JP2017190338A5 - - Google Patents
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- JP2017190338A5 JP2017190338A5 JP2017141932A JP2017141932A JP2017190338A5 JP 2017190338 A5 JP2017190338 A5 JP 2017190338A5 JP 2017141932 A JP2017141932 A JP 2017141932A JP 2017141932 A JP2017141932 A JP 2017141932A JP 2017190338 A5 JP2017190338 A5 JP 2017190338A5
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- Prior art keywords
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- 239000000203 mixture Substances 0.000 claims 26
- 239000003112 inhibitor Substances 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 125000001931 aliphatic group Chemical group 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 230000027455 binding Effects 0.000 claims 7
- 125000004122 cyclic group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical group 0.000 claims 7
- 125000002015 acyclic group Chemical group 0.000 claims 6
- 125000002252 acyl group Chemical group 0.000 claims 6
- 125000002723 alicyclic group Chemical group 0.000 claims 6
- -1 heteroaliphatic Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 229940079156 Proteasome inhibitor Drugs 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 239000003207 proteasome inhibitor Substances 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- 102100022537 Histone deacetylase 6 Human genes 0.000 claims 4
- 101000899330 Homo sapiens Histone deacetylase 6 Proteins 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 239000002184 metal Substances 0.000 claims 4
- 229910052751 metal Inorganic materials 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000005110 aryl thio group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 125000005368 heteroarylthio group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 229960000575 trastuzumab Drugs 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 229960003048 vinblastine Drugs 0.000 claims 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 2
- 230000004572 zinc-binding Effects 0.000 claims 2
- LHTLDFWBUPYUDR-DUXPYHPUSA-N (2e)-3-(2,4-dichlorophenyl)-n-hydroxyacrylamide Chemical compound ONC(=O)\C=C\C1=CC=C(Cl)C=C1Cl LHTLDFWBUPYUDR-DUXPYHPUSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 1
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 1
- 108010069236 Goserelin Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- BHUZLJOUHMBZQY-YXQOSMAKSA-N N-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide Chemical group C1=CC(CO)=CC=C1[C@H]1O[C@@H](C=2C=CC(NC(=O)CCCCCCC(=O)NO)=CC=2)O[C@@H](CSC=2OC(=C(N=2)C=2C=CC=CC=2)C=2C=CC=CC=2)C1 BHUZLJOUHMBZQY-YXQOSMAKSA-N 0.000 claims 1
- WWGBHDIHIVGYLZ-UHFFFAOYSA-N N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester Chemical compound C1=CC(NC(=O)OC(C)(C)C)=CC=C1C1=CC(C(=O)NCCCCCCC(=O)NO)=NO1 WWGBHDIHIVGYLZ-UHFFFAOYSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229940022663 acetate Drugs 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 229960002932 anastrozole Drugs 0.000 claims 1
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 239000003124 biologic agent Substances 0.000 claims 1
