JP2018516566A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018516566A5 JP2018516566A5 JP2017560327A JP2017560327A JP2018516566A5 JP 2018516566 A5 JP2018516566 A5 JP 2018516566A5 JP 2017560327 A JP2017560327 A JP 2017560327A JP 2017560327 A JP2017560327 A JP 2017560327A JP 2018516566 A5 JP2018516566 A5 JP 2018516566A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- enpp1
- pharmaceutical composition
- residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021202984A JP7390349B2 (ja) | 2015-05-19 | 2021-12-15 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
| JP2023196352A JP7778392B2 (ja) | 2015-05-19 | 2023-11-20 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
| JP2025191616A JP2026015456A (ja) | 2015-05-19 | 2025-11-12 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163500P | 2015-05-19 | 2015-05-19 | |
| US62/163,500 | 2015-05-19 | ||
| PCT/US2016/033236 WO2016187408A1 (en) | 2015-05-19 | 2016-05-19 | Compositions for treating pathological calcification conditions, and methods using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021202984A Division JP7390349B2 (ja) | 2015-05-19 | 2021-12-15 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516566A JP2018516566A (ja) | 2018-06-28 |
| JP2018516566A5 true JP2018516566A5 (https=) | 2019-06-20 |
| JP6995627B2 JP6995627B2 (ja) | 2022-02-04 |
Family
ID=57320640
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560327A Active JP6995627B2 (ja) | 2015-05-19 | 2016-05-19 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
| JP2021202984A Active JP7390349B2 (ja) | 2015-05-19 | 2021-12-15 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
| JP2023196352A Active JP7778392B2 (ja) | 2015-05-19 | 2023-11-20 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
| JP2025191616A Pending JP2026015456A (ja) | 2015-05-19 | 2025-11-12 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021202984A Active JP7390349B2 (ja) | 2015-05-19 | 2021-12-15 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
| JP2023196352A Active JP7778392B2 (ja) | 2015-05-19 | 2023-11-20 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
| JP2025191616A Pending JP2026015456A (ja) | 2015-05-19 | 2025-11-12 | 病的石灰化状態を治療するための組成物およびそれを使用する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (10) | US10583170B2 (https=) |
| EP (2) | EP4414028A3 (https=) |
| JP (4) | JP6995627B2 (https=) |
| KR (2) | KR20250078598A (https=) |
| AU (3) | AU2016264364B2 (https=) |
| CA (2) | CA2984947A1 (https=) |
| ES (1) | ES2983910T3 (https=) |
| MX (2) | MX391074B (https=) |
| PL (1) | PL3298140T3 (https=) |
| RU (2) | RU2757417C2 (https=) |
| WO (1) | WO2016187408A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011091065A2 (en) | 2010-01-19 | 2011-07-28 | Northwestern University | Synthetic nanostructures including nucleic acids and/or other entities |
| WO2014126965A2 (en) | 2013-02-13 | 2014-08-21 | Yale University | Compositions and methods for treating pathological calcification and ossification |
| AU2015269412B2 (en) | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| EP3234116B1 (en) | 2014-12-19 | 2021-09-08 | Alexion Pharmaceuticals, Inc. | Methods of treating tissue calcification |
| KR20250078598A (ko) * | 2015-05-19 | 2025-06-02 | 예일 유니버시티 | 병리학적 석회화 병태를 치료하기 위한 조성물, 및 이의 사용 방법 |
| WO2017087936A1 (en) | 2015-11-20 | 2017-05-26 | Yale University | Compositions for treating ectopic calcification disorders, and methods using same |
| US11364284B2 (en) | 2016-06-16 | 2022-06-21 | Inozyme Pharma, Inc. | Methods of treating myointimal proliferation |
