JP7009059B2 - 酸素化コレステロール硫酸塩（ｏｃｓ）の使用 - Google Patents

酸素化コレステロール硫酸塩（ｏｃｓ）の使用 Download PDF

Info

Publication number
JP7009059B2
JP7009059B2 JP2016542662A JP2016542662A JP7009059B2 JP 7009059 B2 JP7009059 B2 JP 7009059B2 JP 2016542662 A JP2016542662 A JP 2016542662A JP 2016542662 A JP2016542662 A JP 2016542662A JP 7009059 B2 JP7009059 B2 JP 7009059B2
Authority
JP
Japan
Prior art keywords
25hc3s
organ
failure
liver
dysfunction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016542662A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017505761A5 (OSRAM
JP2017505761A (ja
Inventor
レン，シュンリン
テーウウェス，フェリックス
ブラウン，ジェームズ，イー．
リン，ウェイチー
Original Assignee
ヴァージニア コモンウェルス ユニバーシティ
デュレクト コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ヴァージニア コモンウェルス ユニバーシティ, デュレクト コーポレーション filed Critical ヴァージニア コモンウェルス ユニバーシティ
Publication of JP2017505761A publication Critical patent/JP2017505761A/ja
Publication of JP2017505761A5 publication Critical patent/JP2017505761A5/ja
Application granted granted Critical
Publication of JP7009059B2 publication Critical patent/JP7009059B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Physiology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Biophysics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nutrition Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2016542662A 2013-12-24 2014-12-23 酸素化コレステロール硫酸塩（ｏｃｓ）の使用 Active JP7009059B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361920617P 2013-12-24 2013-12-24
US61/920,617 2013-12-24
PCT/US2014/072128 WO2015100312A1 (en) 2013-12-24 2014-12-23 Uses of oxygenated cholesterol sulfates (ocs)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020121324A Division JP7289030B2 (ja) 2013-12-24 2020-07-15 酸素化コレステロール硫酸塩（ｏｃｓ）の使用

Publications (3)

Publication Number Publication Date
JP2017505761A JP2017505761A (ja) 2017-02-23
JP2017505761A5 JP2017505761A5 (OSRAM) 2018-03-15
JP7009059B2 true JP7009059B2 (ja) 2022-02-10

Family

ID=53479646

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016542662A Active JP7009059B2 (ja) 2013-12-24 2014-12-23 酸素化コレステロール硫酸塩（ｏｃｓ）の使用
JP2020121324A Active JP7289030B2 (ja) 2013-12-24 2020-07-15 酸素化コレステロール硫酸塩（ｏｃｓ）の使用
JP2022152818A Active JP7364759B2 (ja) 2013-12-24 2022-09-26 酸素化コレステロール硫酸塩（ｏｃｓ）の使用
JP2023173762A Pending JP2024009887A (ja) 2013-12-24 2023-10-05 酸素化コレステロール硫酸塩（ｏｃｓ）の使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020121324A Active JP7289030B2 (ja) 2013-12-24 2020-07-15 酸素化コレステロール硫酸塩（ｏｃｓ）の使用
JP2022152818A Active JP7364759B2 (ja) 2013-12-24 2022-09-26 酸素化コレステロール硫酸塩（ｏｃｓ）の使用
JP2023173762A Pending JP2024009887A (ja) 2013-12-24 2023-10-05 酸素化コレステロール硫酸塩（ｏｃｓ）の使用

Country Status (25)