- 210000000601 blood cell Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 229960004117 capecitabine Drugs 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960001904 epirubicin Drugs 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 229960000255 exemestane Drugs 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 229960001751 fluoxymesterone Drugs 0.000 claims 1
- YLRFCQOZQXIBAB-RBZZARIASA-N fluoxymesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)C[C@@H]2O YLRFCQOZQXIBAB-RBZZARIASA-N 0.000 claims 1
- 229960002258 fulvestrant Drugs 0.000 claims 1
- 229960003690 goserelin acetate Drugs 0.000 claims 1
- 210000003780 hair follicle Anatomy 0.000 claims 1
- 230000011132 hemopoiesis Effects 0.000 claims 1
- 229940125697 hormonal agent Drugs 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 150000002596 lactones Chemical class 0.000 claims 1
- 229960003881 letrozole Drugs 0.000 claims 1
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 229950002736 marizomib Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- BLCLNMBMMGCOAS-UHFFFAOYSA-N n-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amin Chemical compound C1CCC(C(=O)NNC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 BLCLNMBMMGCOAS-UHFFFAOYSA-N 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 1
- 229960003978 pamidronic acid Drugs 0.000 claims 1
- 210000004180 plasmocyte Anatomy 0.000 claims 1
- 229960004622 raloxifene Drugs 0.000 claims 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 claims 1
- NGWSFRIPKNWYAO-SHTIJGAHSA-N salinosporamide A Chemical compound C([C@@H]1[C@H](O)[C@]23C(=O)O[C@]2([C@H](C(=O)N3)CCCl)C)CCC=C1 NGWSFRIPKNWYAO-SHTIJGAHSA-N 0.000 claims 1
- 229960001603 tamoxifen Drugs 0.000 claims 1
- 229960005026 toremifene Drugs 0.000 claims 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
- 229960004276 zoledronic acid Drugs 0.000 claims 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 1
- TUDMPUMHSNEXAA-UHFFFAOYSA-N COCC(C1)OC(c(cc2)ccc2NC(CCCCCCC(NO)=O)=O)OC1c1ccccc1 Chemical compound COCC(C1)OC(c(cc2)ccc2NC(CCCCCCC(NO)=O)=O)OC1c1ccccc1 TUDMPUMHSNEXAA-UHFFFAOYSA-N 0.000 description 1
- REUGDYNZHDZZIH-UHFFFAOYSA-N OCCSCC(C1)OC(c(cc2)ccc2NC(CCCCCCC(NO)=O)=O)OC1c1ccccc1 Chemical compound OCCSCC(C1)OC(c(cc2)ccc2NC(CCCCCCC(NO)=O)=O)OC1c1ccccc1 REUGDYNZHDZZIH-UHFFFAOYSA-N 0.000 description 1
- SBJYFIPULXMNTC-UHFFFAOYSA-N ONC(CCCCCCC(Nc1ccc(C(OC(CSc2ccccn2)C2)OC2c2ccccc2)cc1)=O)=O Chemical compound ONC(CCCCCCC(Nc1ccc(C(OC(CSc2ccccn2)C2)OC2c2ccccc2)cc1)=O)=O SBJYFIPULXMNTC-UHFFFAOYSA-N 0.000 description 1
- YHZHZWCKPHXEEJ-UHFFFAOYSA-N ONC(CCCCCCC(Nc1ccc(C(OC(CSc2ccncc2)C2)OC2c2ccccc2)cc1)=O)=O Chemical compound ONC(CCCCCCC(Nc1ccc(C(OC(CSc2ccncc2)C2)OC2c2ccccc2)cc1)=O)=O YHZHZWCKPHXEEJ-UHFFFAOYSA-N 0.000 description 1
- KKTAUKYIHGLBHO-UHFFFAOYSA-N ONC(CCCCCCC(Nc1ccc(C(OC(CSc2nc(-c3ccccc3)c(-c3ccccc3)[o]2)C2)OC2c2ccccc2)cc1)=O)=O Chemical compound ONC(CCCCCCC(Nc1ccc(C(OC(CSc2nc(-c3ccccc3)c(-c3ccccc3)[o]2)C2)OC2c2ccccc2)cc1)=O)=O KKTAUKYIHGLBHO-UHFFFAOYSA-N 0.000 description 1
- ALLSZRCEHXENHK-UHFFFAOYSA-N ONC(CCCCCCC(Nc1ccc(C(OC(CSc2nc(cccc3)c3[s]2)C2)OC2c2ccccc2)cc1)=O)=O Chemical compound ONC(CCCCCCC(Nc1ccc(C(OC(CSc2nc(cccc3)c3[s]2)C2)OC2c2ccccc2)cc1)=O)=O ALLSZRCEHXENHK-UHFFFAOYSA-N 0.000 description 1
