JP2019532996A5 - - Google Patents
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- JP2019532996A5 JP2019532996A5 JP2019523626A JP2019523626A JP2019532996A5 JP 2019532996 A5 JP2019532996 A5 JP 2019532996A5 JP 2019523626 A JP2019523626 A JP 2019523626A JP 2019523626 A JP2019523626 A JP 2019523626A JP 2019532996 A5 JP2019532996 A5 JP 2019532996A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022080574A JP2022119829A (ja) | 2016-11-08 | 2022-05-17 | 自己免疫疾患を処置するためのil-2変異体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662419118P | 2016-11-08 | 2016-11-08 | |
| US62/419,118 | 2016-11-08 | ||
| PCT/US2017/060534 WO2018089420A1 (en) | 2016-11-08 | 2017-11-08 | Il-2 variants for the treatment of autoimmune diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080574A Division JP2022119829A (ja) | 2016-11-08 | 2022-05-17 | 自己免疫疾患を処置するためのil-2変異体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019532996A JP2019532996A (ja) | 2019-11-14 |
| JP2019532996A5 true JP2019532996A5 (https=) | 2020-11-12 |
Family
ID=62065637
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523626A Pending JP2019532996A (ja) | 2016-11-08 | 2017-11-08 | 自己免疫疾患を処置するためのil−2変異体 |
| JP2022080574A Pending JP2022119829A (ja) | 2016-11-08 | 2022-05-17 | 自己免疫疾患を処置するためのil-2変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080574A Pending JP2022119829A (ja) | 2016-11-08 | 2022-05-17 | 自己免疫疾患を処置するためのil-2変異体 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11077172B2 (https=) |
| EP (1) | EP3538548A4 (https=) |
| JP (2) | JP2019532996A (https=) |
| KR (1) | KR20190083656A (https=) |
| CN (1) | CN110167957A (https=) |
| AU (1) | AU2017359172A1 (https=) |
| CA (1) | CA3041334A1 (https=) |
| CL (1) | CL2019001265A1 (https=) |
| CO (1) | CO2019005922A2 (https=) |
| EA (1) | EA201991142A1 (https=) |
| EC (1) | ECSP19041447A (https=) |
| IL (1) | IL266178A (https=) |
| MX (1) | MX2019005400A (https=) |
| SG (1) | SG11201903882VA (https=) |
| WO (1) | WO2018089420A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20200470T1 (hr) | 2011-01-18 | 2020-10-02 | Bioniz, Llc | Pripravci za modulaciju aktivnosti gama-c-citokina |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| CN119684428A (zh) | 2015-10-09 | 2025-03-25 | 比奥尼斯治疗公司 | 调节γC-细胞因子活性 |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| BR112019018915A2 (pt) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | imunotolerância direcionada |
| US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
| WO2018187499A1 (en) | 2017-04-07 | 2018-10-11 | Bioniz, Llc | Stable modulators of gamma-c-cytokine activity |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| US20200299349A1 (en) | 2017-11-21 | 2020-09-24 | The Board Of Trustees Of The Leland Stanford Junior University | Partial agonists of interleukin-2 |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US11319355B2 (en) | 2017-12-19 | 2022-05-03 | Xencor, Inc. | Engineered IL-2 Fc fusion proteins |
| KR102909650B1 (ko) | 2018-03-13 | 2026-01-08 | 터스크 테라퓨틱스 리미티드 | 종양 특이적 세포 고갈에 대한 항-cd25 |
| JP7464530B2 (ja) | 2018-03-28 | 2024-04-09 | ブリストル-マイヤーズ スクイブ カンパニー | インターロイキン-2/インターロイキン-2受容体アルファ融合タンパク質および使用方法 |
| JP7637415B2 (ja) * | 2018-06-22 | 2025-02-28 | キュージーン インコーポレイテッド | インターロイキン-2バリアントおよびその使用方法 |
| WO2020007937A1 (en) * | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
| MX2021001493A (es) | 2018-08-06 | 2021-07-15 | Medikine Inc | Compuestos de fijación al receptor de il-2. |
| US20220025007A1 (en) * | 2018-12-21 | 2022-01-27 | Hanmi Pharm. Co., Ltd. | Novel immunosuppressive interleukin 2 |
