MX367364B - Formulaciones de lorazepam de liberación sostenida. - Google Patents
Formulaciones de lorazepam de liberación sostenida.Info
- Publication number
- MX367364B MX367364B MX2015008756A MX2015008756A MX367364B MX 367364 B MX367364 B MX 367364B MX 2015008756 A MX2015008756 A MX 2015008756A MX 2015008756 A MX2015008756 A MX 2015008756A MX 367364 B MX367364 B MX 367364B
- Authority
- MX
- Mexico
- Prior art keywords
- lorazepam
- sustained release
- beads
- release formulations
- composition
- Prior art date
Links
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 title abstract 5
- 229960004391 lorazepam Drugs 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000013268 sustained release Methods 0.000 title abstract 3
- 239000012730 sustained-release form Substances 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000011324 bead Substances 0.000 abstract 3
- 230000002035 prolonged effect Effects 0.000 abstract 2
- 230000003111 delayed effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una composición farmacéutica para administrar lorazepam en una forma prolongada se logra con las perlas farmacéuticas de lorazepam de liberación prolongada. La composición contiene típicamente perlas de lorazepam de liberación sostenida y perlas de lorazepam de liberación sostenida retardada. La composición puede proporcionar una dosificación una vez al día que mantiene un efecto terapéutico de 24 horas bajo condiciones de estado permanente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361750797P | 2013-01-09 | 2013-01-09 | |
US201361762833P | 2013-02-08 | 2013-02-08 | |
PCT/US2014/010854 WO2014110245A1 (en) | 2013-01-09 | 2014-01-09 | Sustained release formulations of lorazepam |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015008756A MX2015008756A (es) | 2016-03-31 |
MX367364B true MX367364B (es) | 2019-08-16 |
Family
ID=50064764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015008756A MX367364B (es) | 2013-01-09 | 2014-01-09 | Formulaciones de lorazepam de liberación sostenida. |
Country Status (30)
Country | Link |
---|---|
US (3) | US8999393B1 (es) |
EP (1) | EP2943185B1 (es) |
JP (2) | JP6039823B2 (es) |
KR (1) | KR102318274B1 (es) |
CN (1) | CN105209018B (es) |
AU (1) | AU2014205440B2 (es) |
BR (1) | BR112015016304A8 (es) |
CA (1) | CA2897302C (es) |
CL (1) | CL2015001920A1 (es) |
CY (1) | CY1123933T1 (es) |
DK (1) | DK2943185T3 (es) |
ES (1) | ES2856181T3 (es) |
HK (1) | HK1213770A1 (es) |
HR (1) | HRP20210236T1 (es) |
HU (1) | HUE054005T2 (es) |
IL (1) | IL239777B (es) |
LT (1) | LT2943185T (es) |
MX (1) | MX367364B (es) |
NZ (1) | NZ710860A (es) |
PE (1) | PE20151432A1 (es) |
PH (1) | PH12015501534A1 (es) |
PL (1) | PL2943185T3 (es) |
PT (1) | PT2943185T (es) |
RS (1) | RS61857B1 (es) |
RU (1) | RU2678324C2 (es) |
SG (1) | SG11201505349RA (es) |
SI (1) | SI2943185T1 (es) |
UA (1) | UA117233C2 (es) |
WO (1) | WO2014110245A1 (es) |
ZA (1) | ZA201505082B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190021180A (ko) * | 2017-08-22 | 2019-03-05 | 아주대학교산학협력단 | 퇴행성 신경질환 치료용 복합 제형 조성물 |
KR20200078601A (ko) * | 2017-11-01 | 2020-07-01 | 엣지몬트 파마슈티칼스 엘엘씨 트러스트 | 로라제팜의 내알코올성 경구 약제학적 조성물 |
Family Cites Families (56)
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US4361545A (en) | 1979-05-21 | 1982-11-30 | Rowell Laboratories, Inc. | Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion |
SE8100276L (sv) * | 1980-01-21 | 1981-07-22 | Wellcome Found | Farmaceutiskt aktiv komposition omfattande ketoner och heterocykliska foreningar |
