|
GB1524747A
(en)
|
1976-05-11 |
1978-09-13 |
Ici Ltd |
Polypeptide
|
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
|
ATE28864T1
(de)
|
1982-07-23 |
1987-08-15 |
Ici Plc |
Amide-derivate.
|
|
GB8327256D0
(en)
|
1983-10-12 |
1983-11-16 |
Ici Plc |
Steroid derivatives
|
|
US5093330A
(en)
|
1987-06-15 |
1992-03-03 |
Ciba-Geigy Corporation |
Staurosporine derivatives substituted at methylamino nitrogen
|
|
US5010099A
(en)
|
1989-08-11 |
1991-04-23 |
Harbor Branch Oceanographic Institution, Inc. |
Discodermolide compounds, compositions containing same and method of preparation and use
|
|
NZ243082A
(en)
|
1991-06-28 |
1995-02-24 |
Ici Plc |
4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
|
|
GB9127376D0
(en)
|
1991-12-24 |
1992-02-19 |
Wellcome Found |
Amidino derivatives
|
|
GB9300059D0
(en)
|
1992-01-20 |
1993-03-03 |
Zeneca Ltd |
Quinazoline derivatives
|
|
EP0633776B1
(en)
|
1992-04-02 |
2001-05-09 |
Smithkline Beecham Corporation |
Compounds useful for treating allergic and inflammatory diseases
|
|
TW225528B
(enExample)
|
1992-04-03 |
1994-06-21 |
Ciba Geigy Ag |
|
|
GB9314893D0
(en)
|
1993-07-19 |
1993-09-01 |
Zeneca Ltd |
Quinazoline derivatives
|
|
DK0765308T3
(da)
|
1994-06-15 |
2000-09-11 |
Wellcome Found |
Enzyminhibitorer
|
|
EP2295415A1
(en)
|
1995-03-30 |
2011-03-16 |
OSI Pharmaceuticals, Inc. |
Quinazoline derivatives
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5843901A
(en)
|
1995-06-07 |
1998-12-01 |
Advanced Research & Technology Institute |
LHRH antagonist peptides
|
|
CZ1598A3
(cs)
|
1995-07-06 |
1998-04-15 |
Novartis Ag |
Pyrrolopyrimidiny a způsoby jejich přípravy
|
|
US5760041A
(en)
|
1996-02-05 |
1998-06-02 |
American Cyanamid Company |
4-aminoquinazoline EGFR Inhibitors
|
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
|
GEP20012442B
(en)
|
1996-04-12 |
2001-05-25 |
Warner Lambert Co |
Irreversible Inhibitors of Tyrosine Kinases
|
|
CA2258548C
(en)
|
1996-06-24 |
2005-07-26 |
Pfizer Inc. |
Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
|
|
AU716610B2
(en)
|
1996-08-30 |
2000-03-02 |
Novartis Ag |
Method for producing epothilones, and intermediate products obtained during the production process
|
|
DE69724269T2
(de)
|
1996-09-06 |
2004-06-09 |
Obducat Ab |
Verfahren für das anisotrope ätzen von strukturen in leitende materialien
|
|
CA2265630A1
(en)
|
1996-09-13 |
1998-03-19 |
Gerald Mcmahon |
Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
|
|
EP0837063A1
(en)
|
1996-10-17 |
1998-04-22 |
Pfizer Inc. |
4-Aminoquinazoline derivatives
|
|
CN1196698C
(zh)
|
1996-11-18 |
2005-04-13 |
生物技术研究有限公司(Gbf) |
Epothilone D、E和F,其制备方法,以及作为细胞抑制剂和植物保护剂的应用
|
|
US6441186B1
(en)
|
1996-12-13 |
2002-08-27 |
The Scripps Research Institute |
Epothilone analogs
|
|
MY117948A
(en)
|
1997-01-13 |
2004-08-30 |
Glaxo Group Ltd |
Nitride oxide synthase inhibitors.
