BR112016025234A2 - redução de nicotina para conversão em nornicotina em plantas - Google Patents
redução de nicotina para conversão em nornicotina em plantasInfo
- Publication number
- BR112016025234A2 BR112016025234A2 BR112016025234A BR112016025234A BR112016025234A2 BR 112016025234 A2 BR112016025234 A2 BR 112016025234A2 BR 112016025234 A BR112016025234 A BR 112016025234A BR 112016025234 A BR112016025234 A BR 112016025234A BR 112016025234 A2 BR112016025234 A2 BR 112016025234A2
- Authority
- BR
- Brazil
- Prior art keywords
- nicotine
- demethylase
- sequence
- expression
- nornicotine
- Prior art date
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title abstract 5
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title abstract 5
- 229960002715 nicotine Drugs 0.000 title abstract 5
- MYKUKUCHPMASKF-VIFPVBQESA-N (S)-nornicotine Chemical compound C1CCN[C@@H]1C1=CC=CN=C1 MYKUKUCHPMASKF-VIFPVBQESA-N 0.000 title 1
- MYKUKUCHPMASKF-UHFFFAOYSA-N Nornicotine Natural products C1CCNC1C1=CC=CN=C1 MYKUKUCHPMASKF-UHFFFAOYSA-N 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 abstract 2
- 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 abstract 2
- 102000006374 N-Demethylating Oxidoreductases Human genes 0.000 abstract 2
- 108010058669 N-Demethylating Oxidoreductases Proteins 0.000 abstract 2
- 244000061176 Nicotiana tabacum Species 0.000 abstract 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/13—Plant traits
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Virology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Manufacture Of Tobacco Products (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14167598 | 2014-05-08 | ||
| EP14001645 | 2014-05-09 | ||
| PCT/EP2015/060124 WO2015169927A1 (en) | 2014-05-08 | 2015-05-07 | Reduction of nicotine to nornicotine conversion in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016025234A2 true BR112016025234A2 (pt) | 2017-12-12 |
Family
ID=53276066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016025234A BR112016025234A2 (pt) | 2014-05-08 | 2015-05-07 | redução de nicotina para conversão em nornicotina em plantas |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10415050B2 (https=) |
| EP (1) | EP3140404A1 (https=) |
| JP (1) | JP6871158B2 (https=) |
| KR (1) | KR102442802B1 (https=) |
| CN (1) | CN106459923B (https=) |
| BR (1) | BR112016025234A2 (https=) |
| CA (1) | CA2944965A1 (https=) |
| MX (1) | MX2016014635A (https=) |
| PH (1) | PH12016501718A1 (https=) |
| RU (1) | RU2733837C2 (https=) |
| WO (1) | WO2015169927A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106636146B (zh) * | 2017-02-16 | 2019-09-13 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e5基因突变体及其应用 |
| US11046969B2 (en) * | 2017-05-24 | 2021-06-29 | Epiplanta Biotech Ltd. | Transgenic plant and the method for producing the same |
| WO2018222667A1 (en) * | 2017-05-31 | 2018-12-06 | 22Nd Century Limited, Llc | Genome editing methods for producing low-nicotine tobacco products |
| BR112020011386A2 (pt) | 2017-12-07 | 2020-12-01 | R.J. Reynolds Tobacco Company | fatores de transcrição bzip regulam a conversão de nicotina em nornicotina |
| CN108192900B (zh) * | 2018-01-16 | 2021-11-30 | 西南大学 | 烟草烟碱去甲基化酶基因cyp82e4的编辑失活载体及其应用 |