Country Link
US (4) US10272097B2 (OSRAM)
EP (3) EP3086793B1 (OSRAM)
JP (4) JP7009059B2 (OSRAM)
KR (3) KR102655918B1 (OSRAM)
CN (2) CN105899213B (OSRAM)
AU (3) AU2014369916A1 (OSRAM)
BR (1) BR112016014611A8 (OSRAM)
CA (2) CA3195252A1 (OSRAM)
CY (2) CY1125028T1 (OSRAM)
DK (2) DK3639828T3 (OSRAM)
EA (2) EA032777B1 (OSRAM)
ES (2) ES2906865T3 (OSRAM)
HR (2) HRP20220112T1 (OSRAM)
HU (2) HUE057649T2 (OSRAM)
IL (3) IL294448A (OSRAM)
LT (2) LT3639828T (OSRAM)
MX (4) MX377151B (OSRAM)
PL (2) PL3086793T3 (OSRAM)
PT (2) PT3639828T (OSRAM)
RS (2) RS63002B1 (OSRAM)
SI (2) SI3639828T1 (OSRAM)
SM (2) SMT202200314T1 (OSRAM)
TW (4) TWI816417B (OSRAM)
WO (1) WO2015100312A1 (OSRAM)
ZA (1) ZA201603580B (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
IL294448A (en) 2013-12-24 2022-09-01 Univ Virginia Commonwealth Uses of oxidized cholesterol sulfates
EP3378492A4 (en) 2015-11-20 2019-11-13 Kyushu University National University Corporation IMMUNETRULATORY ACTIVE SUBSTANCE
WO2017189561A1 (en) * 2016-04-25 2017-11-02 Mennerick Steve 25-hydroxycholesterol and methods of use thereof
EP3493810A4 (en) * 2016-08-02 2020-04-08 Durect Corporation COMPOSITIONS COMPRISING OXYGENATED CHOLESTEROL SULFATE AND AT LEAST POLYALKYLENE GLYCOL, CARBOXYMETHYLCELLULOSE OR POLYOXYLGLYCERIDE
US20190374554A1 (en) * 2016-08-02 2019-12-12 Virginia Commonwealth University Use of oxygenated cholesterol sulfates (ocs) to treat inflammatory skin disease and skin lesions
KR102593667B1 (ko) * 2016-08-02 2023-10-24 버지니아 커먼웰스 유니버시티 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물
EP4037650A4 (en) * 2019-09-30 2023-10-18 Durect Corporation TREATMENT OF ALCOHOLIC HEPATITIS
IL294286A (en) * 2019-12-27 2022-08-01 Durect Corp Crystalline and liquid crystalline sodium 25-hydroxycholine-5-yne-5-sulfate and methods for its preparation
AU2021221109A1 (en) * 2020-02-11 2022-08-25 Durect Corporation Treatment of infectious diseases
CN112394102B (zh) * 2020-11-05 2023-05-26 上海交通大学医学院附属瑞金医院 一种检测垂体功能减退症的标志物及其应用
JP7593783B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7593784B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7593781B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7593782B2 (ja) * 2020-11-09 2024-12-03 株式会社三共 遊技機
JP7640986B2 (ja) * 2020-12-03 2025-03-06 学校法人慈恵大学 挫滅症候群の診断補助方法およびそれに使用されるプログラム
CN114306350B (zh) * 2022-01-13 2023-01-24 四川大学华西医院 胆固醇硫酸盐在制备预防脓毒症的药物中的用途
CN114646702B (zh) * 2022-03-03 2023-01-06 四川大学华西医院 胆固醇硫酸酯检测试剂在制备脓毒症辅助诊断、治疗效果监测和预后评估试剂盒中的用途
WO2024097247A1 (en) * 2022-10-31 2024-05-10 Intercept Pharmaceuticals, Inc. Uses of farnesoid x receptor agonists
WO2025101669A1 (en) 2023-11-07 2025-05-15 Durect Corporation Treatment of alcohol-associated hepatitis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120264816A1 (en) 2011-04-06 2012-10-18 Shunlin Ren Sulfated Oxysterol and Oxysterol Sulfation by Hydroxysterol Sulfotransferase Promote Lipid Homeostasis and Liver Proliferation
WO2013154752A1 (en) 2012-04-12 2013-10-17 Virgina Commonwealth University A NOVEL CHOLESTEROL METABOLITE, 5-CHOLESTEN, 3β-25-DIOL, DISULFATE (25HCDS) FOR THERAPY OF METABOLIC DISORDERS, HYPERLIPIDEMIA, DIABETES, FATTY LIVER DISEASES AND ATHEROSCLEROSIS

