JP2017512752A5 - - Google Patents
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- Publication number
- JP2017512752A5 JP2017512752A5 JP2016552268A JP2016552268A JP2017512752A5 JP 2017512752 A5 JP2017512752 A5 JP 2017512752A5 JP 2016552268 A JP2016552268 A JP 2016552268A JP 2016552268 A JP2016552268 A JP 2016552268A JP 2017512752 A5 JP2017512752 A5 JP 2017512752A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- solvate
- pharmaceutically acceptable
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CNC(*)C(NCC(*)NC([C@](CCC(O)=O)N[S+])=O)=O Chemical compound CNC(*)C(NCC(*)NC([C@](CCC(O)=O)N[S+])=O)=O 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461940759P | 2014-02-17 | 2014-02-17 | |
| US61/940,759 | 2014-02-17 | ||
| US201461947368P | 2014-03-03 | 2014-03-03 | |
| US61/947,368 | 2014-03-03 | ||
| PCT/US2015/016185 WO2015123679A1 (en) | 2014-02-17 | 2015-02-17 | Hydrophilic antibody-drug conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020024690A Division JP2020073607A (ja) | 2014-02-17 | 2020-02-17 | 親水性抗体−薬物コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512752A JP2017512752A (ja) | 2017-05-25 |
| JP2017512752A5 true JP2017512752A5 (enExample) | 2018-01-25 |
| JP6716461B2 JP6716461B2 (ja) | 2020-07-01 |
Family
ID=53800705
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552268A Expired - Fee Related JP6716461B2 (ja) | 2014-02-17 | 2015-02-17 | 親水性抗体−薬物コンジュゲート |
| JP2020024690A Withdrawn JP2020073607A (ja) | 2014-02-17 | 2020-02-17 | 親水性抗体−薬物コンジュゲート |
| JP2022078761A Active JP7447183B2 (ja) | 2014-02-17 | 2022-05-12 | 親水性抗体－薬物コンジュゲート |
| JP2022194229A Pending JP2023018157A (ja) | 2014-02-17 | 2022-12-05 | 親水性抗体－薬物コンジュゲート |
| JP2024075020A Pending JP2024096335A (ja) | 2014-02-17 | 2024-05-06 | 親水性抗体－薬物コンジュゲート |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020024690A Withdrawn JP2020073607A (ja) | 2014-02-17 | 2020-02-17 | 親水性抗体−薬物コンジュゲート |
| JP2022078761A Active JP7447183B2 (ja) | 2014-02-17 | 2022-05-12 | 親水性抗体－薬物コンジュゲート |
| JP2022194229A Pending JP2023018157A (ja) | 2014-02-17 | 2022-12-05 | 親水性抗体－薬物コンジュゲート |
| JP2024075020A Pending JP2024096335A (ja) | 2014-02-17 | 2024-05-06 | 親水性抗体－薬物コンジュゲート |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10933112B2 (enExample) |
| EP (2) | EP3107557B1 (enExample) |
| JP (5) | JP6716461B2 (enExample) |
| KR (3) | KR20160120777A (enExample) |
| CN (1) | CN106029083B (enExample) |
| AU (3) | AU2015218202B2 (enExample) |
| CA (1) | CA2937753A1 (enExample) |
| EA (1) | EA201691650A1 (enExample) |
| ES (2) | ES2885686T3 (enExample) |
| IL (4) | IL290116B2 (enExample) |
| MX (2) | MX385823B (enExample) |
| SG (2) | SG10202001468UA (enExample) |
| WO (1) | WO2015123679A1 (enExample) |
| ZA (1) | ZA201605111B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3107557B1 (en) | 2014-02-17 | 2021-06-09 | Seagen Inc. | Hydrophilic antibody-drug conjugates |
