CN107001381A - 制备阿片类化合物的方法 - Google Patents
制备阿片类化合物的方法 Download PDFInfo
- Publication number
- CN107001381A CN107001381A CN201580035299.7A CN201580035299A CN107001381A CN 107001381 A CN107001381 A CN 107001381A CN 201580035299 A CN201580035299 A CN 201580035299A CN 107001381 A CN107001381 A CN 107001381A
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- amount
- molar equivalents
- inorganic base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC*(C)(C)*(C)C(*C)C(*)CNC Chemical compound CC*(C)(C)*(C)C(*C)C(*)CNC 0.000 description 5
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461988523P | 2014-05-05 | 2014-05-05 | |
| US61/988523 | 2014-05-05 | ||
| US14/689712 | 2015-04-17 | ||
| US14/689,712 US9701688B2 (en) | 2014-05-05 | 2015-04-17 | Process for the preparation of opioid compounds |
| PCT/US2015/027912 WO2015171354A2 (en) | 2014-05-05 | 2015-04-28 | Process for the preparation of opioid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107001381A true CN107001381A (zh) | 2017-08-01 |
Family
ID=54354748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580035299.7A Pending CN107001381A (zh) | 2014-05-05 | 2015-04-28 | 制备阿片类化合物的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9701688B2 (enExample) |
| EP (1) | EP3140308B8 (enExample) |
| JP (2) | JP6792745B2 (enExample) |
| CN (1) | CN107001381A (enExample) |
| AU (3) | AU2015256416B2 (enExample) |
| CA (2) | CA3208298A1 (enExample) |
| DK (1) | DK3140308T3 (enExample) |
| ES (1) | ES2946177T3 (enExample) |
| WO (1) | WO2015171354A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201716830D0 (en) * | 2017-10-13 | 2017-11-29 | Cambrex Charles City Inc | New Process |
| WO2023102489A1 (en) * | 2021-12-03 | 2023-06-08 | Board Of Regents Of The University Of Nebraska | Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3474101A (en) | 1960-09-05 | 1969-10-21 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| US20080125592A1 (en) | 2006-10-17 | 2008-05-29 | Penick Corporation | Process for preparing oxymorphone, naltrexone, and buprenorphine |
| CA2674915C (en) | 2006-10-17 | 2015-06-30 | Penick Corporation | Process for preparing oxymorphone |
| JP2010510328A (ja) * | 2006-11-22 | 2010-04-02 | プロジェニックス ファーマスーティカルス インコーポレーテッド | ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体の（ｒ）−ｎ−立体異性体 |
| ATE493416T1 (de) | 2007-05-04 | 2011-01-15 | Mallinckrodt Inc | Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten |
| US8962841B2 (en) | 2007-06-29 | 2015-02-24 | Brock University | Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids |
| EP2221306B1 (en) | 2007-11-20 | 2016-04-13 | Nissan Chemical Industries, Ltd. | Method for producing 2-azaadamantane |
| AU2009233315B2 (en) * | 2008-03-31 | 2013-08-29 | Sun Pharmaceutical Industries Ltd. | An improved process for the preparation of morphinane analogues |
| WO2010017573A1 (en) | 2008-08-11 | 2010-02-18 | Tasmanian Alkaloids Pty Limited | PROCESS FOR MAKING MORPHINAN-6α-OLS |
| WO2010039214A1 (en) | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Processes for increasing the yield of the hydrolysis of the 3-0-methyl and 17-n-nitrile group in the preparation of opiate alkaloid derivatives |
