JP2017529850A5 - - Google Patents
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- Publication number
- JP2017529850A5 JP2017529850A5 JP2017516332A JP2017516332A JP2017529850A5 JP 2017529850 A5 JP2017529850 A5 JP 2017529850A5 JP 2017516332 A JP2017516332 A JP 2017516332A JP 2017516332 A JP2017516332 A JP 2017516332A JP 2017529850 A5 JP2017529850 A5 JP 2017529850A5
- Authority
- JP
- Japan
- Prior art keywords
- tobacco
- nitrate reductase
- relaxed
- tobacco product
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000019505 tobacco product Nutrition 0.000 claims 30
- 108090000913 Nitrate Reductases Proteins 0.000 claims 29
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 19
- 244000061176 Nicotiana tabacum Species 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 12
- 102000040430 polynucleotide Human genes 0.000 claims 12
- 239000002157 polynucleotide Substances 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 6
- 150000001413 amino acids Chemical group 0.000 claims 6
- 241000208125 Nicotiana Species 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 239000000779 smoke Substances 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- ZJOFAFWTOKDIFH-UHFFFAOYSA-N 3-(1-nitroso-3,6-dihydro-2h-pyridin-2-yl)pyridine Chemical compound O=NN1CC=CCC1C1=CC=CN=C1 ZJOFAFWTOKDIFH-UHFFFAOYSA-N 0.000 claims 3
- 238000002485 combustion reaction Methods 0.000 claims 3
- XKABJYQDMJTNGQ-VIFPVBQESA-N n-nitrosonornicotine Chemical compound O=NN1CCC[C@H]1C1=CC=CN=C1 XKABJYQDMJTNGQ-VIFPVBQESA-N 0.000 claims 3
- MYKUKUCHPMASKF-VIFPVBQESA-N (S)-nornicotine Chemical class C1CCN[C@@H]1C1=CC=CN=C1 MYKUKUCHPMASKF-VIFPVBQESA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical class CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- JORUAYHMUWRFNM-UHFFFAOYSA-N 1-pyridin-3-ylbutan-1-one Chemical compound CCCC(=O)C1=CC=CN=C1 JORUAYHMUWRFNM-UHFFFAOYSA-N 0.000 claims 1
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 241000701489 Cauliflower mosaic virus Species 0.000 claims 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 claims 1
- 238000010459 TALEN Methods 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003471 mutagenic agent Substances 0.000 claims 1
- 231100000707 mutagenic chemical Toxicity 0.000 claims 1
- 230000003505 mutagenic effect Effects 0.000 claims 1
- 150000002823 nitrates Chemical class 0.000 claims 1
- 150000003751 zinc Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14186705.1 | 2014-09-26 | ||
| EP14186705 | 2014-09-26 | ||
| EP14194798 | 2014-11-25 | ||
| EP14194798.6 | 2014-11-25 | ||
| PCT/EP2015/071919 WO2016046288A1 (en) | 2014-09-26 | 2015-09-23 | Reducing tobacco specific nitrosamines through alteration of the nitrate assimilation pathway |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017529850A JP2017529850A (ja) | 2017-10-12 |
| JP2017529850A5 true JP2017529850A5 (https=) | 2018-11-08 |
| JP6921740B2 JP6921740B2 (ja) | 2021-08-18 |
Family
ID=54148547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017516332A Active JP6921740B2 (ja) | 2014-09-26 | 2015-09-23 | 硝酸同化経路の変化によるタバコ特異的ニトロソアミンの低減 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11666082B2 (https=) |
| EP (1) | EP3198015A1 (https=) |
| JP (1) | JP6921740B2 (https=) |
| KR (1) | KR102524798B1 (https=) |
| CN (1) | CN106998787A (https=) |
| BR (1) | BR112017003842B1 (https=) |
| CA (1) | CA2959245A1 (https=) |
| CO (1) | CO2017004076A2 (https=) |
| MX (1) | MX2017003932A (https=) |
| PH (1) | PH12017500313A1 (https=) |
| RU (1) | RU2721799C2 (https=) |