| KR20200136921A (ko) | 2018-03-28 | 2020-12-08 | 필립모리스 프로덕츠 에스.에이. | 식물 내 아미노산 함량 조절 |
| WO2019185699A1 (en) | 2018-03-28 | 2019-10-03 | Philip Morris Products S.A. | Modulating reducing sugar content in a plant |
| CN108424921B (zh) * | 2018-04-20 | 2021-04-20 | 云南省烟草农业科学研究院 | 一种降低尼古丁转化率的cyp82e10基因错义突变体m594及其应用 |
| KR102851176B1 (ko) * | 2018-07-26 | 2025-08-28 | 알트리아 클라이언트 서비시즈 엘엘씨 | 알칼로이드 수준이 변경된 담배 식물 및 제품을 생산하기 위한 pmt 공학에 기초한 조성물 및 방법 |
| JP2021532761A (ja) * | 2018-08-02 | 2021-12-02 | アンティドートゥ・セラピューティクス・インコーポレイテッド | 新規ニコチン分解酵素変異体 |
| GB201812603D0 (en) | 2018-08-02 | 2018-09-19 | British American Tobacco Investments Ltd | Method |
| WO2020141062A1 (en) | 2018-12-30 | 2020-07-09 | Philip Morris Products S.A. | Modulation of nitrate levels in plants via mutation of nitrate reductase |
| CN114514321A (zh) | 2019-10-01 | 2022-05-17 | 菲利普莫里斯生产公司 | 调节植物中的糖和氨基酸含量（sultr3） |
| JP7659547B2 (ja) | 2019-10-01 | 2025-04-09 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物における還元糖含有量の調節（ｉｎｖ） |
| EP4069854A1 (en) * | 2019-12-03 | 2022-10-12 | Altria Client Services LLC | Compositions and methods for producing tobacco plants and products having altered alkaloid levels |
| US11331020B2 (en) | 2020-02-06 | 2022-05-17 | Trustees Of Boston University | Enzyme-based electrochemical nicotine biosensor |
| WO2021221752A2 (en) | 2020-02-06 | 2021-11-04 | Trustees Of Boston University | High throughput assay for identifying microbial redox enzymes |
| JP7210806B2 (ja) * | 2020-04-17 | 2023-01-23 | 日本たばこ産業株式会社 | 低アルカロイド含量のタバコ属植物体およびその製造方法 |
| CN111505158B (zh) * | 2020-05-09 | 2022-09-23 | 云南省烟草农业科学研究院 | 一种基于孵化处理的尼古丁转化烟株色质快速筛查方法 |
| WO2023036691A1 (en) | 2021-09-10 | 2023-03-16 | Philip Morris Products S.A. | Modulating alkaloid profiles in nicotiana tabacum |
| CN113980978B (zh) * | 2021-11-22 | 2023-12-26 | 云南中烟工业有限责任公司 | 一种烟草烟碱转运蛋白相关的基因及其应用 |
| US20250043298A1 (en) | 2021-12-20 | 2025-02-06 | Philip Morris Products S.A. | Increasing anatabine in tobacco leaf by regulating methyl putrescine oxidase |
| US20250084427A1 (en) | 2021-12-21 | 2025-03-13 | Philip Morris Products S.A. | Modulation of nicotine production by alteration of nicotinamidase expression or function in plants |
| CN114540382B (zh) * | 2022-02-18 | 2023-07-18 | 贵州省烟草科学研究院 | 烟草镉转运基因NtPLA1及应用 |
| EP4602060A1 (en) | 2022-10-13 | 2025-08-20 | Philip Morris Products S.A. | Increasing leaf biomass and nitrogen use efficiency by regulating ntp2 |
| CN120530195A (zh) | 2023-02-02 | 2025-08-22 | 菲利普莫里斯生产公司 | 糖转运蛋白的调节 |
| KR20250139370A (ko) | 2023-02-02 | 2025-09-23 | 필립모리스 프로덕츠 에스.에이. | 리신 케토글루타레이트 환원효소 코딩 유전자 조절 |
| WO2025003105A1 (en) | 2023-06-29 | 2025-01-02 | Philip Morris Products S.A. | Modulation of genes coding for glutamate dehydrogenase |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5810020A (en) | 1993-09-07 | 1998-09-22 | Osmotek, Inc. | Process for removing nitrogen-containing anions and tobacco-specific nitrosamines from tobacco products |
| US6202649B1 (en) | 1996-12-02 | 2001-03-20 | Regent Court Technologies | Method of treating tobacco to reduce nitrosamine content, and products produced thereby |
| YU68799A (sh) | 1997-06-20 | 2001-05-28 | Regent Court Technologies | Postupak tretiranja duvana u cilju smanjenja sadržaja nitrosamina i proizvodi koji se njime dobijaju |
