JP2017519018A5 - - Google Patents
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- Publication number
- JP2017519018A5 JP2017519018A5 JP2016574175A JP2016574175A JP2017519018A5 JP 2017519018 A5 JP2017519018 A5 JP 2017519018A5 JP 2016574175 A JP2016574175 A JP 2016574175A JP 2016574175 A JP2016574175 A JP 2016574175A JP 2017519018 A5 JP2017519018 A5 JP 2017519018A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- protein
- liquid
- therapeutic
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009472 formulation Methods 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 27
- 102000004169 proteins and genes Human genes 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 230000001225 therapeutic effect Effects 0.000 claims 12
- 239000012669 liquid formulation Substances 0.000 claims 10
- 239000007788 liquid Substances 0.000 claims 7
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 3
- 229960001948 caffeine Drugs 0.000 claims 3
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000003672 processing method Methods 0.000 claims 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 108010011485 Aspartame Proteins 0.000 claims 1
- 108010003272 Hyaluronate lyase Proteins 0.000 claims 1
- 102000001974 Hyaluronidases Human genes 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- DZGWFCGJZKJUFP-UHFFFAOYSA-N Tyramine Natural products NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 claims 1
- 235000010358 acesulfame potassium Nutrition 0.000 claims 1
- 229960004998 acesulfame potassium Drugs 0.000 claims 1
- 239000000619 acesulfame-K Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 239000000605 aspartame Substances 0.000 claims 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims 1
- 235000010357 aspartame Nutrition 0.000 claims 1
- 229960003438 aspartame Drugs 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229960002773 hyaluronidase Drugs 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims 1
- 229960004919 procaine Drugs 0.000 claims 1
- 238000005086 pumping Methods 0.000 claims 1
- 235000019204 saccharin Nutrition 0.000 claims 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 1
- 229940081974 saccharin Drugs 0.000 claims 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 229960003732 tyramine Drugs 0.000 claims 1
- DZGWFCGJZKJUFP-UHFFFAOYSA-O tyraminium Chemical compound [NH3+]CCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-O 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020039681A JP6983266B2 (ja) | 2014-06-20 | 2020-03-09 | タンパク質配合物のための粘度低減賦形剤化合物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462014784P | 2014-06-20 | 2014-06-20 | |
| US62/014,784 | 2014-06-20 | ||
| US201462083623P | 2014-11-24 | 2014-11-24 | |
| US62/083,623 | 2014-11-24 | ||
| US201562136763P | 2015-03-23 | 2015-03-23 | |
| US62/136,763 | 2015-03-23 | ||
| PCT/US2015/036899 WO2015196187A1 (en) | 2014-06-20 | 2015-06-22 | Viscosity-reducing excipient compounds for protein formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020039681A Division JP6983266B2 (ja) | 2014-06-20 | 2020-03-09 | タンパク質配合物のための粘度低減賦形剤化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017519018A JP2017519018A (ja) | 2017-07-13 |
| JP2017519018A5 true JP2017519018A5 (enExample) | 2018-08-02 |
| JP6674910B2 JP6674910B2 (ja) | 2020-04-01 |
Family
ID=54936144
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016574175A Expired - Fee Related JP6674910B2 (ja) | 2014-06-20 | 2015-06-22 | タンパク質配合物のための粘度低減賦形剤化合物 |
| JP2020039681A Expired - Fee Related JP6983266B2 (ja) | 2014-06-20 | 2020-03-09 | タンパク質配合物のための粘度低減賦形剤化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020039681A Expired - Fee Related JP6983266B2 (ja) | 2014-06-20 | 2020-03-09 | タンパク質配合物のための粘度低減賦形剤化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US20160074515A1 (enExample) |
| EP (2) | EP4309643A3 (enExample) |
| JP (2) | JP6674910B2 (enExample) |
| KR (2) | KR102463682B1 (enExample) |
| CN (1) | CN106535918B (enExample) |
| BR (1) | BR112016029906A8 (enExample) |
| CA (1) | CA2951716C (enExample) |
| ES (1) | ES2965722T3 (enExample) |
| WO (2) | WO2015196091A1 (enExample) |
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| IL312865B2 (en) | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
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| US10478498B2 (en) | 2014-06-20 | 2019-11-19 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
| US11357857B2 (en) | 2014-06-20 | 2022-06-14 | Comera Life Sciences, Inc. | Excipient compounds for protein processing |
| SG11201702614SA (en) | 2014-10-01 | 2017-04-27 | Eagle Biolog Inc | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
| WO2017070501A1 (en) * | 2015-10-23 | 2017-04-27 | Reform Biologics, Llc | Excipient compounds for biopolymer formulations |
| WO2018013673A1 (en) | 2016-07-13 | 2018-01-18 | Reform Biologics, Llc | Stabilizing excipients for therapeutic protein formulations |
| EA201990316A1 (ru) * | 2016-08-18 | 2019-07-31 | Ридженерон Фармасьютикалз, Инк. | Анализ для определения потенциала самоассоциации белка с использованием концентрационно-зависимой спектроскопии самовзаимодействия на основе наночастиц |
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| US12103979B2 (en) * | 2017-04-28 | 2024-10-01 | Amgen Inc. | N-acetylated and non-acetylated dipeptides containing arginine to reduce the viscosity of viscous compositions of therapeutic polypeptides |
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-
2015
- 2015-06-19 WO PCT/US2015/036724 patent/WO2015196091A1/en not_active Ceased
- 2015-06-19 US US14/744,847 patent/US20160074515A1/en not_active Abandoned
- 2015-06-22 CA CA2951716A patent/CA2951716C/en active Active
- 2015-06-22 EP EP23194097.4A patent/EP4309643A3/en not_active Withdrawn
- 2015-06-22 KR KR1020177001786A patent/KR102463682B1/ko not_active Expired - Fee Related
- 2015-06-22 WO PCT/US2015/036899 patent/WO2015196187A1/en not_active Ceased
- 2015-06-22 ES ES15809600T patent/ES2965722T3/es active Active
- 2015-06-22 CN CN201580039834.6A patent/CN106535918B/zh not_active Expired - Fee Related
- 2015-06-22 EP EP15809600.8A patent/EP3160484B1/en active Active
- 2015-06-22 JP JP2016574175A patent/JP6674910B2/ja not_active Expired - Fee Related
- 2015-06-22 KR KR1020227038231A patent/KR20220153668A/ko not_active Ceased
- 2015-06-22 BR BR112016029906A patent/BR112016029906A8/pt not_active Application Discontinuation
- 2015-12-11 US US14/966,549 patent/US9605051B2/en not_active Expired - Fee Related
-
2017
- 2017-02-16 US US15/434,379 patent/US9867881B2/en not_active Expired - Fee Related
-
2019
- 2019-02-25 US US16/284,583 patent/US11660343B2/en active Active
-
2020
- 2020-03-09 JP JP2020039681A patent/JP6983266B2/ja not_active Expired - Fee Related
-
2022
- 2022-09-16 US US17/933,071 patent/US11672865B2/en active Active
-
2023
- 2023-04-19 US US18/303,082 patent/US20230381318A1/en not_active Abandoned
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