PH12017500313A1 - Reducing tobacco specific nitrosamines through alteration of the nitrate assimilation pathway - Google Patents
Reducing tobacco specific nitrosamines through alteration of the nitrate assimilation pathwayInfo
- Publication number
- PH12017500313A1 PH12017500313A1 PH12017500313A PH12017500313A PH12017500313A1 PH 12017500313 A1 PH12017500313 A1 PH 12017500313A1 PH 12017500313 A PH12017500313 A PH 12017500313A PH 12017500313 A PH12017500313 A PH 12017500313A PH 12017500313 A1 PH12017500313 A1 PH 12017500313A1
- Authority
- PH
- Philippines
- Prior art keywords
- alteration
- specific nitrosamines
- assimilation pathway
- tobacco specific
- nitrate assimilation
- Prior art date
Links
- 235000002637 Nicotiana tabacum Nutrition 0.000 title abstract 4
- 229910002651 NO3 Inorganic materials 0.000 title abstract 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 title abstract 3
- 241000208125 Nicotiana Species 0.000 title abstract 2
- 150000004005 nitrosamines Chemical class 0.000 title abstract 2
- 230000037361 pathway Effects 0.000 title abstract 2
- 230000004075 alteration Effects 0.000 title 1
- 244000061176 Nicotiana tabacum Species 0.000 abstract 2
- 235000019505 tobacco product Nutrition 0.000 abstract 2
- 230000014509 gene expression Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/245—Nitrosamines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/20—Biochemical treatment
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
- C12Y107/01—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with NAD+ or NADP+ as acceptor (1.7.1)
- C12Y107/01001—Nitrate reductase (NADH) (1.7.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
- C12Y107/01—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with NAD+ or NADP+ as acceptor (1.7.1)
- C12Y107/01002—Nitrate reductase [NAD(P)H] (1.7.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
- C12Y107/01—Oxidoreductases acting on other nitrogenous compounds as donors (1.7) with NAD+ or NADP+ as acceptor (1.7.1)
- C12Y107/01003—Nitrate reductase (NADPH) (1.7.1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y107/00—Oxidoreductases acting on other nitrogenous compounds as donors (1.7)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Manufacture Of Tobacco Products (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Environmental Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Botany (AREA)
- Physiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14186705 | 2014-09-26 | ||
| EP14194798 | 2014-11-25 | ||
| PCT/EP2015/071919 WO2016046288A1 (en) | 2014-09-26 | 2015-09-23 | Reducing tobacco specific nitrosamines through alteration of the nitrate assimilation pathway |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12017500313A1 true PH12017500313A1 (en) | 2017-07-17 |
Family
ID=54148547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12017500313A PH12017500313A1 (en) | 2014-09-26 | 2017-02-21 | Reducing tobacco specific nitrosamines through alteration of the nitrate assimilation pathway |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11666082B2 (https=) |
| EP (1) | EP3198015A1 (https=) |
| JP (1) | JP6921740B2 (https=) |
| KR (1) | KR102524798B1 (https=) |
| CN (1) | CN106998787A (https=) |
| BR (1) | BR112017003842B1 (https=) |
| CA (1) | CA2959245A1 (https=) |
| CO (1) | CO2017004076A2 (https=) |
| MX (1) | MX2017003932A (https=) |
| PH (1) | PH12017500313A1 (https=) |
| RU (1) | RU2721799C2 (https=) |
| WO (1) | WO2016046288A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| EP3280803B1 (en) | 2015-04-06 | 2021-05-26 | The Board of Trustees of the Leland Stanford Junior University | Chemically modified guide rnas for crispr/cas-mediated gene regulation |