| EP3976182A4 (en) | 2019-05-03 | 2023-01-18 | Bioniz, LLC | MODULATION OF THE EFFECTS OF GAMMA CYTOKINE SIGNALING FOR THE TREATMENT OF ALOPECIA AND ALOPECIA-ASSOCIATED DISORDERS |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| CA3147757A1 (en) | 2019-07-26 | 2021-02-04 | Visterra, Inc. | Interleukin-2 agents and uses thereof |
| CN114853874B (zh) * | 2019-09-10 | 2024-05-17 | 中国医学科学院北京协和医院 | 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用 |
| MX2022005404A (es) | 2019-11-05 | 2022-09-09 | Medikine Inc | Compuestos de fijación a il-2r e il-7r dual. |
| KR20220110207A (ko) | 2019-11-05 | 2022-08-05 | 메디카인 인코포레이티드 | IL-2RβγC 결합 화합물 |
| BR112022012112A2 (pt) | 2019-12-20 | 2022-09-06 | Regeneron Pharma | Agonistas de il2 e métodos de uso dos mesmos |
| US11633488B2 (en) | 2020-01-10 | 2023-04-25 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
| CN121319219A (zh) * | 2020-01-14 | 2026-01-13 | 辛德凯因股份有限公司 | Il2突变蛋白 |
| EP4090674A4 (en) | 2020-01-14 | 2024-01-24 | Synthekine, Inc. | Biased il2 muteins methods and compositions |
| JP2023512687A (ja) | 2020-02-03 | 2023-03-28 | メディカイン、インコーポレイテッド | IL-7Rα結合化合物 |
| IL295304A (en) | 2020-02-03 | 2022-10-01 | Medikine Inc | Il-7 receptor alpha gamma c binding compounds, compositions comprising same and uses thereof |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| US12421286B2 (en) | 2020-09-04 | 2025-09-23 | Shandong Simcere Biopharmaceutical Co., Ltd. | Il-2 mutant and application thereof |
| EP4232071A4 (en) | 2020-10-23 | 2024-08-28 | Asher Biotherapeutics, Inc. | FUSIONS WITH CD8 ANTIGEN-BINDING MOLECULES TO MODULATE IMMUNE CELL FUNCTION |
| MX2023005030A (es) | 2020-10-29 | 2023-05-16 | Bristol Myers Squibb Co | Proteinas de fusion para el tratamiento de enfermedades. |
| EP4255466A1 (en) | 2020-12-04 | 2023-10-11 | Visterra, Inc. | Methods of using interleukin-2 agents |
| WO2022192536A1 (en) * | 2021-03-11 | 2022-09-15 | The Methodist Hospital | Methods and compositions for treatment of disease |
| IL304365B2 (en) * | 2021-03-31 | 2025-04-01 | Hanmi Pharmaceutical Co Ltd | A novel conjugate of an IL2 immunostimulatory analog and method of preparation thereof |
| US20240199714A1 (en) * | 2021-04-16 | 2024-06-20 | Orionis Biosciences, Inc. | Il-2 based constructs |
| TW202317623A (zh) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| KR20230095612A (ko) * | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 신규 면역 억제 인터루킨 2 (Interleukin 2) 아날로그 |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| WO2024054868A1 (en) * | 2022-09-07 | 2024-03-14 | Xencor, Inc. | An il-2 fc fusion protein for use in methods for the treatment of plaque psoriasis and atopic dermatitis |
| EP4689123A1 (en) * | 2023-03-29 | 2026-02-11 | WuXi Biologics Ireland Limited | Il-2 variants with improved stability and compositions thereof |
| GB202412853D0 (en) | 2024-09-02 | 2024-10-16 | Ensocell Ltd | Agents and methods directed to disease-associated cells |
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| US4853332A (en) | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
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| US6541610B1 (en) * | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
| US5650150A (en) | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
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| EP1421187B1 (en) | 2001-07-27 | 2007-10-10 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Systems for in vivo site-directed mutagenesis using oligonucleotides |