| WO (1) | WO2016046288A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| EP3280803B1 (en) | 2015-04-06 | 2021-05-26 | The Board of Trustees of the Leland Stanford Junior University | Chemically modified guide rnas for crispr/cas-mediated gene regulation |
| WO2016179356A1 (en) * | 2015-05-05 | 2016-11-10 | North Carolina State University | Methods and compositions for reducing the tobacco specific nitrosamine nnk in tobacco |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| CN106036984B (zh) * | 2016-07-03 | 2017-08-08 | 赖高生 | 一种固定化蜗牛酶制备烟草浸膏的方法 |
| AR115022A1 (es) | 2018-03-28 | 2020-11-18 | Philip Morris Products Sa | Modulación del contenido de aminoácidos en una planta |
| AR115023A1 (es) | 2018-03-28 | 2020-11-18 | Philip Morris Products Sa | Modulación del contenido de azúcar reductor en una planta |
| CN108424922B (zh) * | 2018-04-20 | 2021-04-16 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e10基因错义突变体m271及其应用 |
| GB201812603D0 (en) * | 2018-08-02 | 2018-09-19 | British American Tobacco Investments Ltd | Method |
| DE102018216970A1 (de) * | 2018-10-04 | 2020-04-09 | Robert Bosch Gmbh | Brennstoffeinspritzvorrichtung |
| US11976286B2 (en) * | 2018-12-30 | 2024-05-07 | Philip Morris Products S.A. | Modulation of nitrate levels in plants via mutation of nitrate reductase |
| WO2022192743A1 (en) * | 2021-03-11 | 2022-09-15 | Thermolife International, Llc | Enhanced nitrate, elemental metal, and amino acid compositions and methods of use |
| JP2022552638A (ja) | 2019-10-01 | 2022-12-19 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における糖およびアミノ酸含有量の調節（ｓｕｌｔｒ３） |
| JP7659547B2 (ja) | 2019-10-01 | 2025-04-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における還元糖含有量の調節（ｉｎｖ） |
| CN110747208B (zh) * | 2019-11-28 | 2022-04-22 | 海南大学 | 一种木薯硝酸还原酶基因及其过量表达载体的构建和抗病应用 |
| CN110819640B (zh) * | 2019-12-19 | 2022-06-21 | 中国烟草总公司郑州烟草研究院 | 烟草NtNRP1基因其应用 |
| CN115516098A (zh) * | 2020-01-17 | 2022-12-23 | 奥驰亚客户服务有限公司 | 与改进的氮利用效率有关的方法和组合物 |
| US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
| US12156886B2 (en) | 2020-11-12 | 2024-12-03 | Thermolife International, Llc | Methods of increasing blood oxygen saturation |
| WO2022124361A1 (ja) * | 2020-12-09 | 2022-06-16 | 日本たばこ産業株式会社 | タバコ植物及びたばこ製品 |
| MX2023009015A (es) | 2021-02-11 | 2023-08-08 | Thermolife Int Llc | Un metodo para administrar gas de oxido nitrico. |
| JP2024534945A (ja) | 2021-09-10 | 2024-09-26 | アジレント・テクノロジーズ・インク | 化学修飾を有するプライム編集のためのガイドｒｎａ |
| WO2023117661A1 (en) | 2021-12-20 | 2023-06-29 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
| WO2023117701A1 (en) | 2021-12-21 | 2023-06-29 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
| US20240132900A1 (en) * | 2022-02-24 | 2024-04-25 | University Of Florida Research Foundation, Incorporated | T-DNA Free Gene Editing through Transient Suppressing POLQ in Plants |
| JP2025533986A (ja) | 2022-10-13 | 2025-10-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Ｎｔｐ２を調節することによって葉バイオマスおよび窒素利用効率を増加させる |
| JP2026506774A (ja) | 2023-02-02 | 2026-02-26 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 糖トランスポーターの調節 |
| EP4658670A1 (en) | 2023-02-02 | 2025-12-10 | Philip Morris Products S.A. | Modulation of genes coding for lysine ketoglutarate reductase |
| CN121335615A (zh) | 2023-06-29 | 2026-01-13 | 菲利普莫里斯生产公司 | 编码谷氨酸脱氢酶的基因的调节 |
| WO2026057635A1 (en) | 2024-09-12 | 2026-03-19 | Philip Morris Products S.A. | Modulation of nitrate levels in tobacco via mutation of nitrate reductase |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| US5879918A (en) | 1989-05-12 | 1999-03-09 | Pioneer Hi-Bred International, Inc. | Pretreatment of microprojectiles prior to using in a particle gun |
