BR112016028520A2 - métodos e composições para o tratamento de transtornos com polipeptídeos de folistatina - Google Patents
métodos e composições para o tratamento de transtornos com polipeptídeos de folistatinaInfo
- Publication number
- BR112016028520A2 BR112016028520A2 BR112016028520A BR112016028520A BR112016028520A2 BR 112016028520 A2 BR112016028520 A2 BR 112016028520A2 BR 112016028520 A BR112016028520 A BR 112016028520A BR 112016028520 A BR112016028520 A BR 112016028520A BR 112016028520 A2 BR112016028520 A2 BR 112016028520A2
- Authority
- BR
- Brazil
- Prior art keywords
- folistatin
- polypeptides
- compositions
- methods
- treating disorders
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 210000001519 tissue Anatomy 0.000 abstract 2
- 238000006471 dimerization reaction Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4707—Muscular dystrophy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007908P | 2014-06-04 | 2014-06-04 | |
| PCT/US2015/034245 WO2015187977A1 (en) | 2014-06-04 | 2015-06-04 | Methods and compositions for treatment of disorders with follistatin polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016028520A2 true BR112016028520A2 (pt) | 2017-10-24 |
Family
ID=54767384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016028520A BR112016028520A2 (pt) | 2014-06-04 | 2015-06-04 | métodos e composições para o tratamento de transtornos com polipeptídeos de folistatina |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10023621B2 (https=) |
| EP (2) | EP3152237B1 (https=) |
| JP (3) | JP6568110B2 (https=) |
| KR (4) | KR102305109B1 (https=) |
| CN (2) | CN106795224B (https=) |
| AU (2) | AU2015269333B2 (https=) |
| BR (1) | BR112016028520A2 (https=) |
| CA (1) | CA2950754C (https=) |
| EA (2) | EA035455B1 (https=) |
| MA (2) | MA51074A (https=) |
| MX (2) | MX382908B (https=) |
| WO (1) | WO2015187977A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190006086A (ko) | 2005-11-23 | 2019-01-16 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
| AU2009262970A1 (en) | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
| EA201590719A1 (ru) | 2013-01-25 | 2015-12-30 | Шир Хьюман Дженетик Терапис, Инк. | Фоллистатин в лечении мышечной дистрофии дюшенна |
| US10023621B2 (en) | 2014-06-04 | 2018-07-17 | Acceleron Pharma Inc. | Follistatin-related fusion proteins |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| WO2015192111A1 (en) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| AU2016238254B2 (en) * | 2015-03-26 | 2022-05-05 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
| WO2017152090A2 (en) * | 2016-03-04 | 2017-09-08 | Shire Human Genetic Therapies, Inc. | Recombinant follistatin-fc fusion proteins and use in treating duchenne muscular dystrophy |
| US10905766B2 (en) | 2017-03-23 | 2021-02-02 | Oregon State University | Therapeutic compositions and methods for treatment of muscle wasting diseases |
| KR101822633B1 (ko) * | 2017-08-22 | 2018-01-26 | (주)진셀팜 | 폴리스타틴 유래 생리활성 펩타이드, 및 이의 용도 |
| WO2019046903A1 (en) * | 2017-09-08 | 2019-03-14 | Baker Heart and Diabetes Institute | THERAPEUTIC METHOD FOR INCREASING MUSCLE MASS IN A SUBJECT |
| CN108218985B (zh) * | 2017-12-12 | 2021-04-30 | 山西农业大学 | 一种利用特征多肽制备fst蛋白特异性抗体的方法及其应用 |
| CN111936617A (zh) * | 2018-03-16 | 2020-11-13 | 益缪索夫特公司 | 经遗传工程化以分泌卵泡抑素的b细胞以及使用所述b细胞来治疗卵泡抑素相关的疾病、病况、病症及增强肌肉生长和力量的方法 |
| CN111902157B (zh) * | 2018-03-21 | 2023-08-04 | 松阳生技股份有限公司 | 促进局部肌肉增长、减缓或防止局部肌肉萎缩的组合物及其用途 |
| WO2019191204A1 (en) * | 2018-03-28 | 2019-10-03 | Acceleron Pharma Inc. | Follistatin polypeptides for the treatment of muscle contracture |
| WO2019222690A1 (en) * | 2018-05-17 | 2019-11-21 | Hmi, Inc. | Inhibition of follistatin |
