JP2004530649A5 - - Google Patents

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Publication number
JP2004530649A5
JP2004530649A5 JP2002562710A JP2002562710A JP2004530649A5 JP 2004530649 A5 JP2004530649 A5 JP 2004530649A5 JP 2002562710 A JP2002562710 A JP 2002562710A JP 2002562710 A JP2002562710 A JP 2002562710A JP 2004530649 A5 JP2004530649 A5 JP 2004530649A5
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JP
Japan
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compound
prodrug
pharmaceutically acceptable
stereoisomer
solvate
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JP2002562710A
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English (en)
Japanese (ja)
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JP4330341B2 (ja
JP2004530649A (ja
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Priority claimed from PCT/US2002/003672 external-priority patent/WO2002062750A1/en
Publication of JP2004530649A publication Critical patent/JP2004530649A/ja
Publication of JP2004530649A5 publication Critical patent/JP2004530649A5/ja
Application granted granted Critical
Publication of JP4330341B2 publication Critical patent/JP4330341B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002562710A 2001-02-08 2002-02-07 カンナビノイドレセプターリガンド Expired - Fee Related JP4330341B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26737501P 2001-02-08 2001-02-08
US29260001P 2001-05-22 2001-05-22
PCT/US2002/003672 WO2002062750A1 (en) 2001-02-08 2002-02-07 Cannabinoid receptor ligands

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008186568A Division JP2009024011A (ja) 2001-02-08 2008-07-17 カンナビノイドレセプターリガンド

Publications (3)

Publication Number Publication Date
JP2004530649A JP2004530649A (ja) 2004-10-07
JP2004530649A5 true JP2004530649A5 (enExample) 2005-12-22
JP4330341B2 JP4330341B2 (ja) 2009-09-16

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002562710A Expired - Fee Related JP4330341B2 (ja) 2001-02-08 2002-02-07 カンナビノイドレセプターリガンド
JP2008186568A Withdrawn JP2009024011A (ja) 2001-02-08 2008-07-17 カンナビノイドレセプターリガンド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008186568A Withdrawn JP2009024011A (ja) 2001-02-08 2008-07-17 カンナビノイドレセプターリガンド

Country Status (21)