| US5932782A (en) | 1990-11-14 | 1999-08-03 | Pioneer Hi-Bred International, Inc. | Plant transformation method using agrobacterium species adhered to microprojectiles |
| WO1994002620A2 (en) | 1992-07-27 | 1994-02-03 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| US5981840A (en) | 1997-01-24 | 1999-11-09 | Pioneer Hi-Bred International, Inc. | Methods for agrobacterium-mediated transformation |
| US6911541B2 (en) * | 2000-08-30 | 2005-06-28 | North Carolina State University | Promoter fragment that is recognized by the product of the tobacco Nic gene |
| EA200400013A1 (ru) * | 2001-06-08 | 2004-06-24 | Вектор Тобакко Лтд. | Модификация содержания никотина и нитрозамина в табаке |
| EA200600449A1 (ru) * | 2003-08-19 | 2006-08-25 | ТВЕНТИ СЕКОНД СЕНЧУРИ ЛИМИТИД, эЛэЛСи | Табачное изделие (варианты), способ его изготовления (варианты), трансгенное растение табака, способы повышения содержания никотина, редуцирующих сахаров и уровня биосинтеза алкалоидов в растении и способ изготовления восстановленного табака |
| RU2257711C2 (ru) * | 2003-10-06 | 2005-08-10 | Всероссийский научно-исследовательский институт защиты растений | Композиция на основе хитозана, снижающая содержание нитратов в растениеводческой продукции |
| CN1867674B (zh) * | 2003-10-16 | 2011-11-09 | 美国无烟烟草有限责任公司 | 从烟草克隆细胞色素p450基因 |
| US20070199097A1 (en) * | 2004-09-03 | 2007-08-23 | U.S. Smokeless Tobacco Company | Tobacco plants having a mutation in a nicotine demethylase gene |
| CA2666383C (en) * | 2006-10-13 | 2015-12-22 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| RU2324737C1 (ru) * | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
| CN101686731B (zh) * | 2007-02-23 | 2013-05-08 | 美国无烟烟草有限责任公司 | 新型烟草组合物及制备方法 |
| US8624084B2 (en) * | 2007-03-16 | 2014-01-07 | Gloria Coruzzi | Pericycle-specific expression of microrna 167 in plants |
| US8124851B2 (en) * | 2007-11-12 | 2012-02-28 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes |
| US9247706B2 (en) | 2010-01-15 | 2016-02-02 | North Carolina State University | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| EP2537929B1 (en) * | 2010-02-17 | 2017-04-12 | Japan Tobacco, Inc. | Plant component regulation factor, and use thereof |
| EP2619220A1 (en) * | 2010-09-22 | 2013-07-31 | British American Tobacco (Investments) Limited | Transgenic plants |
| JP2014515596A (ja) | 2011-02-28 | 2014-07-03 | ノース カロライナ ステイト ユニヴァーシティ | タバコ近交系植物ｎｃｂｅｘ１ｆ、ｎｃｂｅｘ１ｍｓ、及びｎｃｅｘ９０ |
| GB201204869D0 (en) * | 2012-03-20 | 2012-05-02 | Cambridge Advanced Tech | Transgenic plants |
| ITMI20121419A1 (it) * | 2012-08-08 | 2014-02-09 | Fattoria Autonoma Tabacchi S C A R L | Metodo per la produzione di tabacco volto a ridurre il tenore di nitrosammine. |
-
2015
- 2015-09-23 KR KR1020177008015A patent/KR102524798B1/ko active Active
- 2015-09-23 MX MX2017003932A patent/MX2017003932A/es unknown
- 2015-09-23 BR BR112017003842-0A patent/BR112017003842B1/pt active IP Right Grant
- 2015-09-23 US US15/513,229 patent/US11666082B2/en active Active
- 2015-09-23 CA CA2959245A patent/CA2959245A1/en not_active Abandoned
- 2015-09-23 CN CN201580049814.7A patent/CN106998787A/zh active Pending
- 2015-09-23 RU RU2017114356A patent/RU2721799C2/ru active
- 2015-09-23 EP EP15766550.6A patent/EP3198015A1/en active Pending
- 2015-09-23 WO PCT/EP2015/071919 patent/WO2016046288A1/en not_active Ceased
- 2015-09-23 JP JP2017516332A patent/JP6921740B2/ja active Active
-
2017
- 2017-02-21 PH PH12017500313A patent/PH12017500313A1/en unknown
- 2017-04-26 CO CONC2017/0004076A patent/CO2017004076A2/es unknown
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