| US7700851B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokeless Tobacco Company | Tobacco nicotine demethylase genomic clone and uses thereof |
| ATE530656T1 (de) * | 2005-02-23 | 2011-11-15 | Univ North Carolina State | Veränderung des alkaloidgehaltes in tabak durch modifikation spezifischer cytochrome p450 gene. |
| BRPI0717355B1 (pt) | 2006-10-13 | 2018-01-16 | North Carolina State University | Método para obtenção de uma planta transgênica de nicotina, método para obtenção de uma semente; construto de ácido nucléico recombinante; método de redução da conversão de nicotina em nornicotina em uma planta de nicotina |
| RU2324737C1 (ru) * | 2006-10-18 | 2008-05-20 | Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) | Способ получения трансгенных растений табака с повышенным содержанием пролина |
| US8319011B2 (en) | 2006-12-15 | 2012-11-27 | U.S. Smokeless Tobacco Company Llc | Tobacco plants having reduced nicotine demethylase activity |
| WO2009064771A2 (en) | 2007-11-12 | 2009-05-22 | North Carolina State University | Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes |
| EP2559766B1 (en) | 2007-12-13 | 2017-10-18 | Philip Morris Products S.A. | Plants modified for reduced cadmium transport, derivative products, and related methods |
| US7883371B1 (en) | 2009-07-22 | 2011-02-08 | Hon Hai Precision Ind. Co., Ltd. | Electrical connector with improved contact footprints |
| PH12012501393B1 (en) | 2010-01-15 | 2017-10-25 | Univ North Carolina State | Compositions and methods for minimizing nornicotine synthesis in tobacco |
| CN103228671B (zh) | 2010-09-03 | 2017-08-15 | 菲利普莫里斯产品有限公司 | 植物中的重金属减少 |
-
2015
- 2015-05-07 EP EP15726007.6A patent/EP3140404A1/en not_active Withdrawn
- 2015-05-07 JP JP2017510762A patent/JP6871158B2/ja not_active Expired - Fee Related
- 2015-05-07 RU RU2016144409A patent/RU2733837C2/ru active
- 2015-05-07 CN CN201580023352.1A patent/CN106459923B/zh not_active Expired - Fee Related
- 2015-05-07 BR BR112016025234A patent/BR112016025234A2/pt not_active Application Discontinuation
- 2015-05-07 US US15/306,172 patent/US10415050B2/en active Active
- 2015-05-07 CA CA2944965A patent/CA2944965A1/en not_active Abandoned
- 2015-05-07 MX MX2016014635A patent/MX2016014635A/es unknown
- 2015-05-07 WO PCT/EP2015/060124 patent/WO2015169927A1/en not_active Ceased
- 2015-05-07 KR KR1020167031693A patent/KR102442802B1/ko active Active
-
2016
- 2016-09-01 PH PH12016501718A patent/PH12016501718A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10415050B2 (en) | 2019-09-17 |
| RU2016144409A3 (https=) | 2018-11-29 |
| CN106459923A (zh) | 2017-02-22 |
| CA2944965A1 (en) | 2015-11-12 |
| RU2016144409A (ru) | 2018-06-13 |
| US20170130239A1 (en) | 2017-05-11 |
| KR20170002444A (ko) | 2017-01-06 |
| RU2733837C2 (ru) | 2020-10-07 |
| WO2015169927A1 (en) | 2015-11-12 |
| CN106459923B (zh) | 2020-08-11 |
| KR102442802B1 (ko) | 2022-09-14 |
| JP2017519519A (ja) | 2017-07-20 |
| JP6871158B2 (ja) | 2021-05-12 |
| PH12016501718A1 (en) | 2016-11-07 |
| MX2016014635A (es) | 2017-02-23 |
| EP3140404A1 (en) | 2017-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
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Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |