JP2017014164A5 - - Google Patents
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- JP2017014164A5 JP2017014164A5 JP2015133935A JP2015133935A JP2017014164A5 JP 2017014164 A5 JP2017014164 A5 JP 2017014164A5 JP 2015133935 A JP2015133935 A JP 2015133935A JP 2015133935 A JP2015133935 A JP 2015133935A JP 2017014164 A5 JP2017014164 A5 JP 2017014164A5
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- vitamin
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- 239000000203 mixture Substances 0.000 claims 7
- 210000000845 Cartilage Anatomy 0.000 claims 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 2
- LNTHITQWFMADLM-UHFFFAOYSA-N Gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims 2
- 229960002442 Glucosamine Drugs 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims 1
- 229960001230 Asparagine Drugs 0.000 claims 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N Aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims 1
- 229960003438 Aspartame Drugs 0.000 claims 1
- 108010011485 Aspartame Proteins 0.000 claims 1
- 229960002747 Betacarotene Drugs 0.000 claims 1
- 229960005069 Calcium Drugs 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L Calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 240000000218 Cannabis sativa Species 0.000 claims 1
- 229940074393 Chlorogenic acid Drugs 0.000 claims 1
- CWVRJTMFETXNAD-JUHZACGLSA-N Chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 claims 1
- 102000000503 Collagen Type II Human genes 0.000 claims 1
- 108010041390 Collagen Type II Proteins 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims 1
- 229940074391 Gallic acid Drugs 0.000 claims 1
- 229960002989 Glutamic Acid Drugs 0.000 claims 1
- 229960002885 Histidine Drugs 0.000 claims 1
- 240000005979 Hordeum vulgare Species 0.000 claims 1
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 1
- 229960000310 ISOLEUCINE Drugs 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 229940053207 Niacin Drugs 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 229960005190 Phenylalanine Drugs 0.000 claims 1
- 244000046146 Pueraria lobata Species 0.000 claims 1
- 235000010575 Pueraria lobata Nutrition 0.000 claims 1
- 229960002477 Riboflavin Drugs 0.000 claims 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 1
- 229940081973 S-Adenosylmethionine Drugs 0.000 claims 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-O S-adenosyl-L-methionine zwitterion Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H]([NH3+])C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-O 0.000 claims 1
- 229940068459 SODIUM PANTOTHENATE Drugs 0.000 claims 1
- 229940082568 Selenium Drugs 0.000 claims 1
- 229940091258 Selenium supplements Drugs 0.000 claims 1
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 1
- 229940088594 Vitamin Drugs 0.000 claims 1
- 229940045997 Vitamin A Drugs 0.000 claims 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
- 229930003451 Vitamin B1 Natural products 0.000 claims 1
- 229930003779 Vitamin B12 Natural products 0.000 claims 1
- 229930003471 Vitamin B2 Natural products 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- 229940046010 Vitamin K Drugs 0.000 claims 1
- 229930003448 Vitamin K Natural products 0.000 claims 1
- 229940019697 Vitamin K containing hemostatics Drugs 0.000 claims 1
- 240000007329 Zingiber officinale Species 0.000 claims 1
- 235000006886 Zingiber officinale Nutrition 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 229960001570 ademetionine Drugs 0.000 claims 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 235000010357 aspartame Nutrition 0.000 claims 1
- 239000000605 aspartame Substances 0.000 claims 1