Country Link
US (2) US7507767B2 (enExample)
EP (1) EP1368308A1 (enExample)
JP (2) JP4330341B2 (enExample)
KR (1) KR20030075175A (enExample)
CN (1) CN1285572C (enExample)
AR (1) AR032569A1 (enExample)
AU (1) AU2002306450B2 (enExample)
BR (1) BR0206955A (enExample)
CA (1) CA2436659C (enExample)
CZ (1) CZ20032122A3 (enExample)
HU (1) HUP0304060A3 (enExample)
IL (1) IL156829A0 (enExample)
MX (1) MXPA03007078A (enExample)
NO (1) NO20033505L (enExample)
NZ (1) NZ526782A (enExample)
PE (1) PE20020851A1 (enExample)
PL (1) PL364624A1 (enExample)
RU (1) RU2003127368A (enExample)
SK (1) SK9952003A3 (enExample)
WO (1) WO2002062750A1 (enExample)
ZA (1) ZA200305933B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067539B2 (en) * 2001-02-08 2006-06-27 Schering Corporation Cannabinoid receptor ligands
US7868204B2 (en) * 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
US6897220B2 (en) * 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
JP3795044B2 (ja) * 2001-09-14 2006-07-12 メシルジーン、インコーポレイテッド ヒストンデアセチラーゼの阻害剤
CN101684091A (zh) 2001-11-14 2010-03-31 先灵公司 类大麻苷受体配体
WO2003061699A1 (en) * 2001-12-27 2003-07-31 Japan Tobacco, Inc. Remedies for allergic diseases
AU2003217961B2 (en) 2002-03-08 2008-02-28 Signal Pharmaceuticals, Llc Combination therapy for treating, preventing or managing proliferative disorders and cancers
MXPA04012704A (es) 2002-06-19 2005-03-23 Schering Corp Agonistas de los receptores canabinoides.
UY27939A1 (es) 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
SI2208727T1 (sl) * 2002-09-19 2012-11-30 Lilly Co Eli Diaril etri kot antagonisti opioidnega receptorja
GB0222493D0 (en) * 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
GB0222495D0 (en) * 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
EP1562905A2 (en) * 2002-10-24 2005-08-17 MERCK PATENT GmbH Methylene urea derivatives as raf-kinase inhibitors
MXPA05005512A (es) 2002-11-25 2005-07-25 Schering Corp Ligandos receptores canabinoides.
US20060172019A1 (en) * 2003-03-07 2006-08-03 Ralston Stuart H Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
US6916852B2 (en) * 2003-05-12 2005-07-12 University Of Tennessee Research Foundation Method for regulation of microvascular tone
US7169942B2 (en) * 2003-05-20 2007-01-30 University Of Tennessee Research Foundation Cannabinoid derivatives, methods of making, and use thereof
WO2005030704A1 (en) * 2003-09-24 2005-04-07 Methylgene, Inc. Inhibitors of histone deacetylase
US7320805B2 (en) * 2003-10-01 2008-01-22 Institut National De La Sante Et De La Recherche Medicale CB2 receptors blocks accumulation of human hepatic myofibroblasts: a novel artifibrogenic pathway in the liver
AU2004287849A1 (en) * 2003-10-30 2005-05-19 Merck Sharp & Dohme Corp. Aralkyl amines as cannabinoid receptor modulators
GB0402355D0 (en) * 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds
GB0402357D0 (en) * 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds
US7253204B2 (en) * 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
EP1797035B1 (en) 2004-09-30 2010-11-17 Merck Sharp & Dohme Corp. Cyclopropyl piperidine glycine transporter inhibitors
CA2632030A1 (en) * 2005-12-15 2007-06-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2007118137A1 (en) * 2006-04-07 2007-10-18 Methylgene Inc. Benzamide derivatives as inhibitors of histone deacetylase
CA2657247A1 (en) 2006-07-28 2008-01-31 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
CN101511808A (zh) * 2006-09-08 2009-08-19 辉瑞产品公司 二芳基醚衍生物及其用途
WO2008039645A1 (en) 2006-09-25 2008-04-03 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
GB0702862D0 (en) * 2007-02-14 2007-03-28 Univ Aberdeen Therapeutic compounds
KR20110063485A (ko) 2008-09-25 2011-06-10 베링거 인겔하임 인터내셔날 게엠베하 Ｃｂ2 수용체를 선택적으로 조절하는 설포닐 화합물
CN102573473B (zh) 2009-06-09 2015-05-27 加利福尼亚资本权益有限责任公司 用作hedgehog 信号转导抑制剂的异喹啉、喹啉和喹唑啉衍生物
KR101457027B1 (ko) 2009-06-09 2014-10-31 캘리포니아 캐피탈 에쿼티, 엘엘씨 트리아진 유도체와 이들의 치료적 용도
JP2012529517A (ja) 2009-06-09 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー ベンジル置換トリアジン誘導体類及びそれらの治療応用
WO2011088015A1 (en) 2010-01-15 2011-07-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
US8846936B2 (en) 2010-07-22 2014-09-30 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the CB2 receptor
US20120309820A1 (en) * 2011-06-04 2012-12-06 Jb Therapeutics Inc. Methods of treating fibrotic diseases using tetrahydrocannabinol-11-oic acids
TW201329025A (zh) 2011-11-01 2013-07-16 Astex Therapeutics Ltd 醫藥化合物
KR101599300B1 (ko) 2012-03-14 2016-03-03 시노켐 코포레이션 치환 디페닐아민 화합물 및 항종양제로서의 용도
KR20160002709A (ko) 2013-02-12 2016-01-08 코버스 파마수티컬스, 아이엔씨. 초고순도 테트라하이드로카나비놀-11-오익산
TW201512171A (zh) 2013-04-19 2015-04-01 Pfizer Ltd 化學化合物
CN103265480B (zh) * 2013-05-11 2015-10-07 浙江大学 喹啉二酮类衍生物及其制备方法和用途
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
US9636298B2 (en) 2014-01-17 2017-05-02 Methylgene Inc. Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs
US9763992B2 (en) 2014-02-13 2017-09-19 Father Flanagan's Boys' Home Treatment of noise induced hearing loss
MX389591B (es) 2014-08-29 2025-03-20 Tes Pharma S R L INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA
CN108752375A (zh) * 2018-07-17 2018-11-06 成都睿智化学研究有限公司 一种4-溴甲基-2-三甲基硅乙炔基苯-1-磺酰氟的制备方法
WO2020263975A1 (en) 2019-06-24 2020-12-30 Diverse Biotech, Inc. Beta-lactam-cannabinoid conjugate molecules
CN112552200B (zh) * 2019-09-10 2024-03-12 烟台药物研究所 一种光学纯4-(1-氨基)乙基苯甲酸酯及其盐的制备方法