| ES2566559T3 (es) | 2008-09-30 | 2016-04-13 | Mallinckrodt Llc | Procesos para la alquilación de grupos amino secundarios de derivados de morfinano |
| US8293906B2 (en) | 2008-09-30 | 2012-10-23 | Mallinckrodt Llc | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
| US8273887B2 (en) | 2008-09-30 | 2012-09-25 | Mallinckrodt Llc | Processes for synthesis of opiate alkaloid derivatives |
| PL2342208T3 (pl) | 2008-09-30 | 2014-11-28 | SpecGx LLC | Proces zawracania do ponownego wykorzystania w celu zwiększania wydajności reakcji grignarda w wytwarzaniu pochodnych alkaloidów opiatowych |
| US8431701B2 (en) | 2009-02-17 | 2013-04-30 | Mallinckrodt Llc | Process for the reductive alkylation of normorphinans |
| JP5824448B2 (ja) | 2009-04-24 | 2015-11-25 | ブロック ユニバーシティ | モルフィナンおよびモルフィノン化合物の調製法 |
| US20110269964A1 (en) * | 2010-04-29 | 2011-11-03 | Mallinckrodt Inc. | N-Alkylation of Opiates |
| TWI471289B (zh) * | 2010-06-11 | 2015-02-01 | Rhodes Technologies | 使三級胺進行ｎ－脫烷反應之方法 |
| DK2635586T3 (en) * | 2010-11-05 | 2017-03-27 | H Lundbeck As | PROCEDURE FOR THE PREPARATION OF NALTREXON |
| CN103596962B (zh) | 2011-05-02 | 2017-02-15 | 布鲁克大学 | 通过使用环化脱水试剂的n‑氧化物的n‑脱甲基化制备吗啡类似物的方法和中间体 |
| HUE040284T2 (hu) | 2011-10-03 | 2019-02-28 | Johnson Matthey Plc | Eljárás buprenorfin elõállítására |
| EP2809674A4 (en) | 2012-02-03 | 2015-09-02 | Univ Brock | METHOD FOR THE PRODUCTION OF MORPHINE ANALOGUE BY REACTION OF ORGANOMETALLIC REAGENTS WITH AN OXAZOLIDINE DERIVED FROM MORPHINANESE |
| WO2013164383A1 (en) * | 2012-05-03 | 2013-11-07 | H. Lundbeck A/S | Method for the manufacturing of naltrexone |
-
2015
- 2015-04-17 US US14/689,712 patent/US9701688B2/en active Active
- 2015-04-28 CA CA3208298A patent/CA3208298A1/en active Pending
- 2015-04-28 AU AU2015256416A patent/AU2015256416B2/en active Active
- 2015-04-28 CN CN201580035299.7A patent/CN107001381A/zh active Pending
- 2015-04-28 CA CA2947012A patent/CA2947012C/en active Active
- 2015-04-28 ES ES15726407T patent/ES2946177T3/es active Active
- 2015-04-28 DK DK15726407.8T patent/DK3140308T3/da active
- 2015-04-28 EP EP15726407.8A patent/EP3140308B8/en active Active
- 2015-04-28 JP JP2016565669A patent/JP6792745B2/ja active Active
- 2015-04-28 WO PCT/US2015/027912 patent/WO2015171354A2/en not_active Ceased
-
2018
- 2018-06-05 AU AU2018203948A patent/AU2018203948B2/en active Active
-
2020
- 2020-02-12 JP JP2020021254A patent/JP2020073598A/ja active Pending
- 2020-03-19 AU AU2020201990A patent/AU2020201990A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015171354A3 (en) | 2016-03-17 |
| AU2015256416A1 (en) | 2016-11-24 |
| AU2015256416B2 (en) | 2018-03-08 |
| EP3140308B1 (en) | 2023-05-24 |
| AU2020201990A1 (en) | 2020-04-09 |
| AU2018203948B2 (en) | 2019-12-19 |
| EP3140308B8 (en) | 2023-06-28 |
| CA3208298A1 (en) | 2015-11-12 |
| EP3140308A2 (en) | 2017-03-15 |
| CA2947012C (en) | 2023-09-26 |
| DK3140308T3 (da) | 2023-06-19 |
| US20150315205A1 (en) | 2015-11-05 |
| JP6792745B2 (ja) | 2020-12-02 |
| AU2018203948A1 (en) | 2018-06-21 |
| CA2947012A1 (en) | 2015-11-12 |
| US9701688B2 (en) | 2017-07-11 |
| JP2020073598A (ja) | 2020-05-14 |
| JP2017514846A (ja) | 2017-06-08 |
| WO2015171354A2 (en) | 2015-11-12 |
| ES2946177T3 (es) | 2023-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170801 |