CA2947012C - Process for the preparation of opioid compounds - Google Patents

Process for the preparation of opioid compounds Download PDF

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Publication number
CA2947012C
CA2947012C CA2947012A CA2947012A CA2947012C CA 2947012 C CA2947012 C CA 2947012C CA 2947012 A CA2947012 A CA 2947012A CA 2947012 A CA2947012 A CA 2947012A CA 2947012 C CA2947012 C CA 2947012C
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CA
Canada
Prior art keywords
formula
compound
range
amount
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2947012A
Other languages
English (en)
French (fr)
Other versions
CA2947012A1 (en
Inventor
Matteo CONZA
Vit Lellek
Hartmut Zinser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noramco LLC
Original Assignee
Noramco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noramco LLC filed Critical Noramco LLC
Priority to CA3208298A priority Critical patent/CA3208298C/en
Publication of CA2947012A1 publication Critical patent/CA2947012A1/en
Application granted granted Critical
Publication of CA2947012C publication Critical patent/CA2947012C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA2947012A 2014-05-05 2015-04-28 Process for the preparation of opioid compounds Active CA2947012C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3208298A CA3208298C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988523P 2014-05-05 2014-05-05
US61/988,523 2014-05-05
US14/689,712 US9701688B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
US14/689,712 2015-04-17
PCT/US2015/027912 WO2015171354A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3208298A Division CA3208298C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (2)

Publication Number Publication Date
CA2947012A1 CA2947012A1 (en) 2015-11-12
CA2947012C true CA2947012C (en) 2023-09-26

Family

ID=54354748

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2947012A Active CA2947012C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds
CA3208298A Active CA3208298C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3208298A Active CA3208298C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Country Status (9)

Country Link
US (1) US9701688B2 (enExample)
EP (1) EP3140308B8 (enExample)
JP (2) JP6792745B2 (enExample)
CN (1) CN107001381A (enExample)
AU (3) AU2015256416B2 (enExample)
CA (2) CA2947012C (enExample)
DK (1) DK3140308T3 (enExample)
ES (1) ES2946177T3 (enExample)
WO (1) WO2015171354A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201716830D0 (en) 2017-10-13 2017-11-29 Cambrex Charles City Inc New Process
WO2023102489A1 (en) * 2021-12-03 2023-06-08 Board Of Regents Of The University Of Nebraska Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
JP2010510329A (ja) 2006-11-22 2010-04-02 プロジェニックス ファーマスーティカルス インコーポレーテッド ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体
ATE493416T1 (de) 2007-05-04 2011-01-15 Mallinckrodt Inc Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
CN101861315B (zh) 2007-11-20 2013-01-16 日产化学工业株式会社 2-氮杂金刚烷类的制造方法
JP2011516464A (ja) * 2008-03-31 2011-05-26 サン・ファーマシューティカル・インダストリーズ・リミテッド モルフィナン類似体の改良された調製方法
EP2328900B1 (en) 2008-08-11 2013-08-28 Tasmanian Alkaloids Pty. Ltd. PROCESS FOR MAKING MORPHINAN-6 alpha-OLS
ES2477190T3 (es) 2008-09-30 2014-07-16 Mallinckrodt Llc Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos
US8293906B2 (en) 2008-09-30 2012-10-23 Mallinckrodt Llc Processes for the alkylation of norbuprenorphine with reduced impurity formation
CN102227433B (zh) 2008-09-30 2015-01-07 马林克罗特有限公司 烷基化吗啡喃衍生物的仲胺基团的方法
ES2529057T3 (es) 2008-09-30 2015-02-16 Mallinckrodt Inc. Procedimientos para la hidrogenación de derivados de alcaloides opiáceos
WO2010039214A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for increasing the yield of the hydrolysis of the 3-0-methyl and 17-n-nitrile group in the preparation of opiate alkaloid derivatives
JP5778042B2 (ja) 2009-02-17 2015-09-16 マリンクロッド エルエルシー ノルモルフィナンの還元的アルキル化のためのプロセス
AU2010239059B2 (en) 2009-04-24 2016-06-09 Brock University Processes for the preparation of morphinane and morphinone compounds
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
TWI471289B (zh) * 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
AU2011325563B2 (en) * 2010-11-05 2015-08-20 H. Lundbeck A/S Method for the manufacturing of naltrexone
EP2705043B1 (en) * 2011-05-02 2016-11-30 Brock University Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents
WO2013050748A2 (en) 2011-10-03 2013-04-11 Johnson Matthey Plc An improved method of preparing buprenorphine
WO2013113120A1 (en) 2012-02-03 2013-08-08 Tomas Hudlicky Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
US20140155608A1 (en) * 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone

Also Published As

Publication number Publication date
JP6792745B2 (ja) 2020-12-02
US9701688B2 (en) 2017-07-11
AU2018203948A1 (en) 2018-06-21
CN107001381A (zh) 2017-08-01
WO2015171354A3 (en) 2016-03-17
JP2020073598A (ja) 2020-05-14
EP3140308B8 (en) 2023-06-28
CA2947012A1 (en) 2015-11-12
AU2015256416B2 (en) 2018-03-08
AU2018203948B2 (en) 2019-12-19
EP3140308B1 (en) 2023-05-24
WO2015171354A2 (en) 2015-11-12
AU2020201990A1 (en) 2020-04-09
ES2946177T3 (es) 2023-07-13
DK3140308T3 (da) 2023-06-19
AU2015256416A1 (en) 2016-11-24
US20150315205A1 (en) 2015-11-05
JP2017514846A (ja) 2017-06-08
EP3140308A2 (en) 2017-03-15
CA3208298C (en) 2026-06-09
CA3208298A1 (en) 2015-11-12

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