JP2017505761A5 - - Google Patents

Download PDF

Info

Publication number
JP2017505761A5
JP2017505761A5 JP2016542662A JP2016542662A JP2017505761A5 JP 2017505761 A5 JP2017505761 A5 JP 2017505761A5 JP 2016542662 A JP2016542662 A JP 2016542662A JP 2016542662 A JP2016542662 A JP 2016542662A JP 2017505761 A5 JP2017505761 A5 JP 2017505761A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
25hc3s
pharmaceutically acceptable
acceptable salt
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016542662A
Other languages
English (en)
Japanese (ja)
Other versions
JP7009059B2 (ja
JP2017505761A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/072128 external-priority patent/WO2015100312A1/en
Publication of JP2017505761A publication Critical patent/JP2017505761A/ja
Publication of JP2017505761A5 publication Critical patent/JP2017505761A5/ja
Application granted granted Critical
Publication of JP7009059B2 publication Critical patent/JP7009059B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016542662A 2013-12-24 2014-12-23 酸素化コレステロール硫酸塩(ocs)の使用 Active JP7009059B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361920617P 2013-12-24 2013-12-24
US61/920,617 2013-12-24
PCT/US2014/072128 WO2015100312A1 (en) 2013-12-24 2014-12-23 Uses of oxygenated cholesterol sulfates (ocs)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020121324A Division JP7289030B2 (ja) 2013-12-24 2020-07-15 酸素化コレステロール硫酸塩(ocs)の使用

Publications (3)

Publication Number Publication Date
JP2017505761A JP2017505761A (ja) 2017-02-23
JP2017505761A5 true JP2017505761A5 (OSRAM) 2018-03-15
JP7009059B2 JP7009059B2 (ja) 2022-02-10

Family

ID=53479646

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016542662A Active JP7009059B2 (ja) 2013-12-24 2014-12-23 酸素化コレステロール硫酸塩(ocs)の使用
JP2020121324A Active JP7289030B2 (ja) 2013-12-24 2020-07-15 酸素化コレステロール硫酸塩(ocs)の使用
JP2022152818A Active JP7364759B2 (ja) 2013-12-24 2022-09-26 酸素化コレステロール硫酸塩(ocs)の使用
JP2023173762A Pending JP2024009887A (ja) 2013-12-24 2023-10-05 酸素化コレステロール硫酸塩(ocs)の使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020121324A Active JP7289030B2 (ja) 2013-12-24 2020-07-15 酸素化コレステロール硫酸塩(ocs)の使用
JP2022152818A Active JP7364759B2 (ja) 2013-12-24 2022-09-26 酸素化コレステロール硫酸塩(ocs)の使用
JP2023173762A Pending JP2024009887A (ja) 2013-12-24 2023-10-05 酸素化コレステロール硫酸塩(ocs)の使用

Country Status (25)

Country Link
US (4) US10272097B2 (OSRAM)
EP (3) EP3639828B8 (OSRAM)
JP (4) JP7009059B2 (OSRAM)
KR (3) KR102655918B1 (OSRAM)
CN (2) CN113599388A (OSRAM)
AU (3) AU2014369916A1 (OSRAM)
BR (1) BR112016014611A8 (OSRAM)
CA (2) CA2932300C (OSRAM)
CY (2) CY1125028T1 (OSRAM)
DK (2) DK3639828T3 (OSRAM)
EA (2) EA201990684A1 (OSRAM)
ES (2) ES2906865T3 (OSRAM)
HR (2) HRP20220112T1 (OSRAM)
HU (2) HUE057649T2 (OSRAM)
IL (3) IL294448A (OSRAM)
LT (2) LT3639828T (OSRAM)
MX (4) MX2021011641A (OSRAM)
PL (2) PL3639828T3 (OSRAM)
PT (2) PT3086793T (OSRAM)
RS (2) RS63002B1 (OSRAM)
SI (2) SI3086793T1 (OSRAM)
SM (2) SMT202200314T1 (OSRAM)
TW (4) TWI816417B (OSRAM)
WO (1) WO2015100312A1 (OSRAM)
ZA (1) ZA201603580B (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
TWI816417B (zh) * 2013-12-24 2023-09-21 維吉尼亞聯邦大學 氧化膽固醇硫酸鹽(ocs)之用途
US11395826B2 (en) * 2015-11-20 2022-07-26 Kyushu University, National University Corporation Immunoregulatory agent
WO2017189561A1 (en) * 2016-04-25 2017-11-02 Mennerick Steve 25-hydroxycholesterol and methods of use thereof
WO2018026781A1 (en) * 2016-08-02 2018-02-08 Virginia Commonwealth University Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
KR102462275B1 (ko) * 2016-08-02 2022-11-01 듀렉트 코퍼레이션 산소화 콜레스테롤 술페이트, 및 폴리알킬렌 글리콜, 카르복시메틸 셀룰로오스 및 폴리옥실글리세리드 중 적어도 하나를 포함하는 조성물
TW202308651A (zh) * 2016-08-02 2023-03-01 美商杜瑞克公司 氧化膽固醇硫酸鹽(ocs)於治療炎性皮膚疾病及皮膚病灶之用途
EP4037650A4 (en) * 2019-09-30 2023-10-18 Durect Corporation TREATMENT OF ALCOHOLIC HEPATITIS
AU2020415462A1 (en) * 2019-12-27 2022-06-23 Durect Corporation Crystalline and liquid crystalline 25-hydroxy-cholest-5-en-3-sulfate sodium and methods for preparing same
US20230141965A1 (en) * 2020-02-11 2023-05-11 Durect Corporation Treatment of infectious diseases
CN112394102B (zh) * 2020-11-05 2023-05-26 上海交通大学医学院附属瑞金医院 一种检测垂体功能减退症的标志物及其应用
JP7593782B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7593781B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7593784B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7593783B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7640986B2 (ja) * 2020-12-03 2025-03-06 学校法人慈恵大学 挫滅症候群の診断補助方法およびそれに使用されるプログラム
CN114306350B (zh) * 2022-01-13 2023-01-24 四川大学华西医院 胆固醇硫酸盐在制备预防脓毒症的药物中的用途
CN114646702B (zh) * 2022-03-03 2023-01-06 四川大学华西医院 胆固醇硫酸酯检测试剂在制备脓毒症辅助诊断、治疗效果监测和预后评估试剂盒中的用途
EP4611888A1 (en) * 2022-10-31 2025-09-10 Intercept Pharmaceuticals, Inc. Uses of farnesoid x receptor agonists
WO2025101669A1 (en) 2023-11-07 2025-05-15 Durect Corporation Treatment of alcohol-associated hepatitis

Family Cites Families (211)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794362A (fr) 1972-01-22 1973-07-23 Merck Patent Gmbh Sulfates hydrosolubles de sterine
US3928397A (en) 1973-03-02 1975-12-23 Eisai Co Ltd New 5-cholestene derivatives and preparation thereof
US3822254A (en) 1973-05-21 1974-07-02 Hoffmann La Roche Synthesis of 25-hydroxycholesterol
US4264512A (en) 1975-09-29 1981-04-28 The Regents Of The University Of California 3-Deoxy-1α-hydroxy- and 3-deoxy-1α,25-dihydroxycholecalciferol and processes for the preparation thereof
US4049803A (en) 1976-04-26 1977-09-20 Bristol-Myers Company Augmentation of blood levels of aspirin
CA1083044A (en) 1976-05-04 1980-08-05 Stewart Wong Antiarthritic potentiation
US4202891A (en) 1977-05-16 1980-05-13 Kandutsch Andrew A 15-Oxygenated sterol compounds and the use of such compounds to inhibit the biosynthesis of sterols
GB1595020A (en) 1977-06-24 1981-08-05 Chugai Pharmaceutical Co Ltd 3a-hydroxy steroid derivatives of the cholestane series
US4207340A (en) 1978-12-18 1980-06-10 Mcneilab, Inc. Analgesic potentiation
US4233317A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4233315A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4242353A (en) 1978-12-18 1980-12-30 Mcneilab, Inc. Analgesic potentiation
US4233314A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4233313A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4233316A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4234601A (en) 1978-12-18 1980-11-18 Mcneilab, Inc. Analgesic potentiation
US4237140A (en) 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US4260629A (en) 1979-10-25 1981-04-07 E. I. Du Pont De Nemours And Company Treating pain with acetaminophen and 1,4-dimethyl-5-p-chlorobenzoyl-pyrrole-2-acetic acid
US4314989A (en) 1980-05-07 1982-02-09 Rosen Gerald M Methionine sulfoxide amflioration of acetaminophen toxicity
US4307073A (en) 1980-08-08 1981-12-22 The Research Foundation Of State University Of New York Method and composition for reducing the toxicity of acetaminophen
US4401665A (en) 1981-04-14 1983-08-30 Bristol-Myers Company Sleep-aid composition containing an analgesic and diphenhydramine dihydrogencitrate, and method of use
US4460368A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication system
US4427668A (en) 1982-04-01 1984-01-24 New York University 26-Hydroxycholesterol and derivatives and analogs thereof in regulation of cholesterol accumulation in body tissue
US4794112A (en) 1982-12-09 1988-12-27 Cooper Stephen A Acetaminophen/hydroxyzine analgesic combinations
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4476115A (en) 1983-07-05 1984-10-09 Reed Raymond E Analgesic composition and method of treating subdermal pain
GB8325627D0 (en) 1983-09-24 1983-10-26 Scras Therapeutic compositions
US4466960A (en) 1983-10-18 1984-08-21 Thompson Medical Co., Inc. Analgesic-diuretic compositions
US4681897A (en) 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US4730007A (en) 1985-09-04 1988-03-08 Seymour Ehrenpreis Novel analgesic compositions
US4743597A (en) 1986-01-27 1988-05-10 Javitt Norman B Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases
US4971960A (en) 1986-03-11 1990-11-20 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
US5238686A (en) 1986-03-27 1993-08-24 Kinaform Technology, Inc. Sustained-release pharmaceutical preparation
US4829064A (en) 1987-06-08 1989-05-09 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US5468482A (en) 1987-07-17 1995-11-21 Calam & Associates, Inc. Palatable orally administered liquid medicaments for relief of discomfort and flavoring combinations therefor
US5011688A (en) 1989-02-02 1991-04-30 Calam Henry D Liquid composition for the relief of premenstrual and menstrual discomforts
US5891801A (en) 1987-07-17 1999-04-06 Calam And Associates, Inc. Palatable liquid-admininstered oral medicaments for relief of discomfort and flavoring combinations therefor
US4822781A (en) 1987-10-08 1989-04-18 American Home Products Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
US6127352A (en) 1988-02-01 2000-10-03 Uribe; Jose R. Pharmaceutical compositions with analgesics containing codeine
US4971785A (en) 1988-03-14 1990-11-20 Spectrum Consumer Products Co., Inc. Non-alcoholic delivery system for orally ingestible active ingredients
US4990535A (en) 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
US5036097A (en) 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5204118A (en) 1989-11-02 1993-04-20 Mcneil-Ppc, Inc. Pharmaceutical compositions and methods for treating the symptoms of overindulgence
US5023085A (en) 1989-11-29 1991-06-11 Pfizer Inc. Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals
JPH0714872B2 (ja) 1990-02-06 1995-02-22 昭和薬品化工株式会社 シロップ剤組成物
CA2020018A1 (en) 1990-06-27 1991-12-28 Don L. Simmons Method and composition for treating the migraine complex
US5296241A (en) 1991-04-03 1994-03-22 Brimberg Barnett J Therapeutic composition and method of using same for treatment of hangover
DK0566709T5 (da) 1991-09-06 2009-05-18 Ortho Mcneil Janssen Pharm Præparat indeholdende et tramadolmateriale og acetaminophen og anvendelse deraf
US5409709A (en) 1991-11-29 1995-04-25 Lion Corporation Antipyretic analgesic preparation containing ibuprofen
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5322689A (en) 1992-03-10 1994-06-21 The Procter & Gamble Company Topical aromatic releasing compositions
US5510340A (en) 1992-06-12 1996-04-23 Sri International Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
US5306711A (en) 1992-06-24 1994-04-26 Georgetown University Organ preservative solution
US5371077A (en) 1992-08-03 1994-12-06 William Marsh Rice University Side chain derivatized 15-oxygenated sterols, methods of using them and a process for preparing them
US6303632B1 (en) 1992-09-03 2001-10-16 Sepracor Inc. Compositions for treating allergic and other disorders using norastemizole in combination with other active ingredients
US5474757A (en) 1992-10-16 1995-12-12 Rutgers University Prevention of acetaminophen overdose toxicity with organosulfur compounds
US5260340A (en) 1992-11-19 1993-11-09 Baranowitz Steven A Prevention and amelioration of acetaminophen toxicity with beta-carotene
US5724957A (en) 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US5599659A (en) * 1993-03-11 1997-02-04 Breonics, Inc. Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate
US5409944A (en) 1993-03-12 1995-04-25 Merck Frosst Canada, Inc. Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
