JP2017538443A5 - - Google Patents
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- Publication number
- JP2017538443A5 JP2017538443A5 JP2017543328A JP2017543328A JP2017538443A5 JP 2017538443 A5 JP2017538443 A5 JP 2017538443A5 JP 2017543328 A JP2017543328 A JP 2017543328A JP 2017543328 A JP2017543328 A JP 2017543328A JP 2017538443 A5 JP2017538443 A5 JP 2017538443A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fusion protein
- hmyd88
- amino acids
- sequence variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108020001507 fusion proteins Proteins 0.000 claims 25
- 102000037865 fusion proteins Human genes 0.000 claims 25
- 102000010168 Myeloid Differentiation Factor 88 Human genes 0.000 claims 9
- 108010077432 Myeloid Differentiation Factor 88 Proteins 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000001565 modulated differential scanning calorimetry Methods 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000004985 myeloid-derived suppressor cell Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462076120P | 2014-11-06 | 2014-11-06 | |
| US62/076,120 | 2014-11-06 | ||
| US201562130092P | 2015-03-09 | 2015-03-09 | |
| US62/130,092 | 2015-03-09 | ||
| PCT/US2015/059510 WO2016073875A1 (en) | 2014-11-06 | 2015-11-06 | CD8α AND T CELL RECEPTOR VARIANTS AND METHODS OF USING SAME IN MODULATING IMMUNE CELL RESPONSES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017538443A JP2017538443A (ja) | 2017-12-28 |
| JP2017538443A5 true JP2017538443A5 (https=) | 2018-11-29 |
| JP6898244B2 JP6898244B2 (ja) | 2021-07-07 |
Family
ID=55909872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017543328A Active JP6898244B2 (ja) | 2014-11-06 | 2015-11-06 | ＣＤ８αおよびＴ細胞受容体の変異体ならびに免疫細胞の応答の調節においてそれらを使用する方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10975137B2 (https=) |
| EP (1) | EP3215521B1 (https=) |
| JP (1) | JP6898244B2 (https=) |
| AU (1) | AU2015342867B2 (https=) |
| WO (1) | WO2016073875A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020011023A (es) | 2018-04-19 | 2021-01-29 | Baylor College Medicine | Reprogramación de células t cd4 en células cd8 citotóxicas por expresión forzada de cd8ab y receptores de células t restringidos de clase 1. |
| EP3962938A4 (en) * | 2019-05-01 | 2023-07-05 | PACT Pharma, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING CD8 MODIFIED T LYMPHOCYTE CELL THERAPY |
| WO2020243134A1 (en) | 2019-05-27 | 2020-12-03 | Immatics US, Inc. | Viral vectors and their use in adoptive cellular therapy |
| KR102152189B1 (ko) * | 2020-02-11 | 2020-09-04 | 재단법인 아산사회복지재단 | T 세포 내 표적 위치로의 t 세포 수용체 삽입을 위한 재조합벡터 및 이를 이용한 t 세포 내 표적 위치로의 t 세포 수용체 삽입용 조성물 |
| AU2021308078A1 (en) * | 2020-07-17 | 2023-02-09 | Children's Hospital Los Angeles | Chimeric MyD88 receptors for redirecting immunosuppressive signaling and related compositions and methods |
| EP4536687A1 (en) | 2022-06-08 | 2025-04-16 | St. Jude Children's Research Hospital, Inc. | Disruption of kdm4a in t cells to enhance immunotherapy |
| WO2024059787A1 (en) | 2022-09-16 | 2024-03-21 | St. Jude Children's Research Hospital, Inc. | Disruption of asxl1 in t cells to enhance immunotherapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712149A (en) * | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| EP2331680B1 (en) * | 2008-09-22 | 2017-05-03 | Baylor College Of Medicine | Methods and compositions for generating an immune response by inducing cd40 and pattern recognition receptor adapters |
| AU2011239569B2 (en) * | 2010-04-16 | 2014-07-24 | Baylor College Of Medicine | Method for treating solid tumors |
| US9359447B2 (en) | 2012-03-23 | 2016-06-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mesothelin chimeric antigen receptors |
| CN104507537A (zh) | 2012-07-13 | 2015-04-08 | 宾夕法尼亚大学董事会 | 用于调节car t细胞的组合物和方法 |
| WO2014039961A1 (en) * | 2012-09-07 | 2014-03-13 | University Of Miami | Fusion proteins for promoting an immune response, nucleic acids encoding same, and methods of making and use thereof |
| WO2014099671A1 (en) | 2012-12-20 | 2014-06-26 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| US10888608B2 (en) * | 2014-09-02 | 2021-01-12 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides |
-
2015
- 2015-11-06 AU AU2015342867A patent/AU2015342867B2/en active Active
- 2015-11-06 JP JP2017543328A patent/JP6898244B2/ja active Active
- 2015-11-06 EP EP15857640.5A patent/EP3215521B1/en active Active
- 2015-11-06 US US15/524,887 patent/US10975137B2/en active Active
- 2015-11-06 WO PCT/US2015/059510 patent/WO2016073875A1/en not_active Ceased
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