (en) | 2014-06-06 | 2015-06-05 | Perfusion culturing methods and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021116795A Division JP7350810B2 (ja) | 2014-06-06 | 2021-07-15 | 灌流培養方法およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017520242A JP2017520242A (ja) | 2017-07-27 |
| JP2017520242A5 true JP2017520242A5 (https=) | 2018-07-12 |
| JP6915992B2 JP6915992B2 (ja) | 2021-08-11 |
Family
ID=53484156
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571259A Active JP6915992B2 (ja) | 2014-06-06 | 2015-06-05 | 灌流培養方法およびその使用 |
| JP2021116795A Active JP7350810B2 (ja) | 2014-06-06 | 2021-07-15 | 灌流培養方法およびその使用 |
| JP2023102970A Active JP7769663B2 (ja) | 2014-06-06 | 2023-06-23 | 灌流培養方法およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021116795A Active JP7350810B2 (ja) | 2014-06-06 | 2021-07-15 | 灌流培養方法およびその使用 |
| JP2023102970A Active JP7769663B2 (ja) | 2014-06-06 | 2023-06-23 | 灌流培養方法およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11060058B2 (https=) |
| EP (1) | EP3152293B1 (https=) |
| JP (3) | JP6915992B2 (https=) |
| KR (2) | KR102479281B1 (https=) |
| CN (1) | CN106795495A (https=) |
| AU (2) | AU2015269184B2 (https=) |
| BR (1) | BR112016028512A8 (https=) |
| CA (1) | CA2951255A1 (https=) |
| ES (1) | ES3040723T3 (https=) |
| IL (1) | IL249384A0 (https=) |
| MX (2) | MX2016016142A (https=) |
| RU (3) | RU2708919C2 (https=) |
| SG (2) | SG11201610167WA (https=) |
| TW (2) | TW202204596A (https=) |
| WO (1) | WO2015188106A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105143443A (zh) | 2013-02-22 | 2015-12-09 | 建新公司 | 微载体灌注培养方法及其用途 |
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| TW202204596A (zh) * | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) * | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| KR20250025516A (ko) | 2014-12-22 | 2025-02-21 | 젠자임 코포레이션 | 포유류 세포의 배양 방법 |
| US11292999B2 (en) | 2016-08-30 | 2022-04-05 | Finesse Solutions, Inc. | Bioreactor with multiple coupled vessels |
| EP3875595A4 (en) * | 2018-11-02 | 2022-07-13 | Kyowa Kirin Co., Ltd. | Liquid medium preparation method |
| US20220250063A1 (en) * | 2021-02-10 | 2022-08-11 | Koniku Inc. | Assay system, methods, and multi-well plate for gas stimulation of biological cells, proteins or materials |
| KR20230170728A (ko) * | 2021-04-14 | 2023-12-19 | 젠자임 코포레이션 | 포유류 세포의 관류 배양 방법 |
| JP7732842B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732840B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732839B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732841B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| JP7732843B2 (ja) * | 2021-10-14 | 2025-09-02 | 株式会社三共 | 遊技機 |
| WO2024112917A1 (en) * | 2022-11-22 | 2024-05-30 | The University Of North Carolina At Chapel Hill | Laminar flow incorporated scaffold-based 3d cell cultures |
| DE102022214275A1 (de) * | 2022-12-22 | 2024-06-27 | Robert Bosch Gesellschaft mit beschränkter Haftung | Vorrichtung und Verfahren zur Kultivierung von Zellen |
| US20240263122A1 (en) * | 2023-02-08 | 2024-08-08 | National Central University | Bioreactor apparatus, ion-exchange substrate and method for regulation of ion concentration and cell culture thereof |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| RU2058992C1 (ru) | 1993-07-14 | 1996-04-27 | Антипин Георгий Васильевич | Способ получения кормового белка и устройство для его осуществления |
| DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| RU2215748C2 (ru) | 1999-04-09 | 2003-11-10 | Сентро Де Инмунология Молекулар | Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция |
| CN100457914C (zh) | 1999-04-15 | 2009-02-04 | 荷兰克鲁塞尔公司 | 用编码腺病毒e1蛋白的序列在人体细胞中生产重组蛋白 |
| AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| UA74557C2 (en) | 1999-09-03 | 2006-01-16 | Applied Research Systems | A method for producing a heterologous secreted protein from chinese hamster ovaries cells grown on microcarriers |