CA2161217A1 (en) 1993-04-30 1994-11-10 Carmelita Macklin Russell Coated pharmaceutical compositions
US5466865A (en) 1993-07-02 1995-11-14 Ibah, Inc. Neomorphic ibuprofen and methods of using same
US5587368A (en) 1993-11-30 1996-12-24 New York University Administration of a 27-hydroxycholesterol or related compound or sterol-27-hydroxylase stimulant to prevent restenosis following vascular endothelial injury
GB9403857D0 (en) 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
US5458879A (en) 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US6077533A (en) 1994-05-25 2000-06-20 Purdue Pharma L.P. Powder-layered oral dosage forms
US6482831B1 (en) 1994-06-16 2002-11-19 Entropin, Inc. Covalently coupled benzoylecgonine, egconine and ecgonidine derivatives
US5612061A (en) 1994-10-14 1997-03-18 Rabkin; Simon W. Composition and method for the treatment of premenstrual syndrome
JP3828603B2 (ja) * 1994-12-26 2006-10-04 株式会社日清製粉グループ本社 ピロリジノン誘導体を含有する医薬組成物
US5538959A (en) 1995-01-26 1996-07-23 Mauskop; Alexander Analgesic composition for treatment of migraine headaches
US5639475A (en) 1995-02-03 1997-06-17 Eurand America, Incorporated Effervescent microcapsules
US5703073A (en) 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US5654334A (en) 1995-06-23 1997-08-05 Oklahoma Medical Research Foundation Analgesic use of N-L-α-aspartyl-L-phenylalanine 1-methyl ester
US6645953B2 (en) 1995-06-23 2003-11-11 Novo Nordisk A/S Meiosis regulating compounds
ATE254628T1 (de) 1995-06-23 2003-12-15 Novo Nordisk As Meiose regulierende verbindungen.
US5840731A (en) 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
JPH0971581A (ja) * 1995-09-08 1997-03-18 Nisshin Flour Milling Co Ltd ラクタム誘導体
US5897880A (en) 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
CN1102852C (zh) 1995-11-13 2003-03-12 皮特迈国际有限公司 含一氧化二氮的止痛药、消炎药和解热药的给药介质及含有这样的介质和药物的药物组合物
US6391337B2 (en) 1995-11-15 2002-05-21 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US5733578A (en) 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
US6214386B1 (en) 1995-11-22 2001-04-10 Recordati, S.A. Prompt-release oral pharmaceutical compositions for extemporaneous suspensions
US5998434A (en) 1995-12-06 1999-12-07 Eli Lilly And Company Composition for treating pain
US5773031A (en) 1996-02-27 1998-06-30 L. Perrigo Company Acetaminophen sustained-release formulation
AU2587297A (en) 1996-03-25 1997-10-17 Eli Lilly And Company Method for treating pain
CN1494907A (zh) 1996-03-25 2004-05-12 治疗疼痛的药物组合物
US5837729A (en) 1996-04-26 1998-11-17 Metatron, Inc. Methods for treating and preventing HIV infection using acetaminophen and derivatives thereof
US5739139A (en) 1996-06-20 1998-04-14 Mcneil-Ppc, Inc. Acetaminophen and dimenhydrinate analgesics
JPH1072421A (ja) * 1996-07-02 1998-03-17 Nisshin Flour Milling Co Ltd イミド誘導体
US5914129A (en) 1996-07-23 1999-06-22 Mauskop; Alexander Analgesic composition for treatment of migraine headaches
FR2751875B1 (fr) 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
US5872145A (en) 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
WO1998007447A1 (en) 1996-08-23 1998-02-26 Algos Pharmaceutical Corporation Anticonvulsant containing composition for treating neuropathic pain
US5919826A (en) 1996-10-24 1999-07-06 Algos Pharmaceutical Corporation Method of alleviating pain
US6077539A (en) 1996-11-12 2000-06-20 Pozen, Inc. Treatment of migraine headache
US5776462A (en) 1996-12-10 1998-07-07 Sage R&D, A Partnership Pogostemon cablin extract for inhibiting H. influenzae adhesion and treating otitis media or sore throat
CA2276183C (en) 1996-12-31 2009-06-09 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof
AU5882298A (en) 1997-01-29 1998-08-18 Chong Kun Dang Corporation New analgesic composition