Family Cites Families (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794362A (fr) 1972-01-22 1973-07-23 Merck Patent Gmbh Sulfates hydrosolubles de sterine
US3928397A (en) 1973-03-02 1975-12-23 Eisai Co Ltd New 5-cholestene derivatives and preparation thereof
US3822254A (en) 1973-05-21 1974-07-02 Hoffmann La Roche Synthesis of 25-hydroxycholesterol
US4264512A (en) 1975-09-29 1981-04-28 The Regents Of The University Of California 3-Deoxy-1α-hydroxy- and 3-deoxy-1α,25-dihydroxycholecalciferol and processes for the preparation thereof
US4049803A (en) 1976-04-26 1977-09-20 Bristol-Myers Company Augmentation of blood levels of aspirin
CA1083044A (en) 1976-05-04 1980-08-05 Stewart Wong Antiarthritic potentiation
US4202891A (en) 1977-05-16 1980-05-13 Kandutsch Andrew A 15-Oxygenated sterol compounds and the use of such compounds to inhibit the biosynthesis of sterols
GB1595020A (en) 1977-06-24 1981-08-05 Chugai Pharmaceutical Co Ltd 3a-hydroxy steroid derivatives of the cholestane series
US4207340A (en) 1978-12-18 1980-06-10 Mcneilab, Inc. Analgesic potentiation
US4233314A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4233317A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4234601A (en) 1978-12-18 1980-11-18 Mcneilab, Inc. Analgesic potentiation
US4233315A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4233316A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4242353A (en) 1978-12-18 1980-12-30 Mcneilab, Inc. Analgesic potentiation
US4233313A (en) 1978-12-18 1980-11-11 Mcneilab, Inc. Analgesic potentiation
US4237140A (en) 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US4260629A (en) 1979-10-25 1981-04-07 E. I. Du Pont De Nemours And Company Treating pain with acetaminophen and 1,4-dimethyl-5-p-chlorobenzoyl-pyrrole-2-acetic acid
US4314989A (en) 1980-05-07 1982-02-09 Rosen Gerald M Methionine sulfoxide amflioration of acetaminophen toxicity
US4307073A (en) 1980-08-08 1981-12-22 The Research Foundation Of State University Of New York Method and composition for reducing the toxicity of acetaminophen
US4401665A (en) 1981-04-14 1983-08-30 Bristol-Myers Company Sleep-aid composition containing an analgesic and diphenhydramine dihydrogencitrate, and method of use
US4460368A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication system
US4427668A (en) 1982-04-01 1984-01-24 New York University 26-Hydroxycholesterol and derivatives and analogs thereof in regulation of cholesterol accumulation in body tissue
US4794112A (en) 1982-12-09 1988-12-27 Cooper Stephen A Acetaminophen/hydroxyzine analgesic combinations
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4476115A (en) 1983-07-05 1984-10-09 Reed Raymond E Analgesic composition and method of treating subdermal pain
GB8325627D0 (en) 1983-09-24 1983-10-26 Scras Therapeutic compositions
US4466960A (en) 1983-10-18 1984-08-21 Thompson Medical Co., Inc. Analgesic-diuretic compositions
US4681897A (en) 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US4730007A (en) 1985-09-04 1988-03-08 Seymour Ehrenpreis Novel analgesic compositions
US4743597A (en) 1986-01-27 1988-05-10 Javitt Norman B Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases
US4971960A (en) 1986-03-11 1990-11-20 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
US5238686A (en) 1986-03-27 1993-08-24 Kinaform Technology, Inc. Sustained-release pharmaceutical preparation
US4829064A (en) 1987-06-08 1989-05-09 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US5468482A (en) 1987-07-17 1995-11-21 Calam & Associates, Inc. Palatable orally administered liquid medicaments for relief of discomfort and flavoring combinations therefor
US5891801A (en) 1987-07-17 1999-04-06 Calam And Associates, Inc. Palatable liquid-admininstered oral medicaments for relief of discomfort and flavoring combinations therefor
US5011688A (en) 1989-02-02 1991-04-30 Calam Henry D Liquid composition for the relief of premenstrual and menstrual discomforts
US4822781A (en) 1987-10-08 1989-04-18 American Home Products Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
US6127352A (en) 1988-02-01 2000-10-03 Uribe; Jose R. Pharmaceutical compositions with analgesics containing codeine
US4971785A (en) 1988-03-14 1990-11-20 Spectrum Consumer Products Co., Inc. Non-alcoholic delivery system for orally ingestible active ingredients
US4990535A (en) 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
US5036097A (en) 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5204118A (en) 1989-11-02 1993-04-20 Mcneil-Ppc, Inc. Pharmaceutical compositions and methods for treating the symptoms of overindulgence
US5023085A (en) 1989-11-29 1991-06-11 Pfizer Inc. Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals
JPH0714872B2 (ja) 1990-02-06 1995-02-22 昭和薬品化工株式会社 シロップ剤組成物
CA2020018A1 (en) 1990-06-27 1991-12-28 Don L. Simmons Method and composition for treating the migraine complex
US5296241A (en) 1991-04-03 1994-03-22 Brimberg Barnett J Therapeutic composition and method of using same for treatment of hangover
DE122004000032I2 (de) 1991-09-06 2006-02-09 Mcneilab Inc Zusammensetzung die eine Tramadol-Verbindung und Acetaminophen enth{lt, und ihre Verwendung
US5409709A (en) 1991-11-29 1995-04-25 Lion Corporation Antipyretic analgesic preparation containing ibuprofen
US5968551A (en) 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5322689A (en) 1992-03-10 1994-06-21 The Procter & Gamble Company Topical aromatic releasing compositions
US5510340A (en) 1992-06-12 1996-04-23 Sri International Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
US5306711A (en) 1992-06-24 1994-04-26 Georgetown University Organ preservative solution
