JP2017518959A5 - - Google Patents
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- JP2017518959A5 JP2017518959A5 JP2016557019A JP2016557019A JP2017518959A5 JP 2017518959 A5 JP2017518959 A5 JP 2017518959A5 JP 2016557019 A JP2016557019 A JP 2016557019A JP 2016557019 A JP2016557019 A JP 2016557019A JP 2017518959 A5 JP2017518959 A5 JP 2017518959A5
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- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- halogen
- hydroxyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952467P | 2014-03-13 | 2014-03-13 | |
| US61/952,467 | 2014-03-13 | ||
| US201462010025P | 2014-06-10 | 2014-06-10 | |
| US62/010,025 | 2014-06-10 | ||
| PCT/US2015/020444 WO2015138895A1 (en) | 2014-03-13 | 2015-03-13 | Hepatitis b core protein allosteric modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019085742A Division JP2019151650A (ja) | 2014-03-13 | 2019-04-26 | Ｂ型肝炎コアタンパク質アロステリックモジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518959A JP2017518959A (ja) | 2017-07-13 |
| JP2017518959A5 true JP2017518959A5 (OSRAM) | 2018-04-26 |
| JP6602311B2 JP6602311B2 (ja) | 2019-11-06 |
Family
ID=54072461
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016557019A Expired - Fee Related JP6602311B2 (ja) | 2014-03-13 | 2015-03-13 | Ｂ型肝炎コアタンパク質アロステリックモジュレーター |
| JP2019085742A Withdrawn JP2019151650A (ja) | 2014-03-13 | 2019-04-26 | Ｂ型肝炎コアタンパク質アロステリックモジュレーター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019085742A Withdrawn JP2019151650A (ja) | 2014-03-13 | 2019-04-26 | Ｂ型肝炎コアタンパク質アロステリックモジュレーター |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10183936B2 (OSRAM) |
| EP (3) | EP3974426A1 (OSRAM) |
| JP (2) | JP6602311B2 (OSRAM) |
| KR (1) | KR102363174B1 (OSRAM) |
| CN (2) | CN110437153A (OSRAM) |
| AP (1) | AP2016009477A0 (OSRAM) |
| AU (2) | AU2015229174B2 (OSRAM) |
| CA (1) | CA2942533C (OSRAM) |
| CL (1) | CL2016002269A1 (OSRAM) |
| DK (1) | DK3116316T3 (OSRAM) |
| DO (1) | DOP2016000233A (OSRAM) |
| ES (1) | ES2748029T3 (OSRAM) |
| HR (1) | HRP20191444T1 (OSRAM) |
| HU (1) | HUE046567T2 (OSRAM) |
| IL (3) | IL247575B (OSRAM) |
| MX (2) | MX363600B (OSRAM) |
| PH (2) | PH12016501762B1 (OSRAM) |
| PL (1) | PL3116316T3 (OSRAM) |
| PT (1) | PT3116316T (OSRAM) |
| RS (1) | RS59430B1 (OSRAM) |
| SG (2) | SG11201607268UA (OSRAM) |
| WO (1) | WO2015138895A1 (OSRAM) |
| ZA (1) | ZA201606209B (OSRAM) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA026368B1 (ru) | 2011-12-21 | 2017-03-31 | Новира Терапьютикс, Инк. | Противовирусные агенты против гепатита в |
| AU2013307337B2 (en) | 2012-08-28 | 2018-07-19 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of Hepatitis B |
| CN105189453B (zh) | 2013-02-28 | 2018-04-10 | 爱尔兰詹森科学公司 | 氨磺酰基‑芳基酰胺及其作为用于乙型肝炎治疗的药物的用途 |
| WO2014161888A1 (en) | 2013-04-03 | 2014-10-09 | Janssen R&D Ireland | N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| BR112015028538A2 (pt) | 2013-05-17 | 2017-07-25 | Janssen Sciences Ireland Uc | derivados de sulfamoiltiofenamida e o uso dos mesmos como medicamentos para o tratamento da hepatite b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| CA2935719C (en) | 2013-07-25 | 2021-11-02 | Janssen Sciences Ireland Uc | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| AU2014338947B2 (en) | 2013-10-23 | 2018-02-22 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| KR20160128305A (ko) | 2014-02-05 | 2016-11-07 | 노비라 테라퓨틱스, 인코포레이티드 | Hbv 감염의 치료를 위한 병용 요법 |
| JP6495929B2 (ja) | 2014-02-06 | 2019-04-03 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | スルファモイルピロールアミド誘導体およびｂ型肝炎の治療のための医薬としてのその使用 |
| PH12016501762B1 (en) | 2014-03-13 | 2023-01-11 | Assembly Biosciences Inc | Hepatitis b core protein allosteric modulators |