| WO2016179356A1 (en) * | 2015-05-05 | 2016-11-10 | North Carolina State University | Methods and compositions for reducing the tobacco specific nitrosamine nnk in tobacco |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| CN106036984B (zh) * | 2016-07-03 | 2017-08-08 | 赖高生 | 一种固定化蜗牛酶制备烟草浸膏的方法 |
| AR115022A1 (es) | 2018-03-28 | 2020-11-18 | Philip Morris Products Sa | Modulación del contenido de aminoácidos en una planta |
| AR115023A1 (es) | 2018-03-28 | 2020-11-18 | Philip Morris Products Sa | Modulación del contenido de azúcar reductor en una planta |
| CN108424922B (zh) * | 2018-04-20 | 2021-04-16 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e10基因错义突变体m271及其应用 |
| GB201812603D0 (en) * | 2018-08-02 | 2018-09-19 | British American Tobacco Investments Ltd | Method |
| DE102018216970A1 (de) * | 2018-10-04 | 2020-04-09 | Robert Bosch Gmbh | Brennstoffeinspritzvorrichtung |
| US11976286B2 (en) * | 2018-12-30 | 2024-05-07 | Philip Morris Products S.A. | Modulation of nitrate levels in plants via mutation of nitrate reductase |
| WO2022192743A1 (en) * | 2021-03-11 | 2022-09-15 | Thermolife International, Llc | Enhanced nitrate, elemental metal, and amino acid compositions and methods of use |
| JP2022552638A (ja) | 2019-10-01 | 2022-12-19 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における糖およびアミノ酸含有量の調節（ｓｕｌｔｒ３） |
| JP7659547B2 (ja) | 2019-10-01 | 2025-04-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における還元糖含有量の調節（ｉｎｖ） |
| CN110747208B (zh) * | 2019-11-28 | 2022-04-22 | 海南大学 | 一种木薯硝酸还原酶基因及其过量表达载体的构建和抗病应用 |
| CN110819640B (zh) * | 2019-12-19 | 2022-06-21 | 中国烟草总公司郑州烟草研究院 | 烟草NtNRP1基因其应用 |
| CN115516098A (zh) * | 2020-01-17 | 2022-12-23 | 奥驰亚客户服务有限公司 | 与改进的氮利用效率有关的方法和组合物 |
| US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
| US12156886B2 (en) | 2020-11-12 | 2024-12-03 | Thermolife International, Llc | Methods of increasing blood oxygen saturation |
| WO2022124361A1 (ja) * | 2020-12-09 | 2022-06-16 | 日本たばこ産業株式会社 | タバコ植物及びたばこ製品 |
| MX2023009015A (es) | 2021-02-11 | 2023-08-08 | Thermolife Int Llc | Un metodo para administrar gas de oxido nitrico. |
| JP2024534945A (ja) | 2021-09-10 | 2024-09-26 | アジレント・テクノロジーズ・インク | 化学修飾を有するプライム編集のためのガイドｒｎａ |
| WO2023117661A1 (en) | 2021-12-20 | 2023-06-29 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
| WO2023117701A1 (en) | 2021-12-21 | 2023-06-29 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
| US20240132900A1 (en) * | 2022-02-24 | 2024-04-25 | University Of Florida Research Foundation, Incorporated | T-DNA Free Gene Editing through Transient Suppressing POLQ in Plants |
| JP2025533986A (ja) | 2022-10-13 | 2025-10-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | Ｎｔｐ２を調節することによって葉バイオマスおよび窒素利用効率を増加させる |
| JP2026506774A (ja) | 2023-02-02 | 2026-02-26 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 糖トランスポーターの調節 |
| EP4658670A1 (en) | 2023-02-02 | 2025-12-10 | Philip Morris Products S.A. | Modulation of genes coding for lysine ketoglutarate reductase |
| CN121335615A (zh) | 2023-06-29 | 2026-01-13 | 菲利普莫里斯生产公司 | 编码谷氨酸脱氢酶的基因的调节 |
| WO2026057635A1 (en) | 2024-09-12 | 2026-03-19 | Philip Morris Products S.A. | Modulation of nitrate levels in tobacco via mutation of nitrate reductase |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5990387A (en) | 1988-06-10 | 1999-11-23 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| US5879918A (en) | 1989-05-12 | 1999-03-09 | Pioneer Hi-Bred International, Inc. | Pretreatment of microprojectiles prior to using in a particle gun |
| US5932782A (en) | 1990-11-14 | 1999-08-03 | Pioneer Hi-Bred International, Inc. | Plant transformation method using agrobacterium species adhered to microprojectiles |
| WO1994002620A2 (en) | 1992-07-27 | 1994-02-03 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| US5981840A (en) | 1997-01-24 | 1999-11-09 | Pioneer Hi-Bred International, Inc. | Methods for agrobacterium-mediated transformation |