| BR112019002355A2 (pt) | 2016-08-05 | 2019-07-16 | Yale University | composições e métodos para prevenção de acidente vascular cerebral em pacientes pediátricos com anemia falciforme |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| EP3687565A1 (en) * | 2017-09-27 | 2020-08-05 | Alexion Pharmaceuticals, Inc. | Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (npp1) |
| JP2021523139A (ja) | 2018-05-08 | 2021-09-02 | イエール ユニバーシティ | 腎石症の進行を遅らせるための組成物および方法 |
| EP3844280A4 (en) * | 2018-08-31 | 2022-09-14 | Yale University | ENPP1 POLYPEPTIDES AND METHODS OF USE |
| KR20210142599A (ko) * | 2019-01-18 | 2021-11-25 | 이노자임 파마, 인코포레이티드 | Enpp1 또는 enpp3 결핍을 수반하는 질환의 치료 |
| CN113613635A (zh) | 2019-01-24 | 2021-11-05 | 西北大学 | 使用脂质缀合的核心支架的高密度脂蛋白模拟纳米颗粒 |
| BR112021020037A2 (pt) * | 2019-04-05 | 2021-12-07 | Univ Yale | Polipeptídeos enpp1 e métodos para o uso dos mesmos |
| CN116406281A (zh) * | 2020-05-27 | 2023-07-07 | 依诺兹梅制药公司 | 用于治疗外周动脉疾病的组合物和方法 |
| IL298853A (en) | 2020-06-09 | 2023-02-01 | Inozyme Pharma Inc | Soluble enpp1 or enpp3 proteins and uses thereof |
| WO2022076848A1 (en) * | 2020-10-08 | 2022-04-14 | Inozyme Pharma, Inc. | Liver specific production of enpp1 or enpp3 |
| AU2021383830A1 (en) * | 2020-11-19 | 2023-06-22 | Biomarin Pharmaceutical Inc. | Treatment of enpp1 deficiency and abcc6 deficiency |
| WO2023049864A1 (en) * | 2021-09-24 | 2023-03-30 | Inozyme Pharma, Inc. | Lyophilized enpp1 polypeptide formulations and uses thereof |
| IL326528A (en) * | 2023-08-22 | 2026-04-01 | Inozyme Pharma Inc | Treatment of ENPP1 deficiency and ABCC6 deficiency in children |
| WO2025255052A1 (en) * | 2024-06-03 | 2025-12-11 | Inozyme Pharma, Inc. | Treatment of enpp1 deficiency and abcc6 deficiency in infants |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4160452A (en) | 1977-04-07 | 1979-07-10 | Alza Corporation | Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法 |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5007790A (en) | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| ATE92107T1 (de) | 1989-04-29 | 1993-08-15 | Delta Biotechnology Ltd | N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen. |
| FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
| US5169645A (en) | 1989-10-31 | 1992-12-08 | Duquesne University Of The Holy Ghost | Directly compressible granules having improved flow properties |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| FR2686901A1 (fr) | 1992-01-31 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant. |
| ATE173159T1 (de) | 1992-03-25 | 1998-11-15 | Depomed Systems Inc | Auf hydroxyethylzellulose basierende oralen arzneidosisformen mit verzoegerter wirkstoffabgabe |
| US5582837A (en) | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| AU1518595A (en) | 1994-01-14 | 1995-08-01 | Genentech Inc. | Antagonists to insulin receptor tyrosine kinase inhibitor |
| WO1997047285A1 (en) | 1996-06-10 | 1997-12-18 | Depomed, Inc. | Gastric-retentive oral controlled drug delivery system with enhanced retention properties |
| US5972389A (en) | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
| US6635280B2 (en) | 1997-06-06 | 2003-10-21 | Depomed, Inc. | Extending the duration of drug release within the stomach during the fed mode |
| CA2290624C (en) | 1997-06-06 | 2006-12-05 | John W. Shell | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
| US6043056A (en) | 1998-11-06 | 2000-03-28 | Incyte Pharmaceuticals, Inc. | Cell surface glycoproteins |
| CA2389236A1 (en) | 1999-11-02 | 2001-05-10 | Depomed, Inc. | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
