JP2017512058A5 - - Google Patents
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- Publication number
- JP2017512058A5 JP2017512058A5 JP2016553562A JP2016553562A JP2017512058A5 JP 2017512058 A5 JP2017512058 A5 JP 2017512058A5 JP 2016553562 A JP2016553562 A JP 2016553562A JP 2016553562 A JP2016553562 A JP 2016553562A JP 2017512058 A5 JP2017512058 A5 JP 2017512058A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- acute
- pancreatitis
- lung
- uti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000037865 fusion proteins Human genes 0.000 claims 10
- 108020001507 fusion proteins Proteins 0.000 claims 10
- 208000019206 urinary tract infection Diseases 0.000 claims 8
- 206010033645 Pancreatitis Diseases 0.000 claims 6
- 206010035664 Pneumonia Diseases 0.000 claims 6
- 230000001154 acute effect Effects 0.000 claims 4
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 2
- 206010003011 Appendicitis Diseases 0.000 claims 2
- 208000002251 Dissecting Aneurysm Diseases 0.000 claims 2
- 206010059284 Epidermal necrosis Diseases 0.000 claims 2
- 208000004852 Lung Injury Diseases 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 206010053159 Organ failure Diseases 0.000 claims 2
- 208000016222 Pancreatic disease Diseases 0.000 claims 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 claims 2
- 206010042033 Stevens-Johnson syndrome Diseases 0.000 claims 2
- 231100000168 Stevens-Johnson syndrome Toxicity 0.000 claims 2
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 2
- 206010069363 Traumatic lung injury Diseases 0.000 claims 2
- 208000009470 Ventilator-Associated Pneumonia Diseases 0.000 claims 2
- 206010069351 acute lung injury Diseases 0.000 claims 2
- 201000003229 acute pancreatitis Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 206010002895 aortic dissection Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 206010009887 colitis Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000009190 disseminated intravascular coagulation Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 231100000283 hepatitis Toxicity 0.000 claims 2
- 208000037906 ischaemic injury Diseases 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 231100000515 lung injury Toxicity 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 208000024691 pancreas disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 230000002588 toxic effect Effects 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 239000013636 protein dimer Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019109054A JP6938565B2 (ja) | 2014-02-24 | 2019-06-11 | Ｕｔｉ融合タンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461943617P | 2014-02-24 | 2014-02-24 | |
| US61/943,617 | 2014-02-24 | ||
| PCT/US2015/017152 WO2015127391A1 (en) | 2014-02-24 | 2015-02-23 | Uti fusion proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019109054A Division JP6938565B2 (ja) | 2014-02-24 | 2019-06-11 | Ｕｔｉ融合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017512058A JP2017512058A (ja) | 2017-05-18 |
| JP2017512058A5 true JP2017512058A5 (cg-RX-API-DMAC7.html) | 2018-04-05 |
| JP6574431B2 JP6574431B2 (ja) | 2019-09-11 |
Family
ID=52629709
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553562A Active JP6574431B2 (ja) | 2014-02-24 | 2015-02-23 | Ｕｔｉ融合タンパク質 |
| JP2019109054A Active JP6938565B2 (ja) | 2014-02-24 | 2019-06-11 | Ｕｔｉ融合タンパク質 |
| JP2021142544A Pending JP2022002513A (ja) | 2014-02-24 | 2021-09-01 | Ｕｔｉ融合タンパク質 |
| JP2023108024A Pending JP2023123763A (ja) | 2014-02-24 | 2023-06-30 | Ｕｔｉ融合タンパク質 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019109054A Active JP6938565B2 (ja) | 2014-02-24 | 2019-06-11 | Ｕｔｉ融合タンパク質 |
| JP2021142544A Pending JP2022002513A (ja) | 2014-02-24 | 2021-09-01 | Ｕｔｉ融合タンパク質 |
| JP2023108024A Pending JP2023123763A (ja) | 2014-02-24 | 2023-06-30 | Ｕｔｉ融合タンパク質 |