| US6911541B2 (en) * | 2000-08-30 | 2005-06-28 | North Carolina State University | Promoter fragment that is recognized by the product of the tobacco Nic gene |
| EA200400013A1 (ru) * | 2001-06-08 | 2004-06-24 | Вектор Тобакко Лтд. | Модификация содержания никотина и нитрозамина в табаке |
| EA200600449A1 (ru) * | 2003-08-19 | 2006-08-25 | ТВЕНТИ СЕКОНД СЕНЧУРИ ЛИМИТИД, эЛэЛСи | Табачное изделие (варианты), способ его изготовления (варианты), трансгенное растение табака, способы повышения содержания никотина, редуцирующих сахаров и уровня биосинтеза алкалоидов в растении и способ изготовления восстановленного табака |
| RU2257711C2 (ru) * | 2003-10-06 | 2005-08-10 | Всероссийский научно-исследовательский институт защиты растений | Композиция на основе хитозана, снижающая содержание нитратов в растениеводческой продукции |
| CN1867674B (zh) * | 2003-10-16 | 2011-11-09 | 美国无烟烟草有限责任公司 | 从烟草克隆细胞色素p450基因 |
| US20070199097A1 (en) * | 2004-09-03 | 2007-08-23 | U.S. Smokeless Tobacco Company | Tobacco plants having a mutation in a nicotine demethylase gene |
| CA2666383C (en) * | 2006-10-13 | 2015-12-22 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| RU2324737C1 (ru) * | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
| CN101686731B (zh) * | 2007-02-23 | 2013-05-08 | 美国无烟烟草有限责任公司 | 新型烟草组合物及制备方法 |
| US8624084B2 (en) * | 2007-03-16 | 2014-01-07 | Gloria Coruzzi | Pericycle-specific expression of microrna 167 in plants |
| US8124851B2 (en) * | 2007-11-12 | 2012-02-28 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes |
| US9247706B2 (en) | 2010-01-15 | 2016-02-02 | North Carolina State University | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| EP2537929B1 (en) * | 2010-02-17 | 2017-04-12 | Japan Tobacco, Inc. | Plant component regulation factor, and use thereof |
| EP2619220A1 (en) * | 2010-09-22 | 2013-07-31 | British American Tobacco (Investments) Limited | Transgenic plants |
| JP2014515596A (ja) | 2011-02-28 | 2014-07-03 | ノース カロライナ ステイト ユニヴァーシティ | タバコ近交系植物ｎｃｂｅｘ１ｆ、ｎｃｂｅｘ１ｍｓ、及びｎｃｅｘ９０ |
| GB201204869D0 (en) * | 2012-03-20 | 2012-05-02 | Cambridge Advanced Tech | Transgenic plants |
| ITMI20121419A1 (it) * | 2012-08-08 | 2014-02-09 | Fattoria Autonoma Tabacchi S C A R L | Metodo per la produzione di tabacco volto a ridurre il tenore di nitrosammine. |
-
2015
- 2015-09-23 KR KR1020177008015A patent/KR102524798B1/ko active Active
- 2015-09-23 MX MX2017003932A patent/MX2017003932A/es unknown
- 2015-09-23 BR BR112017003842-0A patent/BR112017003842B1/pt active IP Right Grant
- 2015-09-23 US US15/513,229 patent/US11666082B2/en active Active
- 2015-09-23 CA CA2959245A patent/CA2959245A1/en not_active Abandoned
- 2015-09-23 CN CN201580049814.7A patent/CN106998787A/zh active Pending
- 2015-09-23 RU RU2017114356A patent/RU2721799C2/ru active
- 2015-09-23 EP EP15766550.6A patent/EP3198015A1/en active Pending
- 2015-09-23 WO PCT/EP2015/071919 patent/WO2016046288A1/en not_active Ceased
- 2015-09-23 JP JP2017516332A patent/JP6921740B2/ja active Active
-
2017
- 2017-02-21 PH PH12017500313A patent/PH12017500313A1/en unknown
- 2017-04-26 CO CONC2017/0004076A patent/CO2017004076A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20170078599A (ko) | 2017-07-07 |
| RU2721799C2 (ru) | 2020-05-22 |
| JP2017529850A (ja) | 2017-10-12 |
| MX2017003932A (es) | 2017-06-30 |
| KR102524798B1 (ko) | 2023-04-24 |
| US11666082B2 (en) | 2023-06-06 |
| CO2017004076A2 (es) | 2017-09-20 |
| RU2017114356A3 (https=) | 2019-04-29 |
| RU2017114356A (ru) | 2018-10-29 |
| CA2959245A1 (en) | 2016-03-31 |
| WO2016046288A1 (en) | 2016-03-31 |
| CN106998787A (zh) | 2017-08-01 |
| BR112017003842B1 (pt) | 2024-02-20 |
| BR112017003842A2 (pt) | 2017-12-19 |
| EP3198015A1 (en) | 2017-08-02 |
| JP6921740B2 (ja) | 2021-08-18 |
| US20170303582A1 (en) | 2017-10-26 |
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