JP2017514818A5 - - Google Patents
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- Publication number
- JP2017514818A5 JP2017514818A5 JP2016564569A JP2016564569A JP2017514818A5 JP 2017514818 A5 JP2017514818 A5 JP 2017514818A5 JP 2016564569 A JP2016564569 A JP 2016564569A JP 2016564569 A JP2016564569 A JP 2016564569A JP 2017514818 A5 JP2017514818 A5 JP 2017514818A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- membered heteroaryl
- compound
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 11
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- -1 C 1 -C 4 alkyl Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 0 C*(c1c(*)c(*)c(N*)nn1)/C(/CC1C2C1)=C/CCC2c1nnc(N*)[s]1 Chemical compound C*(c1c(*)c(*)c(N*)nn1)/C(/CC1C2C1)=C/CCC2c1nnc(N*)[s]1 0.000 description 1
- LXVQODFRWDCAPX-ZWKOTPCHSA-N O=C(Cc1ncccc1)Nc1nnc([C@H]2C[C@@H](Cc3ccc(NC(Cc4ccccn4)=O)nn3)CC2)[s]1 Chemical compound O=C(Cc1ncccc1)Nc1nnc([C@H]2C[C@@H](Cc3ccc(NC(Cc4ccccn4)=O)nn3)CC2)[s]1 LXVQODFRWDCAPX-ZWKOTPCHSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461986876P | 2014-04-30 | 2014-04-30 | |
| US61/986,876 | 2014-04-30 | ||
| PCT/IB2015/052833 WO2015166373A1 (en) | 2014-04-30 | 2015-04-17 | Cycloalkyl-linked diheterocycle derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019149123A Division JP2019214597A (ja) | 2014-04-30 | 2019-08-15 | シクロアルキル結合ジヘテロ環誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514818A JP2017514818A (ja) | 2017-06-08 |
| JP2017514818A5 true JP2017514818A5 (enExample) | 2018-06-14 |
| JP6574203B2 JP6574203B2 (ja) | 2019-09-11 |
Family
ID=53276932
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016564569A Expired - Fee Related JP6574203B2 (ja) | 2014-04-30 | 2015-04-17 | シクロアルキル結合ジヘテロ環誘導体 |
| JP2019149123A Ceased JP2019214597A (ja) | 2014-04-30 | 2019-08-15 | シクロアルキル結合ジヘテロ環誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019149123A Ceased JP2019214597A (ja) | 2014-04-30 | 2019-08-15 | シクロアルキル結合ジヘテロ環誘導体 |
Country Status (40)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6783663B2 (ja) * | 2014-01-06 | 2020-11-11 | ライゼン・ファーマシューティカルズ・エスアー | 新規グルタミナーゼ阻害剤 |
| MA49708A (fr) | 2014-04-30 | 2020-06-03 | Pfizer | Dérivés de dihétérocycle liés à cycloalkyle |
| CN107474024B (zh) * | 2016-06-08 | 2022-12-13 | 北京赛林泰医药技术有限公司 | 一种谷氨酰酶抑制剂及其组合物和用途 |
| CN110746416A (zh) * | 2019-09-05 | 2020-02-04 | 中国药科大学 | 含有三氮唑结构的谷氨酰胺酶gls1抑制剂或其可药用的盐、其制备方法及用途 |
| CN116023375A (zh) * | 2021-10-25 | 2023-04-28 | 成都苑东生物制药股份有限公司 | 一种杂环类衍生物、其制备方法及用途 |
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| JP6943759B2 (ja) | 2017-12-28 | 2021-10-06 | 株式会社東海理化電機製作所 | シフト装置 |
-
2015
- 2015-04-17 MA MA049708A patent/MA49708A/fr unknown
- 2015-04-17 JP JP2016564569A patent/JP6574203B2/ja not_active Expired - Fee Related
- 2015-04-17 MA MA39926A patent/MA39926B1/fr unknown
- 2015-04-17 EA EA201650003A patent/EA033919B1/ru not_active IP Right Cessation
