JP2017519519A5 - - Google Patents
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- Publication number
- JP2017519519A5 JP2017519519A5 JP2017510762A JP2017510762A JP2017519519A5 JP 2017519519 A5 JP2017519519 A5 JP 2017519519A5 JP 2017510762 A JP2017510762 A JP 2017510762A JP 2017510762 A JP2017510762 A JP 2017510762A JP 2017519519 A5 JP2017519519 A5 JP 2017519519A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nicotine demethylase
- mutations
- tobacco plant
- demethylase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14167598.3 | 2014-05-08 | ||
| EP14167598 | 2014-05-08 | ||
| EP14001645 | 2014-05-09 | ||
| EP14001645.2 | 2014-05-09 | ||
| PCT/EP2015/060124 WO2015169927A1 (en) | 2014-05-08 | 2015-05-07 | Reduction of nicotine to nornicotine conversion in plants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017519519A JP2017519519A (ja) | 2017-07-20 |
| JP2017519519A5 true JP2017519519A5 (https=) | 2018-06-14 |
| JP6871158B2 JP6871158B2 (ja) | 2021-05-12 |
Family
ID=53276066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017510762A Expired - Fee Related JP6871158B2 (ja) | 2014-05-08 | 2015-05-07 | 植物体におけるニコチンからノルニコチンへの変換の低減 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10415050B2 (https=) |
| EP (1) | EP3140404A1 (https=) |
| JP (1) | JP6871158B2 (https=) |
| KR (1) | KR102442802B1 (https=) |
| CN (1) | CN106459923B (https=) |
| BR (1) | BR112016025234A2 (https=) |
| CA (1) | CA2944965A1 (https=) |
| MX (1) | MX2016014635A (https=) |
| PH (1) | PH12016501718A1 (https=) |
| RU (1) | RU2733837C2 (https=) |
| WO (1) | WO2015169927A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106636146B (zh) * | 2017-02-16 | 2019-09-13 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e5基因突变体及其应用 |
| US11046969B2 (en) * | 2017-05-24 | 2021-06-29 | Epiplanta Biotech Ltd. | Transgenic plant and the method for producing the same |
| WO2018222667A1 (en) * | 2017-05-31 | 2018-12-06 | 22Nd Century Limited, Llc | Genome editing methods for producing low-nicotine tobacco products |
| BR112020011386A2 (pt) | 2017-12-07 | 2020-12-01 | R.J. Reynolds Tobacco Company | fatores de transcrição bzip regulam a conversão de nicotina em nornicotina |
| CN108192900B (zh) * | 2018-01-16 | 2021-11-30 | 西南大学 | 烟草烟碱去甲基化酶基因cyp82e4的编辑失活载体及其应用 |
| KR20200136921A (ko) | 2018-03-28 | 2020-12-08 | 필립모리스 프로덕츠 에스.에이. | 식물 내 아미노산 함량 조절 |
| WO2019185699A1 (en) | 2018-03-28 | 2019-10-03 | Philip Morris Products S.A. | Modulating reducing sugar content in a plant |
| CN108424921B (zh) * | 2018-04-20 | 2021-04-20 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e10基因错义突变体m594及其应用 |
| KR102851176B1 (ko) * | 2018-07-26 | 2025-08-28 | 알트리아 클라이언트 서비시즈 엘엘씨 | 알칼로이드 수준이 변경된 담배 식물 및 제품을 생산하기 위한 pmt 공학에 기초한 조성물 및 방법 |
| JP2021532761A (ja) * | 2018-08-02 | 2021-12-02 | アンティドートゥ・セラピューティクス・インコーポレイテッド | 新規ニコチン分解酵素変異体 |
| GB201812603D0 (en) | 2018-08-02 | 2018-09-19 | British American Tobacco Investments Ltd | Method |
| WO2020141062A1 (en) | 2018-12-30 | 2020-07-09 | Philip Morris Products S.A. | Modulation of nitrate levels in plants via mutation of nitrate reductase |
| CN114514321A (zh) | 2019-10-01 | 2022-05-17 | 菲利普莫里斯生产公司 | 调节植物中的糖和氨基酸含量（sultr3） |
| JP7659547B2 (ja) | 2019-10-01 | 2025-04-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における還元糖含有量の調節（ｉｎｖ） |
| EP4069854A1 (en) * | 2019-12-03 | 2022-10-12 | Altria Client Services LLC | Compositions and methods for producing tobacco plants and products having altered alkaloid levels |
| US11331020B2 (en) | 2020-02-06 | 2022-05-17 | Trustees Of Boston University | Enzyme-based electrochemical nicotine biosensor |
| WO2021221752A2 (en) | 2020-02-06 | 2021-11-04 | Trustees Of Boston University | High throughput assay for identifying microbial redox enzymes |
| JP7210806B2 (ja) * | 2020-04-17 | 2023-01-23 | 日本たばこ産業株式会社 | 低アルカロイド含量のタバコ属植物体およびその製造方法 |
