LT3086793T - Deguonimi įsodrintų cholesterolio sulfatų (ocs) naudojimas inkstų disfunkcijai gydyti - Google Patents

Deguonimi įsodrintų cholesterolio sulfatų (ocs) naudojimas inkstų disfunkcijai gydyti

Info

Publication number
LT3086793T
LT3086793T LTEPPCT/US2014/072128T LT14072128T LT3086793T LT 3086793 T LT3086793 T LT 3086793T LT 14072128 T LT14072128 T LT 14072128T LT 3086793 T LT3086793 T LT 3086793T
Authority
LT
Lithuania
Prior art keywords
ocs
treatment
kidney dysfunction
oxygenated cholesterol
cholesterol sulfates
Prior art date
Application number
LTEPPCT/US2014/072128T
Other languages
English (en)
Inventor
Shunlin Ren
Felix Theeuwes
James E. Brown
Weiqi Lin
Original Assignee
Virginia Commonwealth University
The United States Government As Represented By The Department Of Veterans Affairs
Durect Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Commonwealth University, The United States Government As Represented By The Department Of Veterans Affairs, Durect Corporation filed Critical Virginia Commonwealth University
Publication of LT3086793T publication Critical patent/LT3086793T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nutrition Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
LTEPPCT/US2014/072128T 2013-12-24 2014-12-23 Deguonimi įsodrintų cholesterolio sulfatų (ocs) naudojimas inkstų disfunkcijai gydyti LT3086793T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361920617P 2013-12-24 2013-12-24
PCT/US2014/072128 WO2015100312A1 (en) 2013-12-24 2014-12-23 Uses of oxygenated cholesterol sulfates (ocs)

Publications (1)

Publication Number Publication Date
LT3086793T true LT3086793T (lt) 2022-08-25

Family

ID=53479646

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEPPCT/US2014/072128T LT3086793T (lt) 2013-12-24 2014-12-23 Deguonimi įsodrintų cholesterolio sulfatų (ocs) naudojimas inkstų disfunkcijai gydyti
LTEP19214560.5T LT3639828T (lt) 2013-12-24 2014-12-23 Deguoninių cholesterolio sulfatų (ocs) panaudojimas ūminio kepenų nepakankamumo gydymui

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP19214560.5T LT3639828T (lt) 2013-12-24 2014-12-23 Deguoninių cholesterolio sulfatų (ocs) panaudojimas ūminio kepenų nepakankamumo gydymui

Country Status (24)

Country Link
US (4) US10272097B2 (lt)
EP (3) EP4082550A1 (lt)
JP (4) JP7009059B2 (lt)
KR (3) KR102655918B1 (lt)
CN (2) CN105899213B (lt)
AU (3) AU2014369916A1 (lt)
BR (1) BR112016014611A8 (lt)
CA (2) CA3195252A1 (lt)
CY (1) CY1125028T1 (lt)
DK (2) DK3639828T3 (lt)
EA (2) EA032777B1 (lt)
ES (2) ES2906865T3 (lt)
HR (2) HRP20220112T1 (lt)
HU (2) HUE059914T2 (lt)
IL (3) IL294448A (lt)
LT (2) LT3086793T (lt)
MX (4) MX2016008459A (lt)
PL (2) PL3639828T3 (lt)
PT (2) PT3639828T (lt)
RS (2) RS63474B1 (lt)
SI (2) SI3639828T1 (lt)
TW (4) TWI734665B (lt)
WO (1) WO2015100312A1 (lt)
ZA (1) ZA201603580B (lt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
LT3086793T (lt) 2013-12-24 2022-08-25 Virginia Commonwealth University Deguonimi įsodrintų cholesterolio sulfatų (ocs) naudojimas inkstų disfunkcijai gydyti
US11395826B2 (en) * 2015-11-20 2022-07-26 Kyushu University, National University Corporation Immunoregulatory agent
WO2017189561A1 (en) * 2016-04-25 2017-11-02 Mennerick Steve 25-hydroxycholesterol and methods of use thereof
PT3494125T (pt) * 2016-08-02 2022-07-07 Durect Corp Composições compreendendo 5-colesten-3, 25-diol, 3-sulfato (25hc3s), ou seu sal farmaceuticamente aceitável, e, pelo menos, um oligossacárido cíclico
KR20230124756A (ko) * 2016-08-02 2023-08-25 버지니아 커먼웰스 유니버시티 염증성 피부 질환 및 피부 병변을 치료하기 위한 산소첨가된콜레스테롤 술페이트 (ocs) 의 용도
AU2017305305A1 (en) * 2016-08-02 2019-02-21 Durect Corporation Compositions comprising oxygenated cholesterol sulfate and at least one of polyalkylene glycol, carboxymethyl cellulose and polyoxylglyceride
CN114555044A (zh) * 2019-09-30 2022-05-27 度勒科特公司 酒精性肝炎的治疗
MX2022008065A (es) * 2019-12-27 2022-07-27 Durect Corp 25-hidroxi-colest-5-en-3-sulfato de sodio cristalino y cristalino liquido y metodos para preparar los mismos.
CA3170320A1 (en) * 2020-02-11 2021-08-19 Durect Corporation Treatment of infectious diseases
CN112394102B (zh) * 2020-11-05 2023-05-26 上海交通大学医学院附属瑞金医院 一种检测垂体功能减退症的标志物及其应用
CN114306350B (zh) * 2022-01-13 2023-01-24 四川大学华西医院 胆固醇硫酸盐在制备预防脓毒症的药物中的用途
CN114646702B (zh) * 2022-03-03 2023-01-06 四川大学华西医院 胆固醇硫酸酯检测试剂在制备脓毒症辅助诊断、治疗效果监测和预后评估试剂盒中的用途

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