US5371077A (en) 1992-08-03 1994-12-06 William Marsh Rice University Side chain derivatized 15-oxygenated sterols, methods of using them and a process for preparing them
US6303632B1 (en) 1992-09-03 2001-10-16 Sepracor Inc. Compositions for treating allergic and other disorders using norastemizole in combination with other active ingredients
US5474757A (en) 1992-10-16 1995-12-12 Rutgers University Prevention of acetaminophen overdose toxicity with organosulfur compounds
US5260340A (en) 1992-11-19 1993-11-09 Baranowitz Steven A Prevention and amelioration of acetaminophen toxicity with beta-carotene
US5724957A (en) 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US5599659A (en) * 1993-03-11 1997-02-04 Breonics, Inc. Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate
US5409944A (en) 1993-03-12 1995-04-25 Merck Frosst Canada, Inc. Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
FI955144A7 (fi) 1993-04-30 1995-10-31 Procter & Gamble Päällystetyt farmaseuttiset koostumukset
US5466865A (en) 1993-07-02 1995-11-14 Ibah, Inc. Neomorphic ibuprofen and methods of using same
US5587368A (en) 1993-11-30 1996-12-24 New York University Administration of a 27-hydroxycholesterol or related compound or sterol-27-hydroxylase stimulant to prevent restenosis following vascular endothelial injury
GB9403857D0 (en) 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
US5458879A (en) 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US6077533A (en) 1994-05-25 2000-06-20 Purdue Pharma L.P. Powder-layered oral dosage forms
US6482831B1 (en) 1994-06-16 2002-11-19 Entropin, Inc. Covalently coupled benzoylecgonine, egconine and ecgonidine derivatives
US5612061A (en) 1994-10-14 1997-03-18 Rabkin; Simon W. Composition and method for the treatment of premenstrual syndrome
JP3828603B2 (ja) * 1994-12-26 2006-10-04 株式会社日清製粉グループ本社 ピロリジノン誘導体を含有する医薬組成物
US5538959A (en) 1995-01-26 1996-07-23 Mauskop; Alexander Analgesic composition for treatment of migraine headaches
US5639475A (en) 1995-02-03 1997-06-17 Eurand America, Incorporated Effervescent microcapsules
US5703073A (en) 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US6645953B2 (en) 1995-06-23 2003-11-11 Novo Nordisk A/S Meiosis regulating compounds
US5654334A (en) 1995-06-23 1997-08-05 Oklahoma Medical Research Foundation Analgesic use of N-L-α-aspartyl-L-phenylalanine 1-methyl ester
WO1997000884A1 (en) 1995-06-23 1997-01-09 Novo Nordisk A/S Meiosis regulating compounds
US5840731A (en) 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
JPH0971581A (ja) * 1995-09-08 1997-03-18 Nisshin Flour Milling Co Ltd ラクタム誘導体
US5897880A (en) 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
AU730495B2 (en) 1995-11-13 2001-03-08 North West University Administration media for analgesic, antiinflammatory and anti-pyretic drugs containing nitrous oxide and pharmaceutical compositions containing such media and drugs
US6391337B2 (en) 1995-11-15 2002-05-21 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US5733578A (en) 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
US6214386B1 (en) 1995-11-22 2001-04-10 Recordati, S.A. Prompt-release oral pharmaceutical compositions for extemporaneous suspensions
WO1997020819A1 (en) 1995-12-06 1997-06-12 Eli Lilly And Company Composition for treating pain
US5773031A (en) 1996-02-27 1998-06-30 L. Perrigo Company Acetaminophen sustained-release formulation
AU725556B2 (en) 1996-03-25 2000-10-12 Eli Lilly And Company Method for treating pain
WO1997035584A1 (en) 1996-03-25 1997-10-02 Eli Lilly And Company Method for treating pain
US5837729A (en) 1996-04-26 1998-11-17 Metatron, Inc. Methods for treating and preventing HIV infection using acetaminophen and derivatives thereof
US5739139A (en) 1996-06-20 1998-04-14 Mcneil-Ppc, Inc. Acetaminophen and dimenhydrinate analgesics
JPH1072421A (ja) * 1996-07-02 1998-03-17 Nisshin Flour Milling Co Ltd イミド誘導体
US5914129A (en) 1996-07-23 1999-06-22 Mauskop; Alexander Analgesic composition for treatment of migraine headaches
FR2751875B1 (fr) 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
US5872145A (en) 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
WO1998007447A1 (en) 1996-08-23 1998-02-26 Algos Pharmaceutical Corporation Anticonvulsant containing composition for treating neuropathic pain
US5919826A (en) 1996-10-24 1999-07-06 Algos Pharmaceutical Corporation Method of alleviating pain
US6077539A (en) 1996-11-12 2000-06-20 Pozen, Inc. Treatment of migraine headache
US5776462A (en) 1996-12-10 1998-07-07 Sage R&D, A Partnership Pogostemon cablin extract for inhibiting H. influenzae adhesion and treating otitis media or sore throat
DE69739663D1 (de) 1996-12-31 2009-12-31 Antioxidant Pharmaceuticals Co Pharmazeutische glutathionpräparate und methoden zu dern verabreichung
WO1998032434A1 (en) 1997-01-29 1998-07-30 Chong Kun Dang Corp. New analgesic composition
US5948787A (en) 1997-02-28 1999-09-07 Alza Corporation Compositions containing opiate analgesics
US5891477A (en) 1997-03-28 1999-04-06 Biohybrid Technologies, Inc. Non-steroidal anti-inflammatory agents inhibition of fibrotic response to an implanted device
US5972916A (en) 1997-07-14 1999-10-26 Bristol-Myers Squibb Company Compositions containing the nonprescription combination of acetaminophen, aspirin and caffeine to alleviate the pain and symptoms of migraine
US6077530A (en) 1997-07-28 2000-06-20 Weinstein; Robert Analgesic dosage units for coordinated administration
GB2328443B (en) 1997-08-21 2001-09-05 Reckitt & Colmann Prod Ltd In situ formation of pharmaceutically acceptable polymeric material
US5942530A (en) 1997-08-28 1999-08-24 Eli Lilly And Company Method for treating pain
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US5965167A (en) 1997-10-07 1999-10-12 Sanghvi; Pradeepkumar P. Dosage units
