JP2017507229A5 - - Google Patents
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- Publication number
- JP2017507229A5 JP2017507229A5 JP2016567120A JP2016567120A JP2017507229A5 JP 2017507229 A5 JP2017507229 A5 JP 2017507229A5 JP 2016567120 A JP2016567120 A JP 2016567120A JP 2016567120 A JP2016567120 A JP 2016567120A JP 2017507229 A5 JP2017507229 A5 JP 2017507229A5
- Authority
- JP
- Japan
- Prior art keywords
- molecular weight
- plla
- lactic acid
- weight poly
- high molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001432 poly(L-lactide) Polymers 0.000 claims description 8
- 239000003054 catalyst Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000001308 synthesis method Methods 0.000 claims description 6
- 239000012190 activator Substances 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 231100000252 nontoxic Toxicity 0.000 claims description 4
- 230000003000 nontoxic effect Effects 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 3
- 238000007151 ring opening polymerisation reaction Methods 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 238000012662 bulk polymerization Methods 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N nitrous oxide Inorganic materials [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims 2
- DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 2
- BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 230000002194 synthesizing effect Effects 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 239000004277 Ferrous carbonate Substances 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229960005069 calcium Drugs 0.000 claims 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims 1
- 239000001639 calcium acetate Substances 0.000 claims 1
- 235000011092 calcium acetate Nutrition 0.000 claims 1
- 229960005147 calcium acetate Drugs 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims 1
- 239000001527 calcium lactate Substances 0.000 claims 1
- 235000011086 calcium lactate Nutrition 0.000 claims 1
- 229960002401 calcium lactate Drugs 0.000 claims 1
- 229960003624 creatine Drugs 0.000 claims 1
- 239000006046 creatine Substances 0.000 claims 1
- 229940109239 creatinine Drugs 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- RAQDACVRFCEPDA-UHFFFAOYSA-L ferrous carbonate Chemical compound [Fe+2].[O-]C([O-])=O RAQDACVRFCEPDA-UHFFFAOYSA-L 0.000 claims 1
- 235000019268 ferrous carbonate Nutrition 0.000 claims 1
- 229960004652 ferrous carbonate Drugs 0.000 claims 1
- -1 guanidine compound Chemical class 0.000 claims 1
- 229910000015 iron(II) carbonate Inorganic materials 0.000 claims 1
- 229940001447 lactate Drugs 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 235000011056 potassium acetate Nutrition 0.000 claims 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 230000035484 reaction time Effects 0.000 claims 1
- 239000011576 zinc lactate Substances 0.000 claims 1
- 229940050168 zinc lactate Drugs 0.000 claims 1
- 235000000193 zinc lactate Nutrition 0.000 claims 1
- MCOGTQGPHPAUJN-UHFFFAOYSA-L zinc;2-hydroxyacetate Chemical compound [Zn+2].OCC([O-])=O.OCC([O-])=O MCOGTQGPHPAUJN-UHFFFAOYSA-L 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410765621.9 | 2014-12-12 | ||
| CN201410765621.9A CN104448261B (zh) | 2014-12-12 | 2014-12-12 | 高性能高分子量聚l-乳酸合成工艺 |