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3715375A (en) * 1970-09-17 1973-02-06 Merck & Co Inc New diphenyl sulfones
US3712888A (en) * 1970-12-14 1973-01-23 American Cyanamid Co Bis-pyridoxazole-stilbene derivatives for optical brightening
US4170648A (en) * 1972-05-26 1979-10-09 Rohm And Haas Company Phosphonothioureide anthelmintics
DE3039208A1 (de) 1980-10-17 1982-05-13 Basf Ag, 6700 Ludwigshafen Neue sulfone, deren herstellung und verwendung
DE3118126A1 (de) 1981-05-07 1982-12-02 Bayer Ag, 5090 Leverkusen Sulfenamide zur verwendung in arzneimitteln
US4618363A (en) 1982-01-25 1986-10-21 Ciba-Geigy Corporation N-phenylsulfonyl-N'-triazinylureas
US4468389A (en) * 1982-05-21 1984-08-28 Rohm And Haas Company Pesticidal N-sulfonyl phosphorodiamido(di)thioates
US4466965A (en) * 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use
US4468965A (en) * 1982-11-05 1984-09-04 Union Carbide Corporation Test method for acetylene cylinders
US4567184A (en) * 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
NZ213986A (en) 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4764889A (en) 1984-12-19 1988-08-16 American Telephone And Telegraph Company, At&T Bell Laboratories Optical logic arrangement with self electro-optic effect devices
US4781866A (en) * 1985-03-15 1988-11-01 Mcneilab, Inc. Process for producing amidine sulfonic acid intermediates for guanidines
US4678855A (en) 1985-10-09 1987-07-07 Merck & Co., Inc. Substituted benzenesulfonamides
HU201448B (en) 1986-03-31 1990-11-28 Rhone Poulenc Bv Plant growth reducing compositions comprising malonic acid derivatives and process for producing new malonic acid derivatives
SK219587A3 (en) 1986-03-31 1997-06-04 Rhone Poulenc Bv Agent for plants growth control
DE3634927A1 (de) 1986-10-14 1988-04-21 Bayer Ag Verfahren zur herstellung von sulfonylisothioharnstoffen
DE3634926A1 (de) 1986-10-14 1988-04-21 Bayer Ag Verfahren zur herstellung von o-aryl-n'-pyrimidin-2-yl-isoharnstoffen
US4851423A (en) 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
CA1293516C (en) 1987-02-10 1991-12-24 Izumi Fujimoto Benzoylurea derivative and its production and use
NZ232493A (en) 1989-02-14 1992-06-25 Toyama Chemical Co Ltd Aryl- or heterocyclyl-substituted 1,2-ethanediol derivatives and pharmaceutical compositions
US5064825A (en) 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
IE902465A1 (en) 1989-07-07 1991-02-13 Schering Corp Pharmaceutically active compounds
IT1240676B (it) 1990-04-24 1993-12-17 Agrimont Spa Composizioni ad attivita' erbicida
NZ239846A (en) 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
PT100639A (pt) 1991-06-27 1993-09-30 Univ Virginia Commonwealth Metodo para o tratamento terapeutico com compostos que sao ligandos ao receptor sigma e compostos ai utilizados, nomeadamente derivados fenilalquil-amina, aminotetralina,piperazina e piperidina
US5506227A (en) 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
US5338753A (en) * 1992-07-14 1994-08-16 Sumner H. Burstein (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
GB9218834D0 (en) 1992-09-05 1992-10-21 Procter & Gamble Nasal spray products
AU7100394A (en) 1993-06-17 1995-01-17 Dunlena Pty. Limited Arthropodicidal sulfonates
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
FR2714057B1 (fr) * 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
DK0754672T3 (da) 1994-04-06 2000-11-13 Shionogi & Co Gamma-Substitueret phenyleddikesyrederivat, fremgangsmåde til fremstilling deraf og landbrugsfungicid indeholdende samme
