JP2017019880A5 - - Google Patents
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- Publication number
- JP2017019880A5 JP2017019880A5 JP2016216160A JP2016216160A JP2017019880A5 JP 2017019880 A5 JP2017019880 A5 JP 2017019880A5 JP 2016216160 A JP2016216160 A JP 2016216160A JP 2016216160 A JP2016216160 A JP 2016216160A JP 2017019880 A5 JP2017019880 A5 JP 2017019880A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- lorazepam
- composition according
- release
- delayed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 claims 20
- 229960004391 lorazepam Drugs 0.000 claims 20
- 239000011324 bead Substances 0.000 claims 15
- 230000003111 delayed effect Effects 0.000 claims 9
- 238000013268 sustained release Methods 0.000 claims 7
- 239000012730 sustained-release form Substances 0.000 claims 7
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 238000007922 dissolution test Methods 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 4
- 238000013270 controlled release Methods 0.000 claims 4
- 239000002702 enteric coating Substances 0.000 claims 4
- 238000009505 enteric coating Methods 0.000 claims 4
- 238000004090 dissolution Methods 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 229920003086 cellulose ether Polymers 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 208000029364 generalized anxiety disease Diseases 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Chemical class 0.000 claims 1
- 229920002689 polyvinyl acetate Chemical class 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Chemical class 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Chemical class 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361750797P | 2013-01-09 | 2013-01-09 | |
| US61/750,797 | 2013-01-09 | ||
| US201361762833P | 2013-02-08 | 2013-02-08 | |
| US61/762,833 | 2013-02-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551869A Division JP6039823B2 (ja) | 2013-01-09 | 2014-01-09 | ロラゼパムの徐放性製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017019880A JP2017019880A (ja) | 2017-01-26 |
| JP2017019880A5 true JP2017019880A5 (enExample) | 2017-03-02 |
Family
ID=50064764
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551869A Active JP6039823B2 (ja) | 2013-01-09 | 2014-01-09 | ロラゼパムの徐放性製剤 |
| JP2016216160A Abandoned JP2017019880A (ja) | 2013-01-09 | 2016-11-04 | ロラゼパムの徐放性製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551869A Active JP6039823B2 (ja) | 2013-01-09 | 2014-01-09 | ロラゼパムの徐放性製剤 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US8999393B1 (enExample) |
| EP (1) | EP2943185B1 (enExample) |
| JP (2) | JP6039823B2 (enExample) |
| KR (1) | KR102318274B1 (enExample) |
| CN (1) | CN105209018B (enExample) |
| AU (1) | AU2014205440B2 (enExample) |
| BR (1) | BR112015016304A8 (enExample) |
| CA (1) | CA2897302C (enExample) |
| CL (1) | CL2015001920A1 (enExample) |
| CY (1) | CY1123933T1 (enExample) |
| DK (1) | DK2943185T3 (enExample) |
| ES (1) | ES2856181T3 (enExample) |
| HR (1) | HRP20210236T1 (enExample) |
| HU (1) | HUE054005T2 (enExample) |
| IL (1) | IL239777B (enExample) |
| LT (1) | LT2943185T (enExample) |
| MX (1) | MX367364B (enExample) |
| NZ (1) | NZ710860A (enExample) |
| PE (1) | PE20151432A1 (enExample) |
| PH (1) | PH12015501534B1 (enExample) |
| PL (1) | PL2943185T3 (enExample) |
| PT (1) | PT2943185T (enExample) |
| RS (1) | RS61857B1 (enExample) |
| RU (1) | RU2678324C2 (enExample) |
| SG (1) | SG11201505349RA (enExample) |
| SI (1) | SI2943185T1 (enExample) |
| SM (1) | SMT202100091T1 (enExample) |
| UA (1) | UA117233C2 (enExample) |
| WO (1) | WO2014110245A1 (enExample) |
| ZA (1) | ZA201505082B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190021180A (ko) * | 2017-08-22 | 2019-03-05 | 아주대학교산학협력단 | 퇴행성 신경질환 치료용 복합 제형 조성물 |
| CN111278434A (zh) * | 2017-11-01 | 2020-06-12 | 埃奇蒙特医药信托有限公司 | 劳拉西泮的耐酒精口服药物组合物 |
Family Cites Families (56)
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| NL298071A (enExample) | 1963-06-04 | |||
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3786813A (en) | 1972-12-27 | 1974-01-22 | Alza Corp | Drug delivery device with self actuated mechanism for retaining device in selected area |
| DD146547A5 (de) | 1978-07-15 | 1981-02-18 | Boehringer Sohn Ingelheim | Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen |
| US4361545A (en) | 1979-05-21 | 1982-11-30 | Rowell Laboratories, Inc. | Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion |
| AU552261B2 (en) * | 1980-01-21 | 1986-05-29 | Wellcome Foundation Limited, The | Use of propiophenone derivatives as adjuncts to benzo- diazepine tranquillisers |
| KR850700212A (ko) * | 1984-03-21 | 1985-12-26 | 죠지 드모트 | 서방성 약제학적 캼셀제 |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US4624847A (en) | 1985-04-22 | 1986-11-25 | Alza Corporation | Drug delivery device for programmed delivery of beneficial drug |
| IT1188212B (it) | 1985-12-20 | 1988-01-07 | Paolo Colombo | Sistema per il rilascio a velocita' controllata di sostanze attive |
| US4794001A (en) | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
| US5009895A (en) | 1990-02-02 | 1991-04-23 | Merck & Co., Inc. | Sustained release with high and low viscosity HPMC |
| IT1241417B (it) | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
| US5273758A (en) | 1991-03-18 | 1993-12-28 | Sandoz Ltd. | Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms |
| US5326570A (en) | 1991-07-23 | 1994-07-05 | Pharmavene, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
| US5795882A (en) * | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| AU682827B2 (en) | 1992-09-18 | 1997-10-23 | Astellas Pharma Inc. | Sustained-release hydrogel preparation |
| US5871776A (en) | 1995-01-31 | 1999-02-16 | Mehta; Atul M. | Controlled-release nifedipine |
| US5945125A (en) | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
| US5567441A (en) | 1995-03-24 | 1996-10-22 | Andrx Pharmaceuticals Inc. | Diltiazem controlled release formulation |
| US6348469B1 (en) | 1995-04-14 | 2002-02-19 | Pharma Pass Llc | Solid compositions containing glipizide and polyethylene oxide |
| AU747549B2 (en) * | 1998-03-23 | 2002-05-16 | General Mills Inc. | Encapsulation of components into edible products |
| US6312728B1 (en) | 1998-07-07 | 2001-11-06 | Cascade Development, Inc. | Sustained release pharmaceutical preparation |
| US6217904B1 (en) * | 1999-04-06 | 2001-04-17 | Pharmaquest Ltd. | Pharmaceutical dosage form for pulsatile delivery of d-threo-methylphenidate and a second CNS stimulant |
| US6500459B1 (en) * | 1999-07-21 | 2002-12-31 | Harinderpal Chhabra | Controlled onset and sustained release dosage forms and the preparation thereof |
| US6610271B2 (en) * | 2000-05-10 | 2003-08-26 | University Of Kentucky Research Foundation | System and method for intranasal administration of lorazepam |
| EP1347748A2 (en) | 2000-12-05 | 2003-10-01 | MacGregor, Alexander | Hydrostatic delivery system for controlled delivery of agent |
| EP1250937B1 (en) | 2001-04-09 | 2009-05-13 | Rohm And Haas Company | Controlled dissolution of active ingredients |
| EA005537B1 (ru) | 2001-07-10 | 2005-04-28 | Тева Фармасьютикал Индастриес Лтд. | Система доставки лекарственного вещества по нулевому порядку, нулевому порядку - двухстадийной, возрастающей или убывающей доставки препарата |
| US20030044458A1 (en) * | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
| US6703045B2 (en) | 2001-08-21 | 2004-03-09 | Council Of Scientific & Industrial Research | Composition and method for maintaining blood glucose level |
| US20030050620A1 (en) * | 2001-09-07 | 2003-03-13 | Isa Odidi | Combinatorial type controlled release drug delivery device |