US5948787A (en) 1997-02-28 1999-09-07 Alza Corporation Compositions containing opiate analgesics
US5891477A (en) 1997-03-28 1999-04-06 Biohybrid Technologies, Inc. Non-steroidal anti-inflammatory agents inhibition of fibrotic response to an implanted device
US5972916A (en) 1997-07-14 1999-10-26 Bristol-Myers Squibb Company Compositions containing the nonprescription combination of acetaminophen, aspirin and caffeine to alleviate the pain and symptoms of migraine
US6077530A (en) 1997-07-28 2000-06-20 Weinstein; Robert Analgesic dosage units for coordinated administration
GB2328443B (en) 1997-08-21 2001-09-05 Reckitt & Colmann Prod Ltd In situ formation of pharmaceutically acceptable polymeric material
US5942530A (en) 1997-08-28 1999-08-24 Eli Lilly And Company Method for treating pain
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US5965167A (en) 1997-10-07 1999-10-12 Sanghvi; Pradeepkumar P. Dosage units
US6162647A (en) 1997-10-14 2000-12-19 Stephens; James Matthew Method for removing interfering substances from a urine sample using a chemical oxidant
US20030153541A1 (en) 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
PT1685839E (pt) 1997-12-22 2013-07-08 Euro Celtique Sa Forma de dosagem farmacêutica por via oral compreendendo uma combinação de um agonista opióide e de um antagonista opióide
US6413512B1 (en) 1998-02-13 2002-07-02 National Enzyme Company Composition and method for treating disease by increasing activated α2 macroglobulin in the blood and extravascular tissue
US6245357B1 (en) 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US6242493B1 (en) 1998-03-13 2001-06-05 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
US6007841A (en) 1998-03-13 1999-12-28 Algos Pharmaceutical Corporation Analgesic composition and method for treating pain
US6054451A (en) 1998-04-21 2000-04-25 Algos Pharmaceutical Corporation Analgesic composition and method for alleviating pain
CN1326461A (zh) 1998-05-13 2001-12-12 诺沃挪第克公司 减数分裂调控化合物
KR20010043558A (ko) 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US6126967A (en) 1998-09-03 2000-10-03 Ascent Pediatrics Extended release acetaminophen particles
US6254891B1 (en) 1998-09-03 2001-07-03 Ascent Pediatrics, Inc. Extended release acetaminophen
US6485747B1 (en) 1998-10-30 2002-11-26 Monsanto Company Coated active tablet(s)
JP2002529499A (ja) 1998-11-13 2002-09-10 イーライ・リリー・アンド・カンパニー 痛みの治療方法
US6627234B1 (en) 1998-12-15 2003-09-30 Wm. Wrigley Jr. Company Method of producing active agent coated chewing gum products
US6586023B1 (en) 1998-12-15 2003-07-01 Wm. Wrigley Jr. Company Process for controlling release of active agents from a chewing gum coating and product thereof
US6139861A (en) 1999-01-14 2000-10-31 Friedman; Mark Intraoral topical anti-inflammatory treatment for relief of migraine, tension-type headache, post-traumatic headache facial pain, and cervical-muscle spasm
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6383527B1 (en) 1999-03-04 2002-05-07 Nps Pharmaceuticals, Inc. Compositions comprising valerian extracts, isovaleric acid or derivatives thereof with a NSAID
US6365338B1 (en) 1999-04-27 2002-04-02 David A. Bull Organ preservative solution containing trehalose, anti-oxidant, cations and an energy source
US20060025393A1 (en) 1999-04-30 2006-02-02 Shutsung Liao Steroid derivatives
BR0010197A (pt) 1999-04-30 2002-07-16 Arch Dev Corp Derivados de esteróides
US6383515B2 (en) 1999-05-28 2002-05-07 Sawyer Maryjean Solvent system for enhancing solubility
US6566361B2 (en) 1999-06-30 2003-05-20 Laboratories, Upsa Azapirone pain treatment
FR2795645B1 (fr) 1999-06-30 2001-09-21 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
MXPA01013109A (es) 1999-07-14 2002-06-04 Coca Cola Co Compartimiento promocional ventilado.