| US6585971B1 (en) | 1999-11-12 | 2003-07-01 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
| CA2431230C (en) | 2000-12-20 | 2011-02-22 | Bayer Pharmaceuticals Corporation | A device and method for seed-train expansion of mammalian cells |
| US6544788B2 (en) | 2001-02-15 | 2003-04-08 | Vijay Singh | Disposable perfusion bioreactor for cell culture |
| JP2005509406A (ja) | 2001-05-09 | 2005-04-14 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 哺乳動物細胞株のための低温保存袋アセンブリー |
| KR100909316B1 (ko) | 2001-08-31 | 2009-07-24 | 바이엘 헬스케어 아게 | 고세포밀도 발효를 수행하기 위한 유닛 및 방법 |
| EP1434857B1 (en) | 2001-10-02 | 2007-08-01 | Novo Nordisk Health Care AG | Method for production of recombinant proteins in eukaryote cells |
| WO2003033935A1 (de) | 2001-10-11 | 2003-04-24 | Siemens Aktiengesellschaft | Dämpfungsvorrichtung sowie verfahren zum bedämpfen von bewegungen in einer dämpfungsvorrichtung |
| AU2002348151A1 (en) | 2001-11-05 | 2003-05-19 | Genvec, Inc. | Viral vector production methods and compositions |
| US20030091976A1 (en) | 2001-11-14 | 2003-05-15 | Ciphergen Biosystems, Inc. | Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry |
| US6953692B2 (en) | 2001-12-18 | 2005-10-11 | Bayer Pharmaceuticals Corporation | Device and method for seed-train expansion of mammalian cells |
| US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
| AR046510A1 (es) | 2003-07-25 | 2005-12-14 | Regeneron Pharma | Composicion de un antagonista de vegf y un agente anti-proliferativo |
| EP1508576A1 (en) | 2003-08-20 | 2005-02-23 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
| BE1016538A3 (fr) | 2004-02-20 | 2007-01-09 | Cesco Bioengineering Co Ltd | Appareil et procede pour la preparation et la mise en culture de cellules. |
| PT1773978E (pt) | 2004-05-19 | 2014-05-29 | Massachusetts Inst Technology | Modelo de doença com células/tecidos tri-dimensionais perfundidos |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US7767446B2 (en) * | 2004-09-16 | 2010-08-03 | Becton, Dickinson And Company | Perfusion bioreactors for culturing cells |
| EP1789528A4 (en) | 2004-09-16 | 2011-07-20 | Becton Dickinson Co | BIOREACTOR FOR CULTIVATION OF CELLS UNDER PERFUSION |
| WO2006039588A2 (en) | 2004-09-30 | 2006-04-13 | Bayer Healthcare Llc | Devices and methods for integrated continuous manufacturing of biological molecules |
| ES2662589T3 (es) | 2005-06-15 | 2018-04-09 | Zhejiang Jinyishengshi Bioengineering Co., Ltd. | Recipientes para cultivo en suspensión |
| WO2006138143A1 (en) | 2005-06-15 | 2006-12-28 | Amprotein Corporation | Suspension culture vessels |
| JP2009529888A (ja) | 2006-03-14 | 2009-08-27 | ユニバーシティ オブ ロチェスター | 超薄多孔質メンブレンを有する細胞培養装置およびその使用 |
| US20080206819A1 (en) | 2006-08-21 | 2008-08-28 | Mary Tsao | Intensified Perfusion Production Method |
| WO2008073620A2 (en) | 2006-11-02 | 2008-06-19 | Neose Technologies, Inc. | Manufacturing process for the production of polypeptides expressed in insect cell-lines |
| JP2010525789A (ja) | 2007-01-08 | 2010-07-29 | ミリポア・コーポレイション | 1つ又はそれ以上のきょう雑物の低下したレベルの存在下で組換えタンパク質を生産するための細胞培養法 |
| US8501462B2 (en) | 2007-02-27 | 2013-08-06 | The Board Of Trustees Of The University Of Illinois | Insert device for multiwell plate |
| EP2522729A1 (en) | 2007-03-02 | 2012-11-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Improvement of protein production |
| JP5140721B2 (ja) | 2007-04-17 | 2013-02-13 | イクスエンド、ホールディング、ベスローテン、フェンノートシャップ | 連続メンブレン吸着方法および装置 |
| TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| US9109193B2 (en) | 2007-07-30 | 2015-08-18 | Ge Healthcare Bio-Sciences Corp. | Continuous perfusion bioreactor system |
