JP2023512501A5 - - Google Patents
Info
- Publication number
- JP2023512501A5 JP2023512501A5 JP2022544188A JP2022544188A JP2023512501A5 JP 2023512501 A5 JP2023512501 A5 JP 2023512501A5 JP 2022544188 A JP2022544188 A JP 2022544188A JP 2022544188 A JP2022544188 A JP 2022544188A JP 2023512501 A5 JP2023512501 A5 JP 2023512501A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- val
- compound according
- cit
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062964180P | 2020-01-22 | 2020-01-22 | |
| US62/964,180 | 2020-01-22 | ||
| US202063085414P | 2020-09-30 | 2020-09-30 | |
| US63/085,414 | 2020-09-30 | ||
| PCT/EP2021/051263 WO2021148501A1 (en) | 2020-01-22 | 2021-01-21 | Compounds and conjugates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023512501A JP2023512501A (ja) | 2023-03-27 |
| JP2023512501A5 true JP2023512501A5 (enExample) | 2024-01-19 |
Family
ID=74418415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022544188A Withdrawn JP2023512501A (ja) | 2020-01-22 | 2021-01-21 | 化合物及びその複合体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20230111996A1 (enExample) |
| EP (1) | EP4093438A1 (enExample) |
| JP (1) | JP2023512501A (enExample) |
| KR (1) | KR20220130191A (enExample) |
| CN (1) | CN115052633A (enExample) |
| AU (1) | AU2021211892A1 (enExample) |
| BR (1) | BR112022013966A2 (enExample) |
| CA (1) | CA3167373A1 (enExample) |
| CO (1) | CO2022011178A2 (enExample) |
| CR (1) | CR20220393A (enExample) |
| EC (1) | ECSP22064855A (enExample) |
| IL (1) | IL294645A (enExample) |
| MX (1) | MX2022008997A (enExample) |
| TW (1) | TW202140076A (enExample) |
| WO (1) | WO2021148501A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118414339A (zh) | 2021-12-16 | 2024-07-30 | 迈威(上海)生物科技股份有限公司 | 一种喜树碱类化合物及其偶联物 |
| CN115160403B (zh) * | 2022-07-05 | 2025-06-27 | 博石丰生命科技(南通)有限公司 | 特异性拓扑异构酶抑制剂和可用于抗体药物偶联物及其制备方法 |
| KR20250049568A (ko) | 2022-07-15 | 2025-04-11 | 페온 테라퓨틱스 리미티드 | Cdcp1에 결합하는 항체 약물 접합체 및 이의 용도 |
| EP4309676A1 (en) * | 2022-07-22 | 2024-01-24 | Emergence Therapeutics AG | Novel anti-nectin-4 antibody camptothecin derivative conjugates |
| WO2024051762A1 (en) * | 2022-09-07 | 2024-03-14 | Xadcera Biopharmaceutical (Suzhou) Co., Ltd. | Anti-trop2/egfr antibodies and uses thereof |
| IL322897A (en) * | 2023-02-23 | 2025-10-01 | Phrontline Biopharma Hangzhou Co Ltd | Camptothecin derivatives and conjugates, methods for their preparation and medical uses |
| IL324453A (en) * | 2023-05-12 | 2026-01-01 | Biocytogen Pharmaceuticals Beijing Co Ltd | Binding agent compounds and ligand-drug conjugates, methods of preparation and uses thereof |
| EP4721767A1 (en) | 2023-06-05 | 2026-04-08 | Jiangsu Mabwell Health Pharmaceutical R&D Co., Ltd. | Anti-b7-h3 antibody or fragment thereof, and antibody drug conjugate targeting b7-h3 |
| TW202540115A (zh) * | 2023-11-16 | 2025-10-16 | 大陸商上海齊魯製藥研究中心有限公司 | 一種氘代喜樹鹼化合物及其製備和應用 |
| CN122374343A (zh) | 2023-11-30 | 2026-07-10 | 江苏康宁杰瑞生物制药有限公司 | 包含pd-l1结合分子与双特异性抗体-药物偶联物的组合物及其用途 |
| AU2024415931A1 (en) | 2023-12-27 | 2026-07-16 | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. | Multi-specific antibody targeting her3 and trop2 and conjugate thereof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| WO2026039718A1 (en) * | 2024-08-16 | 2026-02-19 | Natural State Science, Llc | Cancer treatment using 5,6-dihydro-4h-benzo[de] quinoline-camptothecin |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| JP3008226B2 (ja) * | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
| TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| NZ567140A (en) | 2005-10-07 | 2011-09-30 | Exelixis Inc | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
| DK1813614T3 (da) | 2006-01-25 | 2012-01-23 | Sanofi Sa | Cytotoksiske midler, der omfatter nye tomaymycinderivater |
| PE20090245A1 (es) | 2007-05-08 | 2009-03-17 | Genentech Inc | Anticuerpos anti-muc16 disenados con cisteina y conjugados de anticuerpos y farmacos |
| BRPI0818780A2 (pt) | 2007-10-19 | 2015-04-22 | Genentech Inc | Anticorpo anti-tenb2 planejados por cisteína e conjugados de medicamento com anticorpos |
| GB201506393D0 (en) * | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| MA43354A (fr) * | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| US20190367605A1 (en) | 2016-11-10 | 2019-12-05 | Medimmune, Llc | Binding Molecules Specific For ASCT2 And Uses Thereof |
| KR20240104214A (ko) * | 2019-03-29 | 2024-07-04 | 메디뮨 리미티드 | 화합물 및 이의 접합체 |
| CN116829592A (zh) * | 2020-09-11 | 2023-09-29 | 免疫医疗有限公司 | 治疗性b7-h4结合分子 |
-
2021
- 2021-01-20 TW TW110102103A patent/TW202140076A/zh unknown
- 2021-01-21 JP JP2022544188A patent/JP2023512501A/ja not_active Withdrawn
- 2021-01-21 WO PCT/EP2021/051263 patent/WO2021148501A1/en not_active Ceased
- 2021-01-21 CR CR20220393A patent/CR20220393A/es unknown
- 2021-01-21 CA CA3167373A patent/CA3167373A1/en active Pending
- 2021-01-21 MX MX2022008997A patent/MX2022008997A/es unknown
- 2021-01-21 KR KR1020227028554A patent/KR20220130191A/ko active Pending
- 2021-01-21 US US17/759,078 patent/US20230111996A1/en not_active Abandoned
- 2021-01-21 AU AU2021211892A patent/AU2021211892A1/en not_active Abandoned
- 2021-01-21 EP EP21702401.7A patent/EP4093438A1/en not_active Withdrawn
- 2021-01-21 BR BR112022013966A patent/BR112022013966A2/pt not_active IP Right Cessation
- 2021-01-21 IL IL294645A patent/IL294645A/en unknown
- 2021-01-21 CN CN202180010204.1A patent/CN115052633A/zh active Pending
-
2022
- 2022-08-08 CO CONC2022/0011178A patent/CO2022011178A2/es unknown
- 2022-08-18 EC ECSENADI202264855A patent/ECSP22064855A/es unknown
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