| US12246042B2 (en) | 2018-08-29 | 2025-03-11 | Myos Corp. | Methods for alleviating, inhibiting or reversing muscle disuse atrophy in mammals |
| US12508262B2 (en) | 2020-04-30 | 2025-12-30 | Keros Therapeutics, Inc. | Methods of using ALK2 inhibitors |
| WO2022098812A1 (en) | 2020-11-04 | 2022-05-12 | Keros Therapeutics, Inc. | Methods of treating iron overload |
| AU2022214780A1 (en) * | 2021-01-26 | 2023-09-07 | Immunis, Inc. | Molecular superstructure and methods of use thereof |
| AU2023291641A1 (en) | 2022-06-15 | 2024-12-12 | Five Prime Therapeutics, Inc. | Fusion protein for the prevention, treatment or amelioration of kidney diseases |
| IL317593A (en) | 2022-06-15 | 2025-02-01 | UCB Biopharma SRL | Follistatin-FC fusion proteins |
| WO2024121351A1 (en) * | 2022-12-07 | 2024-06-13 | Lodberg Andreas | Extracellular matrix binding compounds for the localized loading of therapeutic or diagnostic agents |
| WO2025157262A1 (en) * | 2024-01-25 | 2025-07-31 | Sichuan Real & Best Biotech Co., Ltd. | Nucleic acids encoding follistatin and uses thereof |
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| EA201590719A1 (ru) * | 2013-01-25 | 2015-12-30 | Шир Хьюман Дженетик Терапис, Инк. | Фоллистатин в лечении мышечной дистрофии дюшенна |
| WO2014187807A1 (en) * | 2013-05-21 | 2014-11-27 | Arcarios B.V. | Follistatin derivatives |
| US10023621B2 (en) * | 2014-06-04 | 2018-07-17 | Acceleron Pharma Inc. | Follistatin-related fusion proteins |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| AU2016238254B2 (en) * | 2015-03-26 | 2022-05-05 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
| JP2020519291A (ja) | 2017-05-12 | 2020-07-02 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 組み換えフォリスタチン−ｆｃ融合タンパク質およびデュシェンヌ型筋ジストロフィーの治療における使用 |
-
2015
- 2015-06-04 US US14/731,009 patent/US10023621B2/en active Active
- 2015-06-04 KR KR1020207018965A patent/KR102305109B1/ko not_active Expired - Fee Related
- 2015-06-04 MA MA051074A patent/MA51074A/fr unknown
- 2015-06-04 MA MA051075A patent/MA51075A/fr unknown
- 2015-06-04 KR KR1020207003791A patent/KR102132144B1/ko not_active Expired - Fee Related
- 2015-06-04 KR KR1020177000297A patent/KR102077286B1/ko not_active Expired - Fee Related
- 2015-06-04 JP JP2016570806A patent/JP6568110B2/ja not_active Expired - Fee Related
- 2015-06-04 BR BR112016028520A patent/BR112016028520A2/pt not_active Application Discontinuation
- 2015-06-04 EP EP15802909.0A patent/EP3152237B1/en active Active
- 2015-06-04 CA CA2950754A patent/CA2950754C/en active Active
- 2015-06-04 EA EA201692529A patent/EA035455B1/ru not_active IP Right Cessation
- 2015-06-04 MX MX2016015868A patent/MX382908B/es unknown
- 2015-06-04 CN CN201580041740.2A patent/CN106795224B/zh not_active Expired - Fee Related
- 2015-06-04 WO PCT/US2015/034245 patent/WO2015187977A1/en not_active Ceased
- 2015-06-04 CN CN202110533308.2A patent/CN113583104A/zh active Pending
- 2015-06-04 EA EA202090632A patent/EA202090632A1/ru unknown
- 2015-06-04 EP EP20160287.7A patent/EP3721892B1/en active Active
- 2015-06-04 AU AU2015269333A patent/AU2015269333B2/en not_active Ceased
- 2015-06-04 KR KR1020217029755A patent/KR20210119546A/ko not_active Ceased
-
2016
- 2016-12-01 MX MX2021006017A patent/MX2021006017A/es unknown
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2018
- 2018-06-12 US US16/006,025 patent/US10954279B2/en active Active
-
2019
- 2019-08-01 JP JP2019142333A patent/JP6856716B2/ja not_active Expired - Fee Related
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2020
- 2020-08-03 AU AU2020210315A patent/AU2020210315A1/en not_active Abandoned
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2021
- 2021-03-18 JP JP2021044545A patent/JP2021095416A/ja active Pending
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