US6642243B1 (en) 1999-07-22 2003-11-04 Ashkan Imanzahrai Migraine medicine and method for treating same
EP1239848A2 (en) 1999-09-01 2002-09-18 University of British Columbia Compositions and methods for modulating hdl cholesterol and triglyceride levels
US6544548B1 (en) 1999-09-13 2003-04-08 Keraplast Technologies, Ltd. Keratin-based powders and hydrogel for pharmaceutical applications
EP1216241B1 (en) 1999-09-14 2005-12-07 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
CA2384783A1 (en) 1999-09-14 2001-03-22 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
US6524623B1 (en) 1999-11-12 2003-02-25 Milton Hodosh Therapeutic compositions and methods of use thereof
KR100416242B1 (ko) 1999-12-22 2004-01-31 주식회사 삼양사 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법
US6492334B1 (en) 1999-12-30 2002-12-10 Robert James Generale Tri-compound analgesic for treating inflammation and pain
JP4018312B2 (ja) 2000-02-21 2007-12-05 株式会社ルネサステクノロジ 無線通信装置
US6787164B2 (en) 2000-02-23 2004-09-07 Bioselect Innovations, Inc. Composition and method for treating the effects of diseases and maladies
US6841544B2 (en) 2000-02-23 2005-01-11 Bioselect Innovations, Inc. Composition and method for treating the effects of diseases and maladies
US7611830B2 (en) 2000-04-10 2009-11-03 The United States Of America As Represented By The Department Of Veteran's Affairs Device to lavage a blood vessel
AU2001258677A1 (en) 2000-05-22 2001-12-03 Dr. Reddy's Research Foundation Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them
US6306842B1 (en) 2000-06-02 2001-10-23 Medinox, Inc. Protected forms of a combination of pharmacologically active agents and uses therefor
US6833362B2 (en) 2000-06-12 2004-12-21 Ward Beryl Bowen, Jr. Method and composition for the accelerated in vivo removal of ethanol
US6355666B1 (en) 2000-06-23 2002-03-12 Medinox, Inc. Protected forms of pharmacologically active agents and uses therefor
US6429223B1 (en) 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
US20040047910A1 (en) 2000-07-07 2004-03-11 Christian Beckett Suppository and composition comprising at least one polyethylene glycol
US6696238B2 (en) 2000-07-28 2004-02-24 Christopher J. Murphy Transplant media
US6225295B1 (en) 2000-09-27 2001-05-01 Frederick H. Hausheer Method of treating acetaminophen overdose
US6924273B2 (en) 2000-10-03 2005-08-02 Scott W. Pierce Chondroprotective/restorative compositions and methods of use thereof
US6391886B1 (en) 2000-12-04 2002-05-21 The Procter & Gamble Company Oral compositions having improved consumer aesthetics
US6440983B1 (en) 2000-12-21 2002-08-27 Mary Theresa Frank-Kollman Compositions and methods for relieving headache symptoms in aspirin-sensitive headache sufferers
WO2002062302A2 (en) 2001-02-08 2002-08-15 The University Of Chicago Steroidal derivatives
US20020164310A1 (en) 2001-03-02 2002-11-07 Mgvs Ltd. Nucleic acid constructs, cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension
US6566401B2 (en) 2001-03-30 2003-05-20 The Board Of Trustees Of The Leland Stanford Junior University N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity
US6593331B2 (en) 2001-04-17 2003-07-15 Laboratories Upsa Method for treatment of pain
US6622856B2 (en) 2001-04-25 2003-09-23 Johnson & Johnson Consumer Companies, Inc. Relief kit