|
|
DE19723722A1
(de)
|
1997-05-30 |
1998-12-10 |
Schering Ag |
Nichtsteroidale Gestagene
|
|
CO4940418A1
(es)
|
1997-07-18 |
2000-07-24 |
Novartis Ag |
Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
|
|
GB9721069D0
(en)
|
1997-10-03 |
1997-12-03 |
Pharmacia & Upjohn Spa |
Polymeric derivatives of camptothecin
|
|
US6350458B1
(en)
|
1998-02-10 |
2002-02-26 |
Generex Pharmaceuticals Incorporated |
Mixed micellar drug deliver system and method of preparation
|
|
US6506766B1
(en)
|
1998-02-13 |
2003-01-14 |
Abbott Laboratories |
Glucocortiocoid-selective antinflammatory agents
|
|
US6194181B1
(en)
|
1998-02-19 |
2001-02-27 |
Novartis Ag |
Fermentative preparation process for and crystal forms of cytostatics
|
|
EP1058679B1
(en)
|
1998-02-25 |
2005-10-19 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues therof
|
|
GB9811599D0
(en)
|
1998-05-30 |
1998-07-29 |
Glaxo Group Ltd |
Nitric oxide synthase inhibitors
|
|
BR9912938B1
(pt)
|
1998-08-11 |
2011-06-28 |
|
derivados de isoquinolina, composição que os compreende, processo para preparação e uso dos mesmos.
|
|
WO2000031247A2
(en)
|
1998-11-20 |
2000-06-02 |
Kosan Biosciences, Inc. |
Recombinant methods and materials for producing epothilone and epothilone derivatives
|
|
EP1175422A2
(en)
|
1999-05-04 |
2002-01-30 |
Ligand Pharmaceuticals Incorporated |
Tetracyclic progesterone receptor modulator compounds and methods
|
|
ES2165768B1
(es)
|
1999-07-14 |
2003-04-01 |
Almirall Prodesfarma Sa |
Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
CO5180649A1
(es)
|
1999-09-01 |
2002-07-30 |
Abbott Lab |
Antagonistas de los receptores de los glucocorticoides para el tratamiento de la diabetes para el tratamiento de la diabetes
|
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
|
BR0114323A
(pt)
|
2000-09-29 |
2003-07-01 |
Glaxo Group Ltd |
Composto ou um seu sal ou solvato farmaceuticamente aceitável, composição farmacêutica, uso do composto ou de um seu sal ou solvato farmaceuticamente aceitável, método de tratamento ou profilaxia de doenças inflamatórias, e, processo para preparar o composto
|
|
BRPI0115193B1
(pt)
|
2000-11-07 |
2016-08-09 |
Novartis Ag |
derivados de indolilmaleimida, processo para preparação dos mesmos, bem como composição farmacêutica que os compreende
|
|
GB0031179D0
(en)
|
2000-12-21 |
2001-01-31 |
Glaxo Group Ltd |
Nitric oxide synthase inhibitors
|
|
MXPA03005609A
(es)
*
|
2000-12-21 |
2003-10-06 |
Vertex Pharma |
Compuestos de pirazol utiles como inhibidores de la proteina cinasa.
|
|
US6484903B2
(en)
|
2001-01-09 |
2002-11-26 |
Riverwood International Corporation |
Carton with an improved dispensing feature in combination with a unique handle
|
|
AR035885A1
(es)
|
2001-05-14 |
2004-07-21 |
Novartis Ag |
Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
|
|
GB0119249D0
(en)
|
2001-08-07 |
2001-10-03 |
Novartis Ag |
Organic compounds
|
|
WO2003030909A1
(en)
|
2001-09-25 |
2003-04-17 |
Bayer Pharmaceuticals Corporation |
2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
|
|
UY27487A1
(es)
*
|
2001-10-17 |
2003-05-30 |
Boehringer Ingelheim Pharma |
Derivados de pirimidina, medicamentos que contienen estos compuestos, su empleo y procedimiento para su preparación
|
|
DE60309829T2
(de)
|
2002-01-14 |
2007-09-13 |
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield |
Glucocorticoidmimetika, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische formulierungen und ihre verwendungen
|
|
US6831093B2
(en)
|
2002-01-22 |
2004-12-14 |
The Regents Of The University Of California |
Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof
|
|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
JP2005521717A
(ja)
|
2002-03-26 |
2005-07-21 |
ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド |
グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用
|
|
KR101022977B1
(ko)
|
2002-03-26 |
2011-03-18 |
베링거 인겔하임 파마슈티칼즈, 인코포레이티드 |
글루코코르티코이드 모사체, 이의 제조방법, 약제학적조성물 및 이의 용도
|
|
DE10215316C1
(de)
|
2002-04-02 |
2003-12-18 |
Schering Ag |
Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
|
|
PE20040079A1
(es)
|
2002-04-03 |
2004-04-19 |
Novartis Ag |
Derivados de indolilmaleimida
|
|
US7282591B2
(en)
|
2002-04-11 |
2007-10-16 |
Merck & Co., Inc. |
1h-benzo{f}indazol-5-yl derivatives as selective glucocorticoid receptor modulators
|
|
US7186864B2
(en)
|
2002-05-29 |
2007-03-06 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
US7074806B2
(en)
|
2002-06-06 |
2006-07-11 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
EP1521733B1
(en)
|
2002-07-08 |
2014-08-20 |
Pfizer Products Inc. |
Modulators of the glucocorticoid receptor
|
|
PL375442A1
(en)
|
2002-07-18 |
2005-11-28 |
Bristol-Myers Squibb Company |
Modulators of the glucocorticoid receptor and method
|
|
AU2003259747A1
(en)
|
2002-08-21 |
2004-03-11 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
|
|
CA2499150A1
(en)
|
2002-09-20 |
2004-04-01 |
Merck & Co., Inc. |
Octahydro-2-h-naphtho[1,2-f] indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators
|
|
GB0224084D0
(en)
|
2002-10-16 |
2002-11-27 |
Glaxo Group Ltd |
Novel compounds
|
|
US20050014753A1
(en)
*
|
2003-04-04 |
2005-01-20 |
Irm Llc |
Novel compounds and compositions as protein kinase inhibitors
|
|
RS53109B
(sr)
|
2003-07-30 |
2014-06-30 |
Rigel Pharmaceuticals Inc. |
Jedinjenja 2,4 pirimidindiamina za upotrebu u tretmanu ili prevenciji autoimunih bolesti
|
|
EP1763514A2
(en)
|
2004-05-18 |
2007-03-21 |
Rigel Pharmaceuticals, Inc. |
Cycloalkyl substituted pyrimidinediamine compounds and their uses
|
|
WO2006000401A1
(en)
|
2004-06-28 |
2006-01-05 |
Glaxo Group Limited |
Substituted oxazines as glucocorticoid receptor modulators
|
|
WO2006000398A1
(en)
|
2004-06-28 |
2006-01-05 |
Glaxo Group Limited |
2,3-benzoxazin derivatives as non-steroidal glucocorticoid receptor modulators
|
|
GB0418045D0
(en)
|
2004-08-12 |
2004-09-15 |
Glaxo Group Ltd |
Compounds
|
|
ES2367515T3
(es)
|
2004-10-19 |
2011-11-04 |
F. Hoffmann-La Roche Ag |
Derivados de quinolina.
|
|
GB2420559B
(en)
|
2004-11-15 |
2008-08-06 |
Rigel Pharmaceuticals Inc |
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
|
|
JP2008525422A
(ja)
*
|
2004-12-23 |
2008-07-17 |
ファイザー・プロダクツ・インク |
抗癌剤として有用な複素芳香族誘導体
|
|
AU2005322855B2
(en)
|
2004-12-30 |
2012-09-20 |
Exelixis, Inc. |
Pyrimidine derivatives as kinase modulators and method of use
|
|
WO2008045978A1
(en)
|
2006-10-10 |
2008-04-17 |
Rigel Pharmaceuticals, Inc. |
Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors
|
|
GEP20125691B
(en)
|
2006-12-08 |
2012-11-26 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
US7947698B2
(en)
|
2007-03-23 |
2011-05-24 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
CN101903357A
(zh)
|
2007-07-17 |
2010-12-01 |
里格尔药品股份有限公司 |
作为pkc抑制剂的环状胺取代的嘧啶二胺