| US7371371B2 (en) | 2001-08-13 | 2008-05-13 | University Of Southern California | Interleukin-2 mutants with reduced toxicity |
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| ES2866674T3 (es) | 2010-11-12 | 2021-10-19 | Nektar Therapeutics | Conjugados de una fracción de IL-2 y un polímero |
| CN102462837B (zh) | 2010-11-19 | 2016-08-03 | 生物林格斯Ip有限公司 | 抗炎组合物 |
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| CN102174111B (zh) | 2011-01-25 | 2013-01-09 | 江苏省弗泰生物科技有限公司 | 人白介素2-Fc融合蛋白及其用途 |
| HUE029139T2 (hu) * | 2011-02-10 | 2017-02-28 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
| ES2811624T3 (es) | 2011-03-11 | 2021-03-12 | Hopitaux Paris Assist Publique | Régimen de dosificación de IL-2 para tratar lupus eritematoso sistémico |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| US9844582B2 (en) | 2012-05-22 | 2017-12-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| JP2014094898A (ja) | 2012-11-07 | 2014-05-22 | Univ Of Tsukuba | 炎症性腸疾患に関連する、CD300a発現細胞の活性調節剤を含有する医薬品、ならびにCD300a遺伝子欠損マウスおよびCD300a発現細胞の活性調節剤の使用 |
| US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
| EP2970486B1 (en) | 2013-03-15 | 2018-05-16 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
| CN103193887B (zh) | 2013-04-03 | 2015-02-04 | 江苏众红生物工程创药研究院有限公司 | 一种重组猪白细胞介素2-Fc融合蛋白及其编码基因和表达方法 |
| WO2014201378A1 (en) | 2013-06-13 | 2014-12-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il -2 and adoptive cell therapy |
| KR102042246B1 (ko) * | 2014-02-06 | 2019-11-28 | 에프. 호프만-라 로슈 아게 | 인터류킨-2 융합 단백질 및 이의 용도 |
| WO2015164815A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| GB2538666A (en) | 2014-07-21 | 2016-11-23 | Delinia Inc | Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases |
| WO2016025385A1 (en) * | 2014-08-11 | 2016-02-18 | Delinia, Inc. | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| US20170224777A1 (en) | 2014-08-12 | 2017-08-10 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine |
| AU2015328163B2 (en) | 2014-10-09 | 2020-10-15 | Dana-Farber Cancer Institute, Inc. | Multiple-variable IL-2 dose regimen for treating immune disorders |
| US20170204154A1 (en) * | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| KR102687530B1 (ko) * | 2016-05-04 | 2024-07-25 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
-
2017
- 2017-11-08 US US15/806,787 patent/US11077172B2/en not_active Expired - Fee Related
- 2017-11-08 SG SG11201903882VA patent/SG11201903882VA/en unknown
- 2017-11-08 EA EA201991142A patent/EA201991142A1/ru unknown
- 2017-11-08 AU AU2017359172A patent/AU2017359172A1/en not_active Abandoned
- 2017-11-08 MX MX2019005400A patent/MX2019005400A/es unknown
- 2017-11-08 CA CA3041334A patent/CA3041334A1/en active Pending
- 2017-11-08 WO PCT/US2017/060534 patent/WO2018089420A1/en not_active Ceased
- 2017-11-08 EP EP17869254.7A patent/EP3538548A4/en not_active Withdrawn
- 2017-11-08 JP JP2019523626A patent/JP2019532996A/ja active Pending
- 2017-11-08 KR KR1020197016263A patent/KR20190083656A/ko not_active Ceased
- 2017-11-08 CN CN201780068887.XA patent/CN110167957A/zh active Pending
-
2019
- 2019-04-22 IL IL266178A patent/IL266178A/en unknown
- 2019-05-08 CL CL2019001265A patent/CL2019001265A1/es unknown
- 2019-06-06 CO CONC2019/0005922A patent/CO2019005922A2/es unknown
- 2019-06-10 EC ECSENADI201941447A patent/ECSP19041447A/es unknown
-
2021
- 2021-06-22 US US17/353,987 patent/US20210308222A1/en not_active Abandoned
-
2022
- 2022-05-17 JP JP2022080574A patent/JP2022119829A/ja active Pending
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