US6162647A (en) 1997-10-14 2000-12-19 Stephens; James Matthew Method for removing interfering substances from a urine sample using a chemical oxidant
US20030153541A1 (en) 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
DK1041987T3 (da) 1997-12-22 2006-08-21 Euro Celtique Sa Oral farmaceutisk doseringsform omfattende en kombination af en opioid-agonist og naltrexon
US6413512B1 (en) 1998-02-13 2002-07-02 National Enzyme Company Composition and method for treating disease by increasing activated α2 macroglobulin in the blood and extravascular tissue
US6245357B1 (en) 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US6007841A (en) 1998-03-13 1999-12-28 Algos Pharmaceutical Corporation Analgesic composition and method for treating pain
US6242493B1 (en) 1998-03-13 2001-06-05 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
US6054451A (en) 1998-04-21 2000-04-25 Algos Pharmaceutical Corporation Analgesic composition and method for alleviating pain
KR20010043558A (ko) 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
BR9910415A (pt) 1998-05-13 2001-01-09 Novo Nordisk As Novos compostos, uso de compostos, e, processo de regular a meiose
US6254891B1 (en) 1998-09-03 2001-07-03 Ascent Pediatrics, Inc. Extended release acetaminophen
US6126967A (en) 1998-09-03 2000-10-03 Ascent Pediatrics Extended release acetaminophen particles
US6485747B1 (en) 1998-10-30 2002-11-26 Monsanto Company Coated active tablet(s)
CA2350531A1 (en) 1998-11-13 2000-05-25 Smriti Iyengar Method for treating pain
US6627234B1 (en) 1998-12-15 2003-09-30 Wm. Wrigley Jr. Company Method of producing active agent coated chewing gum products
US6586023B1 (en) 1998-12-15 2003-07-01 Wm. Wrigley Jr. Company Process for controlling release of active agents from a chewing gum coating and product thereof
US6139861A (en) 1999-01-14 2000-10-31 Friedman; Mark Intraoral topical anti-inflammatory treatment for relief of migraine, tension-type headache, post-traumatic headache facial pain, and cervical-muscle spasm
US7374779B2 (en) 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6383527B1 (en) 1999-03-04 2002-05-07 Nps Pharmaceuticals, Inc. Compositions comprising valerian extracts, isovaleric acid or derivatives thereof with a NSAID
US6365338B1 (en) 1999-04-27 2002-04-02 David A. Bull Organ preservative solution containing trehalose, anti-oxidant, cations and an energy source
BR0010197A (pt) 1999-04-30 2002-07-16 Arch Dev Corp Derivados de esteróides
US20060025393A1 (en) 1999-04-30 2006-02-02 Shutsung Liao Steroid derivatives
US6383515B2 (en) 1999-05-28 2002-05-07 Sawyer Maryjean Solvent system for enhancing solubility
US6566361B2 (en) 1999-06-30 2003-05-20 Laboratories, Upsa Azapirone pain treatment
FR2795645B1 (fr) 1999-06-30 2001-09-21 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
EP1196332A1 (en) 1999-07-14 2002-04-17 The Coca-Cola Company Vented promotional compartment
US6642243B1 (en) 1999-07-22 2003-11-04 Ashkan Imanzahrai Migraine medicine and method for treating same
EP1239848A2 (en) 1999-09-01 2002-09-18 University of British Columbia Compositions and methods for modulating hdl cholesterol and triglyceride levels
US6544548B1 (en) 1999-09-13 2003-04-08 Keraplast Technologies, Ltd. Keratin-based powders and hydrogel for pharmaceutical applications
CA2384782A1 (en) 1999-09-14 2001-03-22 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
ES2213601T3 (es) 1999-09-14 2004-09-01 MERCK FROSST CANADA & CO. Acidos carboxilicos y acilsulfonamidas, composiciones que contienen tales compuestos y procedimiento de tratamiento.
US6524623B1 (en) 1999-11-12 2003-02-25 Milton Hodosh Therapeutic compositions and methods of use thereof
KR100416242B1 (ko) 1999-12-22 2004-01-31 주식회사 삼양사 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법
US6492334B1 (en) 1999-12-30 2002-12-10 Robert James Generale Tri-compound analgesic for treating inflammation and pain
JP4018312B2 (ja) 2000-02-21 2007-12-05 株式会社ルネサステクノロジ 無線通信装置
US6841544B2 (en) 2000-02-23 2005-01-11 Bioselect Innovations, Inc. Composition and method for treating the effects of diseases and maladies
US6787164B2 (en) 2000-02-23 2004-09-07 Bioselect Innovations, Inc. Composition and method for treating the effects of diseases and maladies
US7611830B2 (en) 2000-04-10 2009-11-03 The United States Of America As Represented By The Department Of Veteran's Affairs Device to lavage a blood vessel
US6686390B2 (en) 2000-05-22 2004-02-03 Dr. Reddy's Laboratories Limited Compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them
US6306842B1 (en) 2000-06-02 2001-10-23 Medinox, Inc. Protected forms of a combination of pharmacologically active agents and uses therefor
US6833362B2 (en) 2000-06-12 2004-12-21 Ward Beryl Bowen, Jr. Method and composition for the accelerated in vivo removal of ethanol
US6429223B1 (en) 2000-06-23 2002-08-06 Medinox, Inc. Modified forms of pharmacologically active agents and uses therefor
US6355666B1 (en) 2000-06-23 2002-03-12 Medinox, Inc. Protected forms of pharmacologically active agents and uses therefor
US20040047910A1 (en) 2000-07-07 2004-03-11 Christian Beckett Suppository and composition comprising at least one polyethylene glycol
AU7907301A (en) 2000-07-28 2002-02-13 Christopher J Murphy Transplant media
US6225295B1 (en) 2000-09-27 2001-05-01 Frederick H. Hausheer Method of treating acetaminophen overdose
US6924273B2 (en) 2000-10-03 2005-08-02 Scott W. Pierce Chondroprotective/restorative compositions and methods of use thereof
US6391886B1 (en) 2000-12-04 2002-05-21 The Procter & Gamble Company Oral compositions having improved consumer aesthetics
US6440983B1 (en) 2000-12-21 2002-08-27 Mary Theresa Frank-Kollman Compositions and methods for relieving headache symptoms in aspirin-sensitive headache sufferers
