JP2017507155A5 - - Google Patents
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- JP2017507155A5 JP2017507155A5 JP2016555590A JP2016555590A JP2017507155A5 JP 2017507155 A5 JP2017507155 A5 JP 2017507155A5 JP 2016555590 A JP2016555590 A JP 2016555590A JP 2016555590 A JP2016555590 A JP 2016555590A JP 2017507155 A5 JP2017507155 A5 JP 2017507155A5
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- Prior art keywords
- antibody
- pharmaceutical composition
- ctla
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- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims 12
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 11
- 229940127084 other anti-cancer agent Drugs 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 5
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 5
- 238000009097 single-agent therapy Methods 0.000 claims 5
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 239000003798 L01XE11 - Pazopanib Substances 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 230000008595 infiltration Effects 0.000 claims 4
- 238000001764 infiltration Methods 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 229960000639 pazopanib Drugs 0.000 claims 4
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims 4
- 206010061818 Disease progression Diseases 0.000 claims 3
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 3
- 102100022338 Integrin alpha-M Human genes 0.000 claims 3
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims 3
- 210000001185 bone marrow Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000005750 disease progression Effects 0.000 claims 3
- 210000000066 myeloid cell Anatomy 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 229960001796 sunitinib Drugs 0.000 claims 3
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 3
- 230000001988 toxicity Effects 0.000 claims 3
- 231100000419 toxicity Toxicity 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 229960005386 ipilimumab Drugs 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 210000003289 regulatory T cell Anatomy 0.000 claims 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 102000043321 human CTLA4 Human genes 0.000 claims 1
- 102000048362 human PDCD1 Human genes 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461948428P | 2014-03-05 | 2014-03-05 | |
| US61/948,428 | 2014-03-05 | ||
| US201461977318P | 2014-04-09 | 2014-04-09 | |
| US61/977,318 | 2014-04-09 | ||
| US201461992729P | 2014-05-13 | 2014-05-13 | |
| US61/992,729 | 2014-05-13 | ||
| US201462005600P | 2014-05-30 | 2014-05-30 | |
| US62/005,600 | 2014-05-30 | ||
| PCT/US2015/018727 WO2015134605A1 (en) | 2014-03-05 | 2015-03-04 | Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019152086A Division JP2020007331A (ja) | 2014-03-05 | 2019-08-22 | 抗ｐｄ−１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017507155A JP2017507155A (ja) | 2017-03-16 |
| JP2017507155A5 true JP2017507155A5 (enExample) | 2018-04-12 |
Family
ID=52686508
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555590A Pending JP2017507155A (ja) | 2014-03-05 | 2015-03-04 | 抗ｐｄ−１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2019152086A Pending JP2020007331A (ja) | 2014-03-05 | 2019-08-22 | 抗ｐｄ−１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2022007365A Pending JP2022058698A (ja) | 2014-03-05 | 2022-01-20 | 抗ｐｄ－１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2024163901A Pending JP2024178325A (ja) | 2014-03-05 | 2024-09-20 | 抗ｐｄ－１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019152086A Pending JP2020007331A (ja) | 2014-03-05 | 2019-08-22 | 抗ｐｄ−１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2022007365A Pending JP2022058698A (ja) | 2014-03-05 | 2022-01-20 | 抗ｐｄ－１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
| JP2024163901A Pending JP2024178325A (ja) | 2014-03-05 | 2024-09-20 | 抗ｐｄ－１抗体と他の抗癌剤の組合せを使用する腎癌の処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20170088626A1 (enExample) |
| EP (2) | EP3114144A1 (enExample) |
| JP (4) | JP2017507155A (enExample) |
| KR (3) | KR20240144452A (enExample) |
| CN (2) | CN114432440A (enExample) |
| WO (1) | WO2015134605A1 (enExample) |
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| TW202608468A (zh) | 2024-05-13 | 2026-03-01 | 美商基利科學股份有限公司 | 組合療法 |
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| CN120501749A (zh) * | 2025-05-28 | 2025-08-19 | 皖南医学院 | Prmt5抑制剂或其与抗pd-1抗体联合在制备治疗肾癌的药物中的应用 |
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| US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| US6051227A (en) | 1995-07-25 | 2000-04-18 | The Regents Of The University Of California, Office Of Technology Transfer | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
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| ES2539411T3 (es) | 1999-08-23 | 2015-06-30 | Dana-Farber Cancer Institute, Inc. | PD-1, receptor para la B7-4 y su utilización |
| NZ517202A (en) | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
| US7605238B2 (en) | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| AU2001233027A1 (en) | 2000-01-27 | 2001-08-07 | Genetics Institute, Llc | Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof |
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| CN103536917B (zh) * | 2013-10-30 | 2015-03-11 | 苏州丁孚靶点生物技术有限公司 | 干扰素在治疗肿瘤中的用途及相关的产品和方法 |
| US10570202B2 (en) * | 2014-02-04 | 2020-02-25 | Pfizer Inc. | Combination of a PD-1 antagonist and a VEGFR inhibitor for treating cancer |
-
2015
- 2015-03-04 EP EP15710681.6A patent/EP3114144A1/en not_active Withdrawn
- 2015-03-04 CN CN202111631085.XA patent/CN114432440A/zh active Pending
- 2015-03-04 JP JP2016555590A patent/JP2017507155A/ja active Pending
- 2015-03-04 EP EP19167467.0A patent/EP3572430A3/en active Pending
- 2015-03-04 KR KR1020247031210A patent/KR20240144452A/ko not_active Ceased
- 2015-03-04 CN CN201580023210.5A patent/CN106255510A/zh active Pending
- 2015-03-04 KR KR1020167027017A patent/KR20160119867A/ko not_active Ceased
- 2015-03-04 WO PCT/US2015/018727 patent/WO2015134605A1/en not_active Ceased
- 2015-03-04 US US15/122,827 patent/US20170088626A1/en not_active Abandoned
- 2015-03-04 KR KR1020227030567A patent/KR20220127940A/ko not_active Ceased
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2019
- 2019-05-06 US US16/404,593 patent/US20190263923A1/en not_active Abandoned
- 2019-08-22 JP JP2019152086A patent/JP2020007331A/ja active Pending
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2022
- 2022-01-20 JP JP2022007365A patent/JP2022058698A/ja active Pending
- 2022-05-04 US US17/662,034 patent/US20220389110A1/en not_active Abandoned
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2024
- 2024-09-20 JP JP2024163901A patent/JP2024178325A/ja active Pending
-
2025
- 2025-04-07 US US19/172,371 patent/US20250297028A1/en active Pending
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