CA3208298A1 - Process for the preparation of opioid compounds - Google Patents

Process for the preparation of opioid compounds

Info

Publication number
CA3208298A1
CA3208298A1 CA3208298A CA3208298A CA3208298A1 CA 3208298 A1 CA3208298 A1 CA 3208298A1 CA 3208298 A CA3208298 A CA 3208298A CA 3208298 A CA3208298 A CA 3208298A CA 3208298 A1 CA3208298 A1 CA 3208298A1
Authority
CA
Canada
Prior art keywords
formula
compound
range
amount
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3208298A
Other languages
English (en)
French (fr)
Inventor
Matteo CONZA
Vit Lellek
Hartmut Zinser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noramco LLC
Original Assignee
Noramco LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noramco LLC filed Critical Noramco LLC
Publication of CA3208298A1 publication Critical patent/CA3208298A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA3208298A 2014-05-05 2015-04-28 Process for the preparation of opioid compounds Pending CA3208298A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988523P 2014-05-05 2014-05-05
US61/988,523 2014-05-05
US14/689,712 US9701688B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
US14/689,712 2015-04-17
CA2947012A CA2947012C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2947012A Division CA2947012C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Publications (1)

Publication Number Publication Date
CA3208298A1 true CA3208298A1 (en) 2015-11-12

Family

ID=54354748

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3208298A Pending CA3208298A1 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds
CA2947012A Active CA2947012C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2947012A Active CA2947012C (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Country Status (9)

Country Link
US (1) US9701688B2 (enExample)
EP (1) EP3140308B8 (enExample)
JP (2) JP6792745B2 (enExample)
CN (1) CN107001381A (enExample)
AU (3) AU2015256416B2 (enExample)
CA (2) CA3208298A1 (enExample)
DK (1) DK3140308T3 (enExample)
ES (1) ES2946177T3 (enExample)
WO (1) WO2015171354A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201716830D0 (en) * 2017-10-13 2017-11-29 Cambrex Charles City Inc New Process
WO2023102489A1 (en) * 2021-12-03 2023-06-08 Board Of Regents Of The University Of Nebraska Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
JP2010510328A (ja) * 2006-11-22 2010-04-02 プロジェニックス ファーマスーティカルス インコーポレーテッド ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体の（ｒ）−ｎ−立体異性体
ATE493416T1 (de) 2007-05-04 2011-01-15 Mallinckrodt Inc Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
EP2221306B1 (en) 2007-11-20 2016-04-13 Nissan Chemical Industries, Ltd. Method for producing 2-azaadamantane
AU2009233315B2 (en) * 2008-03-31 2013-08-29 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
WO2010017573A1 (en) 2008-08-11 2010-02-18 Tasmanian Alkaloids Pty Limited PROCESS FOR MAKING MORPHINAN-6α-OLS
WO2010039214A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for increasing the yield of the hydrolysis of the 3-0-methyl and 17-n-nitrile group in the preparation of opiate alkaloid derivatives
ES2566559T3 (es) 2008-09-30 2016-04-13 Mallinckrodt Llc Procesos para la alquilación de grupos amino secundarios de derivados de morfinano
US8293906B2 (en) 2008-09-30 2012-10-23 Mallinckrodt Llc Processes for the alkylation of norbuprenorphine with reduced impurity formation
US8273887B2 (en) 2008-09-30 2012-09-25 Mallinckrodt Llc Processes for synthesis of opiate alkaloid derivatives
PL2342208T3 (pl) 2008-09-30 2014-11-28 SpecGx LLC Proces zawracania do ponownego wykorzystania w celu zwiększania wydajności reakcji grignarda w wytwarzaniu pochodnych alkaloidów opiatowych
US8431701B2 (en) 2009-02-17 2013-04-30 Mallinckrodt Llc Process for the reductive alkylation of normorphinans
JP5824448B2 (ja) 2009-04-24 2015-11-25 ブロック ユニバーシティ モルフィナンおよびモルフィノン化合物の調製法
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
TWI471289B (zh) * 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
DK2635586T3 (en) * 2010-11-05 2017-03-27 H Lundbeck As PROCEDURE FOR THE PREPARATION OF NALTREXON
CN103596962B (zh) 2011-05-02 2017-02-15 布鲁克大学 通过使用环化脱水试剂的n‑氧化物的n‑脱甲基化制备吗啡类似物的方法和中间体
HUE040284T2 (hu) 2011-10-03 2019-02-28 Johnson Matthey Plc Eljárás buprenorfin elõállítására
EP2809674A4 (en) 2012-02-03 2015-09-02 Univ Brock METHOD FOR THE PRODUCTION OF MORPHINE ANALOGUE BY REACTION OF ORGANOMETALLIC REAGENTS WITH AN OXAZOLIDINE DERIVED FROM MORPHINANESE
WO2013164383A1 (en) * 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone

Also Published As

Publication number Publication date
WO2015171354A3 (en) 2016-03-17
AU2015256416A1 (en) 2016-11-24
AU2015256416B2 (en) 2018-03-08
EP3140308B1 (en) 2023-05-24
AU2020201990A1 (en) 2020-04-09
AU2018203948B2 (en) 2019-12-19
EP3140308B8 (en) 2023-06-28
EP3140308A2 (en) 2017-03-15
CN107001381A (zh) 2017-08-01
CA2947012C (en) 2023-09-26
DK3140308T3 (da) 2023-06-19
US20150315205A1 (en) 2015-11-05
JP6792745B2 (ja) 2020-12-02
AU2018203948A1 (en) 2018-06-21
CA2947012A1 (en) 2015-11-12
US9701688B2 (en) 2017-07-11
JP2020073598A (ja) 2020-05-14
JP2017514846A (ja) 2017-06-08
WO2015171354A2 (en) 2015-11-12
ES2946177T3 (es) 2023-07-13

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