UA117233C2 - Композиція з тривалим вивільненням лоразепаму - Google Patents

Композиція з тривалим вивільненням лоразепаму

Info

Publication number
UA117233C2
UA117233C2 UAA201507784A UAA201507784A UA117233C2 UA 117233 C2 UA117233 C2 UA 117233C2 UA A201507784 A UAA201507784 A UA A201507784A UA A201507784 A UAA201507784 A UA A201507784A UA 117233 C2 UA117233 C2 UA 117233C2
Authority
UA
Ukraine
Prior art keywords
lorazepam
sustained release
beads
release formulations
composition
Prior art date
Application number
UAA201507784A
Other languages
English (en)
Inventor
Дуглас А. Селтел
Майкл ВАШОН
Original Assignee
Еджмонт Фармасьютікал Ллк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50064764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA117233(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Еджмонт Фармасьютікал Ллк filed Critical Еджмонт Фармасьютікал Ллк
Publication of UA117233C2 publication Critical patent/UA117233C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Винахід стосується фармацевтичної композиції для постачання лоразепаму способом пролонгованого вивільнення, який здійснюється за допомогою фармацевтичних гранул з тривалим вивільненням лоразепаму і гранул з затримкою тривалого вивільнення лоразепаму.
UAA201507784A 2013-01-09 2014-01-09 Композиція з тривалим вивільненням лоразепаму UA117233C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361750797P 2013-01-09 2013-01-09
US201361762833P 2013-02-08 2013-02-08
PCT/US2014/010854 WO2014110245A1 (en) 2013-01-09 2014-01-09 Sustained release formulations of lorazepam

Publications (1)

Publication Number Publication Date
UA117233C2 true UA117233C2 (uk) 2018-07-10

Family

ID=50064764

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201507784A UA117233C2 (uk) 2013-01-09 2014-01-09 Композиція з тривалим вивільненням лоразепаму

Country Status (30)

Country Link
US (3) US8999393B1 (uk)
EP (1) EP2943185B1 (uk)
JP (2) JP6039823B2 (uk)
KR (1) KR102318274B1 (uk)
CN (1) CN105209018B (uk)
AU (1) AU2014205440B2 (uk)
BR (1) BR112015016304A8 (uk)
CA (1) CA2897302C (uk)
CL (1) CL2015001920A1 (uk)
CY (1) CY1123933T1 (uk)
DK (1) DK2943185T3 (uk)
ES (1) ES2856181T3 (uk)
HK (1) HK1213770A1 (uk)
HR (1) HRP20210236T1 (uk)
HU (1) HUE054005T2 (uk)
IL (1) IL239777B (uk)
LT (1) LT2943185T (uk)
MX (1) MX367364B (uk)
NZ (1) NZ710860A (uk)
PE (1) PE20151432A1 (uk)
PH (1) PH12015501534B1 (uk)
PL (1) PL2943185T3 (uk)
PT (1) PT2943185T (uk)
RS (1) RS61857B1 (uk)
RU (1) RU2678324C2 (uk)
SG (1) SG11201505349RA (uk)
SI (1) SI2943185T1 (uk)
UA (1) UA117233C2 (uk)
WO (1) WO2014110245A1 (uk)
ZA (1) ZA201505082B (uk)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019039836A2 (ko) * 2017-08-22 2019-02-28 아주대학교산학협력단 퇴행성 신경질환 치료용 복합 제형 조성물
JP7110366B2 (ja) * 2017-11-01 2022-08-01 エッジモント・ファーマシューティカルズ・リミテッド・ライアビリティ・カンパニー・トラスト ロラゼパムのアルコール耐性経口用医薬組成物

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Also Published As

Publication number Publication date
WO2014110245A1 (en) 2014-07-17
DK2943185T3 (da) 2021-02-15
RU2015128915A (ru) 2017-02-10
CN105209018B (zh) 2019-06-25
IL239777B (en) 2019-03-31
LT2943185T (lt) 2021-03-10
CY1123933T1 (el) 2022-05-27
US20150174078A1 (en) 2015-06-25
EP2943185A1 (en) 2015-11-18
SI2943185T1 (sl) 2021-04-30
KR20150118119A (ko) 2015-10-21
US20160228378A1 (en) 2016-08-11
US20150110874A1 (en) 2015-04-23
CA2897302C (en) 2022-05-31
MX367364B (es) 2019-08-16
BR112015016304A8 (pt) 2018-01-23
CN105209018A (zh) 2015-12-30
PL2943185T3 (pl) 2022-01-17
IL239777A0 (en) 2015-08-31
RS61857B1 (sr) 2021-06-30
SG11201505349RA (en) 2015-08-28
AU2014205440B2 (en) 2018-07-05
US8999393B1 (en) 2015-04-07
EP2943185B1 (en) 2020-11-18
JP2017019880A (ja) 2017-01-26
NZ710860A (en) 2020-05-29
BR112015016304A2 (pt) 2017-07-11
RU2678324C2 (ru) 2019-01-28
HK1213770A1 (zh) 2016-07-15
ZA201505082B (en) 2021-04-28
PT2943185T (pt) 2021-02-18
HRP20210236T1 (hr) 2021-03-19
PH12015501534A1 (en) 2015-10-05
PE20151432A1 (es) 2015-09-23
ES2856181T3 (es) 2021-09-27
KR102318274B1 (ko) 2021-10-26
MX2015008756A (es) 2016-03-31
JP2016504390A (ja) 2016-02-12
CL2015001920A1 (es) 2016-01-29
CA2897302A1 (en) 2014-07-17
AU2014205440A1 (en) 2015-08-27
PH12015501534B1 (en) 2015-10-05
HUE054005T2 (hu) 2021-08-30
JP6039823B2 (ja) 2016-12-07

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