JP6792745B2 - オピオイド化合物を調製するプロセス - Google Patents

オピオイド化合物を調製するプロセス Download PDF

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JP6792745B2
JP6792745B2 JP2016565669A JP2016565669A JP6792745B2 JP 6792745 B2 JP6792745 B2 JP 6792745B2 JP 2016565669 A JP2016565669 A JP 2016565669A JP 2016565669 A JP2016565669 A JP 2016565669A JP 6792745 B2 JP6792745 B2 JP 6792745B2
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formula
compound
hpo
range
amount
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Japanese (ja)
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JP2017514846A5 (enExample
JP2017514846A (ja
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コンツァ・マッテオ
レレク・ビット
ツィンザー・ハルトムート
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Noramco LLC
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Noramco LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2016565669A 2014-05-05 2015-04-28 オピオイド化合物を調製するプロセス Active JP6792745B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988523P 2014-05-05 2014-05-05
US61/988,523 2014-05-05
US14/689,712 US9701688B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
US14/689,712 2015-04-17
PCT/US2015/027912 WO2015171354A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020021254A Division JP2020073598A (ja) 2014-05-05 2020-02-12 オピオイド化合物を調製するプロセス

Publications (3)

Publication Number Publication Date
JP2017514846A JP2017514846A (ja) 2017-06-08
JP2017514846A5 JP2017514846A5 (enExample) 2018-06-14
JP6792745B2 true JP6792745B2 (ja) 2020-12-02

Family

ID=54354748

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016565669A Active JP6792745B2 (ja) 2014-05-05 2015-04-28 オピオイド化合物を調製するプロセス
JP2020021254A Pending JP2020073598A (ja) 2014-05-05 2020-02-12 オピオイド化合物を調製するプロセス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020021254A Pending JP2020073598A (ja) 2014-05-05 2020-02-12 オピオイド化合物を調製するプロセス

Country Status (9)

Country Link
US (1) US9701688B2 (enExample)
EP (1) EP3140308B8 (enExample)
JP (2) JP6792745B2 (enExample)
CN (1) CN107001381A (enExample)
AU (3) AU2015256416B2 (enExample)
CA (2) CA3208298A1 (enExample)
DK (1) DK3140308T3 (enExample)
ES (1) ES2946177T3 (enExample)
WO (1) WO2015171354A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201716830D0 (en) 2017-10-13 2017-11-29 Cambrex Charles City Inc New Process
WO2023102489A1 (en) * 2021-12-03 2023-06-08 Board Of Regents Of The University Of Nebraska Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
BRPI0719305A2 (pt) * 2006-11-22 2014-02-04 Progenics Pharm Inc (r)-n-estereoisômeros de análogos de 7,8-saturados-4,5-epóxi-morfinano
AU2008207580B2 (en) 2007-05-04 2011-04-14 SpecGx LLC Improved process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
WO2009066735A1 (ja) 2007-11-20 2009-05-28 Nissan Chemical Industries, Ltd. ２－アザアダマンタン類の製造方法
CN102046631A (zh) * 2008-03-31 2011-05-04 阳光医药工业有限公司 制备吗啡烷类似物的改良方法
WO2010017573A1 (en) 2008-08-11 2010-02-18 Tasmanian Alkaloids Pty Limited PROCESS FOR MAKING MORPHINAN-6α-OLS
PL2344506T3 (pl) 2008-09-30 2016-08-31 SpecGx LLC Sposoby alkilowania grup aminy drugorzędowej pochodnych morfinanowych
CA2738758C (en) 2008-09-30 2016-11-29 Mallinckrodt Inc. Processes for the alkylation of norbuprenorphine with reduced impurity formation
US8232398B2 (en) 2008-09-30 2012-07-31 Mallinckrodt Llc Recycling process for increasing the yield of opiate alkaloid derivatives
PL2342206T3 (pl) 2008-09-30 2015-04-30 SpecGx LLC Sposoby uwodorniania pochodnych alkaloidów opiatowych
EP2344507B2 (en) 2008-09-30 2021-05-26 Mallinckrodt LLC Processes for increasing the yield of the hydrolysis of the 3-o-methyl and 17-n-nitrile group in the preparation of opiate alkaloid derivatives
JP5778042B2 (ja) 2009-02-17 2015-09-16 マリンクロッド エルエルシー ノルモルフィナンの還元的アルキル化のためのプロセス
US8853401B2 (en) 2009-04-24 2014-10-07 Brock University Processes for the preparation of morphinane and morphinone compounds
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
JP2013529595A (ja) * 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
CA2815093C (en) * 2010-11-05 2019-08-06 H. Lundbeck A/S Method for the manufacturing of naltrexone
EP2705043B1 (en) 2011-05-02 2016-11-30 Brock University Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents
ES2805655T3 (es) 2011-10-03 2021-02-15 Johnson Matthey Plc Proceso para preparar intermedios de buprenorfina
WO2013113120A1 (en) 2012-02-03 2013-08-08 Tomas Hudlicky Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
AR090916A1 (es) * 2012-05-03 2014-12-17 Lundbeck & Co As H Metodo para la fabricacion de naltrexona

Also Published As

Publication number Publication date
ES2946177T3 (es) 2023-07-13
CA3208298A1 (en) 2015-11-12
WO2015171354A2 (en) 2015-11-12
AU2015256416B2 (en) 2018-03-08
US9701688B2 (en) 2017-07-11
AU2018203948A1 (en) 2018-06-21
WO2015171354A3 (en) 2016-03-17
JP2017514846A (ja) 2017-06-08
EP3140308B1 (en) 2023-05-24
CA2947012C (en) 2023-09-26
CA2947012A1 (en) 2015-11-12
CN107001381A (zh) 2017-08-01
AU2020201990A1 (en) 2020-04-09
EP3140308B8 (en) 2023-06-28
US20150315205A1 (en) 2015-11-05
AU2018203948B2 (en) 2019-12-19
JP2020073598A (ja) 2020-05-14
DK3140308T3 (da) 2023-06-19
EP3140308A2 (en) 2017-03-15
AU2015256416A1 (en) 2016-11-24

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