JP6792745B2 - オピオイド化合物を調製するプロセス - Google Patents

オピオイド化合物を調製するプロセス Download PDF

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Publication number
JP6792745B2
JP6792745B2 JP2016565669A JP2016565669A JP6792745B2 JP 6792745 B2 JP6792745 B2 JP 6792745B2 JP 2016565669 A JP2016565669 A JP 2016565669A JP 2016565669 A JP2016565669 A JP 2016565669A JP 6792745 B2 JP6792745 B2 JP 6792745B2
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formula
compound
hpo
range
amount
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Japanese (ja)
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JP2017514846A5 (enExample
JP2017514846A (ja
Inventor
コンツァ・マッテオ
レレク・ビット
ツィンザー・ハルトムート
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Noramco LLC
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Noramco LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2016565669A 2014-05-05 2015-04-28 オピオイド化合物を調製するプロセス Active JP6792745B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988523P 2014-05-05 2014-05-05
US61/988,523 2014-05-05
US14/689,712 2015-04-17
US14/689,712 US9701688B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
PCT/US2015/027912 WO2015171354A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020021254A Division JP2020073598A (ja) 2014-05-05 2020-02-12 オピオイド化合物を調製するプロセス

Publications (3)

Publication Number Publication Date
JP2017514846A JP2017514846A (ja) 2017-06-08
JP2017514846A5 JP2017514846A5 (enExample) 2018-06-14
JP6792745B2 true JP6792745B2 (ja) 2020-12-02

Family

ID=54354748

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016565669A Active JP6792745B2 (ja) 2014-05-05 2015-04-28 オピオイド化合物を調製するプロセス
JP2020021254A Pending JP2020073598A (ja) 2014-05-05 2020-02-12 オピオイド化合物を調製するプロセス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020021254A Pending JP2020073598A (ja) 2014-05-05 2020-02-12 オピオイド化合物を調製するプロセス

Country Status (9)

Country Link
US (1) US9701688B2 (enExample)
EP (1) EP3140308B8 (enExample)
JP (2) JP6792745B2 (enExample)
CN (1) CN107001381A (enExample)
AU (3) AU2015256416B2 (enExample)
CA (2) CA3208298A1 (enExample)
DK (1) DK3140308T3 (enExample)
ES (1) ES2946177T3 (enExample)
WO (1) WO2015171354A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201716830D0 (en) * 2017-10-13 2017-11-29 Cambrex Charles City Inc New Process
WO2023102489A1 (en) * 2021-12-03 2023-06-08 Board Of Regents Of The University Of Nebraska Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20090047279A1 (en) * 2006-11-22 2009-02-19 Progenics Pharmaceuticals, Inc. (R)-N-Stereoisomers of 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
MX2008013842A (es) 2007-05-04 2009-03-06 Mallinckrodt Inc Proceso mejorado para la preparacion de opiatos 6-alfa-hidroxi-n-alquilados.
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
CN101861315B (zh) 2007-11-20 2013-01-16 日产化学工业株式会社 2-氮杂金刚烷类的制造方法
WO2009122436A2 (en) * 2008-03-31 2009-10-08 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
WO2010017573A1 (en) 2008-08-11 2010-02-18 Tasmanian Alkaloids Pty Limited PROCESS FOR MAKING MORPHINAN-6α-OLS
AU2009300386B2 (en) 2008-09-30 2015-07-02 SpecGx LLC Processes for the alkylation of norbuprenorphine with reduced impurity formation
US8227608B2 (en) 2008-09-30 2012-07-24 Mallinckrodt Llc Processes for increasing the yield of opiate alkaloid derivatives
WO2010039210A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the hydrogenation of opiate alkaloid derivatives
WO2010039209A2 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the synthesis of tertiary amines
ES2477190T3 (es) 2008-09-30 2014-07-16 Mallinckrodt Llc Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos
WO2010096416A1 (en) 2009-02-17 2010-08-26 Mallinckrodt Inc. Process for the reductive alkylation of normorphinans
MX2011011245A (es) 2009-04-24 2012-04-11 Univ Brock Proceso para la preparacion de compuestos de morfinano.
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
TWI471289B (zh) * 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
SI2635586T1 (sl) * 2010-11-05 2017-07-31 H. Lundbeck A/S Metoda za izdelavo naltreksona
CN105924455A (zh) * 2011-05-02 2016-09-07 布鲁克大学 通过使用环化脱水试剂的n-氧化物的n-脱甲基化制备吗啡类似物的方法和中间体
ES2692885T3 (es) 2011-10-03 2018-12-05 Johnson Matthey Plc Proceso para preparar buprenorfina
MX2014009353A (es) 2012-02-03 2015-11-06 Univ Brock Procedimiento para la preparacion de analogos de morfina mediante la reaccion de reactivos organometalicos con una oxazolidina derivada a partir de morfinanos.
AR090916A1 (es) * 2012-05-03 2014-12-17 Lundbeck & Co As H Metodo para la fabricacion de naltrexona

Also Published As

Publication number Publication date
DK3140308T3 (da) 2023-06-19
WO2015171354A3 (en) 2016-03-17
AU2018203948A1 (en) 2018-06-21
US9701688B2 (en) 2017-07-11
CA2947012C (en) 2023-09-26
US20150315205A1 (en) 2015-11-05
EP3140308B8 (en) 2023-06-28
AU2020201990A1 (en) 2020-04-09
ES2946177T3 (es) 2023-07-13
EP3140308A2 (en) 2017-03-15
JP2017514846A (ja) 2017-06-08
AU2015256416B2 (en) 2018-03-08
EP3140308B1 (en) 2023-05-24
AU2015256416A1 (en) 2016-11-24
CA2947012A1 (en) 2015-11-12
JP2020073598A (ja) 2020-05-14
CA3208298A1 (en) 2015-11-12
CN107001381A (zh) 2017-08-01
AU2018203948B2 (en) 2019-12-19
WO2015171354A2 (en) 2015-11-12

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