| AU2016232801A1 (en) | 2015-03-19 | 2017-10-12 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis B infections |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| EP3322428B1 (en) * | 2015-07-15 | 2024-04-24 | Agency For Science, Technology And Research | Modulation of hepatitis b virus replication |
| TW201720802A (zh) | 2015-09-15 | 2017-06-16 | 艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
| TW201718496A (zh) | 2015-09-29 | 2017-06-01 | 諾維拉治療公司 | B型肝炎抗病毒劑之晶型 |
| BR112018071048A2 (pt) | 2016-04-15 | 2019-05-07 | Janssen Sciences Ireland Uc | combinações e métodos que compreendem um inibidor da montagem de capsídeos |
| EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CA3037151A1 (en) * | 2016-09-15 | 2018-03-22 | Assembly Biosciences, Inc. | Hepatitis b core protein modulators |
| MX2019003887A (es) * | 2016-10-03 | 2019-11-18 | Sigilon Therapeutics Inc | Compuestos, dispositivos y usos de los mismos. |
| CN116751200A (zh) | 2016-11-07 | 2023-09-15 | 爱彼特生物制药公司 | 含有取代的吡啶酮的三环化合物以及使用其的方法 |
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| ES2874656T3 (es) * | 2017-02-23 | 2021-11-05 | Fujian Cosunter Pharmaceutical Co Ltd | Compuesto tricíclico y aplicaciones del mismo |
| JP2020511436A (ja) | 2017-03-02 | 2020-04-16 | アッセンブリー バイオサイエンシズ，インコーポレイテッド | 環状スルファミド化合物およびその使用方法 |
| EP3596070A1 (en) * | 2017-03-13 | 2020-01-22 | Assembly Biosciences, Inc. | Process for making hepatitis b core protein modulators |
| EP3601216B1 (en) | 2017-03-21 | 2023-10-25 | Arbutus Biopharma Corporation | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same for the treatment of hepatitis b virus infection |
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| MA50524A (fr) | 2017-11-02 | 2020-09-09 | Aicuris Gmbh & Co Kg | Nouveaux indole-2-carboxamides à substitution amino-thiazole hautement actifs agissant contre le virus de l'hépatite b (vhb) |
| JP2021501768A (ja) | 2017-11-02 | 2021-01-21 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Ｂ型肝炎ウイルス（ｈｂｖ）に対し活性を有する新規の高活性なピラゾロ−ピペリジン置換インドール−２−カルボキサミド |
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| IL278460B2 (en) * | 2018-05-03 | 2025-04-01 | Univ Emory | Regulators of orphan nuclear receptors for NASH and other metabolic diseases |
| CN110627752B (zh) * | 2018-06-25 | 2021-08-17 | 新发药业有限公司 | 一种3-氨甲基四氢呋喃的制备方法 |
| CN108863884B (zh) * | 2018-07-26 | 2020-07-03 | 南京富润凯德生物医药有限公司 | 一种用dast试剂作为消除试剂合成共轭硝基烯取代系列衍生物的方法 |
| TWI826492B (zh) | 2018-07-27 | 2023-12-21 | 加拿大商愛彼特生物製藥公司 | 經取代四氫環戊[c]吡咯、經取代二氫吡咯，其類似物及使用其之方法 |
| CA3109746C (en) * | 2018-08-23 | 2023-07-11 | Fujian Cosunter Pharmaceutical Co., Ltd. | Crystal form of tri-cycle compound and application thereof |
| AR116946A1 (es) | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[4,3-c]piridinas activas contra el virus de la hepatitis b (vhb) |
| AR116947A1 (es) | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
| AR117189A1 (es) | 2018-11-02 | 2021-07-21 | Aicuris Gmbh & Co Kg | Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb) |
| AR116948A1 (es) | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (vhb) |
| UY38437A (es) | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas activas contra el virus de la hepatitis b (hbv) |
| TWI827760B (zh) | 2018-12-12 | 2024-01-01 | 加拿大商愛彼特生物製藥公司 | 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法 |
| CN120698985A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
| CA3127152A1 (en) | 2019-02-22 | 2020-08-27 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases |
| WO2020221824A1 (en) | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv) |
| US20220306647A1 (en) | 2019-04-30 | 2022-09-29 | Aicuris Gmbh & Co. Kg | Novel indole-2-carboxamides active against the hepatitus b virus (hbv) |
| WO2020221811A1 (en) | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel oxalyl piperazines active against the hepatitis b virus (hbv) |
| US20220227785A1 (en) | 2019-04-30 | 2022-07-21 | Aicuris Gmbh & Co. Kg | Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv) |