- 2015-04-17 PT PT157267014T patent/PT3137460T/pt unknown
- 2015-04-17 UA UAA201610872A patent/UA117861C2/uk unknown
- 2015-04-17 NZ NZ72549615A patent/NZ725496A/en not_active IP Right Cessation
- 2015-04-17 MD MDA20160111A patent/MD20160111A2/ro not_active Application Discontinuation
- 2015-04-17 CA CA2947130A patent/CA2947130C/en not_active Expired - Fee Related
- 2015-04-17 CN CN201580022426.XA patent/CN106232598B/zh not_active Expired - Fee Related
- 2015-04-17 SG SG11201608634RA patent/SG11201608634RA/en unknown
- 2015-04-17 CU CU2016000157A patent/CU24420B1/es unknown
- 2015-04-17 LT LT15726701T patent/LT3137460T/lt unknown
- 2015-04-17 AU AU2015254943A patent/AU2015254943B2/en not_active Ceased
- 2015-04-17 PE PE2016002145A patent/PE20161436A1/es unknown
- 2015-04-17 SI SI201530998T patent/SI3137460T1/sl unknown
- 2015-04-17 RS RS20191540A patent/RS59617B1/sr unknown
- 2015-04-17 US US15/306,979 patent/US20170050958A1/en not_active Abandoned
- 2015-04-17 WO PCT/IB2015/052833 patent/WO2015166373A1/en not_active Ceased
- 2015-04-17 DK DK15726701.4T patent/DK3137460T3/da active
- 2015-04-17 TN TN2016000459A patent/TN2016000459A1/en unknown
- 2015-04-17 CR CR20160497A patent/CR20160497A/es unknown
- 2015-04-17 EP EP15726701.4A patent/EP3137460B1/en active Active
- 2015-04-17 GE GEAP201514314A patent/GEP20186879B/en unknown
- 2015-04-17 MX MX2016014143A patent/MX2016014143A/es unknown
- 2015-04-17 ES ES15726701T patent/ES2759434T3/es active Active
- 2015-04-17 AP AP2016009530A patent/AP2016009530A0/en unknown
- 2015-04-17 PL PL15726701T patent/PL3137460T3/pl unknown
- 2015-04-17 HU HUE15726701A patent/HUE046518T2/hu unknown
- 2015-04-17 HR HRP20192056TT patent/HRP20192056T1/hr unknown
- 2015-04-17 BR BR112016024513A patent/BR112016024513A2/pt not_active IP Right Cessation
- 2015-04-17 KR KR1020167033037A patent/KR20160149256A/ko not_active Withdrawn
- 2015-04-17 GE GEAP201814314A patent/GEAP201814314A/en unknown
- 2015-04-17 EP EP19172254.5A patent/EP3556757A1/en not_active Withdrawn
-
2016
- 2016-10-05 CL CL2016002532A patent/CL2016002532A1/es unknown
- 2016-10-07 PH PH12016501997A patent/PH12016501997A1/en unknown
- 2016-10-21 EC ECIEPI201683017A patent/ECSP16083017A/es unknown
- 2016-10-26 NI NI201600163A patent/NI201600163A/es unknown
- 2016-10-28 GT GT201600232A patent/GT201600232A/es unknown
- 2016-10-28 SV SV2016005310A patent/SV2016005310A/es unknown
- 2016-10-28 DO DO2016000293A patent/DOP2016000293A/es unknown
- 2016-10-30 IL IL248629A patent/IL248629B/en active IP Right Grant
-
2017
- 2017-11-29 US US15/826,027 patent/US10125130B2/en active Active
-
2018
- 2018-10-11 US US16/157,618 patent/US20190040055A1/en not_active Abandoned
-
2019
- 2019-05-20 US US16/416,997 patent/US10676471B2/en active Active
- 2019-08-15 JP JP2019149123A patent/JP2019214597A/ja not_active Ceased
- 2019-11-28 CY CY20191101248T patent/CY1122439T1/el unknown
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