| CN111505158B (zh) * | 2020-05-09 | 2022-09-23 | 云南省烟草农业科学研究院 | 一种基于孵化处理的尼古丁转化烟株色质快速筛查方法 |
| WO2023036691A1 (en) | 2021-09-10 | 2023-03-16 | Philip Morris Products S.A. | Modulating alkaloid profiles in nicotiana tabacum |
| CN113980978B (zh) * | 2021-11-22 | 2023-12-26 | 云南中烟工业有限责任公司 | 一种烟草烟碱转运蛋白相关的基因及其应用 |
| US20250043298A1 (en) | 2021-12-20 | 2025-02-06 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
| US20250084427A1 (en) | 2021-12-21 | 2025-03-13 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
| CN114540382B (zh) * | 2022-02-18 | 2023-07-18 | 贵州省烟草科学研究院 | 烟草镉转运基因NtPLA1及应用 |
| EP4602060A1 (en) | 2022-10-13 | 2025-08-20 | Philip Morris Products S.A. | Increasing leaf biomass and nitrogen use efficiency by regulating ntp2 |
| CN120530195A (zh) | 2023-02-02 | 2025-08-22 | 菲利普莫里斯生产公司 | 糖转运蛋白的调节 |
| KR20250139370A (ko) | 2023-02-02 | 2025-09-23 | 필립모리스 프로덕츠 에스.에이. | 리신 케토글루타레이트 환원효소 코딩 유전자 조절 |
| WO2025003105A1 (en) | 2023-06-29 | 2025-01-02 | Philip Morris Products S.A. | Modulation of genes coding for glutamate dehydrogenase |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5810020A (en) | 1993-09-07 | 1998-09-22 | Osmotek, Inc. | Process for removing nitrogen-containing anions and tobacco-specific nitrosamines from tobacco products |
| US6202649B1 (en) | 1996-12-02 | 2001-03-20 | Regent Court Technologies | Method of treating tobacco to reduce nitrosamine content, and products produced thereby |
| YU68799A (sh) | 1997-06-20 | 2001-05-28 | Regent Court Technologies | Postupak tretiranja duvana u cilju smanjenja sadržaja nitrosamina i proizvodi koji se njime dobijaju |
| US7700851B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokeless Tobacco Company | Tobacco nicotine demethylase genomic clone and uses thereof |
| ATE530656T1 (de) * | 2005-02-23 | 2011-11-15 | Univ North Carolina State | Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. |
| BRPI0717355B1 (pt) | 2006-10-13 | 2018-01-16 | North Carolina State University | Método para obtenção de uma planta transgênica de nicotina, método para obtenção de uma semente; construto de ácido nucléico recombinante; método de redução da conversão de nicotina em nornicotina em uma planta de nicotina |
| RU2324737C1 (ru) * | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
| US8319011B2 (en) | 2006-12-15 | 2012-11-27 | U.S. Smokeless Tobacco Company Llc | Tobacco plants having reduced nicotine demethylase activity |
| WO2009064771A2 (en) | 2007-11-12 | 2009-05-22 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| EP2559766B1 (en) | 2007-12-13 | 2017-10-18 | Philip Morris Products S.A. | Plants modified for reduced cadmium transport, derivative products, and related methods |
| US7883371B1 (en) | 2009-07-22 | 2011-02-08 | Hon Hai Precision Ind. Co., Ltd. | Electrical connector with improved contact footprints |
| PH12012501393B1 (en) | 2010-01-15 | 2017-10-25 | Univ North Carolina State | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| CN103228671B (zh) | 2010-09-03 | 2017-08-15 | 菲利普莫里斯产品有限公司 | 植物中的重金属减少 |
-
2015
- 2015-05-07 EP EP15726007.6A patent/EP3140404A1/en not_active Withdrawn
- 2015-05-07 JP JP2017510762A patent/JP6871158B2/ja not_active Expired - Fee Related
- 2015-05-07 RU RU2016144409A patent/RU2733837C2/ru active
- 2015-05-07 CN CN201580023352.1A patent/CN106459923B/zh not_active Expired - Fee Related
- 2015-05-07 BR BR112016025234A patent/BR112016025234A2/pt not_active Application Discontinuation
- 2015-05-07 US US15/306,172 patent/US10415050B2/en active Active
- 2015-05-07 CA CA2944965A patent/CA2944965A1/en not_active Abandoned
- 2015-05-07 MX MX2016014635A patent/MX2016014635A/es unknown
- 2015-05-07 WO PCT/EP2015/060124 patent/WO2015169927A1/en not_active Ceased
- 2015-05-07 KR KR1020167031693A patent/KR102442802B1/ko active Active
-
2016
- 2016-09-01 PH PH12016501718A patent/PH12016501718A1/en unknown
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