| TWI660741B (zh) | 2015-11-03 | 2019-06-01 | 財團法人工業技術研究院 | 抗體藥物複合物及其製造方法 |
| KR20240010534A (ko) | 2016-08-09 | 2024-01-23 | 씨젠 인크. | 개선된 물리화학적 특성을 갖는 자기 안정화 링커를 구비한 약물 접합체 |
| EP3525826B1 (en) | 2016-10-11 | 2020-07-22 | Byondis B.V | Non-linear self-immolative linkers and conjugates thereof |
| DK3529269T3 (da) | 2016-10-19 | 2026-02-23 | Invenra Inc | Antistof-konstruktioner |
| WO2018115485A1 (en) | 2016-12-22 | 2018-06-28 | Pierfrancesco Tassone | A monoclonal antibody targeting a unique sialoglycosilated cancer-associated epitope of cd43 |
| KR20190133233A (ko) | 2017-03-30 | 2019-12-02 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 항체-약물 접합체를 제조하는 방법 |
| AU2018288029B2 (en) * | 2017-06-19 | 2021-12-23 | Systimmune, Inc. | Antibody-drug conjugate having acidic self-stabilization junction |
| CN108743968B (zh) | 2017-06-20 | 2022-04-19 | 成都百利多特生物药业有限责任公司 | 半胱氨酸改造的抗体-毒素偶联物(tdc)定点偶联位点筛选 |
| CN109106951A (zh) * | 2017-08-18 | 2019-01-01 | 四川百利药业有限责任公司 | 一种喜树碱-抗体偶联物 |
| WO2019034177A1 (zh) * | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | 具有两种不同药物的抗体药物偶联物 |
| CA3082271A1 (en) | 2017-11-14 | 2019-05-23 | Debiopharm Research & Manufacturing S.A. | Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin b |
| MX2020008267A (es) | 2018-02-20 | 2020-09-21 | Seattle Genetics Inc | Compuestos de auristatina f hidrofoba y conjugados de los mismos. |
| CN113227127A (zh) | 2018-06-05 | 2021-08-06 | 伦敦大学国王学院 | 向胃肠系统递送酬载的btnl3/8导引构建体 |
| AU2020348876A1 (en) * | 2019-09-19 | 2022-04-07 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| US20230173113A1 (en) | 2020-03-12 | 2023-06-08 | Technische Universität München | Cyclic peptides and their conjugates for addressing alpha-v-beta-6 integrin in vivo |
| JP2024510435A (ja) | 2021-03-18 | 2024-03-07 | シージェン インコーポレイテッド | 生体活性化合物の内部移行複合体からの選択的薬物放出 |
| WO2022217022A1 (en) | 2021-04-10 | 2022-10-13 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| CA3216459A1 (en) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| CA3224492A1 (en) | 2021-07-19 | 2023-01-26 | Xiaojun Han | Immunoconjugates and methods |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| CA3230737A1 (en) | 2021-09-03 | 2023-03-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
| JP7767613B2 (ja) * | 2021-11-15 | 2025-11-11 | システィミューン，インコーポレイテッド | 二重特異性抗体－カンプトテシン薬物複合体及びその製薬的使用 |
| EP4433096A1 (en) | 2021-11-19 | 2024-09-25 | Ardeagen Corporation | Gpc3 binding agents, conjugates thereof and methods of using the same |
| CN116212044A (zh) * | 2021-12-03 | 2023-06-06 | 成都百利多特生物药业有限责任公司 | 抗人Trop2抗体-喜树碱类药物偶联物及其医药用途 |
| CN119317646A (zh) * | 2022-06-16 | 2025-01-14 | 山东博安生物技术股份有限公司 | 抗liv-1抗体及其药物偶联物 |
| AU2023298568A1 (en) | 2022-06-30 | 2025-01-09 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
| EP4651905A1 (en) * | 2023-01-17 | 2025-11-26 | Eli Lilly and Company | Novel linkers for sustained delivery of therapeutics |