WO2002062302A2 (en) 2001-02-08 2002-08-15 The University Of Chicago Steroidal derivatives
US20020164310A1 (en) 2001-03-02 2002-11-07 Mgvs Ltd. Nucleic acid constructs, cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension
US6566401B2 (en) 2001-03-30 2003-05-20 The Board Of Trustees Of The Leland Stanford Junior University N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity
US6593331B2 (en) 2001-04-17 2003-07-15 Laboratories Upsa Method for treatment of pain
US6622856B2 (en) 2001-04-25 2003-09-23 Johnson & Johnson Consumer Companies, Inc. Relief kit
CN100360550C (zh) 2001-05-03 2008-01-09 芝加哥大学 肝脏x受体激动剂
US20070197484A1 (en) 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
EP1392262A1 (en) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
EP2260837A1 (en) 2001-06-01 2010-12-15 Pozen, Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US6475526B1 (en) 2001-06-05 2002-11-05 Jeffrey B. Smith Zinc containing compositions for anti-viral use
US6602518B2 (en) 2001-06-28 2003-08-05 Wm. Wrigley Jr. Company Chewable product including active ingredient
US6613346B2 (en) 2001-06-28 2003-09-02 Wm. Wrigley, Jr. Company Chewable product including active ingredient
WO2003039480A2 (en) 2001-11-08 2003-05-15 The University Of Chicago Method of treating disorder related to high cholesterol concentration
US6569439B1 (en) 2001-11-13 2003-05-27 Noville Inc. Process for making personal care compositions comprising titanium dioxide and personal care compositions made by the process
US6509380B1 (en) 2001-12-14 2003-01-21 Marshall University Research Corporation Method of treating iron overload with acetaminophen
US6828328B1 (en) 2002-03-01 2004-12-07 Ucb S.A. Analgesic combination of muscarinic agonists
AU2003236297B2 (en) 2002-03-28 2008-12-11 Meiji Seika Kaisha, Ltd. Composition for storing organ and method of storing organ
DE10262084B4 (de) 2002-05-17 2009-12-24 Dr. Franz Köhler Chemie GmbH Protektive Lösung zur Verhinderung von Ischämieschäden
HRP20050149B1 (hr) 2002-08-20 2014-09-12 Otsuka Pharmaceutical Co., Ltd. Formulacija aripiprazol kompleksa i postupak
US6702850B1 (en) 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis
EP1475434A1 (en) 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
CN1980899B (zh) 2004-06-30 2013-07-24 詹森药业有限公司 作为parp抑制剂的喹唑啉酮衍生物
US20060047022A1 (en) 2004-08-30 2006-03-02 Craig Daniel H Thermoplastic compositions including inorganic particulates
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
DE102006021181B3 (de) 2006-05-06 2007-05-03 Laux, Thomas, Dr. Zahnprothesen-Trägerimplantat
CN101134100B (zh) * 2006-09-01 2010-11-10 复旦大学 类固醇激素合成急性调节蛋白在制备防治脂肪肝药物中的用途
JP5120998B2 (ja) 2006-09-06 2013-01-16 国立大学法人 東京医科歯科大学 組織、細胞又は臓器の保存液
GB0625965D0 (en) 2006-12-23 2007-02-07 Renovo Ltd Medicaments for wound healing
US8831674B2 (en) 2007-09-27 2014-09-09 Multi-Tech Systems, Inc. Message server
CN101951929A (zh) 2007-12-28 2011-01-19 水株式会社 用于治疗或预防的外用剂
US20100291533A1 (en) * 2008-01-04 2010-11-18 Soon Ha Kim Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect
US8329450B2 (en) 2008-08-01 2012-12-11 Biomedinnovations, Llc Methods and apparatus for organ support
WO2011035005A2 (en) 2009-09-16 2011-03-24 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for reducing the risk of agent-induced liver toxicity
WO2011077245A2 (en) 2009-12-23 2011-06-30 Fondazione Centro San Raffaele Del Monte Tabor Compositions
EP2608781A4 (en) 2010-08-04 2014-01-29 Tixupharma INCLUSION COMPLEXES OF CYCLODEXTRINS WITH SPERMIDINE AND PROLIFERATIVE BZW. REPAIR COMPOSITIONS THEREWITH
KR101739816B1 (ko) 2010-12-01 2017-05-25 주식회사유한양행 레바프라잔 또는 그의 염을 함유하는 주사용 액제 조성물 또는 주사용 건조 분말
US9585380B2 (en) 2011-09-02 2017-03-07 Temple University—Of the Commonwealth System of Higher Education SSAT mRNA translation repression and activation
SMT202300232T1 (it) 2011-09-08 2023-09-06 Sage Therapeutics Inc Steroidi neuroattivi, composizioni e relativi usi
US8665030B2 (en) 2011-12-14 2014-03-04 Taiwan Semiconductor Manufacturing Company, Ltd. Voltage-controlled oscillator
EP2874709B1 (en) 2012-07-17 2018-12-19 The Regents Of The University Of Michigan Inhibitors of alpha-crystallin aggregation for the treatment for cataract
EP2842547A1 (en) 2013-08-27 2015-03-04 Freund Pharmatec Ltd. Improved fenofibrate compositions
IL294448A (en) 2013-12-24 2022-09-01 Univ Virginia Commonwealth Uses of oxidized cholesterol sulfates
CN112121171A (zh) 2014-10-07 2020-12-25 萨奇治疗股份有限公司 神经活性化合物及其使用方法
EA034524B1 (ru) 2014-10-10 2020-02-17 Вирджиния Коммонвелт Юниверсити Сульфаты окисленного холестерина для лечения пониженной лептиновой активности
CA2993196A1 (en) 2015-07-27 2017-02-02 Catacore, Inc Compositions for the treatment of cataracts
EP3493810A4 (en) 2016-08-02 2020-04-08 Durect Corporation COMPOSITIONS COMPRISING OXYGENATED CHOLESTEROL SULFATE AND AT LEAST POLYALKYLENE GLYCOL, CARBOXYMETHYLCELLULOSE OR POLYOXYLGLYCERIDE
KR102593667B1 (ko) 2016-08-02 2023-10-24 버지니아 커먼웰스 유니버시티 5-콜레스텐-3, 25-디올, 3-술페이트 (25hc3s) 또는 이의 약학적으로 허용 가능한 염, 및 적어도 하나의 시클릭 올리고당을 포함하는 조성물
US20190374554A1 (en) 2016-08-02 2019-12-12 Virginia Commonwealth University Use of oxygenated cholesterol sulfates (ocs) to treat inflammatory skin disease and skin lesions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120264816A1 (en) 2011-04-06 2012-10-18 Shunlin Ren Sulfated Oxysterol and Oxysterol Sulfation by Hydroxysterol Sulfotransferase Promote Lipid Homeostasis and Liver Proliferation
WO2013154752A1 (en) 2012-04-12 2013-10-17 Virgina Commonwealth University A NOVEL CHOLESTEROL METABOLITE, 5-CHOLESTEN, 3β-25-DIOL, DISULFATE (25HCDS) FOR THERAPY OF METABOLIC DISORDERS, HYPERLIPIDEMIA, DIABETES, FATTY LIVER DISEASES AND ATHEROSCLEROSIS