- OENHQHLEOONYIE-VYAWBVGESA-N beta-Carotene Natural products CC=1CCCC(C)(C)C=1\C=C\C(\C)=C/C=C/C(/C)=C\C=C\C=C(\C)/C=C/C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-VYAWBVGESA-N 0.000 claims 1
- 235000013734 beta-carotene Nutrition 0.000 claims 1
- 239000011648 beta-carotene Substances 0.000 claims 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 235000001465 calcium Nutrition 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000001368 chlorogenic acid Nutrition 0.000 claims 1
- 125000003346 cobalamin group Chemical group 0.000 claims 1
- 229960004729 colecalciferol Drugs 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 235000004515 gallic acid Nutrition 0.000 claims 1
- 235000008397 ginger Nutrition 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 235000014304 histidine Nutrition 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 235000014705 isoleucine Nutrition 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 235000010755 mineral Nutrition 0.000 claims 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 235000013824 polyphenols Nutrition 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002633 protecting Effects 0.000 claims 1
- 230000001681 protective Effects 0.000 claims 1
- 229960003471 retinol Drugs 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 239000011669 selenium Substances 0.000 claims 1
- 235000011649 selenium Nutrition 0.000 claims 1
- GQTHJBOWLPZUOI-FJXQXJEOSA-M sodium D-pantothenate Chemical compound [Na+].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O GQTHJBOWLPZUOI-FJXQXJEOSA-M 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- -1 sucrose fatty acid ester Chemical class 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 229960003495 thiamine Drugs 0.000 claims 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 229960004295 valine Drugs 0.000 claims 1
- 239000005418 vegetable material Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 235000019155 vitamin A Nutrition 0.000 claims 1
- 239000011719 vitamin A Substances 0.000 claims 1
- 235000010374 vitamin B1 Nutrition 0.000 claims 1
- 239000011691 vitamin B1 Substances 0.000 claims 1
- 235000019163 vitamin B12 Nutrition 0.000 claims 1
- 239000011715 vitamin B12 Substances 0.000 claims 1
- 235000019164 vitamin B2 Nutrition 0.000 claims 1
- 239000011716 vitamin B2 Substances 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 150000003700 vitamin C derivatives Chemical class 0.000 claims 1
- 235000005282 vitamin D3 Nutrition 0.000 claims 1
- 239000011647 vitamin D3 Substances 0.000 claims 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 1
- 229940021056 vitamin D3 Drugs 0.000 claims 1
- 235000019168 vitamin K Nutrition 0.000 claims 1
- 239000011712 vitamin K Substances 0.000 claims 1
- 150000003721 vitamin K derivatives Chemical class 0.000 claims 1
- 150000003722 vitamin derivatives Chemical class 0.000 claims 1
- 229930003231 vitamins Natural products 0.000 claims 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 1
Claims (7)
- グルコサミンと、下記（ａ）〜（ｆ）からなる群より選ばれる少なくとも１種の成分とを有効成分として含有することを特徴とする組成物。
（ａ）ステアリン酸カルシウム、アスパルテーム、及びショ糖脂肪酸エステルから選ばれる少なくとも１種の機能性添加剤
（ｂ）II型コラーゲン及びプロテオグリカンから選ばれる少なくとも１種の軟骨成分
（ｃ）ビタミンＡ、ビタミンＢ１、ビタミンＢ２、ビタミンＢ１２、ビタミンＣ、ビタミンＤ３、パントテン酸ナトリウム、ナイアシン、ビオチン、ビタミンＫ、β−カロテン、カルシウム及びセレンから選ばれる少なくとも１種のビタミン・ミネラル類
（ｄ）アラニン、アスパラギン、グルタミン酸、ヒスチジン、イソロイシン、ロイシン、フェニルアラニン、プロリン、セリン、チロシン、バリン、及びＳ−アデノシルメチオニンから選ばれる少なくとも１種のアミノ酸
（ｅ）没食子酸、及びクロロゲン酸から選ばれる少なくとも１種のポリフェノール
（ｆ）大麦、長命草、葛、稲、マキベリー、及びショウガから選ばれる少なくとも１種の植物素材 - 軟骨の保護作用を有することを特徴とする請求項１記載の組成物。
- 軟骨の保護作用を有する関節機能改善剤であることを特徴とする請求項１又は２記載の組成物。
- グルコサミンと（ａ）〜（ｆ）からなる群より選ばれる少なくとも１種の成分とからなる有効成分を添加して得たことを特徴とする請求項１〜３のいずれか記載の組成物。