| WO2025027529A1 (en) | 2023-07-31 | 2025-02-06 | Advesya | Anti-il-1rap antibody drug conjugates and methods of use thereof |
| JPWO2025058000A1 (enExample) | 2023-09-13 | 2025-03-20 | ||
| AR133955A1 (es) | 2023-09-26 | 2025-11-19 | Profoundbio Us Co | Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos |
| TW202530255A (zh) | 2023-12-15 | 2025-08-01 | 法商亞維西亞有限公司 | 抗ｉｌ－１ｒａｐ結合結構域及其抗體－藥物偶聯物 |
| TW202547866A (zh) | 2024-01-10 | 2025-12-16 | 丹麥商珍美寶股份有限公司 | Ｓｌｉｔｒｋ６結合劑、其共軛物及使用彼之方法 |
| WO2025181219A1 (en) | 2024-02-29 | 2025-09-04 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
| WO2026007511A1 (en) * | 2024-07-05 | 2026-01-08 | Beijing Innocare Pharma Tech Co., Ltd. | Drug conjugates, their preparation methods and uses |
| WO2026027771A1 (en) | 2024-08-02 | 2026-02-05 | Trimt Gmbh | Alpha v beta 6-integrin binding cyclopeptides with non-natural amino acids, and conjugates thereof |
| WO2026039642A1 (en) | 2024-08-16 | 2026-02-19 | Ardeagen Corporation | Anti-mesothelin antibody conjugates and methods of use thereof |
| WO2026149574A1 (zh) * | 2025-01-13 | 2026-07-16 | 正大天晴药业集团股份有限公司 | 三分支亲水性连接体及其蛋白药物偶联物 |
| WO2026160909A1 (ko) * | 2025-01-24 | 2026-07-30 | 롯데바이오로직스 주식회사 | 친수성이 개선된 표적화 물질-약물 접합체 생성을 위한 분지형 링커 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3628624A (en) | 1967-04-26 | 1971-12-21 | Buero Patent Ag | Guidance system for self-propelled trackless carriages |
| GB2036891B (en) | 1978-12-05 | 1983-05-05 | Windsor Smith C | Change speed gear |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CA2249195A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| EP0941120A4 (en) * | 1996-11-05 | 2004-08-18 | Bristol Myers Squibb Co | BRANCHED PEPTIDLINKERS |
| ES2369542T3 (es) * | 2002-07-31 | 2011-12-01 | Seattle Genetics, Inc. | Conjugados de auristatina y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa. |
| ES2605443T3 (es) * | 2003-11-06 | 2017-03-14 | Seattle Genetics, Inc. | Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia |
| US8067546B2 (en) | 2005-04-19 | 2011-11-29 | Seattle Genetics, Inc. | Humanized anti-CD70 binding agents and uses thereof |
| ES2708763T3 (es) * | 2005-07-07 | 2019-04-11 | Seattle Genetics Inc | Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C |
| WO2007086083A1 (en) | 2006-01-24 | 2007-08-02 | Tecnoimage Srl | Supporting frame for covering elements |
| WO2008025020A2 (en) | 2006-08-25 | 2008-02-28 | Seattle Genetics, Inc. | Cd30 binding agents and uses thereof |
| JP2010519310A (ja) | 2007-02-21 | 2010-06-03 | メダレックス インコーポレイテッド | 単一のアミノ酸を有する化学リンカーおよびその複合体 |
| CN101903403B (zh) | 2007-10-19 | 2016-03-16 | 西雅图基因公司 | Cd19结合剂及其应用 |
| WO2009117531A1 (en) * | 2008-03-18 | 2009-09-24 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| PT3156420T (pt) | 2010-12-06 | 2019-05-27 | Seattle Genetics Inc | Anticorpos humanizados a liv-1 e seu uso para tratar o cancro |
| CN105017420B (zh) | 2012-02-17 | 2019-05-28 | 西雅图基因公司 | 针对整联蛋白αvβ6的抗体和使用该抗体治疗癌症 |