| ES2270982T3 (es) | 2000-02-04 | 2007-04-16 | Depomed, Inc. | Forma de dosificacion de nucleo y carcasa que se aproxima a una liberacion del farmaco de orden cero. |
| US6488962B1 (en) | 2000-06-20 | 2002-12-03 | Depomed, Inc. | Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms |
| US6451808B1 (en) | 2000-10-17 | 2002-09-17 | Depomed, Inc. | Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists |
| WO2002039994A2 (en) | 2000-11-20 | 2002-05-23 | University Of Kansas Medical Center | Methods for the treatment and prevention of urinary stone disease |
| US7888372B2 (en) | 2001-03-23 | 2011-02-15 | National Institutes Of Health (Nih) | Compositions and methods for modulating bone mineral deposition |
| WO2002092020A2 (en) | 2001-03-23 | 2002-11-21 | The Burnham Institute | Compositions and methods for modulating bone mineral deposition |
| US20030191073A1 (en) | 2001-11-07 | 2003-10-09 | Challita-Eid Pia M. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
| JP2004532259A (ja) | 2001-05-29 | 2004-10-21 | デポメッド ディベロップメント リミティド | 胃食道逆流症及び夜間に胃酸分泌が回復する現象の治療方法 |
| WO2003016475A2 (en) * | 2001-08-14 | 2003-02-27 | The General Hospital Corporation | Nucleic acid and amino acid sequences involved in pain |
| JP2005508358A (ja) | 2001-10-25 | 2005-03-31 | デポメド・インコーポレイテッド | 胃滞留型ロサルタン投与量を用いる治療方法 |
| TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| CA2409552A1 (en) | 2001-10-25 | 2003-04-25 | Depomed, Inc. | Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract |
| US20030091630A1 (en) | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
| US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| CA2462653C (en) | 2001-11-07 | 2016-06-07 | Aya Jakobovits | Nucleic acid and corresponding protein entitled 161p2f10b useful in treatment and detection of cancer |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| AU2003213246A1 (en) | 2002-02-21 | 2003-09-09 | University Of Virginia Patent Foundation | Bone targeting peptides |
| JP5199077B2 (ja) | 2005-06-10 | 2013-05-15 | アルタス ファーマシューティカルズ インコーポレイテッド | シュウ酸オキシダーゼ結晶の投与による、シュウ酸塩濃度を低下させるための方法 |
| US7985839B2 (en) * | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
| PT2046373E (pt) | 2006-08-02 | 2013-05-06 | Althea Technologies Inc | Oxalato descarboxilase cristalizada e métodos de utilização |
| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| GB0803352D0 (en) | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
| ES2628841T3 (es) | 2010-03-12 | 2017-08-04 | Alexion Pharmaceuticals, Inc. | Proteínas de fusión npp1 |
| KR100986619B1 (ko) * | 2010-03-12 | 2010-10-08 | 이상훈 | 이동통신단말기를 이용한 멀티입출력장치 및 방법 |
| KR101772366B1 (ko) * | 2011-03-11 | 2017-08-28 | 알렉시온 파마슈티칼스, 인코포레이티드 | Npp1 융합 단백질 |
| WO2014126965A2 (en) | 2013-02-13 | 2014-08-21 | Yale University | Compositions and methods for treating pathological calcification and ossification |
| CN105378075B (zh) | 2013-03-15 | 2022-04-05 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
| EP3234116B1 (en) | 2014-12-19 | 2021-09-08 | Alexion Pharmaceuticals, Inc. | Methods of treating tissue calcification |
| KR20250078598A (ko) * | 2015-05-19 | 2025-06-02 | 예일 유니버시티 | 병리학적 석회화 병태를 치료하기 위한 조성물, 및 이의 사용 방법 |
-
2016
- 2016-05-19 KR KR1020257016455A patent/KR20250078598A/ko active Pending
- 2016-05-19 EP EP24171629.9A patent/EP4414028A3/en active Pending
- 2016-05-19 CA CA2984947A patent/CA2984947A1/en active Pending
- 2016-05-19 PL PL16797290.0T patent/PL3298140T3/pl unknown
- 2016-05-19 AU AU2016264364A patent/AU2016264364B2/en active Active
