JP2017518303A5 - - Google Patents
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- JP2017518303A5 JP2017518303A5 JP2016570806A JP2016570806A JP2017518303A5 JP 2017518303 A5 JP2017518303 A5 JP 2017518303A5 JP 2016570806 A JP2016570806 A JP 2016570806A JP 2016570806 A JP2016570806 A JP 2016570806A JP 2017518303 A5 JP2017518303 A5 JP 2017518303A5
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- JP
- Japan
- Prior art keywords
- acid sequence
- amino acid
- polypeptide
- seq
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims description 104
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 104
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 104
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 83
- 108060003951 Immunoglobulin Proteins 0.000 claims description 15
- 102000018358 immunoglobulin Human genes 0.000 claims description 15
- 230000000694 effects Effects 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 10
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 9
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 8
- 239000004472 Lysine Substances 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 239000000539 dimer Substances 0.000 claims description 7
- 239000000710 homodimer Substances 0.000 claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 7
- 210000004027 cell Anatomy 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 description 42
- 102000016970 Follistatin Human genes 0.000 description 37
- 108010014612 Follistatin Proteins 0.000 description 37
- 210000003205 muscle Anatomy 0.000 description 35
- 108020001507 fusion proteins Proteins 0.000 description 11
- 102000037865 fusion proteins Human genes 0.000 description 11
- 230000004540 complement-dependent cytotoxicity Effects 0.000 description 8
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 6
- 229960002897 heparin Drugs 0.000 description 6
- 229920000669 heparin Polymers 0.000 description 6
- 208000021642 Muscular disease Diseases 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 4
- 108010023082 activin A Proteins 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 201000006938 muscular dystrophy Diseases 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 description 2
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 description 2
- 101000931668 Homo sapiens Follistatin Proteins 0.000 description 2
- 108010056852 Myostatin Proteins 0.000 description 2
- 238000005534 hematocrit Methods 0.000 description 2
- 102000050536 human FST Human genes 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000001995 reticulocyte Anatomy 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 description 1
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 208000029549 Muscle injury Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 108010023079 activin B Proteins 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 201000008319 inclusion body myositis Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000000585 muscular atrophy Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007908P | 2014-06-04 | 2014-06-04 | |
| US62/007,908 | 2014-06-04 | ||
| PCT/US2015/034245 WO2015187977A1 (en) | 2014-06-04 | 2015-06-04 | Methods and compositions for treatment of disorders with follistatin polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019142333A Division JP6856716B2 (ja) | 2014-06-04 | 2019-08-01 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017518303A JP2017518303A (ja) | 2017-07-06 |
| JP2017518303A5 true JP2017518303A5 (https=) | 2018-02-08 |
| JP6568110B2 JP6568110B2 (ja) | 2019-08-28 |
Family
ID=54767384
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570806A Expired - Fee Related JP6568110B2 (ja) | 2014-06-04 | 2015-06-04 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
| JP2019142333A Expired - Fee Related JP6856716B2 (ja) | 2014-06-04 | 2019-08-01 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
| JP2021044545A Pending JP2021095416A (ja) | 2014-06-04 | 2021-03-18 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019142333A Expired - Fee Related JP6856716B2 (ja) | 2014-06-04 | 2019-08-01 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
| JP2021044545A Pending JP2021095416A (ja) | 2014-06-04 | 2021-03-18 | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10023621B2 (https=) |
| EP (2) | EP3152237B1 (https=) |
| JP (3) | JP6568110B2 (https=) |
| KR (4) | KR102305109B1 (https=) |
| CN (2) | CN106795224B (https=) |
| AU (2) | AU2015269333B2 (https=) |
| BR (1) | BR112016028520A2 (https=) |
| CA (1) | CA2950754C (https=) |
| EA (2) | EA035455B1 (https=) |
| MA (2) | MA51074A (https=) |
| MX (2) | MX382908B (https=) |
| WO (1) | WO2015187977A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190006086A (ko) | 2005-11-23 | 2019-01-16 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
| AU2009262970A1 (en) | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
| EA201590719A1 (ru) | 2013-01-25 | 2015-12-30 | Шир Хьюман Дженетик Терапис, Инк. | Фоллистатин в лечении мышечной дистрофии дюшенна |
| US10023621B2 (en) | 2014-06-04 | 2018-07-17 | Acceleron Pharma Inc. | Follistatin-related fusion proteins |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| WO2015192111A1 (en) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| AU2016238254B2 (en) * | 2015-03-26 | 2022-05-05 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
| WO2017152090A2 (en) * | 2016-03-04 | 2017-09-08 | Shire Human Genetic Therapies, Inc. | Recombinant follistatin-fc fusion proteins and use in treating duchenne muscular dystrophy |