| US9751942B2 (en) | 2012-03-29 | 2017-09-05 | Chugai Seiyaku Kabushiki Kaisha | Anti-LAMP5 antibody and utilization thereof |
| US20130309223A1 (en) | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
| EP3107557B1 (en) * | 2014-02-17 | 2021-06-09 | Seagen Inc. | Hydrophilic antibody-drug conjugates |
| AU2020348876A1 (en) | 2019-09-19 | 2022-04-07 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| JP2024510435A (ja) | 2021-03-18 | 2024-03-07 | シージェン インコーポレイテッド | 生体活性化合物の内部移行複合体からの選択的薬物放出 |
| IL305886A (en) | 2021-03-18 | 2023-11-01 | Seagen Inc | Selective release of drugs from internalized conjugates of biologically active compounds |
-
2015
- 2015-02-17 EP EP15748980.8A patent/EP3107557B1/en active Active
- 2015-02-17 KR KR1020167025612A patent/KR20160120777A/ko not_active Ceased
- 2015-02-17 SG SG10202001468UA patent/SG10202001468UA/en unknown
- 2015-02-17 EP EP21168364.4A patent/EP3912641B1/en active Active
- 2015-02-17 US US15/118,031 patent/US10933112B2/en active Active
- 2015-02-17 SG SG11201605886RA patent/SG11201605886RA/en unknown
- 2015-02-17 ES ES15748980T patent/ES2885686T3/es active Active
- 2015-02-17 CA CA2937753A patent/CA2937753A1/en active Pending
- 2015-02-17 ES ES21168364T patent/ES2994375T3/es active Active
- 2015-02-17 WO PCT/US2015/016185 patent/WO2015123679A1/en not_active Ceased
- 2015-02-17 JP JP2016552268A patent/JP6716461B2/ja not_active Expired - Fee Related
- 2015-02-17 AU AU2015218202A patent/AU2015218202B2/en not_active Ceased
- 2015-02-17 KR KR1020237014278A patent/KR102647074B1/ko active Active
- 2015-02-17 IL IL290116A patent/IL290116B2/en unknown
- 2015-02-17 IL IL309933A patent/IL309933A/en unknown
- 2015-02-17 EA EA201691650A patent/EA201691650A1/ru unknown
- 2015-02-17 MX MX2016009862A patent/MX385823B/es unknown
- 2015-02-17 CN CN201580008876.3A patent/CN106029083B/zh not_active Expired - Fee Related
- 2015-02-17 KR KR1020247007857A patent/KR20240036143A/ko not_active Withdrawn
-
2016
- 2016-07-19 IL IL246829A patent/IL246829B/en active IP Right Grant
- 2016-07-21 ZA ZA2016/05111A patent/ZA201605111B/en unknown
- 2016-07-28 MX MX2021010550A patent/MX2021010550A/es unknown
-
2020
- 2020-02-17 JP JP2020024690A patent/JP2020073607A/ja not_active Withdrawn
- 2020-09-24 AU AU2020239744A patent/AU2020239744B2/en not_active Ceased
-
2021
- 2021-01-27 US US17/160,225 patent/US11510959B2/en active Active
- 2021-04-19 IL IL282434A patent/IL282434B/en unknown
-
2022
- 2022-05-12 JP JP2022078761A patent/JP7447183B2/ja active Active
- 2022-10-11 US US17/963,939 patent/US20230132738A1/en not_active Abandoned
- 2022-12-05 JP JP2022194229A patent/JP2023018157A/ja active Pending
-
2023
- 2023-03-06 AU AU2023201373A patent/AU2023201373A1/en not_active Abandoned
- 2023-07-28 US US18/361,558 patent/US12257281B2/en active Active
-
2024
- 2024-05-06 JP JP2024075020A patent/JP2024096335A/ja active Pending
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