DK3140308T3 - Fremgangsmåde til fremstillingen af opioidforbindelser - Google Patents
Fremgangsmåde til fremstillingen af opioidforbindelser Download PDFInfo
- Publication number
- DK3140308T3 DK3140308T3 DK15726407.8T DK15726407T DK3140308T3 DK 3140308 T3 DK3140308 T3 DK 3140308T3 DK 15726407 T DK15726407 T DK 15726407T DK 3140308 T3 DK3140308 T3 DK 3140308T3
- Authority
- DK
- Denmark
- Prior art keywords
- production
- opioid compounds
- opioid
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461988523P | 2014-05-05 | 2014-05-05 | |
| US14/689,712 US9701688B2 (en) | 2014-05-05 | 2015-04-17 | Process for the preparation of opioid compounds |
| PCT/US2015/027912 WO2015171354A2 (en) | 2014-05-05 | 2015-04-28 | Process for the preparation of opioid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3140308T3 true DK3140308T3 (da) | 2023-06-19 |
Family
ID=54354748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15726407.8T DK3140308T3 (da) | 2014-05-05 | 2015-04-28 | Fremgangsmåde til fremstillingen af opioidforbindelser |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9701688B2 (enExample) |
| EP (1) | EP3140308B8 (enExample) |
| JP (2) | JP6792745B2 (enExample) |
| CN (1) | CN107001381A (enExample) |
| AU (3) | AU2015256416B2 (enExample) |
| CA (2) | CA2947012C (enExample) |
| DK (1) | DK3140308T3 (enExample) |
| ES (1) | ES2946177T3 (enExample) |
| WO (1) | WO2015171354A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201716830D0 (en) * | 2017-10-13 | 2017-11-29 | Cambrex Charles City Inc | New Process |
| WO2023102489A1 (en) * | 2021-12-03 | 2023-06-08 | Board Of Regents Of The University Of Nebraska | Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3474101A (en) | 1960-09-05 | 1969-10-21 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| US20080125592A1 (en) | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
| WO2008064351A2 (en) | 2006-11-22 | 2008-05-29 | Progenics Pharmaceuticals, Inc. | (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs |
| MX2008013842A (es) * | 2007-05-04 | 2009-03-06 | Mallinckrodt Inc | Proceso mejorado para la preparacion de opiatos 6-alfa-hidroxi-n-alquilados. |
| US8962841B2 (en) | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| EP2221306B1 (en) | 2007-11-20 | 2016-04-13 | Nissan Chemical Industries, Ltd. | Method for producing 2-azaadamantane |
| KR20110014974A (ko) * | 2008-03-31 | 2011-02-14 | 썬 파마슈티컬 인더스트리스 리미티드 | 모르피난 유사체의 개선된 제조 방법 |
| EP2328900B1 (en) | 2008-08-11 | 2013-08-28 | Tasmanian Alkaloids Pty. Ltd. | PROCESS FOR MAKING MORPHINAN-6 alpha-OLS |
| PL2344507T5 (pl) | 2008-09-30 | 2021-10-11 | SpecGx LLC | Sposoby zwiększania wydajności hydrolizy grupy 3-O-metylowej i 17-N-nitrylowej w wytwarzaniu pochodnych alkaloidów opiatowych |
| AU2009300379B2 (en) | 2008-09-30 | 2015-04-02 | SpecGx LLC | Processes for the alkylation of secondary amine groups of morphinan derivatives |
| ES2529057T3 (es) | 2008-09-30 | 2015-02-16 | Mallinckrodt Inc. | Procedimientos para la hidrogenación de derivados de alcaloides opiáceos |
| US8293906B2 (en) | 2008-09-30 | 2012-10-23 | Mallinckrodt Llc | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
| ES2477190T3 (es) | 2008-09-30 | 2014-07-16 | Mallinckrodt Llc | Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos |
| WO2010096416A1 (en) | 2009-02-17 | 2010-08-26 | Mallinckrodt Inc. | Process for the reductive alkylation of normorphinans |
| US8853401B2 (en) | 2009-04-24 | 2014-10-07 | Brock University | Processes for the preparation of morphinane and morphinone compounds |
| US20110269964A1 (en) * | 2010-04-29 | 2011-11-03 | Mallinckrodt Inc. | N-Alkylation of Opiates |
| TWI471289B (zh) * | 2010-06-11 | 2015-02-01 | Rhodes Technologies | 使三級胺進行ｎ－脫烷反應之方法 |
| SMT201700177T1 (it) * | 2010-11-05 | 2017-05-08 | H Lundbeck As | Procedimento per la fabbricazione di naltrexone |
| EP3042908A1 (en) | 2011-05-02 | 2016-07-13 | Brock University | Intermediates in the preparation of morphine analogs |
| EP2763996B1 (en) | 2011-10-03 | 2018-07-25 | Johnson Matthey PLC | Process for preparing buprenorphine |
| JP2015506952A (ja) | 2012-02-03 | 2015-03-05 | ブロック ユニバーシティ | モルフィナンから誘導されたオキサゾリジンと有機金属試薬との反応によるモルフィンアナログの製造方法 |
| WO2013164383A1 (en) * | 2012-05-03 | 2013-11-07 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
-
2015
- 2015-04-17 US US14/689,712 patent/US9701688B2/en active Active
- 2015-04-28 EP EP15726407.8A patent/EP3140308B8/en active Active
- 2015-04-28 CN CN201580035299.7A patent/CN107001381A/zh active Pending
- 2015-04-28 ES ES15726407T patent/ES2946177T3/es active Active
- 2015-04-28 JP JP2016565669A patent/JP6792745B2/ja active Active
- 2015-04-28 AU AU2015256416A patent/AU2015256416B2/en active Active
- 2015-04-28 DK DK15726407.8T patent/DK3140308T3/da active
- 2015-04-28 CA CA2947012A patent/CA2947012C/en active Active
- 2015-04-28 WO PCT/US2015/027912 patent/WO2015171354A2/en not_active Ceased
- 2015-04-28 CA CA3208298A patent/CA3208298A1/en active Pending
-
2018
- 2018-06-05 AU AU2018203948A patent/AU2018203948B2/en active Active
-
2020
- 2020-02-12 JP JP2020021254A patent/JP2020073598A/ja active Pending
- 2020-03-19 AU AU2020201990A patent/AU2020201990A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020073598A (ja) | 2020-05-14 |
| AU2015256416B2 (en) | 2018-03-08 |
| WO2015171354A2 (en) | 2015-11-12 |
| EP3140308B8 (en) | 2023-06-28 |
| CA3208298A1 (en) | 2015-11-12 |
| JP2017514846A (ja) | 2017-06-08 |
| AU2020201990A1 (en) | 2020-04-09 |
| WO2015171354A3 (en) | 2016-03-17 |
| JP6792745B2 (ja) | 2020-12-02 |
| CN107001381A (zh) | 2017-08-01 |
| EP3140308A2 (en) | 2017-03-15 |
| US9701688B2 (en) | 2017-07-11 |
| EP3140308B1 (en) | 2023-05-24 |
| US20150315205A1 (en) | 2015-11-05 |
| CA2947012A1 (en) | 2015-11-12 |
| AU2018203948B2 (en) | 2019-12-19 |
| ES2946177T3 (es) | 2023-07-13 |
| AU2015256416A1 (en) | 2016-11-24 |
| AU2018203948A1 (en) | 2018-06-21 |
| CA2947012C (en) | 2023-09-26 |
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