- 経口用であることを特徴とする請求項１〜４のいずれか記載の組成物。
- 錠剤、カプセル剤、粉末剤、顆粒剤、又は液剤であることを特徴とする請求項５記載の組成物。
- 請求項１〜６のいずれか記載の組成物を摂取させることを特徴とする関節機能改善方法（ただし、医療行為を除く）。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015133935A JP6742575B2 (ja) | 2015-07-02 | 2015-07-02 | 関節機能改善組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015133935A JP6742575B2 (ja) | 2015-07-02 | 2015-07-02 | 関節機能改善組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019104565A Division JP6744673B2 (ja) | 2019-06-04 | 2019-06-04 | 関節機能改善組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017014164A JP2017014164A (ja) | 2017-01-19 |
| JP2017014164A5 true JP2017014164A5 (ja) | 2019-03-14 |
| JP6742575B2 JP6742575B2 (ja) | 2020-08-19 |
Family
ID=57829050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015133935A Active JP6742575B2 (ja) | 2015-07-02 | 2015-07-02 | 関節機能改善組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6742575B2 (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7404692B2 (ja) * | 2018-07-25 | 2023-12-26 | 味の素株式会社 | ジョイント機能改善用組成物 |
| CN114206330A (zh) | 2019-08-02 | 2022-03-18 | 三得利控股株式会社 | 软骨再生促进用组合物 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000074662A2 (en) * | 1999-06-07 | 2000-12-14 | University Of Sheffield | Arthritis treatment |
| JP2001072582A (ja) * | 1999-09-07 | 2001-03-21 | Sunstar Inc | 機能性経口組成物 |
| JP2001169752A (ja) * | 1999-12-15 | 2001-06-26 | Fancl Corp | 食品組成物 |
| JP2001346545A (ja) * | 2000-06-08 | 2001-12-18 | I Farm:Kk | 栄養補助食品 |
| JP3510861B2 (ja) * | 2001-01-31 | 2004-03-29 | リバテープ製薬株式会社 | 美容食品 |
| JP2003088329A (ja) * | 2001-09-19 | 2003-03-25 | Yamagami Chizuko | 鎮痛用健康補助食品 |
| US20050214413A1 (en) * | 2003-08-26 | 2005-09-29 | Mannatech, Inc. | Methods and compositions for modified release of nutritional supplements |
| JP2005232089A (ja) * | 2004-02-19 | 2005-09-02 | Aloe Seiyaku Kk | 骨量増加作用を有する機能性経口投与剤 |
| JP2006143605A (ja) * | 2004-11-16 | 2006-06-08 | Miyao Shunsuke | 繊維芽細胞の増殖を促進させる経皮投与剤および経口投与剤の製造方法 |
| JPWO2006120974A1 (ja) * | 2005-05-06 | 2008-12-18 | 株式会社アミノアップ化学 | 軟骨代謝異常疾患改善用健康食品及び医薬品組成物 |
| JP2007161688A (ja) * | 2005-12-16 | 2007-06-28 | Hiroshima Univ | 軟骨生成促進剤 |
| US20080131561A1 (en) * | 2006-12-01 | 2008-06-05 | Sahachol Food Supplies Co., Ltd. | Formulation of supplemented carrageenan jelly and manufacturing process |
| US20080318883A1 (en) * | 2007-06-19 | 2008-12-25 | Elson Corporation | Anti-aging supplement |
| JP5204578B2 (ja) * | 2007-07-31 | 2013-06-05 | 全薬工業株式会社 | 関節痛改善用組成物、関節痛改善剤、あるいは食品 |
| US20090176718A1 (en) * | 2007-10-31 | 2009-07-09 | David Ribnicky | Berry Preparations For Treatment Of Diabetes And Metabolic Syndrome |
| JP2011055712A (ja) * | 2009-09-07 | 2011-03-24 | Toyo Shinyaku Co Ltd | 大麦若葉とグルコサミンを含有する組成物 |
| WO2011048479A2 (en) * | 2009-10-21 | 2011-04-28 | Maqui New Life S.A. | Compositions that include anthocyanidins and methods of use |
| CN102224896B (zh) * | 2011-05-13 | 2012-03-21 | 营养屋(成都)生物医药有限公司 | 用于增加人体免疫力及增加骨密度的保健食品及制备方法 |
| JP5740633B2 (ja) * | 2011-06-03 | 2015-06-24 | 株式会社東洋新薬 | 錠剤の製造方法及び錠剤 |
| JP5779075B2 (ja) * | 2011-11-02 | 2015-09-16 | 株式会社ファンケル | 関節炎の予防剤 |
| EP2710901A1 (en) * | 2012-09-20 | 2014-03-26 | Symrise AG | Dietary supplement compositions |
| JP5279946B1 (ja) * | 2012-12-07 | 2013-09-04 | 富士産業株式会社 | 関節痛改善剤 |
| WO2014146039A2 (en) * | 2013-03-15 | 2014-09-18 | Human Biomolecular Research Institute | Compounds and matrices for use in bone growth and repair |
| CN104306959B (zh) * | 2014-10-16 | 2016-08-24 | 河北御芝林生物科技有限公司 | 一种治疗骨质疏松的药物组合物及其制备方法 |
-
2015
- 2015-07-02 JP JP2015133935A patent/JP6742575B2/ja active Active
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