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IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
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IT1188212B (it) | 1985-12-20 | 1988-01-07 | Paolo Colombo | Sistema per il rilascio a velocita' controllata di sostanze attive |
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US5009895A (en) | 1990-02-02 | 1991-04-23 | Merck & Co., Inc. | Sustained release with high and low viscosity HPMC |
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US5273758A (en) | 1991-03-18 | 1993-12-28 | Sandoz Ltd. | Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms |
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US5871776A (en) | 1995-01-31 | 1999-02-16 | Mehta; Atul M. | Controlled-release nifedipine |
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KR20140114887A (ko) * | 2006-08-31 | 2014-09-29 | 앱탈리스 파마테크, 인코포레이티드 | 약 염기성 약물의 고용체를 포함하는 약물 전달 시스템 |
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WO2010053337A2 (ko) | 2008-11-10 | 2010-05-14 | (주)아모레퍼시픽 | 서방성 미립자 및 이의 제조방법 |
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-
2014
- 2014-01-08 US US14/150,375 patent/US8999393B1/en active Active
- 2014-01-09 AU AU2014205440A patent/AU2014205440B2/en active Active
- 2014-01-09 BR BR112015016304A patent/BR112015016304A8/pt not_active Application Discontinuation
- 2014-01-09 WO PCT/US2014/010854 patent/WO2014110245A1/en active Application Filing
- 2014-01-09 PT PT147029771T patent/PT2943185T/pt unknown
- 2014-01-09 UA UAA201507784A patent/UA117233C2/uk unknown
- 2014-01-09 CN CN201480012336.8A patent/CN105209018B/zh active Active
- 2014-01-09 RS RS20210047A patent/RS61857B1/sr unknown
- 2014-01-09 EP EP14702977.1A patent/EP2943185B1/en active Active
- 2014-01-09 PL PL14702977T patent/PL2943185T3/pl unknown
- 2014-01-09 RU RU2015128915A patent/RU2678324C2/ru active
- 2014-01-09 JP JP2015551869A patent/JP6039823B2/ja active Active
- 2014-01-09 HU HUE14702977A patent/HUE054005T2/hu unknown
- 2014-01-09 SG SG11201505349RA patent/SG11201505349RA/en unknown
- 2014-01-09 LT LTEP14702977.1T patent/LT2943185T/lt unknown
- 2014-01-09 DK DK14702977.1T patent/DK2943185T3/da active
- 2014-01-09 SI SI201431768T patent/SI2943185T1/sl unknown
- 2014-01-09 NZ NZ710860A patent/NZ710860A/en unknown
- 2014-01-09 CA CA2897302A patent/CA2897302C/en active Active
- 2014-01-09 KR KR1020157020977A patent/KR102318274B1/ko active IP Right Grant
- 2014-01-09 MX MX2015008756A patent/MX367364B/es active IP Right Grant
- 2014-01-09 PE PE2015001248A patent/PE20151432A1/es active IP Right Grant
- 2014-01-09 ES ES14702977T patent/ES2856181T3/es active Active
-
2015
- 2015-03-04 US US14/639,027 patent/US20150174078A1/en not_active Abandoned
- 2015-07-05 IL IL239777A patent/IL239777B/en active IP Right Grant
- 2015-07-06 CL CL2015001920A patent/CL2015001920A1/es unknown
- 2015-07-07 PH PH12015501534A patent/PH12015501534A1/en unknown
- 2015-07-15 ZA ZA2015/05082A patent/ZA201505082B/en unknown
- 2015-12-23 US US14/757,465 patent/US20160228378A1/en not_active Abandoned
-
2016
- 2016-02-17 HK HK16101696.7A patent/HK1213770A1/zh unknown
- 2016-11-04 JP JP2016216160A patent/JP2017019880A/ja not_active Abandoned
-
2021
- 2021-01-21 CY CY20211100046T patent/CY1123933T1/el unknown
- 2021-02-11 HR HRP20210236TT patent/HRP20210236T1/hr unknown
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