| WO2009023562A2 (en) | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| WO2009034186A2 (en) | 2007-09-13 | 2009-03-19 | Helmholtz-Zentrum für Infektionsforschung GmbH | Process for cell cultivation |
| US20090233334A1 (en) | 2008-03-11 | 2009-09-17 | Excellgene Sa | Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale |
| DE102008019691A1 (de) * | 2008-04-15 | 2009-10-29 | Technische Universität Ilmenau | Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion |
| US8096985B2 (en) | 2008-05-07 | 2012-01-17 | Guided Delivery Systems Inc. | Deflectable guide |
| CN101821378B (zh) | 2008-06-16 | 2015-07-08 | 浙江金仪盛世生物工程有限公司 | 生物反应器 |
| JP2012506257A (ja) * | 2008-10-22 | 2012-03-15 | バイオベスト インターナショナル インコーポレイテッド | 細胞および細胞由来生成物の産生のための、灌流バイオリアクター、細胞培養システム、および方法 |
| SG174435A1 (en) * | 2009-03-26 | 2011-10-28 | Agency Science Tech & Res | Apparatus for cell or tissue culture |
| US8728479B2 (en) | 2009-03-31 | 2014-05-20 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| CN101875917B (zh) | 2009-04-28 | 2012-07-04 | 北京清大天一科技有限公司 | 生物反应器微载体培养动物细胞生产猪瘟疫苗的方法 |
| CA2766902C (en) | 2009-07-06 | 2021-07-06 | Genentech, Inc. | Method of culturing eukaryotic cells |
| US10119112B2 (en) | 2010-03-02 | 2018-11-06 | Universite Technologie de Compiegne—UTC | Multi-reactor unit for dynamic cell culture |
| CN201933090U (zh) | 2010-11-22 | 2011-08-17 | 朱学仁 | 细胞微载体灌注培养截留装置 |
| KR102027596B1 (ko) | 2010-12-06 | 2019-10-01 | 타폰 바이오시스템즈, 인코포레이티드 | 생물학적 산물을 위한 연속 처리 방법 |
| PL2665806T3 (pl) | 2011-01-17 | 2021-12-27 | F.Hoffmann-La Roche Ag | Urządzenie rozdzielające |
| CA2804568A1 (en) | 2011-03-22 | 2012-09-27 | Tokai Hit Co., Ltd. | Culture apparatus for microscopic viewing and method of use therefor |
| DK2707488T3 (en) | 2011-05-12 | 2017-12-11 | Probiogen Ag | IMPROVEMENT OF PROTEIN PREPARATION YIELD MEDIATED BY CDC42 GTPASE ON FAST CYCLES |
| DK2726600T3 (en) | 2011-07-01 | 2017-05-15 | Amgen Inc | Mammalian Cell Culture |
| JP5703449B2 (ja) * | 2011-07-15 | 2015-04-22 | パナソニックIpマネジメント株式会社 | 携帯端末 |
| AR089231A1 (es) | 2011-12-15 | 2014-08-06 | Amgen Inc | Metodo de floculacion |
| EP2620561B1 (en) | 2012-01-30 | 2014-12-31 | Dannrup, Neils | A device and a method for filtering stormwater |
| WO2013116449A1 (en) * | 2012-02-02 | 2013-08-08 | Corning Incorporated | Automatic continuous perfusion cell culture microplate consumables |
| CN106399094A (zh) | 2012-04-01 | 2017-02-15 | Emd密理博公司 | 细胞培养和梯度迁移化验方法和装置 |
| US9946845B2 (en) | 2012-10-02 | 2018-04-17 | Rxsafe Llc | System and method for filling and dispensing orders |
| CN104903436B (zh) | 2012-10-23 | 2018-03-30 | 建新公司 | 灌注培养方法及其用途 |
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| CN105143443A (zh) | 2013-02-22 | 2015-12-09 | 建新公司 | 微载体灌注培养方法及其用途 |
| SG10201709131UA (en) | 2013-03-08 | 2017-12-28 | Genzyme Corp | Continuous purification of therapeutic proteins |
| KR20210095233A (ko) | 2013-03-15 | 2021-07-30 | 젠자임 코포레이션 | 고-밀도 세포 뱅킹 방법 |
| US9481901B2 (en) * | 2013-05-30 | 2016-11-01 | Amgen Inc. | Methods for increasing mannose content of recombinant proteins |
| BR122021001466B1 (pt) | 2013-09-16 | 2021-10-13 | Genzyme Corporation | Sistema de filtração de circuito aberto |
| EP2881622A1 (de) | 2013-12-05 | 2015-06-10 | Continental Automotive GmbH | Aktuator |
| DK3083933T3 (da) | 2013-12-20 | 2026-03-16 | Biogen Ma Inc | Anvendelse af perfusionssåningskulturer til forbedring af biofarmaceutisk fed-batch-produktionskapacitet og -produktkvalitet |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| TWI671312B (zh) | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| PT3152317T (pt) | 2014-06-04 | 2019-04-18 | Amgen Inc | Métodos de colheita de culturas de células de mamíferos |
| TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| CN104480897B (zh) | 2014-11-28 | 2017-01-04 | 上海市政工程设计研究总院(集团)有限公司 | 陆域占地少应用范围广的防汛墙 |