| PCT/CN2015/081253 WO2016090878A1 (zh) | 2014-12-12 | 2015-06-11 | 高性能高分子量聚l-乳酸合成工艺 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507229A JP2017507229A (ja) | 2017-03-16 |
| JP2017507229A5 true JP2017507229A5 (enExample) | 2018-05-31 |
| JP6343031B2 JP6343031B2 (ja) | 2018-06-13 |
Family
ID=52895059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567120A Expired - Fee Related JP6343031B2 (ja) | 2014-12-12 | 2015-06-11 | 高性能高分子量ポリｌ−乳酸合成プロセス |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9845377B2 (enExample) |
| JP (1) | JP6343031B2 (enExample) |
| CN (1) | CN104448261B (enExample) |
| WO (1) | WO2016090878A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104448261B (zh) * | 2014-12-12 | 2016-09-14 | 南京大学 | 高性能高分子量聚l-乳酸合成工艺 |
| CN106146817B (zh) * | 2015-04-21 | 2019-04-05 | 上海浦景化工新材料有限公司 | 羟基烷酸锌聚酯催化剂，其制备方法以及该催化剂的应用 |
| CN105131259B (zh) * | 2015-09-14 | 2017-05-31 | 南京大学 | 生物胍复合体系催化熔融‑固相聚合合成高分子量聚α‑羟基酸 |
| RU2637923C1 (ru) * | 2016-11-30 | 2017-12-08 | Общество с ограниченной ответственностью "Медин-Н" | Способ получения (со)полимера гликолида и/или лактида для изготовления рассасывающихся хирургических изделий |
| CN106831700B (zh) * | 2017-03-28 | 2019-05-24 | 南京大学 | 一种全绿色封闭循环工艺生产光学纯l-/d-丙交酯的方法 |
| CN107540824B (zh) * | 2017-09-21 | 2019-07-05 | 南京大学 | 大分子引发剂暨缩合-开环-固相聚合联用合成超高等规度聚l-/d-乳酸的方法 |
| CN109081909A (zh) * | 2018-07-09 | 2018-12-25 | 南京大学 | 一种利用有机双胍催化剂合成聚对苯二甲酸丙二醇酯的工艺 |
| CN110054762B (zh) * | 2019-05-29 | 2021-09-07 | 南京大学 | 一种催化丙交酯开环聚合的工艺方法 |
| CN111848692B (zh) * | 2020-08-02 | 2021-03-19 | 扬州普立特科技发展有限公司 | 生物质有机胍配合物的制备方法及其催化合成pet或peit聚酯的应用 |
| CN113150254B (zh) * | 2021-03-26 | 2022-07-19 | 天津科技大学 | 一种以乳酸水溶液调控制备无毒性聚乳酸的方法 |
| CN114790282B (zh) * | 2021-12-30 | 2023-03-21 | 康辉新材料科技有限公司 | 一种纳米微颗粒原位聚合催化剂的制备方法及其应用 |
| CN116393174B (zh) * | 2023-04-04 | 2024-06-21 | 大连理工大学 | 一种同时用于制备乙交酯和聚乙交酯的催化剂及制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1234750C (zh) * | 2004-01-08 | 2006-01-04 | 南开大学 | 生物质有机胍化物催化合成医用生物降解材料的工艺方法 |
| CN1241970C (zh) * | 2004-03-02 | 2006-02-15 | 南开大学 | 以醋酸有机胍为催化剂合成医用生物降解材料的工艺方法 |
| JP2009001614A (ja) * | 2007-06-19 | 2009-01-08 | Musashino Chemical Laboratory Ltd | ポリ乳酸ブロック共重合体の製造方法、該製造方法で得られたポリ乳酸ブロック共重合体、およびこれを用いた成形品 |
| CN101367921A (zh) * | 2008-10-06 | 2009-02-18 | 中国人民解放军第二军医大学 | 一种丙交酯开环合成聚乳酸的方法 |
| US8507640B2 (en) * | 2010-08-19 | 2013-08-13 | International Business Machines Corporation | Methods of ring opening polymerization and catalysts therefor |
| CN102161752B (zh) * | 2011-03-14 | 2013-02-27 | 南京大学 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
| CN102146155B (zh) * | 2011-05-09 | 2012-11-28 | 浙江大学宁波理工学院 | 一种丙交酯的催化聚合方法 |
| CN102295765B (zh) * | 2011-06-30 | 2012-11-28 | 南京大学 | 生物质肌酐催化共缩聚法合成聚乳酸-乙醇酸 |
| CN102329269B (zh) * | 2011-06-30 | 2013-07-17 | 南京大学 | 仿生氯化肌酐胍催化缩聚法合成高分子量聚乳酸 |
| CN102675607B (zh) * | 2012-05-22 | 2013-08-14 | 南京大学 | 乳酸自催化熔融缩聚—肌酐催化固相缩聚联用法合成高分子量聚乳酸 |
| CN103396535A (zh) * | 2013-08-09 | 2013-11-20 | 深圳市光华伟业实业有限公司 | 一种由丙交酯和多元醇合成聚丙交酯多元醇的方法 |
| CN104448261B (zh) * | 2014-12-12 | 2016-09-14 | 南京大学 | 高性能高分子量聚l-乳酸合成工艺 |
-
2014
- 2014-12-12 CN CN201410765621.9A patent/CN104448261B/zh not_active Expired - Fee Related
-
2015
- 2015-06-11 JP JP2016567120A patent/JP6343031B2/ja not_active Expired - Fee Related
- 2015-06-11 WO PCT/CN2015/081253 patent/WO2016090878A1/zh not_active Ceased
- 2015-09-14 US US14/854,009 patent/US9845377B2/en not_active Expired - Fee Related
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