- 2016-05-19 ES ES16797290T patent/ES2983910T3/es active Active
- 2016-05-19 JP JP2017560327A patent/JP6995627B2/ja active Active
- 2016-05-19 WO PCT/US2016/033236 patent/WO2016187408A1/en not_active Ceased
- 2016-05-19 EP EP16797290.0A patent/EP3298140B1/en active Active
- 2016-05-19 RU RU2017144183A patent/RU2757417C2/ru active
- 2016-05-19 MX MX2017014805A patent/MX391074B/es unknown
- 2016-05-19 RU RU2021129201A patent/RU2021129201A/ru unknown
- 2016-05-19 CA CA3176123A patent/CA3176123A1/en active Pending
- 2016-05-19 KR KR1020177036279A patent/KR102811896B1/ko active Active
-
2017
- 2017-08-09 US US15/672,899 patent/US10583170B2/en active Active
- 2017-08-09 US US15/672,791 patent/US10064917B2/en active Active
- 2017-11-14 US US15/812,553 patent/US10357541B2/en active Active
- 2017-11-14 US US15/812,342 patent/US10213484B2/en active Active
- 2017-11-14 US US15/812,456 patent/US10960049B2/en active Active
- 2017-11-17 MX MX2022003467A patent/MX2022003467A/es unknown
-
2019
- 2019-04-10 US US16/380,557 patent/US10517927B2/en active Active
- 2019-12-27 US US16/728,129 patent/US11090359B2/en active Active
-
2020
- 2020-03-25 US US16/829,966 patent/US10960050B2/en active Active
-
2021
- 2021-07-07 US US17/369,830 patent/US12128087B2/en active Active
- 2021-12-15 JP JP2021202984A patent/JP7390349B2/ja active Active
-
2022
- 2022-09-23 AU AU2022235636A patent/AU2022235636B2/en active Active
-
2023
- 2023-11-20 JP JP2023196352A patent/JP7778392B2/ja active Active
-
2024
- 2024-10-16 US US18/916,911 patent/US20250295733A1/en active Pending
-
2025
- 2025-08-14 AU AU2025217333A patent/AU2025217333A1/en active Pending
- 2025-11-12 JP JP2025191616A patent/JP2026015456A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018516566A5 (https=) | ||
| US11530260B2 (en) | Compositions and methods of use for treating metabolic disorders | |
| ES2906615T3 (es) | Tratamiento derivado de citocinas con síndrome de fuga vascular reducido | |
| JP2018502836A5 (https=) | ||
| RU2021129201A (ru) | Композиции для лечения патологических состояний кальцификации и способы их применения | |
| JP6383122B2 (ja) | C5関連疾患の治療または予防用の医薬組成物およびc5関連疾患を治療または予防するための方法 | |
| JP2024010052A (ja) | 組織石灰化の治療方法 | |
| JP2010518079A5 (https=) | ||
| JP2017518303A5 (https=) | ||
| RU2017123540A (ru) | Лечение судорог с использованием щелочной фосфатазы | |
| EP3960196A1 (en) | Subcutaneous administration of adamts13 | |
| AU2012228769A1 (en) | Antagonists of the interleukin- 1 receptor | |
| JP2018537093A5 (https=) | ||
| US11299528B2 (en) | Long acting TRAIL receptor agonists for treatment of autoimmune diseases | |
| ES2883417T3 (es) | Composiciones para su uso en el tratamiento o mejora de neuroinflamación, neurodegeneración, dolor neuropático y migraña | |
| WO2023154953A1 (en) | Gdf15 polypeptides for treating and preventing autoimmune diseases | |
| US20140296154A1 (en) | Method of preventing development of psoriatic lesions | |
| US20120157380A1 (en) | Pegylated human apoa-1 and process for production thereof | |
| WO2015200355A1 (en) | Methods for reducing fibrosis induced by peritoneal dialysis | |
| KR20240167914A (ko) | Enpp1 결핍증 및 abcc6 결핍증의 치료 | |
| HK40112655A (zh) | 冻干enpp1多肽制剂及其用途 | |
| US20250241983A1 (en) | Non-opioid methods for treating pain | |
| TW202330017A (zh) | 凍乾的enpp1多肽調配物及其用途 | |
| WO2018079701A1 (ja) | ラクトフェリン活性を有するタンパク質を含む、抗ガン治療補助剤 | |
| RU2024129908A (ru) | Способ и композиции для лечения, облегчения и/или предупреждения диффузного идиопатического скелетного гиперостоза (dish) |