Country Status (38)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20160444A (es) * | 2014-02-24 | 2017-04-21 | Takeda Gmbh | Proteínas de fusión uti |
| PE20251181A1 (es) * | 2017-06-07 | 2025-04-23 | Spark Therapeutics Inc | Agentes potenciadores para la transfeccion celular mejorada y/o la produccion del vector raav |
| WO2020106881A1 (en) * | 2018-11-20 | 2020-05-28 | Diamedica Inc. | Modified ulinastatin polypeptides |
| JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| JP2021080177A (ja) | 2019-11-14 | 2021-05-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| BR112022017718A2 (pt) * | 2020-03-05 | 2022-11-16 | Diamedica Usa Inc | Polipeptídeos de ulinastatina |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| EP0401508B1 (de) * | 1989-05-13 | 1994-11-23 | Bayer Ag | Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
| US5409895A (en) | 1990-11-13 | 1995-04-25 | Mochida Pharmaceutical Co., Ltd. | Protease inhibitory polypeptides derived from urinary trypsin inhibitor and compositions thereof |
| JP2769083B2 (ja) | 1993-02-22 | 1998-06-25 | 日清食品株式会社 | エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法 |
| TR199801794T2 (xx) | 1996-03-11 | 2000-07-21 | Bayer Corporation | �nsan bikunini. |
| DE19725014A1 (de) | 1997-06-13 | 1998-12-17 | Bayer Ag | Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten |
| WO2005095457A2 (en) * | 2004-03-30 | 2005-10-13 | Glaxo Group Limited | Immunoglobulins |
| BRPI0514259A (pt) * | 2004-08-11 | 2008-06-03 | Trubion Pharmaceuticals Inc | proteìna de fusão de domìnio de ligação |
| CN103665168A (zh) * | 2005-06-03 | 2014-03-26 | 持田制药株式会社 | 抗cd14抗体融合蛋白质 |
| EP1981519B1 (en) | 2005-12-29 | 2017-12-27 | Dyax Corp. | Protease inhibition |
| CA2737241C (en) * | 2008-09-26 | 2017-08-29 | Ucb Pharma S.A. | Multivalent antibody fusion proteins |
| CN102580085B (zh) * | 2008-10-13 | 2013-09-18 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗脓毒症药物中的应用 |
| CN101721699B (zh) * | 2008-10-13 | 2012-11-07 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备治疗伴随vegf升高的炎症反应的药物中的应用 |
| JP2012525847A (ja) * | 2009-05-05 | 2012-10-25 | アムジエン・インコーポレーテツド | Ｆｇｆ２１変異体およびその使用 |
| PT3053932T (pt) * | 2010-02-19 | 2020-10-21 | Xencor Inc | Novas imunoadesinas ctla4-ig |
| SI2704737T1 (en) * | 2011-04-29 | 2018-06-29 | University Of Washington | Therapeutic nuclease compositions and methods |
| US8619331B2 (en) | 2011-07-19 | 2013-12-31 | Xerox Corporation | Simulated paper texture using clear toner and glossmark on texture-less stock |
| JP6138815B2 (ja) * | 2011-12-01 | 2017-05-31 | エーピー バイオサイエンシーズ， インコーポレイテッド | 補体経路およびｖｅｇｆ経路に対するタンパク質インヒビターおよびそれらの使用方法 |
| BR112014026162A2 (pt) * | 2012-04-23 | 2017-10-03 | Nrl Pharma Inc | Proteína de fusão ou variante da mesma, molécula de ácido nucleico, vetor de expressão, célula hospedeira, animal não humano geneticamente modificado, planta geneticamente modificada, agente terapêutico para doenças melhoradas por lactoferrina, composição farmacêutica, e, método para preparar a proteína de fusão ou variante da mesma |
| CN103044554B (zh) | 2012-05-14 | 2014-08-27 | 旭华（上海）生物研发中心有限公司 | 重组二聚化人尿胰蛋白酶抑制剂、其制备方法及其应用 |
| JP2013253079A (ja) * | 2012-05-14 | 2013-12-19 | Xuhua (Shanghai) Biological Research & Development Center Co Ltd | 生物学的に活性なヒト尿中トリプシンインヒビターのＦｃ融合タンパク質並びにその調製および使用 |
| CR20160444A (es) * | 2014-02-24 | 2017-04-21 | Takeda Gmbh | Proteínas de fusión uti |
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2015
- 2015-02-23 CR CR20160444A patent/CR20160444A/es unknown
- 2015-02-23 NZ NZ724196A patent/NZ724196A/en unknown
- 2015-02-23 JP JP2016553562A patent/JP6574431B2/ja active Active
- 2015-02-23 LT LTEP15708411.2T patent/LT3110434T/lt unknown
- 2015-02-23 MY MYPI2016703046A patent/MY178774A/en unknown
- 2015-02-23 CA CA2939639A patent/CA2939639C/en active Active