| CN104450597B (zh) | 2014-12-10 | 2020-07-28 | 青岛农业大学 | 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法 |
| KR20250025516A (ko) | 2014-12-22 | 2025-02-21 | 젠자임 코포레이션 | 포유류 세포의 배양 방법 |
-
2015
- 2015-06-04 TW TW110135269A patent/TW202204596A/zh unknown
- 2015-06-04 TW TW104118071A patent/TWI743024B/zh not_active IP Right Cessation
- 2015-06-05 JP JP2016571259A patent/JP6915992B2/ja active Active
- 2015-06-05 WO PCT/US2015/034494 patent/WO2015188106A2/en not_active Ceased
- 2015-06-05 KR KR1020177000144A patent/KR102479281B1/ko active Active
- 2015-06-05 CA CA2951255A patent/CA2951255A1/en not_active Abandoned
- 2015-06-05 RU RU2016152238A patent/RU2708919C2/ru active
- 2015-06-05 ES ES15731177T patent/ES3040723T3/es active Active
- 2015-06-05 KR KR1020227044019A patent/KR102611855B1/ko active Active
- 2015-06-05 SG SG11201610167WA patent/SG11201610167WA/en unknown
- 2015-06-05 AU AU2015269184A patent/AU2015269184B2/en not_active Ceased
- 2015-06-05 RU RU2019138327A patent/RU2733539C2/ru active
- 2015-06-05 MX MX2016016142A patent/MX2016016142A/es unknown
- 2015-06-05 EP EP15731177.0A patent/EP3152293B1/en active Active
- 2015-06-05 BR BR112016028512A patent/BR112016028512A8/pt not_active Application Discontinuation
- 2015-06-05 CN CN201580042017.6A patent/CN106795495A/zh active Pending
- 2015-06-05 US US14/732,325 patent/US11060058B2/en active Active
- 2015-06-05 SG SG10202008131WA patent/SG10202008131WA/en unknown
-
2016
- 2016-12-05 IL IL249384A patent/IL249384A0/en unknown
- 2016-12-06 MX MX2020009670A patent/MX2020009670A/es unknown
-
2020
- 2020-09-22 RU RU2020131199A patent/RU2020131199A/ru unknown
-
2021
- 2021-06-25 US US17/358,889 patent/US12006510B2/en active Active
- 2021-07-13 AU AU2021205004A patent/AU2021205004A1/en not_active Abandoned
- 2021-07-15 JP JP2021116795A patent/JP7350810B2/ja active Active
-
2023
- 2023-06-23 JP JP2023102970A patent/JP7769663B2/ja active Active
-
2024
- 2024-05-06 US US18/656,253 patent/US12378517B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017520242A5 (https=) | ||
| RU2020131199A (ru) | Способ тестирования производственного процесса получения рекомбинантного белка | |
| Yuan et al. | Improved expansion of human bone marrow‐derived mesenchymal stem cells in microcarrier‐based suspension culture | |
| TWI659965B (zh) | 治療性蛋白質藥物物質之整合連續製造 | |
| JP2019201661A5 (https=) | ||
| CN104903436B (zh) | 灌注培养方法及其用途 | |
| ATE414144T1 (de) | Kulturen von e1-immortalisierten zellen und verfahren zu deren kultivierung zur erhöhung der produktausbeuten davon | |
| JP2017538435A5 (https=) | ||
| JP2013524825A5 (https=) | ||
| TW200512297A (en) | Mammalian cell culture processes for protein production | |
| US11104726B2 (en) | Methods of replicating a large scale eculizumab production cell culture | |
| MX2012003654A (es) | Metodos de produccion de glucoproteinas en cultivos de celulas de mamiferos usando glucocorticoides. | |
| RU2014128987A (ru) | Быстрый способ клонирования и экспрессии сегментов гена родственной вариабельной области антитела | |
| DK1576182T4 (da) | Produktkvalitetsforbedring ved fremgangsmåde med dyrkning af pattedyreceller til proteinfremstilling | |
| RU2009143635A (ru) | Улучшение титра полипептида фактора viii в клеточных культурах | |
| JP2016513478A5 (https=) | ||
| MX2012007117A (es) | Metodo para cultivar celulas adherentes. | |
| RU2017126045A (ru) | Способы культивирования клетки млекопитающего | |
| JP2013531967A5 (https=) | ||
| JPWO2020032153A5 (https=) | ||
| MY192147A (en) | Method for obtaining high-yield, stable expression cell clones and antibody molecules obtained thereby | |
| EP1739167A4 (en) | PROCESS FOR VIRUS PRODUCTION | |
| CN102604884B (zh) | 细胞的发酵培养方法 | |
| JP2005511087A5 (https=) | ||
| JPWO2023061409A5 (https=) |