| US10905766B2 (en) | 2017-03-23 | 2021-02-02 | Oregon State University | Therapeutic compositions and methods for treatment of muscle wasting diseases |
| KR101822633B1 (ko) * | 2017-08-22 | 2018-01-26 | (주)진셀팜 | 폴리스타틴 유래 생리활성 펩타이드, 및 이의 용도 |
| WO2019046903A1 (en) * | 2017-09-08 | 2019-03-14 | Baker Heart and Diabetes Institute | THERAPEUTIC METHOD FOR INCREASING MUSCLE MASS IN A SUBJECT |
| CN108218985B (zh) * | 2017-12-12 | 2021-04-30 | 山西农业大学 | 一种利用特征多肽制备fst蛋白特异性抗体的方法及其应用 |
| CN111936617A (zh) * | 2018-03-16 | 2020-11-13 | 益缪索夫特公司 | 经遗传工程化以分泌卵泡抑素的b细胞以及使用所述b细胞来治疗卵泡抑素相关的疾病、病况、病症及增强肌肉生长和力量的方法 |
| CN111902157B (zh) * | 2018-03-21 | 2023-08-04 | 松阳生技股份有限公司 | 促进局部肌肉增长、减缓或防止局部肌肉萎缩的组合物及其用途 |
| WO2019191204A1 (en) * | 2018-03-28 | 2019-10-03 | Acceleron Pharma Inc. | Follistatin polypeptides for the treatment of muscle contracture |
| WO2019222690A1 (en) * | 2018-05-17 | 2019-11-21 | Hmi, Inc. | Inhibition of follistatin |
| US12246042B2 (en) | 2018-08-29 | 2025-03-11 | Myos Corp. | Methods for alleviating, inhibiting or reversing muscle disuse atrophy in mammals |
| US12508262B2 (en) | 2020-04-30 | 2025-12-30 | Keros Therapeutics, Inc. | Methods of using ALK2 inhibitors |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| AU2022214780A1 (en) * | 2021-01-26 | 2023-09-07 | Immunis, Inc. | Molecular superstructure and methods of use thereof |
| AU2023291641A1 (en) | 2022-06-15 | 2024-12-12 | Five Prime Therapeutics, Inc. | Fusion protein for the prevention, treatment or amelioration of kidney diseases |
| IL317593A (en) | 2022-06-15 | 2025-02-01 | UCB Biopharma SRL | Follistatin-FC fusion proteins |
| WO2024121351A1 (en) * | 2022-12-07 | 2024-06-13 | Lodberg Andreas | Extracellular matrix binding compounds for the localized loading of therapeutic or diagnostic agents |
| WO2025157262A1 (en) * | 2024-01-25 | 2025-07-31 | Sichuan Real & Best Biotech Co., Ltd. | Nucleic acids encoding follistatin and uses thereof |
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| AU597574B2 (en) | 1986-03-07 | 1990-06-07 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
| US5182375A (en) | 1987-08-28 | 1993-01-26 | The Salk Institute For Biological Studies | DNA encoding follistatin |
| US5041538A (en) | 1987-08-28 | 1991-08-20 | The Salk Institute For Biological Studies | Mammalian follistatin |
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| CA2144081C (en) | 1992-09-16 | 2004-11-30 | Filip Roos | Protection against liver damage by hgf |
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| US6686198B1 (en) | 1993-10-14 | 2004-02-03 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
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| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
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| AU2009262970A1 (en) * | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
| BR112012005225B8 (pt) * | 2009-09-09 | 2023-01-10 | Acceleron Pharma Inc | Uso de uma proteína de fusão actriib-fc para o tratamento de um transtorno relacionado ao osso ou associado à perda de músculo por crescimento muscular insuficiente |
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| WO2014187807A1 (en) * | 2013-05-21 | 2014-11-27 | Arcarios B.V. | Follistatin derivatives |
| US10023621B2 (en) * | 2014-06-04 | 2018-07-17 | Acceleron Pharma Inc. | Follistatin-related fusion proteins |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| AU2016238254B2 (en) * | 2015-03-26 | 2022-05-05 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
| JP2020519291A (ja) | 2017-05-12 | 2020-07-02 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 組み換えフォリスタチン−ｆｃ融合タンパク質およびデュシェンヌ型筋ジストロフィーの治療における使用 |
-
2015
- 2015-06-04 US US14/731,009 patent/US10023621B2/en active Active
- 2015-06-04 KR KR1020207018965A patent/KR102305109B1/ko not_active Expired - Fee Related
- 2015-06-04 MA MA051074A patent/MA51074A/fr unknown
- 2015-06-04 MA MA051075A patent/MA51075A/fr unknown
- 2015-06-04 KR KR1020207003791A patent/KR102132144B1/ko not_active Expired - Fee Related
- 2015-06-04 KR KR1020177000297A patent/KR102077286B1/ko not_active Expired - Fee Related
- 2015-06-04 JP JP2016570806A patent/JP6568110B2/ja not_active Expired - Fee Related
- 2015-06-04 BR BR112016028520A patent/BR112016028520A2/pt not_active Application Discontinuation
- 2015-06-04 EP EP15802909.0A patent/EP3152237B1/en active Active
- 2015-06-04 CA CA2950754A patent/CA2950754C/en active Active
- 2015-06-04 EA EA201692529A patent/EA035455B1/ru not_active IP Right Cessation
- 2015-06-04 MX MX2016015868A patent/MX382908B/es unknown
- 2015-06-04 CN CN201580041740.2A patent/CN106795224B/zh not_active Expired - Fee Related
- 2015-06-04 WO PCT/US2015/034245 patent/WO2015187977A1/en not_active Ceased
- 2015-06-04 CN CN202110533308.2A patent/CN113583104A/zh active Pending
- 2015-06-04 EA EA202090632A patent/EA202090632A1/ru unknown
- 2015-06-04 EP EP20160287.7A patent/EP3721892B1/en active Active
- 2015-06-04 AU AU2015269333A patent/AU2015269333B2/en not_active Ceased
- 2015-06-04 KR KR1020217029755A patent/KR20210119546A/ko not_active Ceased
-
2016
- 2016-12-01 MX MX2021006017A patent/MX2021006017A/es unknown
-
2018
- 2018-06-12 US US16/006,025 patent/US10954279B2/en active Active
-
2019
- 2019-08-01 JP JP2019142333A patent/JP6856716B2/ja not_active Expired - Fee Related
-
2020
- 2020-08-03 AU AU2020210315A patent/AU2020210315A1/en not_active Abandoned
-
2021
- 2021-03-18 JP JP2021044545A patent/JP2021095416A/ja active Pending
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