- XDHCWRUUURVEJL-UHFFFAOYSA-N [O-][N+](c1ccc(C2OC(c(cc3)ccc3NC(CCCCCCC(NO)=O)=O)OC(CSc3nc(-c4ccccc4)c(-c4ccccc4)[o]3)C2)cc1)=O Chemical compound [O-][N+](c1ccc(C2OC(c(cc3)ccc3NC(CCCCCCC(NO)=O)=O)OC(CSc3nc(-c4ccccc4)c(-c4ccccc4)[o]3)C2)cc1)=O XDHCWRUUURVEJL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66447005P | 2005-03-22 | 2005-03-22 | |
| US60/664,470 | 2005-03-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014180860A Division JP2014224158A (ja) | 2005-03-22 | 2014-09-05 | タンパク質分解障害の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017190338A JP2017190338A (ja) | 2017-10-19 |
| JP2017190338A5 true JP2017190338A5 (https=) | 2017-11-30 |
Family
ID=37024659
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503207A Expired - Lifetime JP5744376B2 (ja) | 2005-03-22 | 2006-03-22 | タンパク質分解障害の治療 |
| JP2012266681A Withdrawn JP2013053157A (ja) | 2005-03-22 | 2012-12-05 | タンパク質分解障害の治療 |
| JP2014180860A Withdrawn JP2014224158A (ja) | 2005-03-22 | 2014-09-05 | タンパク質分解障害の治療 |
| JP2017141932A Pending JP2017190338A (ja) | 2005-03-22 | 2017-07-21 | タンパク質分解障害の治療 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503207A Expired - Lifetime JP5744376B2 (ja) | 2005-03-22 | 2006-03-22 | タンパク質分解障害の治療 |
| JP2012266681A Withdrawn JP2013053157A (ja) | 2005-03-22 | 2012-12-05 | タンパク質分解障害の治療 |
| JP2014180860A Withdrawn JP2014224158A (ja) | 2005-03-22 | 2014-09-05 | タンパク質分解障害の治療 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8999289B2 (https=) |
| EP (3) | EP2491926B1 (https=) |
| JP (4) | JP5744376B2 (https=) |
| CN (1) | CN101495116A (https=) |
| AU (1) | AU2006226861B2 (https=) |
| CA (2) | CA2601706C (https=) |
| SG (1) | SG171690A1 (https=) |
| WO (1) | WO2006102557A2 (https=) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| CN101495116A (zh) | 2005-03-22 | 2009-07-29 | 哈佛大学校长及研究员协会 | 蛋白降解病症的治疗 |
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-
2006
- 2006-03-22 CN CNA2006800177289A patent/CN101495116A/zh active Pending
- 2006-03-22 EP EP12150229.8A patent/EP2491926B1/en not_active Expired - Lifetime
- 2006-03-22 EP EP18157889.9A patent/EP3354265A1/en not_active Withdrawn
- 2006-03-22 EP EP06748614A patent/EP1861126A4/en not_active Withdrawn
- 2006-03-22 SG SG201103495-6A patent/SG171690A1/en unknown
- 2006-03-22 WO PCT/US2006/010676 patent/WO2006102557A2/en not_active Ceased
- 2006-03-22 AU AU2006226861A patent/AU2006226861B2/en not_active Ceased
- 2006-03-22 JP JP2008503207A patent/JP5744376B2/ja not_active Expired - Lifetime
- 2006-03-22 US US11/386,959 patent/US8999289B2/en active Active
- 2006-03-22 CA CA2601706A patent/CA2601706C/en not_active Expired - Fee Related
- 2006-03-22 CA CA2937005A patent/CA2937005A1/en not_active Abandoned
-
2012
- 2012-12-05 JP JP2012266681A patent/JP2013053157A/ja not_active Withdrawn
-
2014
- 2014-09-05 JP JP2014180860A patent/JP2014224158A/ja not_active Withdrawn
-
2015
- 2015-04-06 US US14/679,800 patent/US9572854B2/en not_active Expired - Lifetime
-
2017
- 2017-01-09 US US15/401,902 patent/US10172905B1/en not_active Expired - Lifetime
- 2017-07-21 JP JP2017141932A patent/JP2017190338A/ja active Pending
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