DK3140308T3 - Fremgangsmåde til fremstillingen af opioidforbindelser - Google Patents
Fremgangsmåde til fremstillingen af opioidforbindelser Download PDFInfo
- Publication number
- DK3140308T3 DK3140308T3 DK15726407.8T DK15726407T DK3140308T3 DK 3140308 T3 DK3140308 T3 DK 3140308T3 DK 15726407 T DK15726407 T DK 15726407T DK 3140308 T3 DK3140308 T3 DK 3140308T3
- Authority
- DK
- Denmark
- Prior art keywords
- production
- opioid compounds
- opioid
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461988523P | 2014-05-05 | 2014-05-05 | |
| US14/689,712 US9701688B2 (en) | 2014-05-05 | 2015-04-17 | Process for the preparation of opioid compounds |
| PCT/US2015/027912 WO2015171354A2 (en) | 2014-05-05 | 2015-04-28 | Process for the preparation of opioid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3140308T3 true DK3140308T3 (da) | 2023-06-19 |
Family
ID=54354748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15726407.8T DK3140308T3 (da) | 2014-05-05 | 2015-04-28 | Fremgangsmåde til fremstillingen af opioidforbindelser |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9701688B2 (enExample) |
| EP (1) | EP3140308B8 (enExample) |
| JP (2) | JP6792745B2 (enExample) |
| CN (1) | CN107001381A (enExample) |
| AU (3) | AU2015256416B2 (enExample) |
| CA (2) | CA3208298A1 (enExample) |
| DK (1) | DK3140308T3 (enExample) |
| ES (1) | ES2946177T3 (enExample) |
| WO (1) | WO2015171354A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201716830D0 (en) * | 2017-10-13 | 2017-11-29 | Cambrex Charles City Inc | New Process |
| WO2023102489A1 (en) * | 2021-12-03 | 2023-06-08 | Board Of Regents Of The University Of Nebraska | Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3474101A (en) | 1960-09-05 | 1969-10-21 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| US20080125592A1 (en) | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| CA2670382A1 (en) * | 2006-11-22 | 2008-05-29 | Progenics Pharmaceuticals, Inc. | (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs |
| MX2008013842A (es) * | 2007-05-04 | 2009-03-06 | Mallinckrodt Inc | Proceso mejorado para la preparacion de opiatos 6-alfa-hidroxi-n-alquilados. |
| US8962841B2 (en) | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| WO2009066735A1 (ja) | 2007-11-20 | 2009-05-28 | Nissan Chemical Industries, Ltd. | ２－アザアダマンタン類の製造方法 |
| CA2720034A1 (en) * | 2008-03-31 | 2009-10-08 | Sun Pharmaceutical Industries Ltd. | An improved process for the preparation of morphinane analogues |
| WO2010017573A1 (en) | 2008-08-11 | 2010-02-18 | Tasmanian Alkaloids Pty Limited | PROCESS FOR MAKING MORPHINAN-6α-OLS |
| AU2009300379B2 (en) | 2008-09-30 | 2015-04-02 | SpecGx LLC | Processes for the alkylation of secondary amine groups of morphinan derivatives |
| US8273887B2 (en) | 2008-09-30 | 2012-09-25 | Mallinckrodt Llc | Processes for synthesis of opiate alkaloid derivatives |
| EP2342207B1 (en) | 2008-09-30 | 2015-11-11 | Mallinckrodt LLC | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
| PL2344507T5 (pl) | 2008-09-30 | 2021-10-11 | SpecGx LLC | Sposoby zwiększania wydajności hydrolizy grupy 3-O-metylowej i 17-N-nitrylowej w wytwarzaniu pochodnych alkaloidów opiatowych |
| WO2010039221A1 (en) | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Recycling process for increasing the yield of a grignard reaction in the preparation of opiate alkaloid derivatives |
| PL2398808T3 (pl) | 2009-02-17 | 2014-04-30 | Mallinckrodt Llc | Sposób redukcyjnego alkilowania normorfinanów |
| AU2010239059B2 (en) | 2009-04-24 | 2016-06-09 | Brock University | Processes for the preparation of morphinane and morphinone compounds |
| US20110269964A1 (en) * | 2010-04-29 | 2011-11-03 | Mallinckrodt Inc. | N-Alkylation of Opiates |
| EP2580218B1 (en) * | 2010-06-11 | 2015-02-25 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
| CA2815093C (en) * | 2010-11-05 | 2019-08-06 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
| JP6046119B2 (ja) | 2011-05-02 | 2016-12-14 | ブロック ユニバーシティ | 脱水環化試薬を使用するｎ−オキシドのｎ−脱メチル化によるモルヒネ類似体の調製における方法および中間体 |
| HUE048899T2 (hu) | 2011-10-03 | 2020-08-28 | Johnson Matthey Plc | Eljárás buprenorfin intermedierek elõállítására |
| CA2863242A1 (en) | 2012-02-03 | 2013-08-08 | Tomas Hudlicky | Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans |
| WO2013164383A1 (en) * | 2012-05-03 | 2013-11-07 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
-
2015
- 2015-04-17 US US14/689,712 patent/US9701688B2/en active Active
- 2015-04-28 ES ES15726407T patent/ES2946177T3/es active Active
- 2015-04-28 CA CA3208298A patent/CA3208298A1/en active Pending
- 2015-04-28 CN CN201580035299.7A patent/CN107001381A/zh active Pending
- 2015-04-28 JP JP2016565669A patent/JP6792745B2/ja active Active
- 2015-04-28 DK DK15726407.8T patent/DK3140308T3/da active
- 2015-04-28 WO PCT/US2015/027912 patent/WO2015171354A2/en not_active Ceased
- 2015-04-28 EP EP15726407.8A patent/EP3140308B8/en active Active
- 2015-04-28 CA CA2947012A patent/CA2947012C/en active Active
- 2015-04-28 AU AU2015256416A patent/AU2015256416B2/en active Active
-
2018
- 2018-06-05 AU AU2018203948A patent/AU2018203948B2/en active Active
-
2020
- 2020-02-12 JP JP2020021254A patent/JP2020073598A/ja active Pending
- 2020-03-19 AU AU2020201990A patent/AU2020201990A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3140308B8 (en) | 2023-06-28 |
| WO2015171354A3 (en) | 2016-03-17 |
| AU2015256416A1 (en) | 2016-11-24 |
| JP2017514846A (ja) | 2017-06-08 |
| JP2020073598A (ja) | 2020-05-14 |
| CA2947012C (en) | 2023-09-26 |
| CA2947012A1 (en) | 2015-11-12 |
| ES2946177T3 (es) | 2023-07-13 |
| AU2020201990A1 (en) | 2020-04-09 |
| CN107001381A (zh) | 2017-08-01 |
| AU2018203948B2 (en) | 2019-12-19 |
| AU2018203948A1 (en) | 2018-06-21 |
| EP3140308B1 (en) | 2023-05-24 |
| AU2015256416B2 (en) | 2018-03-08 |
| WO2015171354A2 (en) | 2015-11-12 |
| JP6792745B2 (ja) | 2020-12-02 |
| EP3140308A2 (en) | 2017-03-15 |
| US20150315205A1 (en) | 2015-11-05 |
| CA3208298A1 (en) | 2015-11-12 |
| US9701688B2 (en) | 2017-07-11 |
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