| US6663888B2 (en) | 2001-12-14 | 2003-12-16 | Eurand Pharmaceuticals Ltd. | Pulsatile release histamine H2 antagonist dosage form |
| KR100540035B1 (ko) * | 2002-02-01 | 2005-12-29 | 주식회사 태평양 | 다단계 경구 약물 방출 제어 시스템 |
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| US8216609B2 (en) | 2002-08-05 | 2012-07-10 | Torrent Pharmaceuticals Limited | Modified release composition of highly soluble drugs |
| DE10250084A1 (de) * | 2002-10-25 | 2004-05-06 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US7670627B2 (en) | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
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| TW200824693A (en) * | 2006-08-28 | 2008-06-16 | Jazz Pharmaceuticals Inc | Pharmaceutical compositions of clonazepam and methods of use thereof |
| KR101468053B1 (ko) * | 2006-08-31 | 2014-12-02 | 앱탈리스 파마테크, 인코포레이티드 | 약 염기성 약물의 고용체를 포함하는 약물 전달 시스템 |
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| EP2097067A2 (en) | 2006-12-05 | 2009-09-09 | University Of The Witwatersrand, Johannesburg | A heterogeneously configured multiparticulate gastrointestinal drug delivery system |
| EP2285219B1 (en) * | 2008-05-08 | 2018-07-18 | Supernus Pharmaceuticals, Inc. | Controlled release formulations of alprazolam |
| KR20110075011A (ko) | 2008-11-10 | 2011-07-05 | (주)아모레퍼시픽 | 서방성 미립자 및 이의 제조방법 |
| US20120135050A1 (en) | 2010-07-08 | 2012-05-31 | Wellesley Pharmaceuticals, Llc | Extended-release formulation for reducing the frequency of urination and method of use thereof |
-
2014
- 2014-01-08 US US14/150,375 patent/US8999393B1/en active Active
- 2014-01-09 PE PE2015001248A patent/PE20151432A1/es active IP Right Grant
- 2014-01-09 EP EP14702977.1A patent/EP2943185B1/en active Active
- 2014-01-09 SI SI201431768T patent/SI2943185T1/sl unknown
- 2014-01-09 DK DK14702977.1T patent/DK2943185T3/da active
- 2014-01-09 CN CN201480012336.8A patent/CN105209018B/zh active Active
- 2014-01-09 JP JP2015551869A patent/JP6039823B2/ja active Active
- 2014-01-09 BR BR112015016304A patent/BR112015016304A8/pt not_active Application Discontinuation
- 2014-01-09 PL PL14702977T patent/PL2943185T3/pl unknown
- 2014-01-09 HU HUE14702977A patent/HUE054005T2/hu unknown
- 2014-01-09 KR KR1020157020977A patent/KR102318274B1/ko active Active
- 2014-01-09 CA CA2897302A patent/CA2897302C/en active Active
- 2014-01-09 UA UAA201507784A patent/UA117233C2/uk unknown
- 2014-01-09 MX MX2015008756A patent/MX367364B/es active IP Right Grant
- 2014-01-09 SG SG11201505349RA patent/SG11201505349RA/en unknown
- 2014-01-09 NZ NZ710860A patent/NZ710860A/en unknown
- 2014-01-09 LT LTEP14702977.1T patent/LT2943185T/lt unknown
- 2014-01-09 WO PCT/US2014/010854 patent/WO2014110245A1/en not_active Ceased
- 2014-01-09 RU RU2015128915A patent/RU2678324C2/ru active
- 2014-01-09 PT PT147029771T patent/PT2943185T/pt unknown
- 2014-01-09 RS RS20210047A patent/RS61857B1/sr unknown
- 2014-01-09 AU AU2014205440A patent/AU2014205440B2/en active Active
- 2014-01-09 HR HRP20210236TT patent/HRP20210236T1/hr unknown
- 2014-01-09 ES ES14702977T patent/ES2856181T3/es active Active
- 2014-01-09 SM SM20210091T patent/SMT202100091T1/it unknown
-
2015
- 2015-03-04 US US14/639,027 patent/US20150174078A1/en not_active Abandoned
- 2015-07-05 IL IL239777A patent/IL239777B/en active IP Right Grant
- 2015-07-06 CL CL2015001920A patent/CL2015001920A1/es unknown
- 2015-07-07 PH PH12015501534A patent/PH12015501534B1/en unknown
- 2015-07-15 ZA ZA2015/05082A patent/ZA201505082B/en unknown
- 2015-12-23 US US14/757,465 patent/US20160228378A1/en not_active Abandoned
-
2016
- 2016-11-04 JP JP2016216160A patent/JP2017019880A/ja not_active Abandoned
-
2021
- 2021-01-21 CY CY20211100046T patent/CY1123933T1/el unknown
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