- 2015-02-23 RS RS20181514A patent/RS58285B1/sr unknown
- 2015-02-23 SM SM20180674T patent/SMT201800674T1/it unknown
- 2015-02-23 SI SI201530516T patent/SI3110434T1/sl unknown
- 2015-02-23 CN CN201580014645.3A patent/CN106232135B/zh active Active
- 2015-02-23 KR KR1020167026429A patent/KR102461210B1/ko active Active
- 2015-02-23 EP EP18192690.8A patent/EP3443978A1/en not_active Withdrawn
- 2015-02-23 MX MX2020000537A patent/MX384070B/es unknown
- 2015-02-23 MX MX2016010950A patent/MX2016010950A/es active IP Right Grant
- 2015-02-23 HR HRP20182029TT patent/HRP20182029T1/hr unknown
- 2015-02-23 EP EP15708411.2A patent/EP3110434B1/en active Active
- 2015-02-23 EA EA202091567A patent/EA202091567A1/ru unknown
- 2015-02-23 MA MA39347A patent/MA39347B2/fr unknown
- 2015-02-23 SG SG11201606691QA patent/SG11201606691QA/en unknown
- 2015-02-23 SG SG10201708400QA patent/SG10201708400QA/en unknown
- 2015-02-23 PH PH1/2016/501629A patent/PH12016501629B1/en unknown
- 2015-02-23 CA CA3178241A patent/CA3178241A1/en active Pending
- 2015-02-23 PT PT15708411T patent/PT3110434T/pt unknown
- 2015-02-23 PL PL15708411T patent/PL3110434T3/pl unknown
- 2015-02-23 PE PE2016001522A patent/PE20170257A1/es unknown
- 2015-02-23 AU AU2015218704A patent/AU2015218704B2/en active Active
- 2015-02-23 KR KR1020247035230A patent/KR20240155987A/ko active Pending
- 2015-02-23 BR BR112016019390-3A patent/BR112016019390B1/pt active IP Right Grant
- 2015-02-23 EA EA201691702A patent/EA037256B1/ru unknown
- 2015-02-23 NZ NZ760008A patent/NZ760008A/en unknown
- 2015-02-23 UA UAA201609101A patent/UA118866C2/uk unknown
- 2015-02-23 CN CN201910282497.3A patent/CN110092837B/zh active Active
- 2015-02-23 DK DK15708411.2T patent/DK3110434T3/en active
- 2015-02-23 WO PCT/US2015/017152 patent/WO2015127391A1/en not_active Ceased
- 2015-02-23 ES ES15708411T patent/ES2700149T3/es active Active
- 2015-02-23 US US15/120,956 patent/US9856310B2/en active Active
- 2015-02-23 NZ NZ760789A patent/NZ760789A/en unknown
- 2015-02-23 KR KR1020227037377A patent/KR102722304B1/ko active Active
- 2015-02-23 GE GEAP201514277A patent/GEP20196970B/en unknown
- 2015-08-20 AR ARP150102677A patent/AR101597A1/es unknown
- 2015-08-20 JO JOP/2015/0200A patent/JO3729B1/ar active
- 2015-08-21 TW TW104127393A patent/TWI694084B/zh active
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2016
- 2016-08-10 DO DO2016000202A patent/DOP2016000202A/es unknown
- 2016-08-17 IL IL247321A patent/IL247321B/en active IP Right Grant
- 2016-08-23 MX MX2019013124A patent/MX2019013124A/es unknown
- 2016-08-23 MX MX2024000004A patent/MX2024000004A/es unknown
- 2016-08-24 CL CL2016002136A patent/CL2016002136A1/es unknown
- 2016-09-13 ZA ZA2016/06327A patent/ZA201606327B/en unknown
- 2016-09-23 EC ECIEPI201676535A patent/ECSP16076535A/es unknown
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2017
- 2017-11-27 US US15/823,398 patent/US10351618B2/en active Active
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2018
- 2018-12-18 CY CY181101355T patent/CY1120997T1/el unknown
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2019
- 2019-02-15 US US16/277,606 patent/US20200040062A1/en not_active Abandoned
- 2019-06-11 JP JP2019109054A patent/JP6938565B2/ja active Active
- 2019-06-25 AU AU2019204448A patent/AU2019204448B2/en active Active
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2021
- 2021-06-03 US US17/337,922 patent/US20220127334A1/en not_active Abandoned
- 2021-08-31 AU AU2021225156A patent/AU2021225156B2/en active Active
- 2021-09-01 JP JP2021142544A patent/JP2022002513A/ja active Pending
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2023
- 2023-02-16 AU AU2023200875A patent/AU2023200875A1/en not_active Abandoned
- 2023-06-30 JP JP2023108024A patent/JP2023123763A/ja active Pending