US20070197484A1 (en) 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
DK1392713T3 (da) 2001-05-03 2008-02-18 Univ Chicago Lever-X-receptoragonister
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
EP2260837A1 (en) 2001-06-01 2010-12-15 Pozen, Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US6475526B1 (en) 2001-06-05 2002-11-05 Jeffrey B. Smith Zinc containing compositions for anti-viral use
US6613346B2 (en) 2001-06-28 2003-09-02 Wm. Wrigley, Jr. Company Chewable product including active ingredient
US6602518B2 (en) 2001-06-28 2003-08-05 Wm. Wrigley Jr. Company Chewable product including active ingredient
JP2005508368A (ja) 2001-11-08 2005-03-31 ザ ユニバーシティー オブ シカゴ 高コレステロール濃度に関連した疾患の治療方法
US6569439B1 (en) 2001-11-13 2003-05-27 Noville Inc. Process for making personal care compositions comprising titanium dioxide and personal care compositions made by the process
US6509380B1 (en) 2001-12-14 2003-01-21 Marshall University Research Corporation Method of treating iron overload with acetaminophen
US6828328B1 (en) 2002-03-01 2004-12-07 Ucb S.A. Analgesic combination of muscarinic agonists
JP4570877B2 (ja) 2002-03-28 2010-10-27 明治製菓株式会社 臓器保存用組成物および臓器の保存方法
DE10262084B4 (de) 2002-05-17 2009-12-24 Dr. Franz Köhler Chemie GmbH Protektive Lösung zur Verhinderung von Ischämieschäden
PL212428B1 (pl) 2002-08-20 2012-09-28 Bristol Myers Squibb Co Kompleks aripiprazolu, preparat farmaceutyczny zawierajacy ten kompleks i jego zastosowanie
US6702850B1 (en) 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis
EP1475434A1 (en) 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
ATE540936T1 (de) 2004-06-30 2012-01-15 Janssen Pharmaceutica Nv Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer
US20060047022A1 (en) 2004-08-30 2006-03-02 Craig Daniel H Thermoplastic compositions including inorganic particulates
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
DE102006021181B3 (de) 2006-05-06 2007-05-03 Laux, Thomas, Dr. Zahnprothesen-Trägerimplantat
CN101134100B (zh) * 2006-09-01 2010-11-10 复旦大学 类固醇激素合成急性调节蛋白在制备防治脂肪肝药物中的用途
JP5120998B2 (ja) 2006-09-06 2013-01-16 国立大学法人 東京医科歯科大学 組織、細胞又は臓器の保存液
GB0625965D0 (en) 2006-12-23 2007-02-07 Renovo Ltd Medicaments for wound healing
US8831674B2 (en) 2007-09-27 2014-09-09 Multi-Tech Systems, Inc. Message server
WO2009084743A1 (ja) 2007-12-28 2009-07-09 Miz Co., Ltd. 治療または予防のための外用剤
RU2460525C2 (ru) * 2008-01-04 2012-09-10 Эл Джи Лайф Сайенсиз Лтд. Производные индола и индазола, обладающие консервирующим действием по отношению к клеткам, тканям и органам
US8329450B2 (en) 2008-08-01 2012-12-11 Biomedinnovations, Llc Methods and apparatus for organ support
WO2011035005A2 (en) 2009-09-16 2011-03-24 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for reducing the risk of agent-induced liver toxicity
WO2011077245A2 (en) 2009-12-23 2011-06-30 Fondazione Centro San Raffaele Del Monte Tabor Compositions
EP2608781A4 (en) 2010-08-04 2014-01-29 Tixupharma INCLUSION COMPLEXES OF CYCLODEXTRINS WITH SPERMIDINE AND PROLIFERATIVE BZW. REPAIR COMPOSITIONS THEREWITH
KR101739816B1 (ko) 2010-12-01 2017-05-25 주식회사유한양행 레바프라잔 또는 그의 염을 함유하는 주사용 액제 조성물 또는 주사용 건조 분말
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
WO2013033597A1 (en) 2011-09-02 2013-03-07 Temple University - Of The Commonwealth System Of Higher Education Ssat mrna translation repression and activation