|
|
CA2710118A1
(en)
*
|
2007-12-20 |
2009-07-02 |
Cellzome Limited |
Sulfamides as zap-70 inhibitors
|
|
US8138339B2
(en)
|
2008-04-16 |
2012-03-20 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
CA2723205C
(en)
*
|
2008-04-16 |
2017-03-14 |
Portola Pharmaceuticals, Inc. |
2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinase inhibitors
|
|
AU2009244897B2
(en)
|
2008-04-16 |
2014-11-13 |
Alexion Pharmaceuticals, Inc. |
2, 6-diamino- pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors
|
|
WO2009131687A2
(en)
*
|
2008-04-22 |
2009-10-29 |
Portola Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
BRPI0914682B8
(pt)
|
2008-06-27 |
2021-05-25 |
Avila Therapeutics Inc |
compostos de heteroarila e composições compreendendo os referidos compostos
|
|
AR072937A1
(es)
|
2008-08-20 |
2010-09-29 |
Schering Corp |
Derivados de piridina y pirimidina sustituida y su uso en el tratamiento de infecciones virales
|
|
ES2618889T3
(es)
|
2009-01-14 |
2017-06-22 |
Rigel Pharmaceuticals, Inc. |
Compuestos de 2,4-pirimidindiamina para el tratamiento de trastornos inflamatorios
|
|
EP2389373B1
(en)
|
2009-01-21 |
2017-05-17 |
Rigel Pharmaceuticals, Inc. |
Derivatives of n2-(3-pyridyl or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases
|
|
EP2411012A4
(en)
|
2009-03-24 |
2012-08-22 |
Msd Kk |
NEW AMINO-PYRIDINE DERIVATIVES WITH SELECTIVE AURORA A INHIBITION
|
|
US9908884B2
(en)
|
2009-05-05 |
2018-03-06 |
Dana-Farber Cancer Institute, Inc. |
EGFR inhibitors and methods of treating disorders
|
|
EP2440548A1
(en)
|
2009-06-10 |
2012-04-18 |
Abbott Laboratories |
2- ( lh-pyrazol-4 -ylamino ) -pyrimidine as kinase inhibitors
|
|
WO2011068898A1
(en)
|
2009-12-01 |
2011-06-09 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
US8710223B2
(en)
|
2010-07-21 |
2014-04-29 |
Rigel Pharmaceuticals, Inc. |
Protein kinase C inhibitors and uses thereof
|
|
WO2012059932A1
(en)
*
|
2010-11-01 |
2012-05-10 |
Aurigene Discovery Technologies Limited |
2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors
|
|
PT3124483T
(pt)
*
|
2010-11-10 |
2019-10-02 |
Genentech Inc |
Derivados de pirazol aminopirimidina como moduladores de lrrk2
|
|
CA2860095A1
(en)
|
2011-12-23 |
2013-06-27 |
Cellzome Limited |
Pyrimidine-2,4-diamine derivatives as kinase inhibitors
|
|
EP2836486B1
(en)
*
|
2012-02-17 |
2017-10-04 |
AbbVie Inc. |
Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv)
|
|
JP6113828B2
(ja)
|
2012-04-04 |
2017-04-12 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
プロテインキナーゼc阻害剤およびその使用
|
|
CA2871375C
(en)
*
|
2012-05-03 |
2020-10-27 |
F. Hoffmann-La Roche Ag |
Pyrazole aminopyrimidine derivatives as lrrk2 modulators for use in the treatment of parkinson's disease
|
|
WO2014040555A1
(zh)
|
2012-09-12 |
2014-03-20 |
山东亨利医药科技有限责任公司 |
作为酪氨酸激酶抑制剂的含氮杂芳环衍生物
|
|
EP2903617B1
(en)
|
2012-10-08 |
2019-01-30 |
Merck Sharp & Dohme Corp. |
Inhibitors of irak4 activity
|
|
MX2015006152A
(es)
|
2012-11-20 |
2016-01-20 |
Genentech Inc |
Compuestos de aminopirimidina como inhibidores de mutantes de egfr que contienen t7 9 0m.
|
|
EP2970275B1
(en)
|
2013-03-14 |
2018-05-09 |
Rigel Pharmaceuticals, Inc. |
Protein kinase c inhibitors and uses thereof
|
|
WO2015039613A1
(zh)
|
2013-09-18 |
2015-03-26 |
北京韩美药品有限公司 |
抑制btk和/或jak3激酶活性的化合物
|
|
US9403801B2
(en)
*
|
2014-03-28 |
2016-08-02 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|