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Ａｍ．Ｊ．Ｐｈｙｓｉｏｌ．Ｅｎｄｏｃｒｉｎｏｌ．Ｍｅｔａｂ．，２０１２，３０２，ｐ．Ｅ７８８－Ｅ７９９（ＵＲＬ，ｄｏｉ：１０．１１５２／ａｊｐｅｎｄｏ．０００３３７．２０１１）
Ａｍ．Ｊ．Ｐｈｙｓｉｏｌ．Ｒｅｎａｌ．Ｐｈｙｓｉｏｌ．，２００８，２９４（５），ｐ．Ｆ１０３２－１０４７
Ａｍｅｒｉｃａｎ Ｊｏｕｒｎａｌ ｏｆ Ｎｅｐｈｒｏｌｏｇｙ，２００３，２３，ｐ．２６７－２７６（ＵＲＬ，ＤＯＩ：１０．１１５９／００００７２０８８）
Ｃｌｉｎ．Ｊ．Ａｍ．Ｓｏｃ．Ｎｅｐｈｒｏｌ．，２０１１，６，２５６７－２５７２
Ｊ．Ａｍ．Ｃｏｌｌ．Ｃａｒｄｉｏｌ．，２００８、５１（１５），ｐ．１４４８－１４５４
Ｊｏｕｒｎａｌ ｏｆ Ｓｕｒｇｉｃａｌ Ｒｅｓｅａｒｃｈ，２０１２，１８２，ｐ．１７６－１８４（ＵＲＬ，ｈｔｔｐ：／／ｄｘ．ｄｏｉ．ｏｒｇ／１０．１０１６／ｊ．ｊｓｓ．２０１２．０８．０２０）
Ｋｉｄｎｅｙ Ｉｎｔ．２００５，６８，ｓｕｐ９９，ｐ５８７－５９３
Ｋｉｄｎｅｙ Ｉｎｔｅｒｎａｔｉｏｎａｌ，２００７，７１，ｐ．１２３２－１２３９
Ｎｅｐｈｒｏｌ．Ｄｉａｌ．Ｔｒａｎｓｐｌａｎｔ．，２０１２，２７，ｐ．１７４－１８１（ＵＲＬ，ｄｏｉ：１０．１０９３／ｎｄｔ／ｇｆｒ２４０）