CN107936076B (zh) 2011-09-08 2021-10-15 萨奇治疗股份有限公司 神经活性类固醇、组合物、及其用途
US8665030B2 (en) 2011-12-14 2014-03-04 Taiwan Semiconductor Manufacturing Company, Ltd. Voltage-controlled oscillator
KR102180485B1 (ko) * 2012-04-12 2020-11-18 버지니아 커먼웰스 유니버시티 대사 장애, 고지질혈증, 당뇨병, 지방간 질환 및 죽상동맥경화증의 치료를 위한 신규한 콜레스테롤 대사물질, 5-콜레스텐-3β,25-디올, 디설페이트 (25HCDS)
CN110101708A (zh) 2012-07-17 2019-08-09 密执安大学评议会 治疗白内障的非手术方法
EP2842547A1 (en) 2013-08-27 2015-03-04 Freund Pharmatec Ltd. Improved fenofibrate compositions
TWI816417B (zh) 2013-12-24 2023-09-21 維吉尼亞聯邦大學 氧化膽固醇硫酸鹽(ocs)之用途
RU2764702C2 (ru) 2014-10-07 2022-01-19 Сейдж Терапьютикс, Инк. Нейроактивные соединения и способы их применения
EA034524B1 (ru) 2014-10-10 2020-02-17 Вирджиния Коммонвелт Юниверсити Сульфаты окисленного холестерина для лечения пониженной лептиновой активности
EP3328389A1 (en) 2015-07-27 2018-06-06 Catacore, Inc. Compositions for the treatment of cataracts
TW202308651A (zh) 2016-08-02 2023-03-01 美商杜瑞克公司 氧化膽固醇硫酸鹽(ocs)於治療炎性皮膚疾病及皮膚病灶之用途
WO2018026781A1 (en) 2016-08-02 2018-02-08 Virginia Commonwealth University Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
KR102462275B1 (ko) 2016-08-02 2022-11-01 듀렉트 코퍼레이션 산소화 콜레스테롤 술페이트, 및 폴리알킬렌 글리콜, 카르복시메틸 셀룰로오스 및 폴리옥실글리세리드 중 적어도 하나를 포함하는 조성물

Similar Documents

Publication Publication Date Title
JP2017505761A5 (OSRAM)
JP2023002544A5 (OSRAM)
JP2016511267A5 (OSRAM)
MX2022011804A (es) Uso de agentes para el tratamiento de condiciones respiratorias.
MX393855B (es) Terapia de combinación que comprende un inhibidor de raf y trametinib
WO2011041478A8 (en) Hematopoietic stem cells for use in the treatment of a kidney injury
JP2015535243A5 (OSRAM)
RU2016127558A (ru) Стероидное соединение для применения в лечении печеночной энцефалопатии
GR1007832B (el) Αδρανοποιητες της ακτιβινης και χρηση τους για την θεραπεια ασθενειων που σχετιζονται με παρεκκλινουσα ενεργοποιηση της "αμυντικης αποκρισης του ξενιστη"
JP2016508123A5 (OSRAM)
JP2016509050A5 (OSRAM)
AR074107A1 (es) Metodo para tratar o prevenir la trombosis utilizando etexilato de dabigatran o una sal del mismo con eficacia mejorada sobre la terapia convencional con warfarina
JP2017501154A5 (OSRAM)
EA033298B1 (ru) Комбинированная лекарственная форма тезофензина и метопролола
RU2016137292A (ru) Схема применения соединения fgf-18
CA2986891C (en) Compositions for use in treating parkinson's disease and related disorders
JP2020504129A (ja) 非アルコール性脂肪性肝炎(nash)および肝線維症のための併用療法
WO2019010301A8 (en) Treatment of heart disease by inhibition of the action of muscle a-kinase anchoring protein (makap)
Alsina et al. Can sorafenib increase survival for recurrent hepatocellular carcinoma after liver transplantation? A pilot study
EA201592058A1 (ru) Применение ландиолола гидрохлорида в длительном лечении тахиаритмии
JP5841903B2 (ja) 肝障害の治療または肝機能の向上のための薬剤
AR072954A1 (es) Utilizacion de dronedarona para preparar un medicamento para el tratamiento de pacientes con arritmia y que tienen un incremento del nivel de creatinina debido a la administracion de dronedarona, producto de fabricacion y envase
UA122336C2 (uk) Бісамідна похідна дикарбонової кислоти як засіб, що стимулює регенерацію тканин і відновлення знижених функцій тканин
JP2019535830A5 (OSRAM)
CO2020000529A2 (es) Metodos para tratar hiperinsulinismo congenito