IT1271266B (it) * 1994-12-14 1997-05-27 Valle Francesco Della Impiego terapeutico di ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi
BR9607016A (pt) 1995-02-02 1997-10-28 Smithkline Beecham Plc Derivados de indol como antagonísta de receptor 5-ht
US5532237A (en) * 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
FR2735774B1 (fr) * 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
ATE196629T1 (de) 1995-07-21 2000-10-15 Nycomed Austria Gmbh Derivate von benzosulfonamiden als hemmer des enzym cyclooxygenase ii
DE19533644A1 (de) 1995-09-12 1997-03-13 Nycomed Arzneimittel Gmbh Neue Benzolsulfonamide
FR2742148B1 (fr) * 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
AU1618697A (en) * 1996-02-06 1997-08-28 Japan Tobacco Inc. Novel compounds and pharmaceutical use thereof
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
JP2001500864A (ja) 1996-09-13 2001-01-23 メルク エンド カンパニー インコーポレーテッド トロンビン阻害物質
JP3426890B2 (ja) 1996-12-25 2003-07-14 アルプス電気株式会社 入力ペン
JP2001508799A (ja) 1997-01-21 2001-07-03 スミスクライン・ビーチャム・コーポレイション 新規カンナビノイド受容体モジュレータ
ATA16597A (de) 1997-02-03 1998-04-15 Nycomed Austria Gmbh Neue substituierte p-sulfonylaminobenzol- sulfonsäureamide
DE19740785A1 (de) 1997-02-21 1998-08-27 Bayer Ag Arylsulfonamide und Analoga
HU228509B1 (en) 1997-02-21 2013-03-28 Bayer Ip Gmbh Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases
CA2283797A1 (en) 1997-03-18 1998-09-24 Paul Elliot Bender Novel cannabinoid receptor agonists
WO1999021851A1 (en) 1997-10-24 1999-05-06 Nissan Chemical Industries, Ltd. Sulfamoyl compounds and agricultural or horticultural bactericide
WO1999026612A1 (en) 1997-11-21 1999-06-03 Smithkline Beecham Corporation Novel cannabinoid receptor modulators
CN1142909C (zh) 1998-03-26 2004-03-24 盐野义制药株式会社 具有抗病毒活性的吲哚衍生物
JP2002521436A (ja) 1998-07-28 2002-07-16 スミスクライン・ビーチャム・コーポレイション 置換アニリド化合物および方法
JP2000143650A (ja) 1998-11-13 2000-05-26 Takeda Chem Ind Ltd 新規チアゾリジン誘導体、その製造法および用途
WO2000056707A1 (en) 1999-03-24 2000-09-28 Sepracor, Inc. Diaryl thioethers, compositions and uses thereof
JP4618845B2 (ja) 1999-06-09 2011-01-26 杏林製薬株式会社 ヒトペルオキシゾーム増殖薬活性化受容体（ＰＰＡＲ）αアゴニストとしての置換フェニルプロピオン酸誘導体
KR100700304B1 (ko) * 1999-08-23 2007-03-29 교린 세이야꾸 가부시키 가이샤 치환된 벤질티아졸리딘-2,4-디온 유도체
DE60038687T2 (de) 1999-09-14 2009-05-28 Shionogi & Co., Ltd. 2-imino-1,3-thiazin-derivate
MXPA02005101A (es) 1999-10-18 2003-09-25 Alexipharma Inc Derivados de indol canabimimeticos.
ES2311479T3 (es) 1999-11-26 2009-02-16 SHIONOGI & CO., LTD. Antagonistas de npy-y5.
WO2001044172A1 (en) 1999-12-15 2001-06-21 Axys Pharmaceuticals, Inc. Salicylamides as serine protease and factor xa inhibitors
WO2001044239A2 (en) 1999-12-15 2001-06-21 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
EP1257157B1 (en) 1999-12-31 2004-11-24 Lear Automotive (EEDS) Spain, S.L. Method for manufacturing printed circuit boards
AU2001250783A1 (en) 2000-02-29 2001-09-12 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
JP2003528106A (ja) 2000-03-22 2003-09-24 メルク フロスト カナダ アンド カンパニー Ｐｔｐ−１ｂ阻害薬としての硫黄置換アリールジフルオロメチルホスホン酸類
AU2001253147A1 (en) 2000-04-03 2001-10-15 Phycogen, Inc. Generation of combinatorial synthetic libraries and screening for proadhesins and nonadhesins
WO2001087293A1 (en) 2000-05-19 2001-11-22 Takeda Chemical Industries, Ltd. -secretase inhibitors
GB0028702D0 (en) 2000-11-24 2001-01-10 Novartis Ag Organic compounds
US7067539B2 (en) * 2001-02-08 2006-06-27 Schering Corporation Cannabinoid receptor ligands
CN101684091A (zh) 2001-11-14 2010-03-31 先灵公司 类大麻苷受体配体

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