| US11491148B2 (en) | 2019-05-06 | 2022-11-08 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
| EP3975996A1 (en) * | 2019-05-24 | 2022-04-06 | Assembly Biosciences, Inc. | Pharmaceutical compositions for the treatment of hbv |
| CN110526878A (zh) * | 2019-09-16 | 2019-12-03 | 成都睿智化学研究有限公司 | 一种2-(噁唑基)乙胺的制备方法 |
| CN111072551A (zh) * | 2019-12-30 | 2020-04-28 | 上海睿瓦科技有限公司 | 催化氢化一步法制取哌啶胺的方法 |
| EP4139292A1 (en) * | 2020-04-22 | 2023-03-01 | Assembly Biosciences, Inc. | 5-membered heteroaryl carboxamide compounds for treatment of hbv |
| CN113135848A (zh) * | 2021-04-26 | 2021-07-20 | 深圳市华先医药科技有限公司 | 一种巯基烯酯类化合物的制备方法 |
| CN113636960A (zh) * | 2021-08-24 | 2021-11-12 | 上海皓元医药股份有限公司 | 一种2-(氯磺酰基)环己烷-1-烯甲酸乙酯衍生物的制备方法 |
| CN113717080A (zh) * | 2021-10-09 | 2021-11-30 | 西安瑞联新材料股份有限公司 | 一种4-氯-2-氰基苯磺酰氯的合成方法 |
| CN115353479A (zh) * | 2022-07-27 | 2022-11-18 | 常州琦诺生物科技有限公司 | 一种5-溴-2-碘嘧啶的制备方法 |
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| WO2025069039A1 (en) * | 2023-09-28 | 2025-04-03 | Rajaram Samant | An in situ process for the preparation of primary amine compounds |
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| AU2013307337B2 (en) | 2012-08-28 | 2018-07-19 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of Hepatitis B |
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| CN105189453B (zh) | 2013-02-28 | 2018-04-10 | 爱尔兰詹森科学公司 | 氨磺酰基‑芳基酰胺及其作为用于乙型肝炎治疗的药物的用途 |
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| WO2014161888A1 (en) | 2013-04-03 | 2014-10-09 | Janssen R&D Ireland | N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
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| BR112015028538A2 (pt) | 2013-05-17 | 2017-07-25 | Janssen Sciences Ireland Uc | derivados de sulfamoiltiofenamida e o uso dos mesmos como medicamentos para o tratamento da hepatite b |
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| PH12016501762B1 (en) | 2014-03-13 | 2023-01-11 | Assembly Biosciences Inc | Hepatitis b core protein allosteric modulators |
| CA2950802A1 (en) | 2014-06-10 | 2015-12-17 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds as fungicides |
| TW201720802A (zh) | 2015-09-15 | 2017-06-16 | 艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
| US10811219B2 (en) | 2018-08-07 | 2020-10-20 | Applied Materials Israel Ltd. | Method for evaluating a region of an object |
-
2015
- 2015-03-13 PH PH1/2016/501762A patent/PH12016501762B1/en unknown
- 2015-03-13 EP EP21191660.6A patent/EP3974426A1/en not_active Withdrawn
- 2015-03-13 PL PL15761201T patent/PL3116316T3/pl unknown
- 2015-03-13 SG SG11201607268UA patent/SG11201607268UA/en unknown
- 2015-03-13 SG SG10202001506UA patent/SG10202001506UA/en unknown
- 2015-03-13 HU HUE15761201A patent/HUE046567T2/hu unknown
- 2015-03-13 AP AP2016009477A patent/AP2016009477A0/en unknown
- 2015-03-13 CA CA2942533A patent/CA2942533C/en active Active
- 2015-03-13 ES ES15761201T patent/ES2748029T3/es active Active
- 2015-03-13 PH PH1/2021/553231A patent/PH12021553231A1/en unknown
- 2015-03-13 WO PCT/US2015/020444 patent/WO2015138895A1/en not_active Ceased
- 2015-03-13 EP EP19184535.3A patent/EP3607950A3/en not_active Withdrawn
- 2015-03-13 CN CN201910710699.3A patent/CN110437153A/zh active Pending
- 2015-03-13 AU AU2015229174A patent/AU2015229174B2/en not_active Ceased
- 2015-03-13 JP JP2016557019A patent/JP6602311B2/ja not_active Expired - Fee Related
- 2015-03-13 MX MX2016011800A patent/MX363600B/es unknown
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- 2015-03-13 US US15/125,911 patent/US10183936B2/en active Active
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- 2015-03-13 DK DK15761201.1T patent/DK3116316T3/da active
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2016
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