Also Published As

Publication number Publication date
HUE057649T2 (hu) 2022-05-28
IL246339B (en) 2021-04-29
AU2022204450B2 (en) 2024-08-29
KR102655918B1 (ko) 2024-04-09
CN105899213A (zh) 2016-08-24
MX2019003547A (es) 2019-06-17
MX389828B (es) 2025-03-20
US20230310458A1 (en) 2023-10-05
TW202137988A (zh) 2021-10-16
RS63474B1 (sr) 2022-08-31
CY1125028T1 (el) 2023-06-09
ES2906865T3 (es) 2022-04-20
CA3195252A1 (en) 2015-07-02
EP3086793A4 (en) 2018-01-10
CN105899213B (zh) 2021-03-16
BR112016014611A8 (pt) 2023-05-09
EA201691305A1 (ru) 2016-10-31
JP2023002544A (ja) 2023-01-10
MX2016008459A (es) 2016-10-14
SI3086793T1 (sl) 2022-10-28
AU2014369916A1 (en) 2016-06-16
HRP20220978T1 (hr) 2022-11-11
IL246339A0 (en) 2016-08-31
KR20240051283A (ko) 2024-04-19
LT3639828T (lt) 2022-03-25
SMT202200094T1 (it) 2022-05-12
JP7289030B2 (ja) 2023-06-09
IL294448A (en) 2022-09-01
KR20230065387A (ko) 2023-05-11
US10272097B2 (en) 2019-04-30
SMT202200314T1 (it) 2022-09-14
TWI734665B (zh) 2021-08-01
PL3639828T3 (pl) 2022-05-02
WO2015100312A1 (en) 2015-07-02
CN113599388A (zh) 2021-11-05
EP3639828B8 (en) 2022-01-05
LT3086793T (lt) 2022-08-25
EA201990684A1 (ru) 2020-12-30
US20190350945A1 (en) 2019-11-21
EP3086793A1 (en) 2016-11-02
TW202313060A (zh) 2023-04-01
TW202348234A (zh) 2023-12-16
MX377151B (es) 2025-03-07
MX2023002679A (es) 2023-04-03
AU2020202891A1 (en) 2020-05-21
BR122022016077A2 (OSRAM) 2017-08-08
TW201609110A (zh) 2016-03-16
ZA201603580B (en) 2017-09-27
US20210046091A1 (en) 2021-02-18
EP4082550A1 (en) 2022-11-02
HUE059914T2 (hu) 2023-01-28
HRP20220112T1 (hr) 2022-04-15
DK3086793T3 (da) 2022-08-01
TWI816417B (zh) 2023-09-21
US11612609B2 (en) 2023-03-28
ES2922501T3 (es) 2022-09-15
JP7364759B2 (ja) 2023-10-18
CA2932300C (en) 2023-07-18
SI3639828T1 (sl) 2022-04-29
US20170014429A1 (en) 2017-01-19
EA032777B1 (ru) 2019-07-31
JP2017505761A (ja) 2017-02-23
JP2020186241A (ja) 2020-11-19
DK3639828T3 (da) 2022-02-14
EP3086793B1 (en) 2022-05-11
US10786517B2 (en) 2020-09-29
AU2022204450A1 (en) 2022-07-14
PT3086793T (pt) 2022-07-20
MX2021011641A (es) 2023-03-10
PL3086793T3 (pl) 2023-01-30
IL282010B (en) 2022-07-01
IL282010A (en) 2021-05-31
RS63002B1 (sr) 2022-03-31
EP3639828A1 (en) 2020-04-22
CA2932300A1 (en) 2015-07-02
TWI782421B (zh) 2022-11-01
BR112016014611A2 (pt) 2017-08-08
BR122022016077A8 (pt) 2023-05-09
JP2024009887A (ja) 2024-01-23
KR102530119B1 (ko) 2023-05-08
AU2020202891B2 (en) 2022-03-24
PT3639828T (pt) 2022-02-04
KR20160102301A (ko) 2016-08-29
CY1125475T1 (el) 2025-05-09
EP3639828B1 (en) 2021-12-01

Similar Documents

Publication Publication Date Title
JP7364759B2 (ja) 酸素化コレステロール硫酸塩（ｏｃｓ）の使用
HK40084160A (en) Use of oxygenated cholesterol sulfates (ocs) for treating acute liver failure
HK40015796B (en) Use of oxygenated cholesterol sulfates (ocs) for treating acute liver failure
HK40015796A (en) Use of oxygenated cholesterol sulfates (ocs) for treating acute liver failure
HK1230918A1 (en) Uses of oxygenated cholesterol sulfates (ocs) for the treatment of kidney dysfunction
HK1230918B (en) Uses of oxygenated cholesterol sulfates (ocs) for the treatment of kidney dysfunction

Legal Events

Date Code Title Description
RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20170208

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20170208

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171215

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171215

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180129

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180731

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180731

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20181018

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190709

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190930

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200109

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200317

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200715

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20200715

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20200728

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20200804

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20201002

C211 Notice of termination of reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C211

Effective date: 20201006

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20210601

C302 Record of communication

Free format text: JAPANESE INTERMEDIATE CODE: C302

Effective date: 20210608

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20210810

C302 Record of communication

Free format text: JAPANESE INTERMEDIATE CODE: C302

Effective date: 20210928

C13 Notice of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: C13

Effective date: 20211005

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211020

C23 Notice of termination of proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C23

Effective date: 20211116

C03 Trial/appeal decision taken

Free format text: JAPANESE INTERMEDIATE CODE: C03

Effective date: 20211216

C30A Notification sent

Free format text: JAPANESE INTERMEDIATE CODE: C3012

Effective date: 20211216

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220112

R150 Certificate of patent or registration of utility model

Ref document number: 7009059

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313118

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250