JP2017514846A5 - - Google Patents
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- JP2017514846A5 JP2017514846A5 JP2016565669A JP2016565669A JP2017514846A5 JP 2017514846 A5 JP2017514846 A5 JP 2017514846A5 JP 2016565669 A JP2016565669 A JP 2016565669A JP 2016565669 A JP2016565669 A JP 2016565669A JP 2017514846 A5 JP2017514846 A5 JP 2017514846A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
- molar equivalents
- present
- inorganic base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 68
- 238000000034 method Methods 0.000 claims 64
- 150000007529 inorganic bases Chemical class 0.000 claims 17
- 239000003960 organic solvent Substances 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 11
- YAJYJWXEWKRTPO-UHFFFAOYSA-N 2,3,3,4,4,5-hexamethylhexane-2-thiol Chemical compound CC(C)C(C)(C)C(C)(C)C(C)(C)S YAJYJWXEWKRTPO-UHFFFAOYSA-N 0.000 claims 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 5
- 229910052794 bromium Inorganic materials 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 5
- 239000012649 demethylating agent Substances 0.000 claims 5
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- 150000004703 alkoxides Chemical class 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461988523P | 2014-05-05 | 2014-05-05 | |
| US61/988,523 | 2014-05-05 | ||
| US14/689,712 US9701688B2 (en) | 2014-05-05 | 2015-04-17 | Process for the preparation of opioid compounds |
| US14/689,712 | 2015-04-17 | ||
| PCT/US2015/027912 WO2015171354A2 (en) | 2014-05-05 | 2015-04-28 | Process for the preparation of opioid compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020021254A Division JP2020073598A (ja) | 2014-05-05 | 2020-02-12 | オピオイド化合物を調製するプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514846A JP2017514846A (ja) | 2017-06-08 |
| JP2017514846A5 true JP2017514846A5 (enExample) | 2018-06-14 |
| JP6792745B2 JP6792745B2 (ja) | 2020-12-02 |
Family
ID=54354748
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016565669A Active JP6792745B2 (ja) | 2014-05-05 | 2015-04-28 | オピオイド化合物を調製するプロセス |
| JP2020021254A Pending JP2020073598A (ja) | 2014-05-05 | 2020-02-12 | オピオイド化合物を調製するプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020021254A Pending JP2020073598A (ja) | 2014-05-05 | 2020-02-12 | オピオイド化合物を調製するプロセス |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9701688B2 (enExample) |
| EP (1) | EP3140308B8 (enExample) |
| JP (2) | JP6792745B2 (enExample) |
| CN (1) | CN107001381A (enExample) |
| AU (3) | AU2015256416B2 (enExample) |
| CA (2) | CA3208298A1 (enExample) |
| DK (1) | DK3140308T3 (enExample) |
| ES (1) | ES2946177T3 (enExample) |
| WO (1) | WO2015171354A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201716830D0 (en) | 2017-10-13 | 2017-11-29 | Cambrex Charles City Inc | New Process |
| WO2023102489A1 (en) * | 2021-12-03 | 2023-06-08 | Board Of Regents Of The University Of Nebraska | Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3474101A (en) | 1960-09-05 | 1969-10-21 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| US20080125592A1 (en) | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| BRPI0719305A2 (pt) * | 2006-11-22 | 2014-02-04 | Progenics Pharm Inc | (r)-n-estereoisômeros de análogos de 7,8-saturados-4,5-epóxi-morfinano |
| AU2008207580B2 (en) | 2007-05-04 | 2011-04-14 | SpecGx LLC | Improved process for the preparation of 6-alpha-hydroxy-N-alkylated opiates |
| US8962841B2 (en) | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| WO2009066735A1 (ja) | 2007-11-20 | 2009-05-28 | Nissan Chemical Industries, Ltd. | ２－アザアダマンタン類の製造方法 |
| CN102046631A (zh) * | 2008-03-31 | 2011-05-04 | 阳光医药工业有限公司 | 制备吗啡烷类似物的改良方法 |
| WO2010017573A1 (en) | 2008-08-11 | 2010-02-18 | Tasmanian Alkaloids Pty Limited | PROCESS FOR MAKING MORPHINAN-6α-OLS |
| PL2344506T3 (pl) | 2008-09-30 | 2016-08-31 | SpecGx LLC | Sposoby alkilowania grup aminy drugorzędowej pochodnych morfinanowych |
| CA2738758C (en) | 2008-09-30 | 2016-11-29 | Mallinckrodt Inc. | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
| US8232398B2 (en) | 2008-09-30 | 2012-07-31 | Mallinckrodt Llc | Recycling process for increasing the yield of opiate alkaloid derivatives |
| PL2342206T3 (pl) | 2008-09-30 | 2015-04-30 | SpecGx LLC | Sposoby uwodorniania pochodnych alkaloidów opiatowych |
| EP2344507B2 (en) | 2008-09-30 | 2021-05-26 | Mallinckrodt LLC | Processes for increasing the yield of the hydrolysis of the 3-o-methyl and 17-n-nitrile group in the preparation of opiate alkaloid derivatives |
| JP5778042B2 (ja) | 2009-02-17 | 2015-09-16 | マリンクロッド エルエルシー | ノルモルフィナンの還元的アルキル化のためのプロセス |
| US8853401B2 (en) | 2009-04-24 | 2014-10-07 | Brock University | Processes for the preparation of morphinane and morphinone compounds |
| US20110269964A1 (en) * | 2010-04-29 | 2011-11-03 | Mallinckrodt Inc. | N-Alkylation of Opiates |
| JP2013529595A (ja) * | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| CA2815093C (en) * | 2010-11-05 | 2019-08-06 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| EP2705043B1 (en) | 2011-05-02 | 2016-11-30 | Brock University | Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents |
| ES2805655T3 (es) | 2011-10-03 | 2021-02-15 | Johnson Matthey Plc | Proceso para preparar intermedios de buprenorfina |
| WO2013113120A1 (en) | 2012-02-03 | 2013-08-08 | Tomas Hudlicky | Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans |
| AR090916A1 (es) * | 2012-05-03 | 2014-12-17 | Lundbeck & Co As H | Metodo para la fabricacion de naltrexona |
-
2015
- 2015-04-17 US US14/689,712 patent/US9701688B2/en active Active
- 2015-04-28 AU AU2015256416A patent/AU2015256416B2/en active Active
- 2015-04-28 JP JP2016565669A patent/JP6792745B2/ja active Active
- 2015-04-28 WO PCT/US2015/027912 patent/WO2015171354A2/en not_active Ceased
- 2015-04-28 EP EP15726407.8A patent/EP3140308B8/en active Active
- 2015-04-28 CA CA3208298A patent/CA3208298A1/en active Pending
- 2015-04-28 CA CA2947012A patent/CA2947012C/en active Active
- 2015-04-28 DK DK15726407.8T patent/DK3140308T3/da active
- 2015-04-28 ES ES15726407T patent/ES2946177T3/es active Active
- 2015-04-28 CN CN201580035299.7A patent/CN107001381A/zh active Pending
-
2018
- 2018-06-05 AU AU2018203948A patent/AU2018203948B2/en active Active
-
2020
- 2020-02-12 JP JP2020021254A patent/JP2020073598A/ja active Pending
- 2020-03-19 AU AU2020201990A patent/AU2020201990A1/en not_active Abandoned
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